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    Lea Grinberg, MD, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    Address675 Nelson Rising Lane
    San Francisco CA 94158
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      Collapse Biography 
      Collapse Awards and Honors
      John Doulgas French Alzheimer Foundation2010 - 2012Professorship award
      L'oreal - UNESCO 2009 - 2010For Women in Science

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      Dr. Grinberg is a neuropathologist specializing in brain aging and associated disorders. She received her medical and doctorate degrees in São Paulo, Brazil. In 2003, Dr. Grinberg, along with colleagues from several disciplines founded a brain bank in São Paulo, Brazil, which has developed into an extremely prolific and highly regarded institution. Her doctorate work was focused in the neuropathology of frontotemporal lobar degeneration. From 2007 to 2009, Dr. Grinberg acquired expertise in neuroanatomy and in the use of state-of-the-art methods for tridimensional brain reconstruction at the University of Würzburg, Germany. This knowledge is being utilized in several projects, including a R01 funded study in which the overarching goal is to provide an integrated picture of brainstem vulnerability in AD and FTLD-TDP and to incorporate this understanding into their etiopathogenesis, testing the hypothesis that selected brainstem nuclei are interdependently and consistently involved in very early stages of AD and FTLD-TDP. Currently, Dr. Grinberg is an Associate Professor at the UCSF Memory and Aging Center. In 2009, she was the recipient of the UNESCO-L'Oréal Award "For Women in Science" and in 2010 of the John Douglas French Alzheimer Foundation "Distinguished Research Scholar Award." She is also the chairwoman of the HUPO Brain Proteome Project since 2013.

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. McAleese KE, Alafuzoff I, Charidimou A, De Reuck J, Grinberg LT, Hainsworth AH, Hortobagyi T, Ince P, Jellinger K, Gao J, Kalaria RN, Kovacs GG, Kövari E, Love S, Popovic M, Skrobot O, Taipa R, Thal DR, Werring D, Wharton SB, Attems J. Post-mortem assessment in vascular dementia: advances and aspirations. BMC Med. 2016; 14(1):129. PMID: 27600683; PMCID: PMC5011905.
      2. Nishizawa A, Suemoto CK, Farias DS, Campos FM, da Silva KC, Cuelho A, Leite RE, Ferretti-Rebustini RE, Grinberg LT, Farfel JM, Jacob-Filho W, Pasqualucci CA. Association between adiposity and systemic atherosclerosis: a protocol of a cross-sectional autopsy study. Open Heart. 2016; 3(2):e000433. PMID: 27621828; PMCID: PMC5013354.
      3. Theofilas P, Ehrenberg AJ, Dunlop S, Alho AT, Nguy A, Paraizo Leite RE, Rodriguez RD, Mejia MB, Suemoto CK, de Lucena Ferretti-Rebustini RE, Polichiso L, Nascimento CF, Seeley WW, Nitrini R, Pasqualucci CA, Jacob Filho W, Rueb U, Neuhaus J, Heinsen H, Grinberg LT, et al. Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery. Alzheimers Dement. 2016 Aug 8. PMID: 27513978.
        View in: PubMed
      4. Grinberg LT, Anghinah R, Nascimento CF, Amaro E, Leite RP, Martin MD, Naslavsky MS, Takada LT, Filho WJ, Pasqualucci CA, Nitrini R, et al. Chronic Traumatic Encephalopathy Presenting as Alzheimer's Disease in a Retired Soccer Player. J Alzheimers Dis. 2016 Jul 29; 54(1):169-174. PMID: 27472879.
        View in: PubMed
      5. Ranasinghe KG, Rankin KP, Pressman PS, Perry DC, Lobach IV, Seeley WW, Coppola G, Karydas AM, Grinberg LT, Shany-Ur T, Lee SE, Rabinovici GD, Rosen HJ, Gorno-Tempini ML, Boxer AL, Miller ZA, Chiong W, DeMay M, Kramer JH, Possin KL, Sturm VE, Bettcher BM, Neylan M, Zackey DD, Nguyen LA, Ketelle R, Block N, Wu TQ, Dallich A, Russek N, Caplan A, Geschwind DH, Vossel KA, Miller BL, et al. Distinct Subtypes of Behavioral Variant Frontotemporal Dementia Based on Patterns of Network Degeneration. JAMA Neurol. 2016 Jul 18. PMID: 27429218.
        View in: PubMed
      6. Sohn PD, Tracy TE, Son HI, Zhou Y, Leite RE, Miller BL, Seeley WW, Grinberg LT, Gan L. Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment. Mol Neurodegener. 2016; 11(1):47. PMID: 27356871.
        View in: PubMed
      7. Walsh CM, Ruoff L, Varbel J, Walker K, Grinberg LT, Boxer AL, Kramer JH, Miller BL, Neylan TC. Rest-activity rhythm disruption in progressive supranuclear palsy. Sleep Med. 2016 Jun; 22:50-6. PMID: 27544836; PMCID: PMC4996365 [Available on 06/21/17].
      8. Villela D, Suemoto CK, Pasqualucci CA, Grinberg LT, Rosenberg C. Do Copy Number Changes in CACNA2D2, CACNA2D3, and CACNA1D Constitute a Predisposing Risk Factor for Alzheimer's Disease? Front Genet. 2016; 7:107. PMID: 27379157.
        View in: PubMed
      9. Rodriguez RD, Suemoto CK, Molina M, Nascimento CF, Leite RE, de Lucena Ferretti-Rebustini RE, Farfel JM, Heinsen H, Nitrini R, Ueda K, Pasqualucci CA, Jacob-Filho W, Yaffe K, Grinberg LT. Argyrophilic Grain Disease: Demographics, Clinical, and Neuropathological Features From a Large Autopsy Study. J Neuropathol Exp Neurol. 2016 Jul; 75(7):628-35. PMID: 27283329.
        View in: PubMed
      10. Santos-Santos MA, Mandelli ML, Binney RJ, Ogar J, Wilson SM, Henry ML, Hubbard HI, Meese M, Attygalle S, Rosenberg L, Pakvasa M, Trojanowski JQ, Grinberg LT, Rosen H, Boxer AL, Miller BL, Seeley WW, Gorno-Tempini ML. Features of Patients With Nonfluent/Agrammatic Primary Progressive Aphasia With Underlying Progressive Supranuclear Palsy Pathology or Corticobasal Degeneration. JAMA Neurol. 2016 Jun 1; 73(6):733-42. PMID: 27111692.
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      11. Villela D, Ramalho RF, Silva AR, Brentani H, Suemoto CK, Pasqualucci CA, Grinberg LT, Krepischi AC, Rosenberg C. Differential DNA Methylation of MicroRNA Genes in Temporal Cortex from Alzheimer's Disease Individuals. Neural Plast. 2016; 2016:2584940. PMID: 27213057.
        View in: PubMed
      12. Takada LT, Bahia VS, Guimarães HC, Costa TV, Vale TC, Rodriguez RD, Porto FH, Machado JC, Beato RG, Cesar KG, Smid J, Nascimento CF, Grinberg LT, Brucki SM, Maximino JR, Camargos ST, Chadi G, Caramelli P, Nitrini R, et al. GRN and MAPT Mutations in 2 Frontotemporal Dementia Research Centers in Brazil. Alzheimer Dis Assoc Disord. 2016 Apr 14. PMID: 27082848.
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      13. Schrötter A, Park YM, Meyer HE, Grinberg LT. Key players in neurodegenerative disorders in focus-New insights into the proteomic profile of Alzheimer's disease, schizophrenia, ALS, and multiple sclerosis-24th HUPO BPP Workshop: September 29, 2015, Vancouver, Canada. Proteomics. 2016 Apr; 16(7):1047-50. PMID: 26872682.
        View in: PubMed
      14. Rosenberg GA, Wallin A, Wardlaw JM, Markus HS, Montaner J, Wolfson L, Iadecola C, Zlokovic BV, Joutel A, Dichgans M, Duering M, Schmidt R, Korczyn AD, Grinberg LT, Chui HC, Hachinski V. Consensus statement for diagnosis of subcortical small vessel disease. J Cereb Blood Flow Metab. 2016 Jan; 36(1):6-25. PMID: 26198175.
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      15. Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B, Halliday GM, Ironside JW, Love S, Mackenzie IR, Munoz DG, Murray ME, Nelson PT, Takahashi H, Trojanowski JQ, Ansorge O, Arzberger T, Baborie A, Beach TG, Bieniek KF, Bigio EH, Bodi I, Dugger BN, Feany M, Gelpi E, Gentleman SM, Giaccone G, Hatanpaa KJ, Heale R, Hof PR, Hofer M, Hortobágyi T, Jellinger K, Jicha GA, Ince P, Kofler J, Kövari E, Kril JJ, Mann DM, Matej R, McKee AC, McLean C, Milenkovic I, Montine TJ, Murayama S, Lee EB, Rahimi J, Rodriguez RD, Rozemüller A, Schneider JA, Schultz C, Seeley W, Seilhean D, Smith C, Tagliavini F, Takao M, Thal DR, Toledo JB, Tolnay M, Troncoso JC, Vinters HV, Weis S, Wharton SB, White CL, Wisniewski T, Woulfe JM, Yamada M, Dickson DW. Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta Neuropathol. 2016 Jan; 131(1):87-102. PMID: 26659578.
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      16. Fredericks CA, Koestler M, Seeley W, Miller B, Boxer A, Grinberg LT. Primary chronic traumatic encephalopathy in an older patient with late-onset AD phenotype. Neurol Clin Pract. 2015 Dec; 5(6):475-479. PMID: 26716062.
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      17. Ferretti-Rebustini RE, Balbinotti MA, Jacob-Filho W, Rebustini F, Suemoto CK, Pasqualucci CA, Farfel JM, Leite RE, Grinberg LT, Nitrini R. Validity of the Katz Index to assess activities of daily living by informants in neuropathological studies. Rev Esc Enferm USP. 2015 Dec; 49(6):944-50. PMID: 27419678.
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      18. Oliveira-Pinto AV, Andrade-Moraes CH, Oliveira LM, Parente-Bruno DR, Santos RM, Coutinho RA, Alho AT, Leite RE, Suemoto CK, Grinberg LT, Pasqualucci CA, Jacob-Filho W, Lent R. Do age and sex impact on the absolute cell numbers of human brain regions? Brain Struct Funct. 2015 Sep 28. PMID: 26416171.
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      19. Di Lorenzo Alho AT, Suemoto CK, Polichiso L, Tampellini E, de Oliveira KC, Molina M, Santos GA, Nascimento C, Leite RE, de Lucena Ferreti-Rebustini RE, da Silva AV, Nitrini R, Pasqualucci CA, Jacob-Filho W, Heinsen H, Grinberg LT. Three-dimensional and stereological characterization of the human substantia nigra during aging. Brain Struct Funct. 2015 Sep 19. PMID: 26386691.
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      20. Nascimento C, Suemoto CK, Rodriguez RD, Alho AT, Leite RP, Farfel JM, Pasqualucci CA, Jacob-Filho W, Grinberg LT. Higher Prevalence of TDP-43 Proteinopathy in Cognitively Normal Asians: A Clinicopathological Study on a Multiethnic Sample. Brain Pathol. 2016 Mar; 26(2):177-85. PMID: 26260327.
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      21. Magraoui FE, Schrötter A, Heinsen H, Leite R, Park YM, Meyer HE, Grinberg LT. A Long Journey from Childhood to Senility: The 23rd HUPO BPP Workshop: 16-17 April 2015, São Paulo, Brazil. Proteomics. 2015 Sep; 15(17):2895-7. PMID: 26331911.
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      22. Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K. Evidence for a-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proc Natl Acad Sci U S A. 2015 Sep 22; 112(38):E5308-17. PMID: 26324905; PMCID: PMC4586853 [Available on 03/22/16].
      23. Stratmann K, Heinsen H, Korf HW, Del Turco D, Ghebremedhin E, Seidel K, Bouzrou M, Grinberg LT, Bohl J, Wharton SB, den Dunnen W, Rüb U. Precortical Phase of Alzheimer's Disease (AD)-Related Tau Cytoskeletal Pathology. Brain Pathol. 2016 May; 26(3):371-86. PMID: 26193084.
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      24. Gardner RC, Possin KL, Hess CP, Huang EJ, Grinberg LT, Nolan AL, Cohn-Sheehy BI, Ghosh PM, Lanata S, Merrilees J, Kramer JH, Berger MS, Miller BL, Yaffe K, Rabinovici GD. Evaluating and treating neurobehavioral symptoms in professional American football players: Lessons from a case series. Neurol Clin Pract. 2015 Aug; 5(4):285-295. PMID: 26336629.
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      25. Ossenkoppele R, Pijnenburg YA, Perry DC, Cohn-Sheehy BI, Scheltens NM, Vogel JW, Kramer JH, van der Vlies AE, Joie RL, Rosen HJ, van der Flier WM, Grinberg LT, Rozemuller AJ, Huang EJ, van Berckel BN, Miller BL, Barkhof F, Jagust WJ, Scheltens P, Seeley WW, Rabinovici GD. The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features. Brain. 2015 Sep; 138(Pt 9):2732-49. PMID: 26141491; PMCID: PMC4623840 [Available on 09/01/16].
      26. Molina M, Steinbach S, Park YM, Yun SY, Di Lorenzo Alho AT, Heinsen H, Grinberg LT, Marcus K, Leite RE, May C. Enrichment of single neurons and defined brain regions from human brain tissue samples for subsequent proteome analysis. J Neural Transm (Vienna). 2015 Jul; 122(7):993-1005. PMID: 26123835.
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      27. Naasan G, Rabinovici GD, Ghosh P, Elofson JD, Miller BL, Coppola G, Karydas A, Fong J, Perry D, Lee SE, Yokoyama JS, Seeley WW, Kramer JH, Weiner MW, Schuff N, Jagust WJ, Grinberg LT, Pribadi M, Yang Z, Sears R, Klein E, Wojta K, Rosen HJ. Amyloid in dementia associated with familial FTLD: not an innocent bystander. Neurocase. 2016 Feb; 22(1):76-83. PMID: 26040468; PMCID: PMC4662906 [Available on 02/01/17].
      28. Theofilas P, Dunlop S, Heinsen H, Grinberg LT. Turning on the Light Within: Subcortical Nuclei of the Isodentritic Core and their Role in Alzheimer's Disease Pathogenesis. J Alzheimers Dis. 2015 May 7; 46(1):17-34. PMID: 25720408; PMCID: PMC4550582 [Available on 05/07/16].
      29. Villeneuve S, Rabinovici GD, Cohn-Sheehy BI, Madison C, Ayakta N, Ghosh PM, La Joie R, Arthur-Bentil SK, Vogel JW, Marks SM, Lehmann M, Rosen HJ, Reed B, Olichney J, Boxer AL, Miller BL, Borys E, Jin LW, Huang EJ, Grinberg LT, DeCarli C, Seeley WW, Jagust W. Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation. Brain. 2015 Jul; 138(Pt 7):2020-33. PMID: 25953778.
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      30. Madeira C, Lourenco MV, Vargas-Lopes C, Suemoto CK, Brandão CO, Reis T, Leite RE, Laks J, Jacob-Filho W, Pasqualucci CA, Grinberg LT, Ferreira ST, Panizzutti R. d-serine levels in Alzheimer's disease: implications for novel biomarker development. Transl Psychiatry. 2015; 5:e561. PMID: 25942042; PMCID: PMC4471283.
      31. Grinberg LT, Jimenez CR, Li KW. Neuroproteomics: applications in neuroscience and neurology. Biochim Biophys Acta. 2015 Jul; 1854(7):703-4. PMID: 25858468.
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      32. Moreno F, Rabinovici GD, Karydas A, Miller Z, Hsu SC, Legati A, Fong J, Schonhaut D, Esselmann H, Watson C, Stephens ML, Kramer J, Wiltfang J, Seeley WW, Miller BL, Coppola G, Grinberg LT. A novel mutation P112H in the TARDBP gene associated with frontotemporal lobar degeneration without motor neuron disease and abundant neuritic amyloid plaques. Acta Neuropathol Commun. 2015; 3:19. PMID: 25853458; PMCID: PMC4382926.
      33. Grothe MJ, Heinsen H, Amaro E, Grinberg LT, Teipel SJ. Cognitive Correlates of Basal Forebrain Atrophy and Associated Cortical Hypometabolism in Mild Cognitive Impairment. Cereb Cortex. 2016 Jun; 26(6):2411-26. PMID: 25840425.
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      34. Sha SJ, Ghosh PM, Lee SE, Corbetta-Rastelli C, Jagust WJ, Kornak J, Rankin KP, Grinberg LT, Vinters HV, Mendez MF, Dickson DW, Seeley WW, Gorno-Tempini M, Kramer J, Miller BL, Boxer AL, Rabinovici GD. Predicting amyloid status in corticobasal syndrome using modified clinical criteria, magnetic resonance imaging and fluorodeoxyglucose positron emission tomography. Alzheimers Res Ther. 2015; 7(1):8. PMID: 25733984; PMCID: PMC4346122.
      35. Liljegren M, Naasan G, Temlett J, Perry DC, Rankin KP, Merrilees J, Grinberg LT, Seeley WW, Englund E, Miller BL. Criminal behavior in frontotemporal dementia and Alzheimer disease. JAMA Neurol. 2015 Mar; 72(3):295-300. PMID: 25559744; PMCID: PMC4432918 [Available on 03/01/16].
      36. Schrötter A, Magraoui FE, Marcus K, Park YM, Meyer HE, Grinberg LT. New milestones in the development of characterization tools for neurodegenerative diseases in proteomics: 22nd HUPO BPP Workshop 7 October 2014, Madrid, Spain. Proteomics. 2015 Feb; 15(4):627-9. PMID: 25676247.
        View in: PubMed
      37. Corradini BR, Iamashita P, Tampellini E, Farfel JM, Grinberg LT, Moreira-Filho CA. Complex network-driven view of genomic mechanisms underlying Parkinson's disease: analyses in dorsal motor vagal nucleus, locus coeruleus, and substantia nigra. Biomed Res Int. 2014; 2014:543673. PMID: 25525598; PMCID: PMC4261556.
      38. Oliveira-Pinto AV, Santos RM, Coutinho RA, Oliveira LM, Santos GB, Alho AT, Leite RE, Farfel JM, Suemoto CK, Grinberg LT, Pasqualucci CA, Jacob-Filho W, Lent R. Sexual dimorphism in the human olfactory bulb: females have more neurons and glial cells than males. PLoS One. 2014; 9(11):e111733. PMID: 25372872; PMCID: PMC4221136.
      39. Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, Hyman BT, Jellinger K, Jicha GA, Kovacs GG, Knopman DS, Kofler J, Kukull WA, Mackenzie IR, Masliah E, McKee A, Montine TJ, Murray ME, Neltner JH, Santa-Maria I, Seeley WW, Serrano-Pozo A, Shelanski ML, Stein T, Takao M, Thal DR, Toledo JB, Troncoso JC, Vonsattel JP, White CL, Wisniewski T, Woltjer RL, Yamada M, Nelson PT. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol. 2014 Dec; 128(6):755-66. PMID: 25348064; PMCID: PMC4257842 [Available on 12/01/15].
      40. Shinagawa S, Naasan G, Karydas AM, Coppola G, Pribadi M, Seeley WW, Trojanowski JQ, Miller BL, Grinberg LT. Clinicopathological Study of Patients With C9ORF72-Associated Frontotemporal Dementia Presenting With Delusions. J Geriatr Psychiatry Neurol. 2015 Jun; 28(2):99-107. PMID: 25342578; PMCID: PMC4408221 [Available on 06/01/16].
      41. Nascimento C, Kim HK, Young LT, Mendonça KM, Grinberg LT, Lafer B, Andreazza AC. Glutathione-mediated effects of lithium in decreasing protein oxidation induced by mitochondrial complex I dysfunction. J Neural Transm (Vienna). 2015 Jun; 122(6):741-6. PMID: 25261015.
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      42. van Blitterswijk M, Mullen B, Wojtas A, Heckman MG, Diehl NN, Baker MC, DeJesus-Hernandez M, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, Weintraub S, Mesulam M, Hatanpaa KJ, White CL, Neumann M, Strong MJ, Beach TG, Wszolek ZK, Lippa C, Caselli R, Petrucelli L, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Mackenzie IR, Seeley WW, Grinberg LT, Miller BL, Boylan KB, Graff-Radford NR, Boeve BF, Dickson DW, Rademakers R. Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene. Mol Neurodegener. 2014; 9:38. PMID: 25239657; PMCID: PMC4190282.
      43. Seidel K, Mahlke J, Siswanto S, Krüger R, Heinsen H, Auburger G, Bouzrou M, Grinberg LT, Wicht H, Korf HW, den Dunnen W, Rüb U. The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies. Brain Pathol. 2015 Mar; 25(2):121-35. PMID: 24995389; PMCID: PMC4397912 [Available on 03/01/16].
      44. Villela D, Schlesinger D, Suemoto CK, Grinberg LT, Rosenberg C. A microdeletion in Alzheimer's disease disrupts NAMPT gene. J Genet. 2014 Aug; 93(2):535-7. PMID: 25189255.
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      45. Silva AR, Santos AC, Farfel JM, Grinberg LT, Ferretti RE, Campos AH, Cunha IW, Begnami MD, Rocha RM, Carraro DM, de Bragança Pereira CA, Jacob-Filho W, Brentani H. Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease. PLoS One. 2014; 9(6):e99897. PMID: 24936870; PMCID: PMC4061071.
      46. Schrötter A, El Magraoui F, Gröttrup B, Heinsen H, Marcus K, Meyer HE, Park YM, Grinberg LT. Frontiers in neurodegeneration--new insights and prospects--20th HUPO BPP Workshop: 15 September 2013, Yokohama, Japan. Proteomics. 2014 Jun; 14(11):1305-7. PMID: 24903697.
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      47. Sanders DW, Kaufman SK, DeVos SL, Sharma AM, Mirbaha H, Li A, Barker SJ, Foley AC, Thorpe JR, Serpell LC, Miller TM, Grinberg LT, Seeley WW, Diamond MI. Distinct tau prion strains propagate in cells and mice and define different tauopathies. Neuron. 2014 Jun 18; 82(6):1271-88. PMID: 24857020; PMCID: PMC4171396.
      48. van Blitterswijk M, Mullen B, Heckman MG, Baker MC, DeJesus-Hernandez M, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, Weintraub S, Mesulam M, Hatanpaa KJ, White CL, Neumann M, Strong MJ, Beach TG, Wszolek ZK, Lippa C, Caselli R, Petrucelli L, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Mackenzie IR, Seeley WW, Grinberg LT, Miller BL, Boylan KB, Graff-Radford NR, Boeve BF, Dickson DW, Rademakers R. Ataxin-2 as potential disease modifier in C9ORF72 expansion carriers. Neurobiol Aging. 2014 Oct; 35(10):2421.e13-7. PMID: 24866401; PMCID: PMC4105839.
      49. El Magraoui F, Eisenacher M, Schrötter A, Kuhlmann K, Heinsen H, Andrén P, Nilsson P, Häggmark A, Schmitz G, Verhaert P, Borchers C, Yoo JS, Lee BH, Meyer HE, Grinberg LT. Developing new methods to answer old and new questions in neurodegenerative diseases: 21(st) Workshop of the HUPO Brain Proteome Project (HBPP) 23-24 January 2014, Honolulu, Hawaii. Proteomics. 2014 Jun; 14(11):1308-10. PMID: 24753468; PMCID: PMC4120949.
      50. Theofilas P, Polichiso L, Wang X, Lima LC, Alho AT, Leite RE, Suemoto CK, Pasqualucci CA, Jacob-Filho W, Heinsen H, Grinberg LT. A novel approach for integrative studies on neurodegenerative diseases in human brains. J Neurosci Methods. 2014 Apr 15; 226:171-83. PMID: 24503023; PMCID: PMC4083099.
      51. van Blitterswijk M, Mullen B, Nicholson AM, Bieniek KF, Heckman MG, Baker MC, DeJesus-Hernandez M, Finch NA, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, Weintraub S, Mesulam M, Hatanpaa KJ, White CL, Strong MJ, Beach TG, Wszolek ZK, Lippa C, Caselli R, Petrucelli L, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Mackenzie IR, Seeley WW, Grinberg LT, Miller BL, Boylan KB, Graff-Radford NR, Boeve BF, Dickson DW, Rademakers R. TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia. Acta Neuropathol. 2014 Mar; 127(3):397-406. PMID: 24385136; PMCID: PMC3944829.
      52. Scherling CS, Hall T, Berisha F, Klepac K, Karydas A, Coppola G, Kramer JH, Rabinovici G, Ahlijanian M, Miller BL, Seeley W, Grinberg LT, Rosen H, Meredith J, Boxer AL. Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degeneration. Ann Neurol. 2014 Jan; 75(1):116-26. PMID: 24242746; PMCID: PMC4020786.
      53. Kilimann I, Grothe M, Heinsen H, Alho EJ, Grinberg L, Amaro E, Dos Santos GA, da Silva RE, Mitchell AJ, Frisoni GB, Bokde AL, Fellgiebel A, Filippi M, Hampel H, Klöppel S, Teipel SJ. Subregional basal forebrain atrophy in Alzheimer's disease: a multicenter study. J Alzheimers Dis. 2014; 40(3):687-700. PMID: 24503619; PMCID: PMC4120953.
      54. Sánchez-Juan P, Ghosh PM, Hagen J, Gesierich B, Henry M, Grinberg LT, O'Neil JP, Janabi M, Huang EJ, Trojanowski JQ, Vinters HV, Gorno-Tempini M, Seeley WW, Boxer AL, Rosen HJ, Kramer JH, Miller BL, Jagust WJ, Rabinovici GD. Practical utility of amyloid and FDG-PET in an academic dementia center. Neurology. 2014 Jan 21; 82(3):230-8. PMID: 24353340; PMCID: PMC3902757.
      55. Caso F, Mandelli ML, Henry M, Gesierich B, Bettcher BM, Ogar J, Filippi M, Comi G, Magnani G, Sidhu M, Trojanowski JQ, Huang EJ, Grinberg LT, Miller BL, Dronkers N, Seeley WW, Gorno-Tempini ML. In vivo signatures of nonfluent/agrammatic primary progressive aphasia caused by FTLD pathology. Neurology. 2014 Jan 21; 82(3):239-47. PMID: 24353332; PMCID: PMC3902758.
      56. Teipel SJ, Flatz W, Ackl N, Grothe M, Kilimann I, Bokde AL, Grinberg L, Amaro E, Kljajevic V, Alho E, Knels C, Ebert A, Heinsen H, Danek A. Brain atrophy in primary progressive aphasia involves the cholinergic basal forebrain and Ayala's nucleus. Psychiatry Res. 2014 Mar 30; 221(3):187-94. PMID: 24434193; PMCID: PMC4086659.
      57. Villela D, Kimura L, Schlesinger D, Gonçalves A, Pearson PL, Suemoto CK, Pasqualucci C, Krepischi AC, Grinberg LT, Rosenberg C. Germline DNA copy number variation in individuals with Argyrophilic grain disease reveals CTNS as a plausible candidate gene. Genet Mol Biol. 2013 Dec; 36(4):498-501. PMID: 24385851; PMCID: PMC3873179.
      58. Teipel S, Heinsen H, Amaro E, Grinberg LT, Krause B, Grothe M. Cholinergic basal forebrain atrophy predicts amyloid burden in Alzheimer's disease. Neurobiol Aging. 2014 Mar; 35(3):482-91. PMID: 24176625; PMCID: PMC4120959.
      59. Andrade-Moraes CH, Oliveira-Pinto AV, Castro-Fonseca E, da Silva CG, Guimarães DM, Szczupak D, Parente-Bruno DR, Carvalho LR, Polichiso L, Gomes BV, Oliveira LM, Rodriguez RD, Leite RE, Ferretti-Rebustini RE, Jacob-Filho W, Pasqualucci CA, Grinberg LT, Lent R. Cell number changes in Alzheimer's disease relate to dementia, not to plaques and tangles. Brain. 2013 Dec; 136(Pt 12):3738-52. PMID: 24136825; PMCID: PMC3859218.
      60. Schrötter A, Magraoui FE, Gröttrup B, Wiltfang J, Heinsen H, Marcus K, Meyer HE, Grinberg LT, Park YM. Early diagnosis of neurodegenerative diseases - the long awaited Holy Grail and bottleneck of modern brain research - 19th HUPO BPP workshop: May 22-24, 2013, Dortmund, Germany. Proteomics. 2013 Oct; 13(20):2938-41. PMID: 24108682; PMCID: PMC4086650.
      61. Ribeiro PF, Ventura-Antunes L, Gabi M, Mota B, Grinberg LT, Farfel JM, Ferretti-Rebustini RE, Leite RE, Filho WJ, Herculano-Houzel S. The human cerebral cortex is neither one nor many: neuronal distribution reveals two quantitatively different zones in the gray matter, three in the white matter, and explains local variations in cortical folding. Front Neuroanat. 2013; 7:28. PMID: 24032005; PMCID: PMC3759024.
      62. Plum S, Helling S, Theiss C, Leite RE, May C, Jacob-Filho W, Eisenacher M, Kuhlmann K, Meyer HE, Riederer P, Grinberg LT, Gerlach M, Marcus K. Combined enrichment of neuromelanin granules and synaptosomes from human substantia nigra pars compacta tissue for proteomic analysis. J Proteomics. 2013 Dec 6; 94:202-6. PMID: 23917253; PMCID: PMC4083096.
      63. Farfel JM, Nitrini R, Suemoto CK, Grinberg LT, Ferretti RE, Leite RE, Tampellini E, Lima L, Farias DS, Neves RC, Rodriguez RD, Menezes PR, Fregni F, Bennett DA, Pasqualucci CA, Jacob Filho W. Very low levels of education and cognitive reserve: a clinicopathologic study. Neurology. 2013 Aug 13; 81(7):650-7. PMID: 23873971; PMCID: PMC3775692.
      64. Perry DC, Lehmann M, Yokoyama JS, Karydas A, Lee JJ, Coppola G, Grinberg LT, Geschwind D, Seeley WW, Miller BL, Rosen H, Rabinovici G. Progranulin mutations as risk factors for Alzheimer disease. JAMA Neurol. 2013 Jun; 70(6):774-8. PMID: 23609919; PMCID: PMC3743672.
      65. Miller ZA, Rankin KP, Graff-Radford NR, Takada LT, Sturm VE, Cleveland CM, Criswell LA, Jaeger PA, Stan T, Heggeli KA, Hsu SC, Karydas A, Khan BK, Grinberg LT, Gorno-Tempini ML, Boxer AL, Rosen HJ, Kramer JH, Coppola G, Geschwind DH, Rademakers R, Seeley WW, Wyss-Coray T, Miller BL. TDP-43 frontotemporal lobar degeneration and autoimmune disease. J Neurol Neurosurg Psychiatry. 2013 Sep; 84(9):956-62. PMID: 23543794; PMCID: PMC3840954.
      66. Grinberg LT, Wang X, Wang C, Sohn PD, Theofilas P, Sidhu M, Arevalo JB, Heinsen H, Huang EJ, Rosen H, Miller BL, Gan L, Seeley WW. Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation. Acta Neuropathol. 2013 Apr; 125(4):581-93. PMID: 23371364; PMCID: PMC3692283.
      67. Grinberg LT, Nitrini R, Suemoto CK, Lucena Ferretti-Rebustini RE, Leite RE, Farfel JM, Santos E, Andrade MP, Alho AT, Lima Mdo C, Oliveira KC, Tampellini E, Polichiso L, Santos GB, Rodriguez RD, Ueda K, Pasqualucci CA, Jacob-Filho W. Prevalence of dementia subtypes in a developing country: a clinicopathological study. Clinics (Sao Paulo). 2013; 68(8):1140-5. PMID: 24037011; PMCID: PMC3752642.
      68. Gröttrup B, May C, Meyer HE, Grinberg LT, Park YM. Progresses in neuroproteomics of neurodegenerative diseases--18th HUPO BPP workshop: September 12, 2012, Boston, USA. Proteomics. 2013 Jan; 13(2):217-8. PMID: 23341065.
        View in: PubMed
      69. Gröttrup B, Esselmann H, May C, Schrötter A, Woitalla D, Heinsen H, Marcus K, Wiltfang J, Meyer HE, Grinberg LT, Park YM. Challenges in modern biomarker discovery--17th HUPO BPP workshop: May 24-25, 2012, Sao Paulo, Brazil. Proteomics. 2013 Jan; 13(2):210-6. PMID: 23341064.
        View in: PubMed
      70. Silva AR, Grinberg LT, Farfel JM, Diniz BS, Lima LA, Silva PJ, Ferretti RE, Rocha RM, Filho WJ, Carraro DM, Brentani H. Transcriptional alterations related to neuropathology and clinical manifestation of Alzheimer's disease. PLoS One. 2012; 7(11):e48751. PMID: 23144955; PMCID: PMC3492444.
      71. Grinberg LT, Korczyn AD, Heinsen H. Cerebral amyloid angiopathy impact on endothelium. Exp Gerontol. 2012 Nov; 47(11):838-42. PMID: 22944481; PMCID: PMC3500138.
      72. Laforce R, Kerchner GA, Rabinovici GD, Fong JC, Miller BL, Seeley WW, Grinberg LT. A 44-year-old man with profound behavioural changes. Can J Neurol Sci. 2012 Jul; 39(4):527-30. PMID: 22728864; PMCID: PMC3859341.
      73. Suemoto CK, Damico MV, Ferretti RE, Grinberg LT, Farfel JM, Leite RE, Nitrini R, Lafer B, Jacob-Filho W, Pasqualucci CA. Depression and cardiovascular risk factors: evidence from a large postmortem sample. Int J Geriatr Psychiatry. 2013 May; 28(5):487-93. PMID: 22744836.
        View in: PubMed
      74. Thal DR, Grinberg LT, Attems J. Vascular dementia: different forms of vessel disorders contribute to the development of dementia in the elderly brain. Exp Gerontol. 2012 Nov; 47(11):816-24. PMID: 22705146; PMCID: PMC3470831.
      75. Korczyn AD, Vakhapova V, Grinberg LT. Vascular dementia. J Neurol Sci. 2012 Nov 15; 322(1-2):2-10. PMID: 22575403; PMCID: PMC3435447.
      76. Gröttrup B, Böckmann M, Stephan C, Marcus K, Grinberg LT, Meyer HE, Park YM. Translational proteomics in neurodegenerative diseases--16th HUPO BPP workshop September 5, 2011 Geneva, Switzerland. Proteomics. 2012 Feb; 12(3):356-8. PMID: 22290803.
        View in: PubMed
      77. Rabinovici GD, Rosen HJ, Alkalay A, Kornak J, Furst AJ, Agarwal N, Mormino EC, O'Neil JP, Janabi M, Karydas A, Growdon ME, Jang JY, Huang EJ, Dearmond SJ, Trojanowski JQ, Grinberg LT, Gorno-Tempini ML, Seeley WW, Miller BL, Jagust WJ. Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD. Neurology. 2011 Dec 6; 77(23):2034-42. PMID: 22131541; PMCID: PMC3236517.
      78. Schlesinger D, Grinberg LT, Alba JG, Naslavsky MS, Licinio L, Farfel JM, Suemoto CK, de Lucena Ferretti RE, Leite RE, de Andrade MP, dos Santos AC, Brentani H, Pasqualucci CA, Nitrini R, Jacob-Filho W, Zatz M. African ancestry protects against Alzheimer's disease-related neuropathology. Mol Psychiatry. 2013 Jan; 18(1):79-85. PMID: 22064377; PMCID: PMC3526728.
      79. Gröttrup B, Böckmann M, Marcus K, Wiltfang J, Grinberg LT, Meyer HE, Park YM. Clinical aspects of neurodegenerative diseases - 15th HUPO BPP Workshop April 8-9, 2011, Bochum, Germany. Proteomics. 2011 Nov; 11(22):4279-83. PMID: 22045679.
        View in: PubMed
      80. Middleton LE, Grinberg LT, Miller B, Kawas C, Yaffe K. Neuropathologic features associated with Alzheimer disease diagnosis: age matters. Neurology. 2011 Nov 8; 77(19):1737-44. PMID: 22031532; PMCID: PMC3208952.
      81. Moreira MS, Velasco IT, Ferreira LS, Ariga SK, Abatepaulo F, Grinberg LT, Marques MM. Effect of laser phototherapy on wound healing following cerebral ischemia by cryogenic injury. J Photochem Photobiol B. 2011 Dec 2; 105(3):207-15. PMID: 22024356.
        View in: PubMed
      82. Suemoto CK, Nitrini R, Grinberg LT, Ferretti RE, Farfel JM, Leite RE, Menezes PR, Fregni F, Jacob-Filho W, Pasqualucci CA. Atherosclerosis and dementia: a cross-sectional study with pathological analysis of the carotid arteries. Stroke. 2011 Dec; 42(12):3614-5. PMID: 21940957.
        View in: PubMed
      83. Gröttrup B, Marcus K, Grinberg LT, Lee SK, Meyer HE, Park YM. Creating a human brain proteome atlas--14th HUPO BPP workshop September 20-21, 2010, Sydney, Australia. Proteomics. 2011 Aug; 11(16):3269-72. PMID: 21796782.
        View in: PubMed
      84. Grinberg LT, Rueb U, Heinsen H. Brainstem: neglected locus in neurodegenerative diseases. Front Neurol. 2011; 2:42. PMID: 21808630; PMCID: PMC3135867.
      85. Gröttrup B, Stephan C, Marcus K, Grinberg LT, Wiltfang J, Lee SK, Kim YH, Meyer HE, Park YM. Creating a human brain proteome atlas--13th HUPO BPP Workshop March 30-31, 2010, Ochang, Korea. Proteomics. 2011 Jul; 11(14):2759-62. PMID: 21717571.
        View in: PubMed
      86. Ewers M, Frisoni GB, Teipel SJ, Grinberg LT, Amaro E, Heinsen H, Thompson PM, Hampel H. Staging Alzheimer's disease progression with multimodality neuroimaging. Prog Neurobiol. 2011 Dec; 95(4):535-46. PMID: 21718750; PMCID: PMC3223355.
      87. de Oliveira KC, Nery FG, Ferreti RE, Lima MC, Cappi C, Machado-Lima A, Polichiso L, Carreira LL, Ávila C, Alho AT, Brentani HP, Miguel EC, Heinsen H, Jacob-Filho W, Pasqualucci CA, Lafer B, Grinberg LT. Brazilian psychiatric brain bank: a new contribution tool to network studies. Cell Tissue Bank. 2012 Jun; 13(2):315-26. PMID: 21562728.
        View in: PubMed
      88. Gigante AD, Young LT, Yatham LN, Andreazza AC, Nery FG, Grinberg LT, Heinsen H, Lafer B. Morphometric post-mortem studies in bipolar disorder: possible association with oxidative stress and apoptosis. Int J Neuropsychopharmacol. 2011 Sep; 14(8):1075-89. PMID: 21205433.
        View in: PubMed
      89. Grinberg LT, Heinsen H. Toward a pathological definition of vascular dementia. J Neurol Sci. 2010 Dec 15; 299(1-2):136-8. PMID: 20920816; PMCID: PMC3038202.
      90. Teipel SJ, Meindl T, Grinberg L, Grothe M, Cantero JL, Reiser MF, Möller HJ, Heinsen H, Hampel H. The cholinergic system in mild cognitive impairment and Alzheimer's disease: an in vivo MRI and DTI study. Hum Brain Mapp. 2011 Sep; 32(9):1349-62. PMID: 20672311.
        View in: PubMed
      91. Grinberg LT, Thal DR. Vascular pathology in the aged human brain. Acta Neuropathol. 2010 Mar; 119(3):277-90. PMID: 20155424.
        View in: PubMed
      92. Grinberg LT, Rueb U, Alho AT, Heinsen H. Brainstem pathology and non-motor symptoms in PD. J Neurol Sci. 2010 Feb 15; 289(1-2):81-8. PMID: 19758601.
        View in: PubMed
      93. Kim YH, Marcus K, Grinberg LT, Goehler H, Wiltfang J, Stephan C, Eisenacher M, Hardt T, Martens L, J Dunn M, Park YM, Meyer HE. Toward a Successful Clinical Neuroproteomics The 11th HUPO Brain Proteome Project Workshop 3 March, 2009, Kolymbari, Greece. Proteomics Clin Appl. 2009 Sep; 3(9):1012-6. PMID: 21137003.
        View in: PubMed
      94. Grinberg LT, Rüb U, Ferretti RE, Nitrini R, Farfel JM, Polichiso L, Gierga K, Jacob-Filho W, Heinsen H. The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer's disease. A precocious onset? Neuropathol Appl Neurobiol. 2009 Aug; 35(4):406-16. PMID: 19508444.
        View in: PubMed
      95. Azevedo FA, Carvalho LR, Grinberg LT, Farfel JM, Ferretti RE, Leite RE, Jacob Filho W, Lent R, Herculano-Houzel S. Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain. J Comp Neurol. 2009 Apr 10; 513(5):532-41. PMID: 19226510.
        View in: PubMed
      96. Grinberg LT, Amaro Junior E, da Silva AV, da Silva RE, Sato JR, dos Santos DD, de Paula Pacheco S, de Lucena Ferretti RE, Paraizo Leite RE, Pasqualucci CA, Teipel SJ, Flatz WH, Heinsen H. Improved detection of incipient vascular changes by a biotechnological platform combining post mortem MRI in situ with neuropathology. J Neurol Sci. 2009 Aug 15; 283(1-2):2-8. PMID: 19289241.
        View in: PubMed
      97. Paula-Lima AC, Tricerri MA, Brito-Moreira J, Bomfim TR, Oliveira FF, Magdesian MH, Grinberg LT, Panizzutti R, Ferreira ST. Human apolipoprotein A-I binds amyloid-beta and prevents Abeta-induced neurotoxicity. Int J Biochem Cell Biol. 2009 Jun; 41(6):1361-70. PMID: 19130896.
        View in: PubMed
      98. Ravid R, Grinberg LT. How to run a brain bank--revisited. Cell Tissue Bank. 2008 Sep; 9(3):149-50. PMID: 18581260.
        View in: PubMed
      99. Grinberg LT, Ferraz da Silva LF, Galtarossa Xavier AC, Nascimento Saldiva PH, Mauad T. Clinico-pathological discrepancies in the diagnoses of solid malignancies. Pathol Res Pract. 2008; 204(12):867-73. PMID: 18755553.
        View in: PubMed
      100. Liscic RM, Grinberg LT, Zidar J, Gitcho MA, Cairns NJ. ALS and FTLD: two faces of TDP-43 proteinopathy. Eur J Neurol. 2008 Aug; 15(8):772-80. PMID: 18684309; PMCID: PMC2801606.
      101. Grinberg LT, Amaro E, Teipel S, dos Santos DD, Pasqualucci CA, Leite RE, Camargo CR, Gonçalves JA, Sanches AG, Santana M, Ferretti RE, Jacob-Filho W, Nitrini R, Heinsen H. Assessment of factors that confound MRI and neuropathological correlation of human postmortem brain tissue. Cell Tissue Bank. 2008 Sep; 9(3):195-203. PMID: 18548334.
        View in: PubMed
      102. Teipel SJ, Meindl T, Grinberg L, Heinsen H, Hampel H. Novel MRI techniques in the assessment of dementia. Eur J Nucl Med Mol Imaging. 2008 Mar; 35 Suppl 1:S58-69. PMID: 18205002.
        View in: PubMed
      103. Cairns NJ, Bigio EH, Mackenzie IR, Neumann M, Lee VM, Hatanpaa KJ, White CL, Schneider JA, Grinberg LT, Halliday G, Duyckaerts C, Lowe JS, Holm IE, Tolnay M, Okamoto K, Yokoo H, Murayama S, Woulfe J, Munoz DG, Dickson DW, Ince PG, Trojanowski JQ, Mann DM. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol. 2007 Jul; 114(1):5-22. PMID: 17579875; PMCID: PMC2827877.
      104. Behrens MI, Mukherjee O, Tu PH, Liscic RM, Grinberg LT, Carter D, Paulsmeyer K, Taylor-Reinwald L, Gitcho M, Norton JB, Chakraverty S, Goate AM, Morris JC, Cairns NJ. Neuropathologic heterogeneity in HDDD1: a familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation. Alzheimer Dis Assoc Disord. 2007 Jan-Mar; 21(1):1-7. PMID: 17334266.
        View in: PubMed
      105. Grinberg LT, Ferretti RE, Farfel JM, Leite R, Pasqualucci CA, Rosemberg S, Nitrini R, Saldiva PH, Filho WJ. Brain bank of the Brazilian aging brain study group - a milestone reached and more than 1,600 collected brains. Cell Tissue Bank. 2007; 8(2):151-62. PMID: 17075689.
        View in: PubMed
      106. Mauad T, Silva LF, Santos MA, Grinberg L, Bernardi FD, Martins MA, Saldiva PH, Dolhnikoff M. Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma. Am J Respir Crit Care Med. 2004 Oct 15; 170(8):857-62. PMID: 15151920.
        View in: PubMed
      107. Lorentzen JE, Schroeder T, Aabech J, Sørensen S. [Femoro-crural in situ bypass]. Chirurg. 1989 Apr; 60(4):283-6. PMID: 2721305.
        View in: PubMed
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