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    Carolyn Calfee, MD, MAS

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address505 Parnassus Ave, Moffitt
    San Francisco CA 94143
    Phone415-476-5756
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      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoM.A.S. in Clinical Research Graduate Division (Advance Training in Clinical Research)2009
      University of California, San Francisco Residency School of Medicine
      University of PensylvanniaM.D.School of Medicine1999

      Collapse Overview 
      Collapse Overview
      Carolyn S. Calfee, MD MAS is Associate Professor in Residence of Medicine and Anesthesia at UCSF, where she attends in the intensive care units at Moffitt-Long Hospital. Dr. Calfee received her undergraduate degree from Yale University and her medical degree from the University of Pennsylvania School of Medicine. She came to UCSF for residency in Internal Medicine and stayed to complete her chief residency and Pulmonary/Critical Care Medicine fellowship. She also completed her Masters in Clinical Research at UCSF in 2009. After research training with Drs. Michael Matthay and Mark Eisner, she joined the faculty of the division in 2007. Dr. Calfee is also a member of UCSF’s Center for Tobacco Control Research and Education and an associate member of the UCSF Cancer Center.

      RESEARCH INTERESTS
      Dr. Calfee’s primary academic focus is the prevention, diagnosis, prognosis, and treatment of acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS). Current research projects include: (1) the role of biomarkers in investigating ALI/ARDS pathogenesis, early diagnosis, treatment, and prognosis; (2) the role of cigarette smoke exposure in susceptibility to lung injury; and (3) novel treatments for acute lung injury.


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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay MA, Ware LB. Distinct Molecular Phenotypes of Direct vs Indirect ARDS in Single-Center and Multicenter Studies. Chest. 2015 Jun 1; 147(6):1539-48.
        View in: PubMed
      2. Howard BM, Kornblith LZ, Hendrickson CM, Redick BJ, Conroy AS, Nelson MF, Callcut RA, Calfee CS, Cohen MJ. Differences in degree, differences in kind: Characterizing lung injury in trauma. J Trauma Acute Care Surg. 2015 Apr; 78(4):735-41.
        View in: PubMed
      3. Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers AJ, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS. Increased Expression Of Neutrophil-Related Genes In Patients With Early Sepsis-Induced ARDS. Am J Physiol Lung Cell Mol Physiol. 2015 Mar 20; ajplung.00380.2014.
        View in: PubMed
      4. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA. Erratum to: Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):574.
        View in: PubMed
      5. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbot J, Matthay MA. Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):470-8.
        View in: PubMed
      6. Moazed F, Calfee CS. Clearing the air. Smoking and incident asthma in adults. Am J Respir Crit Care Med. 2015 Jan 15; 191(2):123-4.
        View in: PubMed
      7. Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay MA. Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial. Lancet Respir Med. 2015 Jan; 3(1):24-32.
        View in: PubMed
      8. Ware LB, Bastarache JA, Calfee CS. ARDS: New Mechanistic Insights, New Therapeutic Directions. Clin Chest Med. 2014 Dec; 35(4):xv-xvi.
        View in: PubMed
      9. Moazed F, Calfee CS. Environmental risk factors for acute respiratory distress syndrome. Clin Chest Med. 2014 Dec; 35(4):625-37.
        View in: PubMed
      10. Hsieh SJ, Zhuo H, Benowitz NL, Thompson BT, Liu KD, Matthay MA, Calfee CS. Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome. Crit Care Med. 2014 Sep; 42(9):2058-68.
        View in: PubMed
      11. Ware LB, Lee JW, Wickersham N, Nguyen J, Matthay MA, Calfee CS. Donor smoking is associated with pulmonary edema, inflammation and epithelial dysfunction in ex vivo human donor lungs. Am J Transplant. 2014 Oct; 14(10):2295-302.
        View in: PubMed
      12. Krupa A, Fol M, Rahman M, Stokes KY, Florence JM, Leskov IL, Khoretonenko MV, Matthay MA, Liu KD, Calfee CS, Tvinnereim A, Rosenfield GR, Kurdowska AK. Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15; 307(6):L435-48.
        View in: PubMed
      13. Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA. Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Ann Intensive Care. 2014; 4:22.
        View in: PubMed
      14. Moseson EM, Zhuo H, Chu J, Stein JC, Matthay MA, Kangelaris KN, Liu KD, Calfee CS. Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study. J Intensive Care. 2014; 2:40.
        View in: PubMed
      15. Shyamsundar M, McAuley DF, Ingram RJ, Gibson DS, O'Kane D, McKeown ST, Edwards A, Taggart C, Elborn JS, Calfee CS, Matthay MA, O'Kane CM. Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury. Am J Respir Crit Care Med. 2014 Jun 15; 189(12):1520-9.
        View in: PubMed
      16. Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA. Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Lancet Respir Med. 2014 Aug; 2(8):611-20.
        View in: PubMed
      17. Wong HR, Liu KD, Kangelaris KN, Lahni P, Calfee CS. Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults. J Crit Care. 2014 Oct; 29(5):718-22.
        View in: PubMed
      18. Kangelaris KN, Calfee CS, May AK, Zhuo H, Matthay MA, Ware LB. Is there still a role for the lung injury score in the era of the Berlin definition ARDS? Ann Intensive Care. 2014; 4(1):4.
        View in: PubMed
      19. Kornblith LZ, Kutcher ME, Redick BJ, Calfee CS, Vilardi RF, Cohen MJ. Fibrinogen and platelet contributions to clot formation: implications for trauma resuscitation and thromboprophylaxis. J Trauma Acute Care Surg. 2014 Feb; 76(2):255-6; discussion 262-3.
        View in: PubMed
      20. Wang CY, Calfee CS, Paul DW, Janz DR, May AK, Zhuo H, Bernard GR, Matthay MA, Ware LB, Kangelaris KN. One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome. Intensive Care Med. 2014 Mar; 40(3):388-96.
        View in: PubMed
      21. Shyamsundar M, McAuley DF, Shields MO, MacSweeney R, Duffy MJ, Johnston JR, McGuigan J, Backman JT, Calfee CS, Matthay MM, Griffiths MJ, McDowell C, Elborn SJ, O'Kane CM. Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial. Ann Surg. 2014 Jan; 259(1):26-31.
        View in: PubMed
      22. Kallet RH, Zhuo H, Liu KD, Calfee CS, Matthay MA. The Association Between Physiologic Dead-Space Fraction and Mortality in Subjects With ARDS Enrolled in a Prospective Multi-Center Clinical Trial. Respir Care. 2014 Nov; 59(11):1611-8.
        View in: PubMed
      23. Ware LB, Koyama T, Zhao Z, Janz DR, Wickersham N, Bernard GR, May AK, Calfee CS, Matthay MA. Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Crit Care. 2013; 17(5):R253.
        View in: PubMed PMC4056313
      24. Brown LM, Calfee CS, Howard JP, Craig TR, Matthay MA, McAuley DF. Comparison of thermodilution measured extravascular lung water with chest radiographic assessment of pulmonary oedema in patients with acute lung injury. Ann Intensive Care. 2013; 3(1):25.
        View in: PubMed PMC3846630
      25. Levitt JE, Calfee CS, Goldstein BA, Vojnik R, Matthay MA. Early acute lung injury: criteria for identifying lung injury prior to the need for positive pressure ventilation*. Crit Care Med. 2013 Aug; 41(8):1929-37.
        View in: PubMed
      26. Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS. Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. Am J Respir Crit Care Med. 2013 Apr 1; 187(7):736-42.
        View in: PubMed
      27. Spicer A, Calfee CS. Fixing the leak: targeting the vascular endothelium in sepsis. Crit Care. 2012; 16(6):177.
        View in: PubMed
      28. Calfee CS, Pugin J. The search for diagnostic markers in sepsis: many miles yet to go. Am J Respir Crit Care Med. 2012 Jul 1; 186(1):2-4.
        View in: PubMed
      29. Rackley CR, Levitt JE, Zhuo H, Matthay MA, Calfee CS. Clinical evidence of early acute lung injury often precedes the diagnosis of ALI. J Intensive Care Med. 2013 Jul-Aug; 28(4):241-6.
        View in: PubMed
      30. Calfee CS, Gallagher D, Abbott J, Thompson BT, Matthay MA. Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance. Crit Care Med. 2012 Jun; 40(6):1731-7.
        View in: PubMed
      31. Ware LB, Neyrinck A, O'Neal HR, Lee JW, Landeck M, Johnson E, Calfee CS, Matthay MA. Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors. Clin Transplant. 2012 Sep-Oct; 26(5):665-71.
        View in: PubMed
      32. Cohen MJ, Call M, Nelson M, Calfee CS, Esmon CT, Brohi K, Pittet JF. Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg. 2012 Feb; 255(2):379-85.
        View in: PubMed
      33. Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay M, Meyer NJ, Kim C, Li M, Akey J, Barnes KC, Sevransky J, Lanken PN, May AK, Aplenc R, Maloney JP, Hakonarson H. Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. PLoS One. 2012; 7(1):e28268.
        View in: PubMed
      34. Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA. The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury. Chest. 2012 May; 141(5):1160-9.
        View in: PubMed
      35. Brown LM, Calfee CS, Matthay MA, Brower RG, Thompson BT, Checkley W. A simple classification model for hospital mortality in patients with acute lung injury managed with lung protective ventilation. Crit Care Med. 2011 Dec; 39(12):2645-51.
        View in: PubMed
      36. Zhang M, Hsu R, Hsu CY, Kordesch K, Nicasio E, Cortez A, McAlpine I, Brady S, Zhuo H, Kangelaris KN, Stein J, Calfee CS, Liu KD. FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study. Ann Intensive Care. 2011; 1(1):21.
        View in: PubMed
      37. Calfee CS, Ware LB, Glidden DV, Eisner MD, Parsons PE, Thompson BT, Matthay MA. Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury. Crit Care Med. 2011 Apr; 39(4):711-7.
        View in: PubMed
      38. Calfee CS, Matthay MA, Eisner MD, Benowitz N, Call M, Pittet JF, Cohen MJ. Active and passive cigarette smoking and acute lung injury after severe blunt trauma. Am J Respir Crit Care Med. 2011 Jun 15; 183(12):1660-5.
        View in: PubMed
      39. Meyer NJ, Li M, Feng R, Bradfield J, Gallop R, Bellamy S, Fuchs BD, Lanken PN, Albelda SM, Rushefski M, Aplenc R, Abramova H, Atochina-Vasserman EN, Beers MF, Calfee CS, Cohen MJ, Pittet JF, Christiani DC, O'Keefe GE, Ware LB, May AK, Wurfel MM, Hakonarson H, Christie JD. ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio. Am J Respir Crit Care Med. 2011 May 15; 183(10):1344-53.
        View in: PubMed
      40. Hsieh SJ, Ware LB, Eisner MD, Yu L, Jacob P, Havel C, Goniewicz ML, Matthay MA, Benowitz NL, Calfee CS. Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patients. Crit Care Med. 2011 Jan; 39(1):40-5.
        View in: PubMed
      41. Matthay MA, Thompson BT, Read EJ, McKenna DH, Liu KD, Calfee CS, Lee JW. Therapeutic potential of mesenchymal stem cells for severe acute lung injury. Chest. 2010 Oct; 138(4):965-72.
        View in: PubMed
      42. Diaz JV, Brower R, Calfee CS, Matthay MA. Therapeutic strategies for severe acute lung injury. Crit Care Med. 2010 Aug; 38(8):1644-50.
        View in: PubMed
      43. Calfee CS, Thompson BT, Parsons PE, Ware LB, Matthay MA, Wong HR. Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock. Crit Care Med. 2010 Jun; 38(6):1436-41.
        View in: PubMed
      44. Cohen MJ, Carles M, Brohi K, Calfee CS, Rahn P, Call MS, Chesebro BB, West MA, Pittet JF. Early release of soluble receptor for advanced glycation endproducts after severe trauma in humans. J Trauma. 2010 Jun; 68(6):1273-8.
        View in: PubMed
      45. Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR, Mitchell D, Wickersham N, Bernard GR, Matthay MA, May AK, Ware LB. Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma. 2010 May; 68(5):1121-7.
        View in: PubMed
      46. Collard HR, Calfee CS, Wolters PJ, Song JW, Hong SB, Brady S, Ishizaka A, Jones KD, King TE, Matthay MA, Kim DS. Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2010 Jul; 299(1):L3-7.
        View in: PubMed
      47. Calfee CS, Matthay MA. Clinical immunology: Culprits with evolutionary ties. Nature. 2010 Mar 4; 464(7285):41-2.
        View in: PubMed
      48. Cohen MJ, Brohi K, Calfee CS, Rahn P, Chesebro BB, Christiaans SC, Carles M, Howard M, Pittet JF. Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion. Crit Care. 2009; 13(6):R174.
        View in: PubMed
      49. Ware LB, Fremont RD, Bastarache JA, Calfee CS, Matthay MA. Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio. Eur Respir J. 2010 Feb; 35(2):331-7.
        View in: PubMed
      50. Suratt BT, Eisner MD, Calfee CS, Allard JB, Whittaker LA, Engelken DT, Petty JM, Trimarchi T, Gauthier L, Parsons PE. Plasma granulocyte colony-stimulating factor levels correlate with clinical outcomes in patients with acute lung injury. Crit Care Med. 2009 Apr; 37(4):1322-8.
        View in: PubMed
      51. Kropski JA, Fremont RD, Calfee CS, Ware LB. Clara cell protein (CC16), a marker of lung epithelial injury, is decreased in plasma and pulmonary edema fluid from patients with acute lung injury. Chest. 2009 Jun; 135(6):1440-7.
        View in: PubMed
      52. Levitt JE, Bedi H, Calfee CS, Gould MK, Matthay MA. Identification of early acute lung injury at initial evaluation in an acute care setting prior to the onset of respiratory failure. Chest. 2009 Apr; 135(4):936-43.
        View in: PubMed
      53. Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay MA. Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs. Chest. 2009 Feb; 135(2):269-75.
        View in: PubMed
      54. Calfee CS, Eisner MD, Parsons PE, Thompson BT, Conner ER, Matthay MA, Ware LB. Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury. Intensive Care Med. 2009 Feb; 35(2):248-57.
        View in: PubMed
      55. Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA. Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury. Thorax. 2008 Dec; 63(12):1083-9.
        View in: PubMed
      56. Matthay MA, Calfee CS. Aerosolized beta-adrenergic agonist therapy reduces pulmonary edema following lung surgery. Chest. 2008 Apr; 133(4):833-5.
        View in: PubMed
      57. Calfee CS, Eisner MD, Ware LB, Thompson BT, Parsons PE, Wheeler AP, Korpak A, Matthay MA. Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Crit Care Med. 2007 Oct; 35(10):2243-50.
        View in: PubMed
      58. Calfee CS, Ware LB. Biomarkers of lung injury in primary graft dysfunction following lung transplantation. Biomark Med. 2007 Aug; 1(2):285-91.
        View in: PubMed
      59. Calfee CS, Budev MM, Matthay MA, Church G, Brady S, Uchida T, Ishizaka A, Lara A, Ranes JL, deCamp MM, Arroliga AC. Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation. J Heart Lung Transplant. 2007 Jul; 26(7):675-80.
        View in: PubMed
      60. Calfee CS, Matthay MA. Nonventilatory treatments for acute lung injury and ARDS. Chest. 2007 Mar; 131(3):913-20.
        View in: PubMed
      61. Calfee CS, Shah SJ, Wolters PJ, Saint S, King TE. Clinical problem-solving. Anchors away. N Engl J Med. 2007 Feb 1; 356(5):504-9.
        View in: PubMed
      62. Calfee CS, Katz PP, Yelin EH, Iribarren C, Eisner MD. The influence of perceived control of asthma on health outcomes. Chest. 2006 Nov; 130(5):1312-8.
        View in: PubMed
      63. Matthay MA, Calfee CS. Therapeutic value of a lung protective ventilation strategy in acute lung injury. Chest. 2005 Nov; 128(5):3089-91.
        View in: PubMed
      64. Calfee CS, Matthay MA. Recent advances in mechanical ventilation. Am J Med. 2005 Jun; 118(6):584-91.
        View in: PubMed
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