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    Henry Vanbrocklin, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentRadiology and Biomedical Imaging
    Address185 Berry Street
    San Francisco CA 94143
    Phone415-353-4569

       Biography 
       Awards and Honors
      Molecular Imaging 2011Editor-in-Chief
      Society of Nuclear Medicine2006SNM Presidents Distinguished Service Award
      US Department of Energy1990Alexander Hollaender Distinguished Postdoctoral Fellow
      Society of Nuclear Medicine2010SNM Presidents Distinguished Service Award

       Overview 
       Overview
      Henry VanBrocklin, PhD, is a Professor in Residence, Director of the Radiopharmaceutical Research Program in the Center for Molecular and Functional Imaging (CMFI) at the University of California, San Francisco China Basin, and he is a Joint Faculty Scientist at the Lawrence Berkeley National Laboratory. Dr. VanBrocklin obtained his PhD in Radiopharmaceutical Chemistry from Washington University, St. Louis in 1990, and he completed a two-year postdoctoral program at the University of Illinois, Urbana in 1992. He maintains an active radiotracer research program in addition to providing tracers for collaborative basic science and translational clinical research. His research interests include short-lived radioisotope production to the creation of fluorine-18 and carcbon-11 labeling chemistry strategies for new radiotracer preparations and applications.

      Dr. VanBrocklin is one of the core faculty for the Master's in Biomedical Imaging (MSBI) program and a member of the MSBI executive committee.

      Dr. VanBrocklin was awarded the Alexander Hollaender Distinguished Postdoctoral Fellowship from the U.S. Department of Energy for developing positron-labeled estrogens, progestins, and androgens for tumor imaging. He has 70 published research articles.

      Expertise:
      Radiopharmaceutical

      Specialty:
      Short-lived radioisotope production to the creation of fluorine-18 and carbon-11 labeling chemistry strategies for new radiotracer preparations and applications, development of positron-labeled estrogens, progestin’s, androgens for tumor imaging

      Professional Interests:
      Developing radiopharmaceutical probes for PET and SPECT imaging applications including tracers for blood flow measurement, receptor-targeted tracers for prostate, pancreatic and breast cancer, and neurological imaging agents for neuroinflammation and excititory amino acid transport.

      Education and Training:
      • Doctor of Philosophy: Washington University, St. Louis - Radiopharmaceutical Chemistry
      • Postdoctoral Fellow: University of Illinois, Urbana

       Interests
      Developing radiopharmaceutical probes for PET and SPECT blood flow measurement and receptor-based targeted tracers for cancer, prostate, kidney, cancer.

       ORNG Applications 
       Websites
       Awarded Grants
       More Info

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Keshari KR, Sai V, Wang ZJ, Vanbrocklin HF, Kurhanewicz J, Wilson DM. Hyperpolarized [1-13C]dehydroascorbate MR spectroscopy in a murine model of prostate cancer: comparison with 18F-FDG PET. J Nucl Med. 2013 Jun; 54(6):922-8.
        View in: PubMed
      2. LeBeau AM, Duriseti S, Murphy ST, Pepin F, Hann B, Gray JW, VanBrocklin HF, Craik CS. Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer. Cancer Res. 2013 Apr 1; 73(7):2070-81.
        View in: PubMed
      3. LeBeau AM, Lee M, Murphy ST, Hann BC, Warren RS, Delos Santos R, Kurhanewicz J, Hanash SM, VanBrocklin HF, Craik CS. Imaging a functional tumorigenic biomarker in the transformed epithelium. Proc Natl Acad Sci U S A. 2013 Jan 2; 110(1):93-8.
        View in: PubMed
      4. Seo Y, Gustafson WC, Dannoon SF, Nekritz EA, Lee CL, Murphy ST, VanBrocklin HF, Hernandez-Pampaloni M, Haas-Kogan DA, Weiss WA, Matthay KK. Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft model. Mol Imaging Biol. 2012 Dec; 14(6):735-42.
        View in: PubMed
      5. Vaquero JJ, Gao DW, García-Villaba C, Bacharach S, Vanbrocklin H, Fang Q, Desco M, Lee R, Dae M. Approach to assessing myocardial perfusion in rats using static [13N]-ammonia images and a small-animal PET. Mol Imaging Biol. 2012 Oct; 14(5):541-5.
        View in: PubMed
      6. McCarthy TJ, Vanbrocklin HF. In memoriam: Michael John Welch, Ph.D 1939-2012. Mol Imaging Biol. 2012 Aug; 14(4):393-4.
        View in: PubMed
      7. Wilson KJ, Mill CP, Gallo RM, Cameron EM, VanBrocklin H, Settleman J, Riese DJ. The Q43L mutant of neuregulin 2ß is a pan-ErbB receptor antagonist. Biochem J. 2012 Apr 1; 443(1):133-44.
        View in: PubMed
      8. VanBrocklin H. Accepting the torch. Mol Imaging. 2012 Feb; 11(1):1.
        View in: PubMed
      9. Broisat A, Ruiz M, Goodman NC, Hanrahan SM, Reutter BW, Brennan KM, Janabi M, Schaefer S, Watson DD, Beller GA, VanBrocklin HF, Glover DK. Myocardial uptake of 7'-(Z)-[(123)I]iodorotenone during vasodilator stress in dogs with critical coronary stenoses. Circ Cardiovasc Imaging. 2011 Nov; 4(6):685-92.
        View in: PubMed
      10. Norenberg JP, Schwarz S, VanBrocklin H. FDA cGMP requirements for PET drugs. J Nucl Med. 2011 May; 52(5):16N.
        View in: PubMed
      11. Iyer AK, Lan X, Zhu X, Su Y, Feng J, Zhang X, Gao D, Seo Y, Vanbrocklin HF, Broaddus VC, Liu B, He J. Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas. Cancer Res. 2011 Apr 1; 71(7):2428-32.
        View in: PubMed
      12. Vasdev N, Dorff PN, O'Neil JP, Chin FT, Hanrahan S, VanBrocklin HF. Metabolic stability of 6,7-dialkoxy-4-(2-, 3- and 4-[18F]fluoroanilino)quinazolines, potential EGFR imaging probes. Bioorg Med Chem. 2011 May 1; 19(9):2959-65.
        View in: PubMed
      13. More SS, Itsara M, Yang X, Geier EG, Tadano MK, Seo Y, Vanbrocklin HF, Weiss WA, Mueller S, Haas-Kogan DA, Dubois SG, Matthay KK, Giacomini KM. Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems. Clin Cancer Res. 2011 Apr 15; 17(8):2339-49.
        View in: PubMed
      14. Iyer AK, Su Y, Feng J, Lan X, Zhu X, Liu Y, Gao D, Seo Y, Vanbrocklin HF, Courtney Broaddus V, Liu B, He J. The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma. Biomaterials. 2011 Apr; 32(10):2605-13.
        View in: PubMed
      15. Vanbrocklin H, Schwarz S. CGMP for PET drugs: important steps to take now. J Nucl Med. 2010 Dec; 51(12):17N.
        View in: PubMed
      16. Hicks JW, VanBrocklin HF, Wilson AA, Houle S, Vasdev N. Radiolabeled small molecule protein kinase inhibitors for imaging with PET or SPECT. Molecules. 2010 Nov; 15(11):8260-78.
        View in: PubMed
      17. Lee CL, Wahnishe H, Sayre GA, Cho HM, Kim HJ, Hernandez-Pampaloni M, Hawkins RA, Dannoon SF, VanBrocklin HF, Itsara M, Weiss WA, Yang X, Haas-Kogan DA, Matthay KK, Seo Y. Radiation dose estimation using preclinical imaging with 124I-metaiodobenzylguanidine (MIBG) PET. Med Phys. 2010 Sep; 37(9):4861-7.
        View in: PubMed
      18. Mihardja SS, Gao D, Sievers RE, Fang Q, Feng J, Wang J, Vanbrocklin HF, Larrick JW, Huang M, Dae M, Lee RJ. Targeted in vivo extracellular matrix formation promotes neovascularization in a rodent model of myocardial infarction. PLoS One. 2010; 5(4):e10384.
        View in: PubMed
      19. Anderson CJ, Bulte JW, Chen K, Chen X, Khaw BA, Shokeen M, Wooley KL, VanBrocklin HF. Design of targeted cardiovascular molecular imaging probes. J Nucl Med. 2010 May 1; 51 Suppl 1:3S-17S.
        View in: PubMed
      20. He J, Wang Y, Feng J, Zhu X, Lan X, Iyer AK, Zhang N, Seo Y, VanBrocklin HF, Liu B. Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single-chain antibody fragment. J Nucl Med. 2010 Mar; 51(3):427-32.
        View in: PubMed
      21. Lapi SE, Wahnishe H, Pham D, Wu LY, Nedrow-Byers JR, Liu T, Vejdani K, VanBrocklin HF, Berkman CE, Jones EF. Assessment of an 18F-labeled phosphoramidate peptidomimetic as a new prostate-specific membrane antigen-targeted imaging agent for prostate cancer. J Nucl Med. 2009 Dec; 50(12):2042-8.
        View in: PubMed
      22. Christine CW, Starr PA, Larson PS, Eberling JL, Jagust WJ, Hawkins RA, VanBrocklin HF, Wright JF, Bankiewicz KS, Aminoff MJ. Safety and tolerability of putaminal AADC gene therapy for Parkinson disease. Neurology. 2009 Nov 17; 73(20):1662-9.
        View in: PubMed
      23. VanBrocklin HF. Introduction to special issue. Mol Imaging. 2009 Mar-Apr; 8(2):55.
        View in: PubMed
      24. Watkins GA, Jones EF, Scott Shell M, VanBrocklin HF, Pan MH, Hanrahan SM, Feng JJ, He J, Sounni NE, Dill KA, Contag CH, Coussens LM, Franc BL. Development of an optimized activatable MMP-14 targeted SPECT imaging probe. Bioorg Med Chem. 2009 Jan 15; 17(2):653-9.
        View in: PubMed
      25. VanBrocklin HF. Advancing molecular imaging from the laboratory to everyday practice. J Nucl Med. 2008 Dec; 49(12):22N-23N.
        View in: PubMed
      26. Jones EF, Gould RG, VanBrocklin HF. Bruce H. Hasegawa, PhD, 1951-2008. J Nucl Med. 2008 Sep; 49(9):37N-38N.
        View in: PubMed
      27. VanBrocklin H. Session 2: strategies for fast-track technological development and regulatory issues. J Nucl Med. 2008 Jun; 49(6):38N-39N.
        View in: PubMed
      28. VanBrocklin H, Herscovitch P. Molecular imaging update: advances in MI of the brain. J Nucl Med. 2007 May; 48(5):24N, 29N.
        View in: PubMed
      29. VanBrocklin HF, Hanrahan SM, Enas JD, Nandanan E, O'Neil JP. Mitochondrial avid radioprobes. Preparation and evaluation of 7'(Z)-[125I]iodorotenone and 7'(Z)-[125I]iodorotenol. Nucl Med Biol. 2007 Jan; 34(1):109-16.
        View in: PubMed
      30. VanBrocklin HF, Lim JK, Coffing SL, Hom DL, Negash K, Ono MY, Gilmore JL, Bryant I, Riese DJ. Anilinodialkoxyquinazolines: screening epidermal growth factor receptor tyrosine kinase inhibitors for potential tumor imaging probes. J Med Chem. 2005 Nov 17; 48(23):7445-56.
        View in: PubMed
      31. VanBrocklin HF, Blagoev M, Hoepping A, O'Neil JP, Klose M, Schubiger PA, Ametamey S. A new precursor for the preparation of 6-[18F]Fluoro-L-m-tyrosine ([18F]FMT): efficient synthesis and comparison of radiolabeling. Appl Radiat Isot. 2004 Dec; 61(6):1289-94.
        View in: PubMed
      32. Marshall RC, Powers-Risius P, Reutter BW, O'Neil JP, La Belle M, Huesman RH, VanBrocklin HF. Kinetic analysis of 18F-fluorodihydrorotenone as a deposited myocardial flow tracer: comparison to 201Tl. J Nucl Med. 2004 Nov; 45(11):1950-9.
        View in: PubMed
      33. Hung JC, VanBrocklin HF. Exemption of radiopharmaceuticals from <797>. J Nucl Med. 2004 Oct; 45(10):14N.
        View in: PubMed
      34. Eberling JL, Roberts JA, Taylor SE, VanBrocklin HF, O'Neil JP, Nordahl TE. No effect of age and estrogen on aromatic L- amino acid decarboxylase activity in rhesus monkey brain. Neurobiol Aging. 2002 May-Jun; 23(3):479-83.
        View in: PubMed
      35. Collier TL, Lecomte R, McCarthy TJ, Meikle S, Ruth TJ, Scopinaro F, Signore A, VanBrocklin H, van De Wiele C, Waterhouse RN. Assessment of cancer-associated biomarkers by positron emission tomography: advances and challenges. Dis Markers. 2002; 18(5-6):211-47.
        View in: PubMed
      36. Marshall RC, Powers-Risius P, Reutter BW, Taylor SE, VanBrocklin HF, Huesman RH, Budinger TF. Kinetic analysis of 125I-iodorotenone as a deposited myocardial flow tracer: comparison with 99mTc-sestamibi. J Nucl Med. 2001 Feb; 42(2):272-81.
        View in: PubMed
      37. Eberling JL, Jagust WJ, Taylor S, Bringas J, Pivirotto P, VanBrocklin HF, Bankiewicz KS. A novel MPTP primate model of Parkinson's disease: neurochemical and clinical changes. Brain Res. 1998 Sep 14; 805(1-2):259-62.
        View in: PubMed
      38. Jordan S, Bankiewicz KS, Eberling JL, VanBrocklin HF, O'Neil JP, Jagust WJ. An in vivo microdialysis study of striatal 6-[18F]fluoro-L-m-tyrosine metabolism. Neurochem Res. 1998 Apr; 23(4):513-7.
        View in: PubMed
      39. Eberling JL, Bankiewicz KS, Jordan S, VanBrocklin HF, Jagust WJ. PET studies of functional compensation in a primate model of Parkinson's disease. Neuroreport. 1997 Aug 18; 8(12):2727-33.
        View in: PubMed
      40. Jordan S, Eberling JL, Bankiewicz KS, Rosenberg D, Coxson PG, VanBrocklin HF, O'Neil JP, Emborg ME, Jagust WJ. 6-[18F]fluoro-L-m-tyrosine: metabolism, positron emission tomography kinetics, and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine lesions in primates. Brain Res. 1997 Mar 7; 750(1-2):264-76.
        View in: PubMed
      41. Jagust WJ, Eberling JL, Biegon A, Taylor SE, VanBrocklin HF, Jordan S, Hanrahan SM, Roberts JA, Brennan KM, Mathis CA. Iodine-123-5-iodo-6-nitroquipazine: SPECT radiotracer to image the serotonin transporter. J Nucl Med. 1996 Jul; 37(7):1207-14.
        View in: PubMed
      42. Eberling JL, Roberts JA, De Manincor DJ, Brennan KM, Hanrahan SM, Vanbrocklin HF, Roos MS, Jagust WJ. PET studies of cerebral glucose metabolism in conscious rhesus macaques. Neurobiol Aging. 1995 Sep-Oct; 16(5):825-32.
        View in: PubMed
      43. Buckman BO, VanBrocklin HF, Dence CS, Bergmann SR, Welch MJ, Katzenellenbogen JA. Synthesis and tissue biodistribution of [omega-11C]palmitic acid. A novel PET imaging agent for cardiac fatty acid metabolism. J Med Chem. 1994 Jul 22; 37(15):2481-5.
        View in: PubMed
      44. VanBrocklin HF, Liu A, Welch MJ, O'Neil JP, Katzenellenbogen JA. The synthesis of 7 alpha-methyl-substituted estrogens labeled with fluorine-18: potential breast tumor imaging agents. Steroids. 1994 Jan; 59(1):34-45.
        View in: PubMed
      45. Jagust WJ, Eberling JL, Roberts JA, Brennan KM, Hanrahan SM, VanBrocklin H, Enas JD, Biegon A, Mathis CA. In vivo imaging of the 5-hydroxytryptamine reuptake site in primate brain using single photon emission computed tomography and [123I]5-iodo-6-nitroquipazine. Eur J Pharmacol. 1993 Sep 28; 242(2):189-93.
        View in: PubMed
      46. Katzenellenbogen JA, Mathias CJ, VanBrocklin HF, Brodack JW, Welch MJ. Titration of the in vivo uptake of 16 alpha-[18F]fluoroestradiol by target tissues in the rat: competition by tamoxifen, and implications for quantitating estrogen receptors in vivo and the use of animal models in receptor-binding radiopharmaceutical development. Nucl Med Biol. 1993 Aug; 20(6):735-45.
        View in: PubMed
      47. VanBrocklin HF, Carlson KE, Katzenellenbogen JA, Welch MJ. 16 beta-([18F]fluoro)estrogens: systematic investigation of a new series of fluorine-18-labeled estrogens as potential imaging agents for estrogen-receptor-positive breast tumors. J Med Chem. 1993 May 28; 36(11):1619-29.
        View in: PubMed
      48. Kochanny MJ, VanBrocklin HF, Kym PR, Carlson KE, O'Neil JP, Bonasera TA, Welch MJ, Katzenellenbogen JA. Fluorine-18-labeled progestin ketals: synthesis and target tissue uptake selectivity of potential imaging agents for receptor-positive breast tumors. J Med Chem. 1993 Apr 30; 36(9):1120-7.
        View in: PubMed
      49. French AN, Napolitano E, VanBrocklin HF, Hanson RN, Welch MJ, Katzenellenbogen JA. Synthesis, radiolabeling and tissue distribution of 11 beta-fluoroalkyl- and 11 beta-fluoroalkoxy-substituted estrogens: target tissue uptake selectivity and defluorination of a homologous series of fluorine-18-labeled estrogens. Nucl Med Biol. 1993 Jan; 20(1):31-47.
        View in: PubMed
      50. VanBrocklin HF, Rocque PA, Lee HV, Carlson KE, Katzenellenbogen JA, Welch MJ. 16 beta-[18F]fluoromoxestrol: a potent, metabolically stable positron emission tomography imaging agent for estrogen receptor positive human breast tumors. Life Sci. 1993; 53(10):811-9.
        View in: PubMed
      51. Pomper MG, Kochanny MJ, Thieme AM, Carlson KE, VanBrocklin HF, Mathias CJ, Welch MJ, Katzenellenbogen JA. Fluorine-substituted corticosteroids: synthesis and evaluation as potential receptor-based imaging agents for positron emission tomography of the brain. Int J Rad Appl Instrum B. 1992 May; 19(4):461-80.
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      52. VanBrocklin HF, Pomper MG, Carlson KE, Welch MJ, Katzenellenbogen JA. Preparation and evaluation of 17-ethynyl-substituted 16 alpha-[18F]fluoroestradiols: selective receptor-based PET imaging agents. Int J Rad Appl Instrum B. 1992 Apr; 19(3):363-74.
        View in: PubMed
      53. Liu AJ, Katzenellenbogen JA, VanBrocklin HF, Mathias CJ, Welch MJ. 20-[18F]fluoromibolerone, a positron-emitting radiotracer for androgen receptors: synthesis and tissue distribution studies. J Nucl Med. 1991 Jan; 32(1):81-8.
        View in: PubMed
      54. Pomper MG, VanBrocklin H, Thieme AM, Thomas RD, Kiesewetter DO, Carlson KE, Mathias CJ, Welch MJ, Katzenellenbogen JA. 11 beta-methoxy-, 11 beta-ethyl- and 17 alpha-ethynyl-substituted 16 alpha-fluoroestradiols: receptor-based imaging agents with enhanced uptake efficiency and selectivity. J Med Chem. 1990 Dec; 33(12):3143-55.
        View in: PubMed
      55. Pochapsky SS, VanBrocklin HF, Welch MJ, Katzenellenbogen JA. Synthesis and tissue distribution of fluorine-18 labeled trifluorohexadecanoic acids. Considerations in the development of metabolically blocked myocardial imaging agents. Bioconjug Chem. 1990 Jul-Aug; 1(4):231-44.
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      56. VanBrocklin HF, Brodack JW, Mathias CJ, Welch MJ, Katzenellenbogen JA, Keenan JF, Mizejewski GJ. Binding of 16 alpha-[18F]fluoro-17 beta-estradiol to alphafetoprotein in Sprague-Dawley female rats affects blood levels. Int J Rad Appl Instrum B. 1990; 17(8):769-73.
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