Loading...

Henry Vanbrocklin, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentRadiology
Address185 Berry Street Bldg B
San Francisco CA 94158
Phone415-353-4569
vCardDownload vCard

    Collapse Biography 
    Collapse Awards and Honors
    Molecular Imaging 2011Editor-in-Chief
    Society of Nuclear Medicine2006SNM Presidents Distinguished Service Award
    US Department of Energy1990Alexander Hollaender Distinguished Postdoctoral Fellow
    Society of Nuclear Medicine2010SNM Presidents Distinguished Service Award

    Collapse Overview 
    Collapse Overview
    Henry VanBrocklin, PhD, is a Professor in Residence, Director of the Radiopharmaceutical Research Program in the Center for Molecular and Functional Imaging (CMFI) at the University of California, San Francisco China Basin, and he is a Joint Faculty Scientist at the Lawrence Berkeley National Laboratory. Dr. VanBrocklin obtained his PhD in Radiopharmaceutical Chemistry from Washington University, St. Louis in 1990, and he completed a two-year postdoctoral program at the University of Illinois, Urbana in 1992. He maintains an active radiotracer research program in addition to providing tracers for collaborative basic science and translational clinical research. His research interests include short-lived radioisotope production to the creation of fluorine-18 and carcbon-11 labeling chemistry strategies for new radiotracer preparations and applications.

    Dr. VanBrocklin is one of the core faculty for the Master's in Biomedical Imaging (MSBI) program and a member of the MSBI executive committee.

    Dr. VanBrocklin was awarded the Alexander Hollaender Distinguished Postdoctoral Fellowship from the U.S. Department of Energy for developing positron-labeled estrogens, progestins, and androgens for tumor imaging. He has 70 published research articles.

    Expertise:
    Radiopharmaceutical

    Specialty:
    Short-lived radioisotope production to the creation of fluorine-18 and carbon-11 labeling chemistry strategies for new radiotracer preparations and applications, development of positron-labeled estrogens, progestin’s, androgens for tumor imaging

    Professional Interests:
    Developing radiopharmaceutical probes for PET and SPECT imaging applications including tracers for blood flow measurement, receptor-targeted tracers for prostate, pancreatic and breast cancer, and neurological imaging agents for neuroinflammation and excititory amino acid transport.

    Education and Training:
    • Doctor of Philosophy: Washington University, St. Louis - Radiopharmaceutical Chemistry
    • Postdoctoral Fellow: University of Illinois, Urbana


    Collapse Research 
    Collapse Research Activities and Funding
    Mitigation of quality and compliance risks in radio-pharmaceutical production by implementation of an automated release testing technology.
    FDA U01FD005517Sep 15, 2015 - Aug 31, 2018
    Role: Co-Principal Investigator
    Molecular Imaging of Chemical Threats and Countermeasures
    NIH/NINDS U01NS092495Aug 1, 2015 - Jul 31, 2020
    Role: Co-Principal Investigator
    In vivo reporters of gene expression
    NIH/NIAID R21AI114283Jul 15, 2014 - Jun 30, 2016
    Role: Co-Principal Investigator
    PET and MR-Compatible Bioreactor for Cross-Platform Biomarker Development
    NIH/NCI R21CA171766Aug 1, 2012 - Jul 31, 2014
    Role: Principal Investigator
    In Vivo Pharmacokinetic and Pharmacodynamic Dispositions of Positron Radiolabeled
    NIH/NINDS R21NS072079Sep 30, 2010 - Aug 31, 2013
    Role: Co-Principal Investigator
    MicroPET/CT for Small Animal Imaging
    NIH/NCRR S10RR023051Jun 1, 2007 - May 31, 2009
    Role: Principal Investigator
    Evaluation of Iodorotenone, A SPECT Perfusion Tracer
    NIH/NIBIB R01EB000482Mar 10, 2003 - Feb 29, 2008
    Role: Principal Investigator
    Targeted Molecular Probes for Tumor Imaging
    NIH/NCI R01CA094253Sep 5, 2002 - Aug 31, 2008
    Role: Principal Investigator
    DEVELOPMENT OF CANCER IMAGING AGENTS
    NIH/NCI R21CA079823Feb 1, 1999 - Jan 31, 2001
    Role: Principal Investigator
    MYOCARDIAL FLOW, FUNCTION AND METABOLISM BY PET AND MRI
    NIH P01HL025840Aug 1, 1980 - Aug 30, 2002
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Arentson-Lantz EJ, Saeed IH, Frassetto LA, Masharani U, Harnish RJ, Seo Y, VanBrocklin HF, Hawkins RA, Mari-Aparici C, Pampaloni MH, Slater J, Paddon-Jones D, Lang TF. (11)C-L-methyl methionine dynamic PET/CT of skeletal muscle: response to protein supplementation compared to L-[ring (13)C6] phenylalanine infusion with serial muscle biopsy. Ann Nucl Med. 2017 Mar 04. PMID: 28260185.
      View in: PubMed
    2. Kondapavulur S, Cote AM, Neumann KD, Jordan CD, McCoy D, Mabray MC, Liu D, Sze CH, Gautam A, VanBrocklin HF, Wilson M, Hetts SW. Optimization of an endovascular magnetic filter for maximized capture of magnetic nanoparticles. Biomed Microdevices. 2016 Dec; 18(6):109. PMID: 27830455.
      View in: PubMed
    3. Dannoon S, Ganguly T, Cahaya H, Geruntho JJ, Galliher MS, Beyer SK, Choy CJ, Hopkins MR, Regan M, Blecha JE, Skultetyova L, Drake CR, Jivan S, Barinka C, Jones EF, Berkman CE, VanBrocklin HF. Structure-Activity Relationship of (18)F-Labeled Phosphoramidate Peptidomimetic Prostate-Specific Membrane Antigen (PSMA)-Targeted Inhibitor Analogues for PET Imaging of Prostate Cancer. J Med Chem. 2016 Jun 23; 59(12):5684-94. PMID: 27228467.
      View in: PubMed
    4. Li L, Che L, Wang C, Blecha JE, Li X, VanBrocklin HF, Calvisi DF, Puchowicz M, Chen X, Seo Y. [(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice. Mol Imaging Biol. 2016 Jun; 18(3):360-7. PMID: 26567114.
      View in: PubMed
    5. Schankin CJ, Maniyar FH, Seo Y, Kori S, Eller M, Chou DE, Blecha J, Murphy ST, Hawkins RA, Sprenger T, VanBrocklin HF, Goadsby PJ. Ictal lack of binding to brain parenchyma suggests integrity of the blood-brain barrier for 11C-dihydroergotamine during glyceryl trinitrate-induced migraine. Brain. 2016 Jul; 139(Pt 7):1994-2001. PMID: 27234268.
      View in: PubMed
    6. Drake CR, Sevillano N, Truillet C, Craik CS, VanBrocklin HF, Evans MJ. Site-Specific Radiofluorination of Biomolecules with 8-[(18)F]-Fluorooctanoic Acid Catalyzed by Lipoic Acid Ligase. ACS Chem Biol. 2016 Jun 17; 11(6):1587-94. PMID: 27008570.
      View in: PubMed
    7. Carroll VN, Truillet C, Shen B, Flavell RR, Shao X, Evans MJ, VanBrocklin HF, Scott PJ, Chin FT, Wilson DM. [(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography. Chem Commun (Camb). 2016 Apr 7; 52(27):4888-90. PMID: 26963495.
      View in: PubMed
    8. Korenchan DE, Flavell RR, Baligand C, Sriram R, Neumann K, Sukumar S, VanBrocklin H, Vigneron DB, Wilson DM, Kurhanewicz J. Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging. Chem Commun (Camb). 2016 Feb 9; 52(14):3030-3. PMID: 26792559.
      View in: PubMed
    9. Flavell RR, Truillet C, Regan MK, Ganguly T, Blecha JE, Kurhanewicz J, VanBrocklin HF, Keshari KR, Chang CJ, Evans MJ, Wilson DM. Caged [(18)F]FDG Glycosylamines for Imaging Acidic Tumor Microenvironments Using Positron Emission Tomography. Bioconjug Chem. 2016 Jan 20; 27(1):170-8. PMID: 26649808.
      View in: PubMed
    10. Page MJ, Lourenço AL, David T, LeBeau AM, Cattaruzza F, Castro HC, VanBrocklin HF, Coughlin SR, Craik CS. Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography. Nat Commun. 2015; 6:8448. PMID: 26423607; PMCID: PMC4593073.
    11. Hope TA, Pampaloni MH, Nakakura E, VanBrocklin H, Slater J, Jivan S, Aparici CM, Yee J, Bergsland E. Simultaneous (68)Ga-DOTA-TOC PET/MRI with gadoxetate disodium in patients with neuroendocrine tumor. Abdom Imaging. 2015 Aug; 40(6):1432-40. PMID: 25820755.
      View in: PubMed
    12. Keshari KR, Wilson DM, Van Criekinge M, Sriram R, Koelsch BL, Wang ZJ, VanBrocklin HF, Peehl DM, O'Brien T, Sampath D, Carano RA, Kurhanewicz J. Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor. Prostate. 2015 Oct; 75(14):1601-9. PMID: 26177608; PMCID: PMC4537380 [Available on 10/01/16].
    13. Ganguly T, Dannoon S, Hopkins MR, Murphy S, Cahaya H, Blecha JE, Jivan S, Drake CR, Barinka C, Jones EF, VanBrocklin HF, Berkman CE. A high-affinity [(18)F]-labeled phosphoramidate peptidomimetic PSMA-targeted inhibitor for PET imaging of prostate cancer. Nucl Med Biol. 2015 Oct; 42(10):780-7. PMID: 26169882; PMCID: PMC4624265.
    14. Hope TA, Aggarwal R, Simko JP, VanBrocklin HF, Ryan CJ. Somatostatin imaging of neuroendocrine-differentiated prostate cancer. Clin Nucl Med. 2015 Jun; 40(6):540-1. PMID: 25783510.
      View in: PubMed
    15. Ley CR, Beattie NR, Dannoon S, Regan M, VanBrocklin H, Berkman CE. Synthesis and evaluation of constrained phosphoramidate inhibitors of prostate-specific membrane antigen. Bioorg Med Chem Lett. 2015 Jun 15; 25(12):2536-9. PMID: 25956413.
      View in: PubMed
    16. LeBeau AM, Sevillano N, Markham K, Winter MB, Murphy ST, Hostetter DR, West J, Lowman H, Craik CS, VanBrocklin HF. Imaging active urokinase plasminogen activator in prostate cancer. Cancer Res. 2015 Apr 1; 75(7):1225-35. PMID: 25672980; PMCID: PMC4383704 [Available on 04/01/16].
    17. Carroll V, Michel BW, Blecha J, VanBrocklin H, Keshari K, Wilson D, Chang CJ. A boronate-caged [¹8F]FLT probe for hydrogen peroxide detection using positron emission tomography. J Am Chem Soc. 2014 Oct 22; 136(42):14742-5. PMID: 25310369; PMCID: PMC4210116.
    18. Schwarz SW, Dick D, VanBrocklin HF, Hoffman JM. Regulatory Requirements for PET Drug Production. J Nucl Med. 2014 Jul; 55(7):1132-7. PMID: 24914057.
      View in: PubMed
    19. James SL, Ahmed SK, Murphy S, Braden MR, Belabassi Y, VanBrocklin HF, Thompson CM, Gerdes JM. A novel fluorine-18 ß-fluoroethoxy organophosphate positron emission tomography imaging tracer targeted to central nervous system acetylcholinesterase. ACS Chem Neurosci. 2014 Jul 16; 5(7):519-24. PMID: 24716794; PMCID: PMC4102964.
    20. LeBeau AM, Sevillano N, King ML, Duriseti S, Murphy ST, Craik CS, Murphy LL, VanBrocklin HF. Imaging the urokinase plasminongen activator receptor in preclinical breast cancer models of acquired drug resistance. Theranostics. 2014; 4(3):267-79. PMID: 24505235; PMCID: PMC3915090.
    21. Nordstrom R, Cherry S, Azhdarinia A, Sevick-Muraca E, Vanbrocklin H. Photons across medicine: relating optical and nuclear imaging. Biomed Opt Express. 2013; 4(12):2751-62. PMID: 24409377; PMCID: PMC3862159.
    22. Keshari KR, Sai V, Wang ZJ, Vanbrocklin HF, Kurhanewicz J, Wilson DM. Hyperpolarized [1-13C]dehydroascorbate MR spectroscopy in a murine model of prostate cancer: comparison with 18F-FDG PET. J Nucl Med. 2013 Jun; 54(6):922-8. PMID: 23575993; PMCID: PMC3682497.
    23. LeBeau AM, Duriseti S, Murphy ST, Pepin F, Hann B, Gray JW, VanBrocklin HF, Craik CS. Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer. Cancer Res. 2013 Apr 1; 73(7):2070-81. PMID: 23400595; PMCID: PMC3618559.
    24. LeBeau AM, Lee M, Murphy ST, Hann BC, Warren RS, Delos Santos R, Kurhanewicz J, Hanash SM, VanBrocklin HF, Craik CS. Imaging a functional tumorigenic biomarker in the transformed epithelium. Proc Natl Acad Sci U S A. 2013 Jan 2; 110(1):93-8. PMID: 23248318; PMCID: PMC3538269.
    25. Seo Y, Gustafson WC, Dannoon SF, Nekritz EA, Lee CL, Murphy ST, VanBrocklin HF, Hernandez-Pampaloni M, Haas-Kogan DA, Weiss WA, Matthay KK. Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft model. Mol Imaging Biol. 2012 Dec; 14(6):735-42. PMID: 22382618; PMCID: PMC3369020.
    26. Vaquero JJ, Gao DW, García-Villaba C, Bacharach S, Vanbrocklin H, Fang Q, Desco M, Lee R, Dae M. Approach to assessing myocardial perfusion in rats using static [13N]-ammonia images and a small-animal PET. Mol Imaging Biol. 2012 Oct; 14(5):541-5. PMID: 22278106.
      View in: PubMed
    27. McCarthy TJ, Vanbrocklin HF. In memoriam: Michael John Welch, Ph.D 1939-2012. Mol Imaging Biol. 2012 Aug; 14(4):393-4. PMID: 22718105.
      View in: PubMed
    28. Wilson KJ, Mill CP, Gallo RM, Cameron EM, VanBrocklin H, Settleman J, Riese DJ. The Q43L mutant of neuregulin 2ß is a pan-ErbB receptor antagonist. Biochem J. 2012 Apr 1; 443(1):133-44. PMID: 22216880; PMCID: PMC3960720.
    29. VanBrocklin H. Accepting the torch. Mol Imaging. 2012 Feb; 11(1):1. PMID: 22418022.
      View in: PubMed
    30. Broisat A, Ruiz M, Goodman NC, Hanrahan SM, Reutter BW, Brennan KM, Janabi M, Schaefer S, Watson DD, Beller GA, VanBrocklin HF, Glover DK. Myocardial uptake of 7'-(Z)-[(123)I]iodorotenone during vasodilator stress in dogs with critical coronary stenoses. Circ Cardiovasc Imaging. 2011 Nov; 4(6):685-92. PMID: 21917783; PMCID: PMC3587960.
    31. Norenberg JP, Schwarz S, VanBrocklin H. FDA cGMP requirements for PET drugs. J Nucl Med. 2011 May; 52(5):16N. PMID: 21536923.
      View in: PubMed
    32. Iyer AK, Lan X, Zhu X, Su Y, Feng J, Zhang X, Gao D, Seo Y, Vanbrocklin HF, Broaddus VC, Liu B, He J. Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas. Cancer Res. 2011 Apr 1; 71(7):2428-32. PMID: 21447742; PMCID: PMC3071798.
    33. Vasdev N, Dorff PN, O'Neil JP, Chin FT, Hanrahan S, VanBrocklin HF. Metabolic stability of 6,7-dialkoxy-4-(2-, 3- and 4-[18F]fluoroanilino)quinazolines, potential EGFR imaging probes. Bioorg Med Chem. 2011 May 1; 19(9):2959-65. PMID: 21478021; PMCID: PMC3099137.
    34. More SS, Itsara M, Yang X, Geier EG, Tadano MK, Seo Y, Vanbrocklin HF, Weiss WA, Mueller S, Haas-Kogan DA, Dubois SG, Matthay KK, Giacomini KM. Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems. Clin Cancer Res. 2011 Apr 15; 17(8):2339-49. PMID: 21421857; PMCID: PMC3247296.
    35. Iyer AK, Su Y, Feng J, Lan X, Zhu X, Liu Y, Gao D, Seo Y, Vanbrocklin HF, Courtney Broaddus V, Liu B, He J. The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma. Biomaterials. 2011 Apr; 32(10):2605-13. PMID: 21255833; PMCID: PMC3040448.
    36. Vanbrocklin H, Schwarz S. CGMP for PET drugs: important steps to take now. J Nucl Med. 2010 Dec; 51(12):17N. PMID: 21098789.
      View in: PubMed
    37. Hicks JW, VanBrocklin HF, Wilson AA, Houle S, Vasdev N. Radiolabeled small molecule protein kinase inhibitors for imaging with PET or SPECT. Molecules. 2010 Nov; 15(11):8260-78. PMID: 21079565.
      View in: PubMed
    38. Lee CL, Wahnishe H, Sayre GA, Cho HM, Kim HJ, Hernandez-Pampaloni M, Hawkins RA, Dannoon SF, VanBrocklin HF, Itsara M, Weiss WA, Yang X, Haas-Kogan DA, Matthay KK, Seo Y. Radiation dose estimation using preclinical imaging with 124I-metaiodobenzylguanidine (MIBG) PET. Med Phys. 2010 Sep; 37(9):4861-7. PMID: 20964203; PMCID: PMC2937055.
    39. Mihardja SS, Gao D, Sievers RE, Fang Q, Feng J, Wang J, Vanbrocklin HF, Larrick JW, Huang M, Dae M, Lee RJ. Targeted in vivo extracellular matrix formation promotes neovascularization in a rodent model of myocardial infarction. PLoS One. 2010; 5(4):e10384. PMID: 20442783; PMCID: PMC2860995.
    40. Anderson CJ, Bulte JW, Chen K, Chen X, Khaw BA, Shokeen M, Wooley KL, VanBrocklin HF. Design of targeted cardiovascular molecular imaging probes. J Nucl Med. 2010 May 1; 51 Suppl 1:3S-17S. PMID: 20395345; PMCID: PMC3629978.
    41. He J, Wang Y, Feng J, Zhu X, Lan X, Iyer AK, Zhang N, Seo Y, VanBrocklin HF, Liu B. Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single-chain antibody fragment. J Nucl Med. 2010 Mar; 51(3):427-32. PMID: 20150269; PMCID: PMC2832590.
    42. Lapi SE, Wahnishe H, Pham D, Wu LY, Nedrow-Byers JR, Liu T, Vejdani K, VanBrocklin HF, Berkman CE, Jones EF. Assessment of an 18F-labeled phosphoramidate peptidomimetic as a new prostate-specific membrane antigen-targeted imaging agent for prostate cancer. J Nucl Med. 2009 Dec; 50(12):2042-8. PMID: 19910433; PMCID: PMC3575752.
    43. Christine CW, Starr PA, Larson PS, Eberling JL, Jagust WJ, Hawkins RA, VanBrocklin HF, Wright JF, Bankiewicz KS, Aminoff MJ. Safety and tolerability of putaminal AADC gene therapy for Parkinson disease. Neurology. 2009 Nov 17; 73(20):1662-9. PMID: 19828868; PMCID: PMC2839805.
    44. VanBrocklin HF. Introduction to special issue. Mol Imaging. 2009 Mar-Apr; 8(2):55. PMID: 19397850.
      View in: PubMed
    45. Watkins GA, Jones EF, Scott Shell M, VanBrocklin HF, Pan MH, Hanrahan SM, Feng JJ, He J, Sounni NE, Dill KA, Contag CH, Coussens LM, Franc BL. Development of an optimized activatable MMP-14 targeted SPECT imaging probe. Bioorg Med Chem. 2009 Jan 15; 17(2):653-9. PMID: 19109023; PMCID: PMC2639212.
    46. VanBrocklin HF. Advancing molecular imaging from the laboratory to everyday practice. J Nucl Med. 2008 Dec; 49(12):22N-23N. PMID: 19038993.
      View in: PubMed
    47. Jones EF, Gould RG, VanBrocklin HF. Bruce H. Hasegawa, PhD, 1951-2008. J Nucl Med. 2008 Sep; 49(9):37N-38N. PMID: 18765579.
      View in: PubMed
    48. VanBrocklin H. Session 2: strategies for fast-track technological development and regulatory issues. J Nucl Med. 2008 Jun; 49(6):38N-39N. PMID: 18511821.
      View in: PubMed
    49. VanBrocklin H, Herscovitch P. Molecular imaging update: advances in MI of the brain. J Nucl Med. 2007 May; 48(5):24N, 29N. PMID: 17475948.
      View in: PubMed
    50. VanBrocklin HF, Hanrahan SM, Enas JD, Nandanan E, O'Neil JP. Mitochondrial avid radioprobes. Preparation and evaluation of 7'(Z)-[125I]iodorotenone and 7'(Z)-[125I]iodorotenol. Nucl Med Biol. 2007 Jan; 34(1):109-16. PMID: 17210467; PMCID: PMC1852529.
    51. VanBrocklin HF, Lim JK, Coffing SL, Hom DL, Negash K, Ono MY, Gilmore JL, Bryant I, Riese DJ. Anilinodialkoxyquinazolines: screening epidermal growth factor receptor tyrosine kinase inhibitors for potential tumor imaging probes. J Med Chem. 2005 Nov 17; 48(23):7445-56. PMID: 16279804.
      View in: PubMed
    52. VanBrocklin HF, Blagoev M, Hoepping A, O'Neil JP, Klose M, Schubiger PA, Ametamey S. A new precursor for the preparation of 6-[18F]Fluoro-L-m-tyrosine ([18F]FMT): efficient synthesis and comparison of radiolabeling. Appl Radiat Isot. 2004 Dec; 61(6):1289-94. PMID: 15388123.
      View in: PubMed
    53. Marshall RC, Powers-Risius P, Reutter BW, O'Neil JP, La Belle M, Huesman RH, VanBrocklin HF. Kinetic analysis of 18F-fluorodihydrorotenone as a deposited myocardial flow tracer: comparison to 201Tl. J Nucl Med. 2004 Nov; 45(11):1950-9. PMID: 15534068.
      View in: PubMed
    54. Hung JC, VanBrocklin HF. Exemption of radiopharmaceuticals from <797>. J Nucl Med. 2004 Oct; 45(10):14N. PMID: 15551510.
      View in: PubMed
    55. Eberling JL, Roberts JA, Taylor SE, VanBrocklin HF, O'Neil JP, Nordahl TE. No effect of age and estrogen on aromatic L- amino acid decarboxylase activity in rhesus monkey brain. Neurobiol Aging. 2002 May-Jun; 23(3):479-83. PMID: 11959410.
      View in: PubMed
    56. Collier TL, Lecomte R, McCarthy TJ, Meikle S, Ruth TJ, Scopinaro F, Signore A, VanBrocklin H, van De Wiele C, Waterhouse RN. Assessment of cancer-associated biomarkers by positron emission tomography: advances and challenges. Dis Markers. 2002; 18(5-6):211-47. PMID: 14646039; PMCID: PMC3851410.
    57. Marshall RC, Powers-Risius P, Reutter BW, Taylor SE, VanBrocklin HF, Huesman RH, Budinger TF. Kinetic analysis of 125I-iodorotenone as a deposited myocardial flow tracer: comparison with 99mTc-sestamibi. J Nucl Med. 2001 Feb; 42(2):272-81. PMID: 11216526.
      View in: PubMed
    58. Eberling JL, Jagust WJ, Taylor S, Bringas J, Pivirotto P, VanBrocklin HF, Bankiewicz KS. A novel MPTP primate model of Parkinson's disease: neurochemical and clinical changes. Brain Res. 1998 Sep 14; 805(1-2):259-62. PMID: 9733979.
      View in: PubMed
    59. Jordan S, Bankiewicz KS, Eberling JL, VanBrocklin HF, O'Neil JP, Jagust WJ. An in vivo microdialysis study of striatal 6-[18F]fluoro-L-m-tyrosine metabolism. Neurochem Res. 1998 Apr; 23(4):513-7. PMID: 9566585.
      View in: PubMed
    60. Eberling JL, Bankiewicz KS, Jordan S, VanBrocklin HF, Jagust WJ. PET studies of functional compensation in a primate model of Parkinson's disease. Neuroreport. 1997 Aug 18; 8(12):2727-33. PMID: 9295108.
      View in: PubMed
    61. Jordan S, Eberling JL, Bankiewicz KS, Rosenberg D, Coxson PG, VanBrocklin HF, O'Neil JP, Emborg ME, Jagust WJ. 6-[18F]fluoro-L-m-tyrosine: metabolism, positron emission tomography kinetics, and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine lesions in primates. Brain Res. 1997 Mar 7; 750(1-2):264-76. PMID: 9098552.
      View in: PubMed
    62. Jagust WJ, Eberling JL, Biegon A, Taylor SE, VanBrocklin HF, Jordan S, Hanrahan SM, Roberts JA, Brennan KM, Mathis CA. Iodine-123-5-iodo-6-nitroquipazine: SPECT radiotracer to image the serotonin transporter. J Nucl Med. 1996 Jul; 37(7):1207-14. PMID: 8965200.
      View in: PubMed
    63. Eberling JL, Roberts JA, De Manincor DJ, Brennan KM, Hanrahan SM, Vanbrocklin HF, Roos MS, Jagust WJ. PET studies of cerebral glucose metabolism in conscious rhesus macaques. Neurobiol Aging. 1995 Sep-Oct; 16(5):825-32. PMID: 8532117.
      View in: PubMed
    64. Buckman BO, VanBrocklin HF, Dence CS, Bergmann SR, Welch MJ, Katzenellenbogen JA. Synthesis and tissue biodistribution of [omega-11C]palmitic acid. A novel PET imaging agent for cardiac fatty acid metabolism. J Med Chem. 1994 Jul 22; 37(15):2481-5. PMID: 8057294.
      View in: PubMed
    65. VanBrocklin HF, Liu A, Welch MJ, O'Neil JP, Katzenellenbogen JA. The synthesis of 7 alpha-methyl-substituted estrogens labeled with fluorine-18: potential breast tumor imaging agents. Steroids. 1994 Jan; 59(1):34-45. PMID: 8140600.
      View in: PubMed
    66. Jagust WJ, Eberling JL, Roberts JA, Brennan KM, Hanrahan SM, VanBrocklin H, Enas JD, Biegon A, Mathis CA. In vivo imaging of the 5-hydroxytryptamine reuptake site in primate brain using single photon emission computed tomography and [123I]5-iodo-6-nitroquipazine. Eur J Pharmacol. 1993 Sep 28; 242(2):189-93. PMID: 8253114.
      View in: PubMed
    67. Katzenellenbogen JA, Mathias CJ, VanBrocklin HF, Brodack JW, Welch MJ. Titration of the in vivo uptake of 16 alpha-[18F]fluoroestradiol by target tissues in the rat: competition by tamoxifen, and implications for quantitating estrogen receptors in vivo and the use of animal models in receptor-binding radiopharmaceutical development. Nucl Med Biol. 1993 Aug; 20(6):735-45. PMID: 8401374.
      View in: PubMed
    68. VanBrocklin HF, Carlson KE, Katzenellenbogen JA, Welch MJ. 16 beta-([18F]fluoro)estrogens: systematic investigation of a new series of fluorine-18-labeled estrogens as potential imaging agents for estrogen-receptor-positive breast tumors. J Med Chem. 1993 May 28; 36(11):1619-29. PMID: 7684451.
      View in: PubMed
    69. Kochanny MJ, VanBrocklin HF, Kym PR, Carlson KE, O'Neil JP, Bonasera TA, Welch MJ, Katzenellenbogen JA. Fluorine-18-labeled progestin ketals: synthesis and target tissue uptake selectivity of potential imaging agents for receptor-positive breast tumors. J Med Chem. 1993 Apr 30; 36(9):1120-7. PMID: 8487253.
      View in: PubMed
    70. French AN, Napolitano E, VanBrocklin HF, Hanson RN, Welch MJ, Katzenellenbogen JA. Synthesis, radiolabeling and tissue distribution of 11 beta-fluoroalkyl- and 11 beta-fluoroalkoxy-substituted estrogens: target tissue uptake selectivity and defluorination of a homologous series of fluorine-18-labeled estrogens. Nucl Med Biol. 1993 Jan; 20(1):31-47. PMID: 8461878.
      View in: PubMed
    71. VanBrocklin HF, Rocque PA, Lee HV, Carlson KE, Katzenellenbogen JA, Welch MJ. 16 beta-[18F]fluoromoxestrol: a potent, metabolically stable positron emission tomography imaging agent for estrogen receptor positive human breast tumors. Life Sci. 1993; 53(10):811-9. PMID: 8355567.
      View in: PubMed
    72. Pomper MG, Kochanny MJ, Thieme AM, Carlson KE, VanBrocklin HF, Mathias CJ, Welch MJ, Katzenellenbogen JA. Fluorine-substituted corticosteroids: synthesis and evaluation as potential receptor-based imaging agents for positron emission tomography of the brain. Int J Rad Appl Instrum B. 1992 May; 19(4):461-80. PMID: 1526811.
      View in: PubMed
    73. VanBrocklin HF, Pomper MG, Carlson KE, Welch MJ, Katzenellenbogen JA. Preparation and evaluation of 17-ethynyl-substituted 16 alpha-[18F]fluoroestradiols: selective receptor-based PET imaging agents. Int J Rad Appl Instrum B. 1992 Apr; 19(3):363-74. PMID: 1629026.
      View in: PubMed
    74. Liu AJ, Katzenellenbogen JA, VanBrocklin HF, Mathias CJ, Welch MJ. 20-[18F]fluoromibolerone, a positron-emitting radiotracer for androgen receptors: synthesis and tissue distribution studies. J Nucl Med. 1991 Jan; 32(1):81-8. PMID: 1988641.
      View in: PubMed
    75. Pomper MG, VanBrocklin H, Thieme AM, Thomas RD, Kiesewetter DO, Carlson KE, Mathias CJ, Welch MJ, Katzenellenbogen JA. 11 beta-methoxy-, 11 beta-ethyl- and 17 alpha-ethynyl-substituted 16 alpha-fluoroestradiols: receptor-based imaging agents with enhanced uptake efficiency and selectivity. J Med Chem. 1990 Dec; 33(12):3143-55. PMID: 1701833.
      View in: PubMed
    76. Pochapsky SS, VanBrocklin HF, Welch MJ, Katzenellenbogen JA. Synthesis and tissue distribution of fluorine-18 labeled trifluorohexadecanoic acids. Considerations in the development of metabolically blocked myocardial imaging agents. Bioconjug Chem. 1990 Jul-Aug; 1(4):231-44. PMID: 2096916.
      View in: PubMed
    77. VanBrocklin HF, Brodack JW, Mathias CJ, Welch MJ, Katzenellenbogen JA, Keenan JF, Mizejewski GJ. Binding of 16 alpha-[18F]fluoro-17 beta-estradiol to alphafetoprotein in Sprague-Dawley female rats affects blood levels. Int J Rad Appl Instrum B. 1990; 17(8):769-73. PMID: 1706690.
      View in: PubMed
    Henry's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _
    Back to TOP