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    Richard Locksley, MD

    SchoolUCSF School of Medicine
    Address513 Parnassus Ave, Med Sci
    San Francisco CA 94143
      Other Positions
      TitleHoward Hughes Investigator

       Education and Training
      University of California, San FranciscoResidency

       ORNG Applications 
       Awarded Grants
       Global Health

      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Seaman WE, Locksley RM, Welsh MJ. New blood: Creative funding of disease-specific research. Sci Transl Med. 2015 May 20; 7(288):288ed5.
        View in: PubMed
      2. Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. J Exp Med. 2015 Apr 6; 212(4):513-24.
        View in: PubMed
      3. Reinhardt RL, Liang HE, Bao K, Price AE, Mohrs M, Kelly BL, Locksley RM. A Novel Model for IFN-?-Mediated Autoinflammatory Syndromes. J Immunol. 2015 Mar 1; 194(5):2358-68.
        View in: PubMed
      4. Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC, Yun K, Locksley RM, Chawla A. Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell. 2015 Jan 15; 160(1-2):74-87.
        View in: PubMed
      5. Bando JK, Liang HE, Locksley RM. Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine. Nat Immunol. 2015 Feb; 16(2):153-60.
        View in: PubMed
      6. Cheng LE, Locksley RM. Allergic inflammation--innately homeostatic. Cold Spring Harb Perspect Biol. 2015 Mar; 7(3):a016352.
        View in: PubMed
      7. Van Gool F, Molofsky AB, Morar MM, Rosenzwajg M, Liang HE, Klatzmann D, Locksley RM, Bluestone JA. Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy. Blood. 2014 Dec 4; 124(24):3572-6.
        View in: PubMed
      8. von Moltke J, Locksley RM. I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis. Curr Opin Immunol. 2014 Dec; 31:58-65.
        View in: PubMed
      9. Qiu Y, Nguyen KD, Odegaard JI, Cui X, Tian X, Locksley RM, Palmiter RD, Chawla A. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell. 2014 Jun 5; 157(6):1292-308.
        View in: PubMed PMC4129510
      10. Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen SD. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med. 2014 Jun 30; 211(7):1281-8.
        View in: PubMed PMC4076593
      11. O'Dea EM, Amarsaikhan N, Li H, Downey J, Steele E, Van Dyken SJ, Locksley RM, Templeton SP. Eosinophils are recruited in response to chitin exposure and enhance Th2-mediated immune pathology in Aspergillus fumigatus infection. Infect Immun. 2014 Aug; 82(8):3199-205.
        View in: PubMed PMC4136210
      12. Locksley RM, Fahy JV. Asthma and the flu: a tricky two-step. Immunol Cell Biol. 2014 May-Jun; 92(5):389-91.
        View in: PubMed
      13. Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM. Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and ?d T cells. Immunity. 2014 Mar 20; 40(3):414-24.
        View in: PubMed PMC4019510
      14. Hams E, Locksley RM, McKenzie AN, Fallon PG. Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J Immunol. 2013 Dec 1; 191(11):5349-53.
        View in: PubMed PMC3847854
      15. Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10; 502(7470):245-8.
        View in: PubMed PMC3795960
      16. Bando JK, Nussbaum JC, Liang HE, Locksley RM. Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung. J Leukoc Biol. 2013 Nov; 94(5):877-84.
        View in: PubMed PMC3800063
      17. Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE. Traumatic brain injury induces macrophage subsets in the brain. Eur J Immunol. 2013 Aug; 43(8):2010-22.
        View in: PubMed PMC4210355
      18. Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley RM, Chawla A. Eosinophils secrete IL-4 to facilitate liver regeneration. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9914-9.
        View in: PubMed PMC3683773
      19. Heredia JE, Mukundan L, Chen FM, Mueller AA, Deo RC, Locksley RM, Rando TA, Chawla A. Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell. 2013 Apr 11; 153(2):376-88.
        View in: PubMed PMC3663598
      20. Locksley RM. Raggin' on T-bet. Cell Metab. 2013 Apr 2; 17(4):473-4.
        View in: PubMed
      21. Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med. 2013 Mar 11; 210(3):535-49.
        View in: PubMed PMC3600903
      22. Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie AN, Mebius RE, Powrie F, Vivier E. Innate lymphoid cells--a proposal for uniform nomenclature. Nat Rev Immunol. 2013 Feb; 13(2):145-9.
        View in: PubMed
      23. Oghumu S, Dong R, Varikuti S, Shawler T, Kampfrath T, Terrazas CA, Lezama-Davila C, Ahmer BM, Whitacre CC, Rajagopalan S, Locksley R, Sharpe AH, Satoskar AR. Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse. J Immunol. 2013 Mar 1; 190(5):2229-40.
        View in: PubMed PMC3683850
      24. Van Dyken SJ, Locksley RM. Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease. Annu Rev Immunol. 2013; 31:317-43.
        View in: PubMed PMC3606684
      25. Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity. 2013 Jan 24; 38(1):166-75.
        View in: PubMed PMC3576928
      26. Dickgreber N, Farrand KJ, van Panhuys N, Knight DA, McKee SJ, Chong ML, Miranda-Hernandez S, Baxter AG, Locksley RM, Le Gros G, Hermans IF. Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion. J Leukoc Biol. 2012 Nov; 92(5):999-1009.
        View in: PubMed PMC4050521
      27. Price AE, Reinhardt RL, Liang HE, Locksley RM. Marking and quantifying IL-17A-producing cells in vivo. PLoS One. 2012; 7(6):e39750.
        View in: PubMed PMC3387253
      28. Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF. Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med. 2012 Jun 4; 209(6):1183-99.
        View in: PubMed PMC3371730
      29. Nussbaum JC, Locksley RM. Infectious (Non)tolerance--frustrated commensalism gone awry? Cold Spring Harb Perspect Biol. 2012 May; 4(5).
        View in: PubMed PMC3331693
      30. Liang HE, Reinhardt RL, Bando JK, Sullivan BM, Ho IC, Locksley RM. Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Nat Immunol. 2012 Jan; 13(1):58-66.
        View in: PubMed PMC3242938
      31. Nguyen KD, Qiu Y, Cui X, Goh YP, Mwangi J, David T, Mukundan L, Brombacher F, Locksley RM, Chawla A. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature. 2011 Dec 1; 480(7375):104-8.
        View in: PubMed PMC3371761
      32. Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley RM, Lowell CA. Deletion of Syk in neutrophils prevents immune complex arthritis. J Immunol. 2011 Oct 15; 187(8):4319-30.
        View in: PubMed PMC3186826
      33. Gordon ED, Sidhu SS, Wang ZE, Woodruff PG, Yuan S, Solon MC, Conway SJ, Huang X, Locksley RM, Fahy JV. A protective role for periostin and TGF-ß in IgE-mediated allergy and airway hyperresponsiveness. Clin Exp Allergy. 2012 Jan; 42(1):144-55.
        View in: PubMed PMC3271792
      34. Fahy JV, Locksley RM. The airway epithelium as a regulator of Th2 responses in asthma. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):390-2.
        View in: PubMed
      35. Van Dyken SJ, Garcia D, Porter P, Huang X, Quinlan PJ, Blanc PD, Corry DB, Locksley RM. Fungal chitin from asthma-associated home environments induces eosinophilic lung infiltration. J Immunol. 2011 Sep 1; 187(5):2261-7.
        View in: PubMed PMC3159725
      36. Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM. Genetic analysis of basophil function in vivo. Nat Immunol. 2011 Jun; 12(6):527-35.
        View in: PubMed PMC3271435
      37. Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science. 2011 Apr 8; 332(6026):243-7.
        View in: PubMed PMC3144160
      38. Svensson M, Bell L, Little MC, DeSchoolmeester M, Locksley RM, Else KJ. Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection. Parasite Immunol. 2011 Jan; 33(1):1-11.
        View in: PubMed PMC3058490
      39. Ricardo-Gonzalez RR, Red Eagle A, Odegaard JI, Jouihan H, Morel CR, Heredia JE, Mukundan L, Wu D, Locksley RM, Chawla A. IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22617-22.
        View in: PubMed PMC3012500
      40. Duerr CU, Salzman NH, Dupont A, Szabo A, Normark BH, Normark S, Locksley RM, Mellroth P, Hornef MW. Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes. Mucosal Immunol. 2011 May; 4(3):325-34.
        View in: PubMed
      41. Yang Z, Wang ZE, Doulias PT, Wei W, Ischiropoulos H, Locksley RM, Liu L. Lymphocyte development requires S-nitrosoglutathione reductase. J Immunol. 2010 Dec 1; 185(11):6664-9.
        View in: PubMed PMC3070165
      42. Cheng LE, Wang ZE, Locksley RM. Murine B cells regulate serum IgE levels in a CD23-dependent manner. J Immunol. 2010 Nov 1; 185(9):5040-7.
        View in: PubMed PMC3085987
      43. Price AE, Liang HE, Sullivan BM, Reinhardt RL, Eisley CJ, Erle DJ, Locksley RM. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25):11489-94.
        View in: PubMed PMC2895098
      44. Locksley RM. Asthma and allergic inflammation. Cell. 2010 Mar 19; 140(6):777-83.
        View in: PubMed PMC3134388
      45. Barbalat R, Lau L, Locksley RM, Barton GM. Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nat Immunol. 2009 Nov; 10(11):1200-7.
        View in: PubMed PMC2821672
      46. Mingueneau M, Roncagalli R, Grégoire C, Kissenpfennig A, Miazek A, Archambaud C, Wang Y, Perrin P, Bertosio E, Sansoni A, Richelme S, Locksley RM, Aguado E, Malissen M, Malissen B. Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor. Immunity. 2009 Aug 21; 31(2):197-208.
        View in: PubMed
      47. Voehringer D, Wu D, Liang HE, Locksley RM. Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates. BMC Biotechnol. 2009; 9:69.
        View in: PubMed PMC2724507
      48. Locksley RM. Nine lives: plasticity among T helper cell subsets. J Exp Med. 2009 Aug 3; 206(8):1643-6.
        View in: PubMed PMC2722180
      49. Rothfuchs AG, Egen JG, Feng CG, Antonelli LR, Bafica A, Winter N, Locksley RM, Sher A. In situ IL-12/23p40 production during mycobacterial infection is sustained by CD11bhigh dendritic cells localized in tissue sites distinct from those harboring bacilli. J Immunol. 2009 Jun 1; 182(11):6915-25.
        View in: PubMed PMC2786988
      50. Kroeger KM, Sullivan BM, Locksley RM. IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway. J Leukoc Biol. 2009 Oct; 86(4):769-78.
        View in: PubMed PMC2752018
      51. Seibold MA, Reese TA, Choudhry S, Salam MT, Beckman K, Eng C, Atakilit A, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Fahy JV, Rodriguez-Santana J, Rodriguez-Cintron W, Boot RG, Sheppard D, Gilliland FD, Locksley RM, Burchard EG. Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein. J Biol Chem. 2009 Jul 17; 284(29):19650-8.
        View in: PubMed PMC2740590
      52. Reinhardt RL, Liang HE, Locksley RM. Cytokine-secreting follicular T cells shape the antibody repertoire. Nat Immunol. 2009 Apr; 10(4):385-93.
        View in: PubMed PMC2714053
      53. Kang SJ, Locksley RM. The inflammasome and alum-mediated adjuvanticity. F1000 Biol Rep. 2009; 1:15.
        View in: PubMed PMC2920669
      54. Sullivan BM, Locksley RM. Basophils: a nonredundant contributor to host immunity. Immunity. 2009 Jan 16; 30(1):12-20.
        View in: PubMed
      55. Scheu S, Dresing P, Locksley RM. Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20416-21.
        View in: PubMed PMC2629269
      56. Kang SJ, Liang HE, Reizis B, Locksley RM. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity. 2008 Nov 14; 29(5):819-33.
        View in: PubMed PMC2858430
      57. Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL. Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J Immunol. 2008 Oct 15; 181(8):5374-85.
        View in: PubMed PMC2657555
      58. Robinson RT, Khader SA, Locksley RM, Lien E, Smiley ST, Cooper AM. Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration. J Immunol. 2008 Oct 15; 181(8):5560-7.
        View in: PubMed PMC2640496
      59. Cisse B, Caton ML, Lehner M, Maeda T, Scheu S, Locksley R, Holmberg D, Zweier C, den Hollander NS, Kant SG, Holter W, Rauch A, Zhuang Y, Reizis B. Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell. 2008 Oct 3; 135(1):37-48.
        View in: PubMed PMC2631034
      60. Jensen KD, Su X, Shin S, Li L, Youssef S, Yamasaki S, Steinman L, Saito T, Locksley RM, Davis MM, Baumgarth N, Chien YH. Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity. 2008 Jul 18; 29(1):90-100.
        View in: PubMed PMC2601709
      61. Voehringer D, Liang HE, Locksley RM. Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice. J Immunol. 2008 Apr 1; 180(7):4742-53.
        View in: PubMed PMC2670614
      62. Locksley RM. The Roaring Twenties. Immunity. 2008 Apr; 28(4):437-9.
        View in: PubMed
      63. Van Dyken SJ, Locksley RM. Autoimmunity: altered self-N-glycans trigger innate-mediated autoimmunity. Immunol Cell Biol. 2007 Nov-Dec; 85(8):572-4.
        View in: PubMed
      64. Mueller SN, Hosiawa-Meagher KA, Konieczny BT, Sullivan BM, Bachmann MF, Locksley RM, Ahmed R, Matloubian M. Regulation of homeostatic chemokine expression and cell trafficking during immune responses. Science. 2007 Aug 3; 317(5838):670-4.
        View in: PubMed
      65. Nurieva RI, Chuvpilo S, Wieder ED, Elkon KB, Locksley R, Serfling E, Dong C. A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes. J Immunol. 2007 Jul 15; 179(2):1096-103.
        View in: PubMed
      66. Launois P, Pingel S, Himmelrich H, Locksley R, Louis J. Different epitopes of the LACK protein are recognized by V beta 4 V alpha 8 CD4+ T cells in H-2b and H-2d mice susceptible to Leishmania major. Microbes Infect. 2007 Sep; 9(11):1260-6.
        View in: PubMed
      67. Reese TA, Liang HE, Tager AM, Luster AD, Van Rooijen N, Voehringer D, Locksley RM. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature. 2007 May 3; 447(7140):92-6.
        View in: PubMed PMC2527589
      68. Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, Cilley GE, Shen F, Eaton SM, Gaffen SL, Swain SL, Locksley RM, Haynes L, Randall TD, Cooper AM. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol. 2007 Apr; 8(4):369-77.
        View in: PubMed
      69. Voehringer D, Stanley SA, Cox JS, Completo GC, Lowary TL, Locksley RM. Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection. Exp Parasitol. 2007 Aug; 116(4):458-66.
        View in: PubMed PMC2699772
      70. Voehringer D, van Rooijen N, Locksley RM. Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages. J Leukoc Biol. 2007 Jun; 81(6):1434-44.
        View in: PubMed
      71. Xu X, Zhang D, Zhang H, Wolters PJ, Killeen NP, Sullivan BM, Locksley RM, Lowell CA, Caughey GH. Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med. 2006 Dec 25; 203(13):2907-17.
        View in: PubMed PMC2118183
      72. Locksley RM. A failure to launch: fuelling cytokine secretion in iNKT cells. Immunity. 2006 Sep; 25(3):393-5.
        View in: PubMed
      73. Fife BT, Griffin MD, Abbas AK, Locksley RM, Bluestone JA. Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. J Clin Invest. 2006 Aug; 116(8):2252-61.
        View in: PubMed PMC1523399
      74. Reinhardt RL, Hong S, Kang SJ, Wang ZE, Locksley RM. Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation. J Immunol. 2006 Aug 1; 177(3):1618-27.
        View in: PubMed
      75. Gumy A, Aseffa A, Rachinel N, Breton M, Otten L, Tacchini-Cottier F, Röcken M, Doyen N, Acha-Orbea H, Locksley RM, MacDonald HR, Launois P, Louis J. LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major. Eur J Immunol. 2006 Jun; 36(6):1465-73.
        View in: PubMed
      76. Voehringer D, Reese TA, Huang X, Shinkai K, Locksley RM. Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J Exp Med. 2006 Jun 12; 203(6):1435-46.
        View in: PubMed PMC2118302
      77. Scheu S, Stetson DB, Reinhardt RL, Leber JH, Mohrs M, Locksley RM. Activation of the integrated stress response during T helper cell differentiation. Nat Immunol. 2006 Jun; 7(6):644-51.
        View in: PubMed
      78. Hayashida T, Oda M, Ohsawa K, Yamaguchi A, Hosozawa T, Locksley RM, Giacca M, Masai H, Miyatake S. Replication initiation from a novel origin identified in the Th2 cytokine cluster locus requires a distant conserved noncoding sequence. J Immunol. 2006 May 1; 176(9):5446-54.
        View in: PubMed
      79. Reinhardt RL, Kang SJ, Liang HE, Locksley RM. T helper cell effector fates--who, how and where? Curr Opin Immunol. 2006 Jun; 18(3):271-7.
        View in: PubMed
      80. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006 Feb; 24(2):179-89.
        View in: PubMed
      81. Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, Santamaria P, Locksley RM, Krummel MF, Bluestone JA. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol. 2006 Jan; 7(1):83-92.
        View in: PubMed PMC3057888
      82. Im W, Kim H, Yun D, Seo SY, Park SH, Locksley RM, Hong S. Cytokine reporter mouse system for screening novel IL12/23 p40-inducing compounds. Mol Cells. 2005 Oct 31; 20(2):288-96.
        View in: PubMed
      83. Mohrs K, Wakil AE, Killeen N, Locksley RM, Mohrs M. A two-step process for cytokine production revealed by IL-4 dual-reporter mice. Immunity. 2005 Oct; 23(4):419-29.
        View in: PubMed PMC2826320
      84. Loke P, Zang X, Hsuan L, Waitz R, Locksley RM, Allen JE, Allison JP. Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection. Proc Natl Acad Sci U S A. 2005 Jul 12; 102(28):9872-7.
        View in: PubMed PMC1175004
      85. Ohmura K, Nguyen LT, Locksley RM, Mathis D, Benoist C. Interleukin-4 can be a key positive regulator of inflammatory arthritis. Arthritis Rheum. 2005 Jun; 52(6):1866-75.
        View in: PubMed
      86. Kelly BL, Locksley RM. The Leishmania major LACK antigen with an immunodominant epitope at amino acids 156 to 173 is not required for early Th2 development in BALB/c mice. Infect Immun. 2004 Dec; 72(12):6924-31.
        View in: PubMed PMC529165
      87. Voehringer D, Rosen DB, Lanier LL, Locksley RM. CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells. J Biol Chem. 2004 Dec 24; 279(52):54117-23.
        View in: PubMed
      88. Xu M, Wang Z, Locksley RM. Innate immune responses in peptidoglycan recognition protein L-deficient mice. Mol Cell Biol. 2004 Sep; 24(18):7949-57.
        View in: PubMed PMC515053
      89. Voehringer D, Shinkai K, Locksley RM. Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity. 2004 Mar; 20(3):267-77.
        View in: PubMed
      90. Stetson DB, Voehringer D, Grogan JL, Xu M, Reinhardt RL, Scheu S, Kelly BL, Locksley RM. Th2 cells: orchestrating barrier immunity. Adv Immunol. 2004; 83:163-89.
        View in: PubMed
      91. Grogan JL, Wang ZE, Stanley S, Harmon B, Loots GG, Rubin EM, Locksley RM. Basal chromatin modification at the IL-4 gene in helper T cells. J Immunol. 2003 Dec 15; 171(12):6672-9.
        View in: PubMed
      92. Kelly BL, Stetson DB, Locksley RM. Leishmania major LACK antigen is required for efficient vertebrate parasitization. J Exp Med. 2003 Dec 1; 198(11):1689-98.
        View in: PubMed PMC2194132
      93. Stetson DB, Mohrs M, Reinhardt RL, Baron JL, Wang ZE, Gapin L, Kronenberg M, Locksley RM. Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J Exp Med. 2003 Oct 6; 198(7):1069-76.
        View in: PubMed PMC2194220
      94. Matsuda JL, Gapin L, Baron JL, Sidobre S, Stetson DB, Mohrs M, Locksley RM, Kronenberg M. Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo. Proc Natl Acad Sci U S A. 2003 Jul 8; 100(14):8395-400.
        View in: PubMed PMC166240
      95. Hadeiba H, Locksley RM. Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity. J Immunol. 2003 Jun 1; 170(11):5502-10.
        View in: PubMed
      96. Mohrs M, Lacy DA, Locksley RM. Stat signals release activated naive Th cells from an anergic checkpoint. J Immunol. 2003 Feb 15; 170(4):1870-6.
        View in: PubMed
      97. Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA. CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment. Nat Immunol. 2003 Feb; 4(2):182-8.
        View in: PubMed
      98. Shinkai K, Mohrs M, Locksley RM. Helper T cells regulate type-2 innate immunity in vivo. Nature. 2002 Dec 19-26; 420(6917):825-9.
        View in: PubMed
      99. Stetson DB, Mohrs M, Mallet-Designe V, Teyton L, Locksley RM. Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo. Immunity. 2002 Aug; 17(2):191-200.
        View in: PubMed
      100. Locksley RM. Blood lines. Nat Immunol. 2002 Aug; 3(8):705-6.
        View in: PubMed
      101. Grogan JL, Locksley RM. T helper cell differentiation: on again, off again. Curr Opin Immunol. 2002 Jun; 14(3):366-72.
        View in: PubMed
      102. Launois P, Gumy A, Himmelrich H, Locksley RM, Röcken M, Louis JA. Rapid IL-4 production by Leishmania homolog of mammalian RACK1-reactive CD4(+) T cells in resistant mice treated once with anti-IL-12 or -IFN-gamma antibodies at the onset of infection with Leishmania major instructs Th2 cell development, resulting in nonhealing lesions. J Immunol. 2002 May 1; 168(9):4628-35.
        View in: PubMed
      103. Baron JL, Gardiner L, Nishimura S, Shinkai K, Locksley R, Ganem D. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity. 2002 Apr; 16(4):583-94.
        View in: PubMed
      104. Riese RJ, Shi GP, Villadangos J, Stetson D, Driessen C, Lennon-Dumenil AM, Chu CL, Naumov Y, Behar SM, Ploegh H, Locksley R, Chapman HA. Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S. Immunity. 2001 Dec; 15(6):909-19.
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      105. Davies SJ, Grogan JL, Blank RB, Lim KC, Locksley RM, McKerrow JH. Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes. Science. 2001 Nov 9; 294(5545):1358-61.
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      106. Mohrs M, Blankespoor CM, Wang ZE, Loots GG, Afzal V, Hadeiba H, Shinkai K, Rubin EM, Locksley RM. Deletion of a coordinate regulator of type 2 cytokine expression in mice. Nat Immunol. 2001 Sep; 2(9):842-7.
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      107. Mohrs M, Shinkai K, Mohrs K, Locksley RM. Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity. 2001 Aug; 15(2):303-11.
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      108. Bottrel RL, Dutra WO, Martins FA, Gontijo B, Carvalho E, Barral-Netto M, Barral A, Almeida RP, Mayrink W, Locksley R, Gollob KJ. Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble Leishmania antigen in human cutaneous leishmaniasis. Infect Immun. 2001 May; 69(5):3232-9.
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      109. Maillard I, Launois P, Himmelrich H, Acha-Orbea H, Diggelmann H, Locksley RM, Louis JA. Functional plasticity of the LACK-reactive Vbeta4-Valpha8 CD4(+) T cells normally producing the early IL-4 instructing Th2 cell development and susceptibility to Leishmania major in BALB / c mice. Eur J Immunol. 2001 Apr; 31(4):1288-96.
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      110. Grogan JL, Mohrs M, Harmon B, Lacy DA, Sedat JW, Locksley RM. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity. 2001 Mar; 14(3):205-15.
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      111. Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell. 2001 Feb 23; 104(4):487-501.
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      112. Locksley RM. Flying doctors. Nat Immunol. 2000 Dec; 1(6):457-8.
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      113. Kelly BL, Locksley RM. Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns. J Immunol. 2000 Sep 15; 165(6):2982-6.
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      114. Gurunathan S, Stobie L, Prussin C, Sacks DL, Glaichenhaus N, Iwasaki A, Fowell DJ, Locksley RM, Chang JT, Wu CY, Seder RA. Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells. J Immunol. 2000 Jul 15; 165(2):915-24.
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      115. Himmelrich H, Launois P, Maillard I, Biedermann T, Tacchini-Cottier F, Locksley RM, Röcken M, Louis JA. In BALB/c mice, IL-4 production during the initial phase of infection with Leishmania major is necessary and sufficient to instruct Th2 cell development resulting in progressive disease. J Immunol. 2000 May 1; 164(9):4819-25.
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      116. Lacy DA, Wang ZE, Symula DJ, McArthur CJ, Rubin EM, Frazer KA, Locksley RM. Faithful expression of the human 5q31 cytokine cluster in transgenic mice. J Immunol. 2000 May 1; 164(9):4569-74.
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      117. Hadeiba H, Corry DB, Locksley RM. Baseline airway hyperreactivity in A/J mice is not mediated by cells of the adaptive immune system. J Immunol. 2000 May 1; 164(9):4933-40.
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      118. Loots GG, Locksley RM, Blankespoor CM, Wang ZE, Miller W, Rubin EM, Frazer KA. Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. Science. 2000 Apr 7; 288(5463):136-40.
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      119. Shinkai K, Locksley RM. CD1, tuberculosis, and the evolution of major histocompatibility complex molecules. J Exp Med. 2000 Mar 20; 191(6):907-14.
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      120. Pippig SD, Peña-Rossi C, Long J, Godfrey WR, Fowell DJ, Reiner SL, Birkeland ML, Locksley RM, Barclay AN, Killeen N. Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). J Immunol. 1999 Dec 15; 163(12):6520-9.
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      121. Symula DJ, Frazer KA, Ueda Y, Denefle P, Stevens ME, Wang ZE, Locksley R, Rubin EM. Functional screening of an asthma QTL in YAC transgenic mice. Nat Genet. 1999 Oct; 23(2):241-4.
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      122. Fowell DJ, Shinkai K, Liao XC, Beebe AM, Coffman RL, Littman DR, Locksley RM. Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells. Immunity. 1999 Oct; 11(4):399-409.
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      123. Fowell DJ, Locksley RM. Leishmania major infection of inbred mice: unmasking genetic determinants of infectious diseases. Bioessays. 1999 Jun; 21(6):510-8.
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      124. Pingel S, Launois P, Fowell DJ, Turck CW, Southwood S, Sette A, Glaichenhaus N, Louis JA, Locksley RM. Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope. J Exp Med. 1999 Apr 5; 189(7):1111-20.
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      125. Locksley RM, Pingel S, Lacy D, Wakil AE, Bix M, Fowell DJ. Susceptibility to infectious diseases: Leishmania as a paradigm. J Infect Dis. 1999 Mar; 179 Suppl 2:S305-8.
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      126. Corry DB, Locksley RM. Construction of polycompetitors for competitive PCR. Methods Mol Med. 1999; 26:253-64.
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      127. Bix M, Wang ZE, Thiel B, Schork NJ, Locksley RM. Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism. J Exp Med. 1998 Dec 21; 188(12):2289-99.
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      128. Grünig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB. Requirement for IL-13 independently of IL-4 in experimental asthma. Science. 1998 Dec 18; 282(5397):2261-3.
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      129. Wakil AE, Wang ZE, Ryan JC, Fowell DJ, Locksley RM. Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development. J Exp Med. 1998 Nov 2; 188(9):1651-6.
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      130. Fowell DJ, Bix M, Shinkai K, Lacy D, Locksley RM. Disease susceptibility and development of the cytokine repertoire in the murine Leishmania major model. Eur Cytokine Netw. 1998 Sep; 9(3 Suppl):102-6.
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      131. Bix M, Locksley RM. Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells. Science. 1998 Aug 28; 281(5381):1352-4.
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      132. Joiner KA, Powderly WG, Blaser MJ, Klempner MS, Locksley RM, Mandell GL, Preheim LC, Remington JS, Slama TG, Steigbigel NH, Bartlett JG. Fellowship training in infectious diseases: a report from the regional and national meetings of infectious diseases division chiefs and program directors. Clin Infect Dis. 1998 May; 26(5):1060-5.
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      133. Corry DB, Grünig G, Hadeiba H, Kurup VP, Warnock ML, Sheppard D, Rennick DM, Locksley RM. Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice. Mol Med. 1998 May; 4(5):344-55.
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      134. Brossay L, Tangri S, Bix M, Cardell S, Locksley R, Kronenberg M. Mouse CD1-autoreactive T cells have diverse patterns of reactivity to CD1+ targets. J Immunol. 1998 Apr 15; 160(8):3681-8.
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      135. Pingel S, Wang ZE, Locksley RM. Distribution of protein kinase C isoforms after infection of macrophages with Leishmania major. Infect Immun. 1998 Apr; 66(4):1795-9.
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      136. Reiner SL, Fowell DJ, Moskowitz NH, Swier K, Brown DR, Brown CR, Turck CW, Scott PA, Killeen N, Locksley RM. Control of Leishmania major by a monoclonal alpha beta T cell repertoire. J Immunol. 1998 Jan 15; 160(2):884-9.
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      137. Locksley RM, Fowell DJ, Shinkai K, Wakil AE, Lacy D, Bix M. Development of CD4+ effector T cells and susceptibility to infectious diseases. Adv Exp Med Biol. 1998; 452:45-52.
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      138. McSorley SJ, Soldera S, Malherbe L, Carnaud C, Locksley RM, Flavell RA, Glaichenhaus N. Immunological tolerance to a pancreatic antigen as a result of local expression of TNFalpha by islet beta cells. Immunity. 1997 Sep; 7(3):401-9.
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      139. Hagenbaugh A, Sharma S, Dubinett SM, Wei SH, Aranda R, Cheroutre H, Fowell DJ, Binder S, Tsao B, Locksley RM, Moore KW, Kronenberg M. Altered immune responses in interleukin 10 transgenic mice. J Exp Med. 1997 Jun 16; 185(12):2101-10.
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      140. Launois P, Maillard I, Pingel S, Swihart KG, Xénarios I, Acha-Orbea H, Diggelmann H, Locksley RM, MacDonald HR, Louis JA. IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice. Immunity. 1997 May; 6(5):541-9.
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      141. Fowell DJ, Magram J, Turck CW, Killeen N, Locksley RM. Impaired Th2 subset development in the absence of CD4. Immunity. 1997 May; 6(5):559-69.
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      142. Stevenson FT, Turck J, Locksley RM, Lovett DH. The N-terminal propiece of interleukin 1 alpha is a transforming nuclear oncoprotein. Proc Natl Acad Sci U S A. 1997 Jan 21; 94(2):508-13.
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      143. Brown DR, Swier K, Moskowitz NH, Naujokas MF, Locksley RM, Reiner SL. T helper subset differentiation in the absence of invariant chain. J Exp Med. 1997 Jan 6; 185(1):31-41.
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      144. Locksley RM. Exploitation of immune and other defence mechanisms by parasites: an overview. Parasitology. 1997; 115 Suppl:S5-7.
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      145. Wakil AE, Wang ZE, Locksley RM. Leishmania major: targeting IL-4 in successful immunomodulation of murine infection. Exp Parasitol. 1996 Nov; 84(2):214-22.
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      146. Brown DR, Fowell DJ, Corry DB, Wynn TA, Moskowitz NH, Cheever AW, Locksley RM, Reiner SL. Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses. J Exp Med. 1996 Oct 1; 184(4):1295-304.
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      147. Corry DB, Ampel NM, Christian L, Locksley RM, Galgiani JN. Cytokine production by peripheral blood mononuclear cells in human coccidioidomycosis. J Infect Dis. 1996 Aug; 174(2):440-3.
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      148. Roth I, Corry DB, Locksley RM, Abrams JS, Litton MJ, Fisher SJ. Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10. J Exp Med. 1996 Aug 1; 184(2):539-48.
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      149. Fearon DT, Locksley RM. The instructive role of innate immunity in the acquired immune response. Science. 1996 Apr 5; 272(5258):50-3.
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      150. Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener-Kronish JP, Locksley RM. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J Exp Med. 1996 Jan 1; 183(1):109-17.
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      151. Fowell DJ, Wakil AE, Locksley RM. Interleukin-12 in murine leishmaniasis--match, flame or fuel? Res Immunol. 1995 Sep-Oct; 146(7-8):566-75.
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      152. Bix M, Locksley RM. Natural T cells. Cells that co-express NKRP-1 and TCR. J Immunol. 1995 Aug 1; 155(3):1020-2.
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      153. Mougneau E, Altare F, Wakil AE, Zheng S, Coppola T, Wang ZE, Waldmann R, Locksley RM, Glaichenhaus N. Expression cloning of a protective Leishmania antigen. Science. 1995 Apr 28; 268(5210):563-6.
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      154. Locksley RM, Wakil AE, Corry DB, Pingel S, Bix M, Fowell DJ. The development of effector T cell subsets in murine Leishmania major infection. Ciba Found Symp. 1995; 195:110-7; discussion 117-22.
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      155. Reiner SL, Locksley RM. The regulation of immunity to Leishmania major. Annu Rev Immunol. 1995; 13:151-77.
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      156. Wang ZE, Zheng S, Corry DB, Dalton DK, Seder RA, Reiner SL, Locksley RM. Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12932-6.
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      157. Corry DB, Reiner SL, Linsley PS, Locksley RM. Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis. J Immunol. 1994 Nov 1; 153(9):4142-8.
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      158. Reiner SL, Zheng S, Corry DB, Locksley RM. Constructing polycompetitor cDNAs for quantitative PCR (J. Immunol. Methods 165 (1993) 37-46; 173(1994) 133). J Immunol Methods. 1994 Oct 14; 175(2):275.
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      159. Reiner SL, Zheng S, Corry DB, Locksley RM. Constructing polycompetitor cDNAs for quantitative PCR (J. Immunol. Methods 165 (1993) 37-46). J Immunol Methods. 1994 Jul 12; 173(1):133.
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      160. Locksley RM. Th2 cells: help for helminths. J Exp Med. 1994 May 1; 179(5):1405-7.
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      161. Wang ZE, Reiner SL, Zheng S, Dalton DK, Locksley RM. CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major. J Exp Med. 1994 Apr 1; 179(4):1367-71.
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      162. Reiner SL, Zheng S, Wang ZE, Stowring L, Locksley RM. Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection. J Exp Med. 1994 Feb 1; 179(2):447-56.
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      163. Reiner SL, Locksley RM. Cytokines in the differentiation of Th1/Th2 CD4+ subsets in leishmaniasis. J Cell Biochem. 1993 Dec; 53(4):323-8.
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      164. Holaday BJ, Pompeu MM, Jeronimo S, Texeira MJ, Sousa Ade A, Vasconcelos AW, Pearson RD, Abrams JS, Locksley RM. Potential role for interleukin-10 in the immunosuppression associated with kala azar. J Clin Invest. 1993 Dec; 92(6):2626-32.
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      165. Reiner SL, Zheng S, Corry DB, Locksley RM. Constructing polycompetitor cDNAs for quantitative PCR. J Immunol Methods. 1993 Sep 27; 165(1):37-46.
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      166. Locksley RM, Reiner SL, Hatam F, Littman DR, Killeen N. Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science. 1993 Sep 10; 261(5127):1448-51.
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      167. Azouaou N, Gelber RH, Abel K, Sasaki DT, Murray LP, Locksley RM, Mohagheghpour N. Reconstitution of Mycobacterium leprae immunity in severe combined immunodeficient mice using a T-cell line. Int J Lepr Other Mycobact Dis. 1993 Sep; 61(3):398-405.
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      168. Wang ZE, Reiner SL, Hatam F, Heinzel FP, Bouvier J, Turck CW, Locksley RM. Targeted activation of CD8 cells and infection of beta 2-microglobulin-deficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmaniasis. J Immunol. 1993 Aug 15; 151(4):2077-86.
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      169. Stevenson FT, Bursten SL, Fanton C, Locksley RM, Lovett DH. The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece. Proc Natl Acad Sci U S A. 1993 Aug 1; 90(15):7245-9.
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      170. Locksley RM. Interleukin 12 in host defense against microbial pathogens. Proc Natl Acad Sci U S A. 1993 Jul 1; 90(13):5879-80.
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      171. Reiner SL, Locksley RM. The worm and the protozoa: stereotyped responses or distinct antigens? Parasitol Today. 1993 Jul; 9(7):258-60.
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      172. Tobin JF, Reiner SL, Hatam F, Zheng S, Leptak CL, Wirth DF, Locksley RM. Transfected Leishmania expressing biologically active IFN-gamma. J Immunol. 1993 Jun 1; 150(11):5059-69.
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      173. Heinzel FP, Rerko RM, Hatam F, Locksley RM. IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts. J Immunol. 1993 May 1; 150(9):3924-31.
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      174. Reiner SL, Wang ZE, Hatam F, Scott P, Locksley RM. TH1 and TH2 cell antigen receptors in experimental leishmaniasis. Science. 1993 Mar 5; 259(5100):1457-60.
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      175. Stevenson FT, Bursten SL, Locksley RM, Lovett DH. Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues. J Exp Med. 1992 Oct 1; 176(4):1053-62.
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      176. Locksley RM, Louis JA. Immunology of leishmaniasis. Curr Opin Immunol. 1992 Aug; 4(4):413-8.
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      177. Stevenson FT, Torrano F, Locksley RM, Lovett DH. Interleukin 1: the patterns of translation and intracellular distribution support alternative secretory mechanisms. J Cell Physiol. 1992 Aug; 152(2):223-31.
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      178. Amiri P, Locksley RM, Parslow TG, Sadick M, Rector E, Ritter D, McKerrow JH. Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice. Nature. 1992 Apr 16; 356(6370):604-7.
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      179. Reiner SL, Locksley RM. Lessons from Leishmania: a model for investigations of CD4+ subset differentiation. Infect Agents Dis. 1992 Feb; 1(1):33-42.
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      180. Sadick MD, Street N, Mosmann TR, Locksley RM. Cytokine regulation of murine leishmaniasis: interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice. Infect Immun. 1991 Dec; 59(12):4710-4.
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      181. Holaday BJ, Sadick MD, Wang ZE, Reiner SL, Heinzel FP, Parslow TG, Locksley RM. Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines. J Immunol. 1991 Sep 1; 147(5):1653-8.
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      182. Heinzel FP, Sadick MD, Mutha SS, Locksley RM. Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7011-5.
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      183. Bernstein MS, Tong-Starksen SE, Locksley RM. Activation of human monocyte--derived macrophages with lipopolysaccharide decreases human immunodeficiency virus replication in vitro at the level of gene expression. J Clin Invest. 1991 Aug; 88(2):540-5.
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      184. Allen JE, Locksley RM, Stephens RS. A single peptide from the major outer membrane protein of Chlamydia trachomatis elicits T cell help for the production of antibodies to protective determinants. J Immunol. 1991 Jul 15; 147(2):674-9.
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      185. Gardner KD, Burnside JS, Elzinga LW, Locksley RM. Cytokines in fluids from polycystic kidneys. Kidney Int. 1991 Apr; 39(4):718-24.
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      186. Locksley RM, Scott P. Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function. Immunol Today. 1991 Mar; 12(3):A58-61.
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      187. Locksley RM, Heinzel FP, Holaday BJ, Mutha SS, Reiner SL, Sadick MD. Induction of Th1 and Th2 CD4+ subsets during murine Leishmania major infection. Res Immunol. 1991 Jan; 142(1):28-32.
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      188. Sadick MD, Heinzel FP, Holaday BJ, Pu RT, Dawkins RS, Locksley RM. Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism. J Exp Med. 1990 Jan 1; 171(1):115-27.
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      189. Guglielmo BJ, Jacobs RA, Locksley RM. The exposure of health care workers to ribavirin aerosol. JAMA. 1989 Apr 7; 261(13):1880-1.
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      190. Heinzel FP, Sadick MD, Holaday BJ, Coffman RL, Locksley RM. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med. 1989 Jan 1; 169(1):59-72.
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      191. Locksley RM, Crowe S, Sadick MD, Heinzel FP, Gardner KD, McGrath MS, Mills J. Release of interleukin 1 inhibitory activity (contra-IL-1) by human monocyte-derived macrophages infected with human immunodeficiency virus in vitro and in vivo. J Clin Invest. 1988 Dec; 82(6):2097-105.
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      192. Bursten SL, Locksley RM, Ryan JL, Lovett DH. Acylation of monocyte and glomerular mesangial cell proteins. Myristyl acylation of the interleukin 1 precursors. J Clin Invest. 1988 Nov; 82(5):1479-88.
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      193. Hamadeh R, Ardehali A, Locksley RM, York MK. Fatal aspergillosis associated with smoking contaminated marijuana, in a marrow transplant recipient. Chest. 1988 Aug; 94(2):432-3.
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      194. Heinzel FP, Sadick MD, Locksley RM. Leishmania major: analysis of lymphocyte and macrophage cellular phenotypes during infection of susceptible and resistant mice. Exp Parasitol. 1988 Apr; 65(2):258-68.
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      195. Locksley RM, Heinzel FP, Fankhauser JE, Nelson CS, Sadick MD. Cutaneous host defense in leishmaniasis: interaction of isolated dermal macrophages and epidermal Langerhans cells with the insect-stage promastigote. Infect Immun. 1988 Feb; 56(2):336-42.
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      196. Locksley RM, Heinzel FP, Shepard HM, Agosti J, Eessalu TE, Aggarwal BB, Harlan JM. Tumor necrosis factors alpha and beta differ in their capacities to generate interleukin 1 release from human endothelial cells. J Immunol. 1987 Sep 15; 139(6):1891-5.
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      197. Locksley RM, Heinzel FP, Sadick MD, Holaday BJ, Gardner KD. Murine cutaneous leishmaniasis: susceptibility correlates with differential expansion of helper T-cell subsets. Ann Inst Pasteur Immunol. 1987 Sep-Oct; 138(5):744-9.
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      198. Sadick MD, Heinzel FP, Shigekane VM, Fisher WL, Locksley RM. Cellular and humoral immunity to Leishmania major in genetically susceptible mice after in vivo depletion of L3T4+ T cells. J Immunol. 1987 Aug 15; 139(4):1303-9.
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      199. Locksley RM, Nelson CS, Fankhauser JE, Klebanoff SJ. Loss of granule myeloperoxidase during in vitro culture of human monocytes correlates with decay in antiprotozoa activity. Am J Trop Med Hyg. 1987 May; 36(3):541-8.
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      200. Hickstein DD, Ozols J, Williams SA, Baenziger JU, Locksley RM, Roth GJ. Isolation and characterization of the receptor on human neutrophils that mediates cellular adherence. J Biol Chem. 1987 Apr 25; 262(12):5576-80.
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      201. Hickstein DD, Smith A, Fisher W, Beatty PG, Schwartz BR, Harlan JM, Root RK, Locksley RM. Expression of leukocyte adherence-related glycoproteins during differentiation of HL-60 promyelocytic leukemia cells. J Immunol. 1987 Jan 15; 138(2):513-9.
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      202. Hickstein DD, Locksley RM, Beatty PG, Smith A, Stone DM, Root RK. Monoclonal antibodies binding to the human neutrophil C3bi receptor have disparate functional effects. Blood. 1986 Apr; 67(4):1054-62.
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      203. Sadick MD, Locksley RM, Tubbs C, Raff HV. Murine cutaneous leishmaniasis: resistance correlates with the capacity to generate interferon-gamma in response to Leishmania antigens in vitro. J Immunol. 1986 Jan; 136(2):655-61.
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      204. Locksley RM, Flournoy N, Sullivan KM, Meyers JD. Infection with varicella-zoster virus after marrow transplantation. J Infect Dis. 1985 Dec; 152(6):1172-81.
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      205. Locksley RM, Fankhauser J, Henderson WR. Alteration of leukotriene release by macrophages ingesting Toxoplasma gondii. Proc Natl Acad Sci U S A. 1985 Oct; 82(20):6922-6.
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      206. Sadick MD, Locksley RM, Raff HV. Development of cellular immunity in cutaneous leishmaniasis due to Leishmania tropica. J Infect Dis. 1984 Jul; 150(1):135-8.
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      207. Jacobs RF, Locksley RM, Wilson CB, Haas JE, Klebanoff SJ. Interaction of primate alveolar macrophages and Legionella pneumophila. J Clin Invest. 1984 Jun; 73(6):1515-23.
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      208. Ryser RJ, Locksley RM, Eng SC, Dobbins WO, Schoenknecht FD, Rubin CE. Reversal of dementia associated with Whipple's disease by trimethoprim-sulfamethoxazole, drugs that penetrate the blood-brain barrier. Gastroenterology. 1984 Apr; 86(4):745-52.
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      209. Locksley RM, Wilson CB, Klebanoff SJ. Increased respiratory burst in myeloperoxidase-deficient monocytes. Blood. 1983 Oct; 62(4):902-9.
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      210. Klebanoff SJ, Locksley RM, Jong EC, Rosen H. Oxidative response of phagocytes to parasite invasion. Ciba Found Symp. 1983; 99:92-112.
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      211. Locksley RM, Klebanoff SJ. Oxygen-dependent microbicidal systems of phagocytes and host defense against intracellular protozoa. J Cell Biochem. 1983; 22(3):173-85.
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      212. Locksley RM, Jacobs RF, Wilson CB, Weaver WM, Klebanoff SJ. Susceptibility of Legionella pneumophila to oxygen-dependent microbicidal systems. J Immunol. 1982 Nov; 129(5):2192-7.
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      213. Locksley RM, Cohen ML, Quinn TC, Tompkins LS, Coyle MB, Kirihara JM, Counts GW. Multiply antibiotic-resistant Staphylococcus aureus: introduction, transmission, and evolution of nosocomial infection. Ann Intern Med. 1982 Sep; 97(3):317-24.
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      214. Locksley RM, Wilson CB, Klebanoff SJ. Role for endogenous and acquired peroxidase in the toxoplasmacidal activity of murine and human mononuclear phagocytes. J Clin Invest. 1982 May; 69(5):1099-111.
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      215. Ashraf N, Locksley R, Arieff AI. Thiazide-induced hyponatremia associated with death or neurologic damage in outpatients. Am J Med. 1981 Jun; 70(6):1163-8.
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      216. Moss AJ, DeCamilla J, Mietlowski W, Greene WA, Goldstein S, Locksley R. Prognostic grading and significance of ventricular premature beats after recovery from myocardial infarction. Circulation. 1975 Dec; 52(6 Suppl):III204-10.
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      217. Stam AC, Sole M, Locksley R, Weglicki WB, Sonnenblick EH. Two improvements in the preparation of cardiac microsomes. Recent Adv Stud Cardiac Struct Metab. 1974; 4:409-16.
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