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    Ophir Klein, PhD, MD

    SchoolUCSF School of Dentistry
    DepartmentOrofacial Sciences
    Address513 Parnassus Ave
    San Francisco CA 94143
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      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoGenetics residencySchool of Medicine2007
      Yale UniversityPediatrics residencySchool of Medicine2003
      Yale UniversityM.D.School of Medicine2000
      Yale UniversityPh.D.School of Medicine 1999
      University of California, BerkeleyB.A.1993

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Klein OD, Nör JE. Craniofacial Stem Cells in Health and Disease. J Dent Res. 2015 Nov; 94(11):1485-6.
        View in: PubMed
      2. Marangoni P, Charles C, Tafforeau P, Laugel-Haushalter V, Joo A, Bloch-Zupan A, Klein OD, Viriot L. Phenotypic and evolutionary implications of modulating the ERK-MAPK cascade using the dentition as a model. Sci Rep. 2015; 5:11658.
        View in: PubMed
      3. Tapaltsyan V, Charles C, Hu J, Mindell D, Ahituv N, Wilson GM, Black BL, Viriot L, Klein OD. Identification of novel Fgf enhancers and their role in dental evolution. Evol Dev. 2015 Jun 18.
        View in: PubMed
      4. Finkbeiner SR, Hill DR, Altheim CH, Dedhia PH, Taylor MJ, Tsai YH, Chin AM, Mahe MM, Watson CL, Freeman JJ, Nattiv R, Thomson M, Klein OD, Shroyer NF, Helmrath MA, Teitelbaum DH, Dempsey PJ, Spence JR. Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo. Stem Cell Reports. 2015 Jun 3.
        View in: PubMed
      5. Wu D, Mandal S, Choi A, Anderson A, Prochazkova M, Perry H, Gil-Da-Silva-Lopes VL, Lao R, Wan E, Tang PL, Kwok PY, Klein O, Zhuan B, Slavotinek AM. DLX4 is associated with orofacial clefting and abnormal jaw development. Hum Mol Genet. 2015 Aug 1; 24(15):4340-52.
        View in: PubMed
      6. Zarate YA, Perry H, Ben-Omran T, Sellars EA, Stein Q, Almureikhi M, Simmons K, Klein O, Fish J, Feingold M, Douglas J, Kruer MC, Si Y, Mao R, McKnight D, Gibellini F, Retterer K, Slavotinek A. Further supporting evidence for the SATB2-associated syndrome found through whole exome sequencing. Am J Med Genet A. 2015 May; 167(5):1026-32.
        View in: PubMed
      7. Thys A, Vandenberghe P, Hague P, Klein OD, Erneux C, Vanderwinden JM. Hyperplasia of interstitial cells of cajal in sprouty homolog 4 deficient mice. PLoS One. 2015; 10(4):e0124861.
        View in: PubMed
      8. Tapaltsyan V, Eronen JT, Lawing AM, Sharir A, Janis C, Jernvall J, Klein OD. Continuously Growing Rodent Molars Result from a Predictable Quantitative Evolutionary Change over 50 Million Years. Cell Rep. 2015 May 5; 11(5):673-80.
        View in: PubMed
      9. Tian H, Biehs B, Chiu C, Siebel CW, Wu Y, Costa M, de Sauvage FJ, Klein OD. Opposing activities of notch and wnt signaling regulate intestinal stem cells and gut homeostasis. Cell Rep. 2015 Apr 7; 11(1):33-42.
        View in: PubMed
      10. Dye BR, Hill DR, Ferguson MA, Tsai YH, Nagy MS, Dyal R, Wells JM, Mayhew CN, Nattiv R, Klein OD, White ES, Deutsch GH, Spence JR. In vitro generation of human pluripotent stem cell derived lung organoids. Elife. 2015; 4.
        View in: PubMed
      11. Jheon AH, Prochazkova M, Sherman M, Manoli DS, Shah NM, Carbone L, Klein O. Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles (Microtus ochrogaster). Int J Oral Sci. 2015 Mar; 7(1):23-6.
        View in: PubMed
      12. Barlow LA, Klein OD. Developing and regenerating a sense of taste. Curr Top Dev Biol. 2015; 111:401-19.
        View in: PubMed
      13. Harjunmaa E, Seidel K, Häkkinen T, Renvoisé E, Corfe IJ, Kallonen A, Zhang ZQ, Evans AR, Mikkola ML, Salazar-Ciudad I, Klein OD, Jernvall J. Replaying evolutionary transitions from the dental fossil record. Nature. 2014 Aug 7; 512(7512):44-8.
        View in: PubMed
      14. Castillo D, Seidel K, Salcedo E, Ahn C, de Sauvage FJ, Klein OD, Barlow LA. Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium. Development. 2014 Aug; 141(15):2993-3002.
        View in: PubMed PMC4197660
      15. Michailovici I, Harrington HA, Azogui HH, Yahalom-Ronen Y, Plotnikov A, Ching S, Stumpf MP, Klein OD, Seger R, Tzahor E. Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells. Development. 2014 Jul; 141(13):2611-20.
        View in: PubMed PMC4067960
      16. Goodwin AF, Larson JR, Jones KB, Liberton DK, Landan M, Wang Z, Boekelheide A, Langham M, Mushegyan V, Oberoi S, Brao R, Wen T, Johnson R, Huttner K, Grange DK, Spritz RA, Hallgrímsson B, Jheon AH, Klein OD. Craniofacial morphometric analysis of individuals with X-linked hypohidrotic ectodermal dysplasia. Mol Genet Genomic Med. 2014 Sep; 2(5):422-9.
        View in: PubMed PMC4190877
      17. Chavez MG, Hu J, Seidel K, Li C, Jheon A, Naveau A, Horst O, Klein OD. Isolation and culture of dental epithelial stem cells from the adult mouse incisor. J Vis Exp. 2014; (87).
        View in: PubMed PMC4141628
      18. Sun F, Wan M, Xu X, Gao B, Zhou Y, Sun J, Cheng L, Klein OD, Zhou X, Zheng L. Crosstalk between miR-34a and Notch Signaling Promotes Differentiation in Apical Papilla Stem Cells (SCAPs). J Dent Res. 2014 Apr 7; 93(6):589-595.
        View in: PubMed
      19. Mues G, Bonds J, Xiang L, Vieira AR, Seymen F, Klein O, D'Souza RN. The WNT10A gene in ectodermal dysplasias and selective tooth agenesis. Am J Med Genet A. 2014 Oct; 164A(10):2455-60.
        View in: PubMed PMC4167166
      20. Mendelsohn BA, Jeng LL, Oberoi S, Klein OD. Dental findings in 14q terminal deletion syndrome. Clin Dysmorphol. 2014 Apr; 23(2):60-2.
        View in: PubMed
      21. Goodwin AF, Oberoi S, Landan M, Charles C, Massie JC, Fairley C, Rauen KA, Klein OD. Craniofacial and dental development in Costello syndrome. Am J Med Genet A. 2014 Jun; 164A(6):1425-30.
        View in: PubMed PMC4115793
      22. Naveau A, Seidel K, Klein OD. Tooth, hair and claw: comparing epithelial stem cell niches of ectodermal appendages. Exp Cell Res. 2014 Jul 15; 325(2):96-103.
        View in: PubMed PMC4072742
      23. Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y. Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell. 2014 Feb 6; 14(2):160-73.
        View in: PubMed PMC3951379
      24. Ching ST, Cunha GR, Baskin LS, Basson MA, Klein OD. Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia. Dev Biol. 2014 Feb 1; 386(1):1-11.
        View in: PubMed PMC3921686
      25. Li CY, Prochazka J, Goodwin AF, Klein OD. Fibroblast growth factor signaling in mammalian tooth development. Odontology. 2014 Jan; 102(1):1-13.
        View in: PubMed
      26. Kuang-Hsien Hu J, Mushegyan V, Klein OD. On the cutting edge of organ renewal: Identification, regulation, and evolution of incisor stem cells. Genesis. 2014 Feb; 52(2):79-92.
        View in: PubMed
      27. Yamada Y, Nakamura S, Klein OD, Ito K. Current trends in stem cell therapy for improvement of bone quality. Histol Histopathol. 2014 Jun; 29(6):691-7.
        View in: PubMed
      28. Klein OD, Bush JO, Knox SM, Jheon AH, Cordero DR, Richtsmeier JT. American Journal of Medical Genetics Part A. The society of craniofacial genetics and developmental biology 35th annual meeting. 2013; 161(12):2938-2952.
      29. Klein OD, Oberoi S, Huysseune A, Hovorakova M, Peterka M, Peterkova R. Developmental disorders of the dentition: an update. Am J Med Genet C Semin Med Genet. 2013 Nov; 163C(4):318-32.
        View in: PubMed PMC3844689
      30. Goodwin AF, Tidyman WE, Jheon AH, Sharir A, Zheng X, Charles C, Fagin JA, McMahon M, Diekwisch TG, Ganss B, Rauen KA, Klein OD. Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation. Hum Mol Genet. 2014 Feb 1; 23(3):682-92.
        View in: PubMed PMC3888259
      31. Oishi PE, Klein OD, Keller RL. Developing physician-scientists in the fields of neonatology and pediatric critical care medicine: an effort to formulate a departmental policy. J Pediatr. 2013 Sep; 163(3):616-7.e1.
        View in: PubMed
      32. Zheng L, Warotayanont R, Stahl J, Kunimatsu R, Klein O, DenBesten PK, Zhang Y. Inductive ability of human developing and differentiated dental mesenchyme. Cells Tissues Organs. 2013; 198(2):99-110.
        View in: PubMed
      33. Jones KB, Klein OD. Oral epithelial stem cells in tissue maintenance and disease: the first steps in a long journey. Int J Oral Sci. 2013 Sep; 5(3):121-9.
        View in: PubMed PMC3967329
      34. Cao H, Jheon A, Li X, Sun Z, Wang J, Florez S, Zhang Z, McManus MT, Klein OD, Amendt BA. The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation. Development. 2013 Aug; 140(16):3348-59.
        View in: PubMed PMC3737717
      35. Biehs B, Hu JK, Strauli NB, Sangiorgi E, Jung H, Heber RP, Ho S, Goodwin AF, Dasen JS, Capecchi MR, Klein OD. BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor. Nat Cell Biol. 2013 Jul; 15(7):846-52.
        View in: PubMed PMC3735916
      36. Jones KB, Goodwin AF, Landan M, Seidel K, Tran DK, Hogue J, Chavez M, Fete M, Yu W, Hussein T, Johnson R, Huttner K, Jheon AH, Klein OD. Characterization of X-linked hypohidrotic ectodermal dysplasia (XL-HED) hair and sweat gland phenotypes using phototrichogram analysis and live confocal imaging. Am J Med Genet A. 2013 Jul; 161A(7):1585-93.
        View in: PubMed
      37. Lagronova-Churava S, Spoutil F, Vojtechova S, Lesot H, Peterka M, Klein OD, Peterkova R. The dynamics of supernumerary tooth development are differentially regulated by Sprouty genes. J Exp Zool B Mol Dev Evol. 2013 Jul; 320(5):307-20.
        View in: PubMed
      38. Nusse YM, Klein OD. If a stem cell dies in the crypt, and no one is around to see it…. Cell Stem Cell. 2013 Apr 4; 12(4):389-90.
        View in: PubMed
      39. Juuri E, Jussila M, Seidel K, Holmes S, Wu P, Richman J, Heikinheimo K, Chuong CM, Arnold K, Hochedlinger K, Klein O, Michon F, Thesleff I. Sox2 marks epithelial competence to generate teeth in mammals and reptiles. Development. 2013 Apr; 140(7):1424-32.
        View in: PubMed PMC3596986
      40. Yamada Y, Nakamura S, Ito K, Umemura E, Hara K, Nagasaka T, Abe A, Baba S, Furuichi Y, Izumi Y, Klein OD, Wakabayashi T. Injectable bone tissue engineering using expanded mesenchymal stem cells. Stem Cells. 2013 Mar; 31(3):572-80.
        View in: PubMed PMC4043220
      41. Plaks V, Brenot A, Lawson DA, Linnemann JR, Van Kappel EC, Wong KC, de Sauvage F, Klein OD, Werb Z. Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep. 2013 Jan 31; 3(1):70-8.
        View in: PubMed PMC3563842
      42. Felfly H, Klein OD. Sprouty genes regulate proliferation and survival of human embryonic stem cells. Sci Rep. 2013; 3:2277.
        View in: PubMed PMC3721083
      43. Wan M, Gao B, Sun F, Tang Y, Ye L, Fan Y, Klein OD, Zhou X, Zheng L. microRNA miR-34a regulates cytodifferentiation and targets multi-signaling pathways in human dental papilla cells. PLoS One. 2012; 7(11):e50090.
        View in: PubMed PMC3511455
      44. Griffin JN, Compagnucci C, Hu D, Fish J, Klein O, Marcucio R, Depew MJ. Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules. Dev Biol. 2013 Feb 1; 374(1):185-97.
        View in: PubMed PMC4086262
      45. Justice CM, Yagnik G, Kim Y, Peter I, Jabs EW, Erazo M, Ye X, Ainehsazan E, Shi L, Cunningham ML, Kimonis V, Roscioli T, Wall SA, Wilkie AO, Stoler J, Richtsmeier JT, Heuzé Y, Sanchez-Lara PA, Buckley MF, Druschel CM, Mills JL, Caggana M, Romitti PA, Kay DM, Senders C, Taub PJ, Klein OD, Boggan J, Zwienenberg-Lee M, Naydenov C, Kim J, Wilson AF, Boyadjiev SA. A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9. Nat Genet. 2012 Dec; 44(12):1360-4.
        View in: PubMed PMC3736322
      46. Goodwin AF, Oberoi S, Landan M, Charles C, Groth J, Martinez A, Fairley C, Weiss LA, Tidyman WE, Klein OD, Rauen KA. Craniofacial and dental development in cardio-facio-cutaneous syndrome: the importance of Ras signaling homeostasis. Clin Genet. 2013 Jun; 83(6):539-44.
        View in: PubMed PMC4115672
      47. Chavez MG, Yu W, Biehs B, Harada H, Snead ML, Lee JS, Desai TA, Klein OD. Characterization of dental epithelial stem cells from the mouse incisor with two-dimensional and three-dimensional platforms. Tissue Eng Part C Methods. 2013 Jan; 19(1):15-24.
        View in: PubMed PMC3522131
      48. Juuri E, Saito K, Ahtiainen L, Seidel K, Tummers M, Hochedlinger K, Klein OD, Thesleff I, Michon F. Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors. Dev Cell. 2012 Aug 14; 23(2):317-28.
        View in: PubMed PMC3690347
      49. Horst OV, Chavez MG, Jheon AH, Desai T, Klein OD. Stem cell and biomaterials research in dental tissue engineering and regeneration. Dent Clin North Am. 2012 Jul; 56(3):495-520.
        View in: PubMed PMC3494412
      50. Kyrylkova K, Kyryachenko S, Biehs B, Klein O, Kioussi C, Leid M. BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor. PLoS One. 2012; 7(5):e37670.
        View in: PubMed PMC3358280
      51. Jheon AH, Seidel K, Biehs B, Klein OD. From molecules to mastication: the development and evolution of teeth. Wiley Interdiscip Rev Dev Biol. 2013 Mar-Apr; 2(2):165-82.
        View in: PubMed PMC3632217
      52. Li CY, Cha W, Luder HU, Charles RP, McMahon M, Mitsiadis TA, Klein OD. E-cadherin regulates the behavior and fate of epithelial stem cells and their progeny in the mouse incisor. Dev Biol. 2012 Jun 15; 366(2):357-66.
        View in: PubMed PMC3690274
      53. Purcell P, Jheon A, Vivero MP, Rahimi H, Joo A, Klein OD. Spry1 and spry2 are essential for development of the temporomandibular joint. J Dent Res. 2012 Apr; 91(4):387-93.
        View in: PubMed PMC3310757
      54. Tian H, Biehs B, Warming S, Leong KG, Rangell L, Klein OD, de Sauvage FJ. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature. 2011 Oct 13; 478(7368):255-9.
        View in: PubMed
      55. Jheon AH, Li CY, Wen T, Michon F, Klein OD. Expression of microRNAs in the stem cell niche of the adult mouse incisor. PLoS One. 2011; 6(9):e24536.
        View in: PubMed PMC3169592
      56. Charles C, Hovorakova M, Ahn Y, Lyons DB, Marangoni P, Churava S, Biehs B, Jheon A, Lesot H, Balooch G, Krumlauf R, Viriot L, Peterkova R, Klein OD. Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling. Development. 2011 Sep; 138(18):4063-73.
        View in: PubMed PMC3160100
      57. Petersen CI, Jheon AH, Mostowfi P, Charles C, Ching S, Thirumangalathu S, Barlow LA, Klein OD. FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size. PLoS Genet. 2011 Jun; 7(6):e1002098.
        View in: PubMed PMC3107195
      58. Hochheiser H, Aronow BJ, Artinger K, Beaty TH, Brinkley JF, Chai Y, Clouthier D, Cunningham ML, Dixon M, Donahue LR, Fraser SE, Hallgrimsson B, Iwata J, Klein O, Marazita ML, Murray JC, Murray S, de Villena FP, Postlethwait J, Potter S, Shapiro L, Spritz R, Visel A, Weinberg SM, Trainor PA. The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol. 2011 Jul 15; 355(2):175-82.
        View in: PubMed PMC3440302
      59. Hovorakova M, Prochazka J, Lesot H, Smrckova L, Churava S, Boran T, Kozmik Z, Klein O, Peterkova R, Peterka M. Shh expression in a rudimentary tooth offers new insights into development of the mouse incisor. J Exp Zool B Mol Dev Evol. 2011 Jul 15; 316(5):347-58.
        View in: PubMed
      60. Jheon AH, Mostowfi P, Snead ML, Ihrie RA, Sone E, Pramparo T, Attardi LD, Klein OD. PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. J Cell Sci. 2011 Mar 1; 124(Pt 5):745-54.
        View in: PubMed PMC3039019
      61. Milunsky JM, Maher TM, Zhao G, Wang Z, Mulliken JB, Chitayat D, Clemens M, Stalker HJ, Bauer M, Burch M, Chénier S, Cunningham ML, Drack AV, Janssens S, Karlea A, Klatt R, Kini U, Klein O, Lachmeijer AM, Megarbane A, Mendelsohn NJ, Meschino WS, Mortier GR, Parkash S, Ray CR, Roberts A, Roberts A, Reardon W, Schnur RE, Smith R, Splitt M, Tezcan K, Whiteford ML, Wong DA, Zori R, Lin AE. Genotype-phenotype analysis of the branchio-oculo-facial syndrome. Am J Med Genet A. 2011 Jan; 155A(1):22-32.
        View in: PubMed
      62. Parsa S, Kuremoto K, Seidel K, Tabatabai R, Mackenzie B, Yamaza T, Akiyama K, Branch J, Koh CJ, Al Alam D, Klein OD, Bellusci S. Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors. Development. 2010 Nov; 137(22):3743-52.
        View in: PubMed PMC3049274
      63. Seidel K, Ahn CP, Lyons D, Nee A, Ting K, Brownell I, Cao T, Carano RA, Curran T, Schober M, Fuchs E, Joyner A, Martin GR, de Sauvage FJ, Klein OD. Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development. 2010 Nov; 137(22):3753-61.
        View in: PubMed PMC3049275
      64. Jelin A, Perry H, Hogue J, Oberoi S, Cotter PD, Klein OD. Clefting in trisomy 9p patients: genotype-phenotype correlation using microarray comparative genomic hybridization. J Craniofac Surg. 2010 Sep; 21(5):1376-9.
        View in: PubMed
      65. Ahn Y, Sanderson BW, Klein OD, Krumlauf R. Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning. Development. 2010 Oct; 137(19):3221-31.
        View in: PubMed
      66. Prochazka J, Pantalacci S, Churava S, Rothova M, Lambert A, Lesot H, Klein O, Peterka M, Laudet V, Peterkova R. Patterning by heritage in mouse molar row development. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15497-502.
        View in: PubMed PMC2932592
      67. Kettunen P, Kivimäe S, Keshari P, Klein OD, Cheyette BN, Luukko K. Dact1-3 mRNAs exhibit distinct expression domains during tooth development. Gene Expr Patterns. 2010 Feb-Mar; 10(2-3):140-3.
        View in: PubMed PMC2849867
      68. Charles C, Lazzari V, Tafforeau P, Schimmang T, Tekin M, Klein O, Viriot L. Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22364-8.
        View in: PubMed PMC2799759
      69. Boran T, Peterkova R, Lesot H, Lyons DB, Peterka M, Klein OD. Temporal analysis of ectopic enamel production in incisors from sprouty mutant mice. J Exp Zool B Mol Dev Evol. 2009 Jul 15; 312B(5):473-85.
        View in: PubMed PMC2837846
      70. Peterkova R, Churava S, Lesot H, Rothova M, Prochazka J, Peterka M, Klein OD. Revitalization of a diastemal tooth primordium in Spry2 null mice results from increased proliferation and decreased apoptosis. J Exp Zool B Mol Dev Evol. 2009 Jun 15; 312B(4):292-308.
        View in: PubMed PMC2880865
      71. Catón J, Luder HU, Zoupa M, Bradman M, Bluteau G, Tucker AS, Klein O, Mitsiadis TA. Enamel-free teeth: Tbx1 deletion affects amelogenesis in rodent incisors. Dev Biol. 2009 Apr 15; 328(2):493-505.
        View in: PubMed PMC2880856
      72. Kalfa N, Liu B, Klein O, Wang MH, Cao M, Baskin LS. Genomic variants of ATF3 in patients with hypospadias. J Urol. 2008 Nov; 180(5):2183-8; discussion 2188.
        View in: PubMed
      73. Kalfa N, Liu B, Klein O, Ophir K, Audran F, Wang MH, Mei C, Sultan C, Baskin LS. Mutations of CXorf6 are associated with a range of severities of hypospadias. Eur J Endocrinol. 2008 Oct; 159(4):453-8.
        View in: PubMed
      74. Klein OD, Kostiner DR, Weisiger K, Moffatt E, Lindeman N, Goodman S, Tuchman M, Packman S. Acute fatal presentation of ornithine transcarbamylase deficiency in a previously healthy male. Hepatol Int. 2008 Sep; 2(3):390-4.
        View in: PubMed PMC2716892
      75. Metzger RJ, Klein OD, Martin GR, Krasnow MA. The branching programme of mouse lung development. Nature. 2008 Jun 5; 453(7196):745-50.
        View in: PubMed PMC2892995
      76. Klein OD, Lyons DB, Balooch G, Marshall GW, Basson MA, Peterka M, Boran T, Peterkova R, Martin GR. An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors. Development. 2008 Jan; 135(2):377-85.
        View in: PubMed PMC2555979
      77. Klein OD, Cotter PD, Moore MW, Zanko A, Gilats M, Epstein CJ, Conte F, Rauen KA. Interstitial deletions of chromosome 6q: genotype-phenotype correlation utilizing array CGH. Clin Genet. 2007 Mar; 71(3):260-6.
        View in: PubMed
      78. D'Souza RN, Klein OD. Unraveling the molecular mechanisms that lead to supernumerary teeth in mice and men: current concepts and novel approaches. Cells Tissues Organs. 2007; 186(1):60-9.
        View in: PubMed
      79. Klein OD, Minowada G, Peterkova R, Kangas A, Yu BD, Lesot H, Peterka M, Jernvall J, Martin GR. Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling. Dev Cell. 2006 Aug; 11(2):181-90.
        View in: PubMed PMC2847684
      80. Klein OD, Cotter PD, Schmidt AM, Bick DP, Tidyman WE, Albertson DG, Pinkel D, Rauen KA. Interstitial deletion of chromosome 12q: genotype-phenotype correlation of two patients utilizing array comparative genomic hybridization. Am J Med Genet A. 2005 Nov 1; 138(4):349-54.
        View in: PubMed
      81. Ahn CP, Lachman RS, Cox VA, Blumberg B, Klein OD. Brachydactylic multiple delta phalanges plus syndrome. Am J Med Genet A. 2005 Sep 15; 138(1):41-4.
        View in: PubMed
      82. Klein OD, Backstrand K, Cotter PD, Marco E, Sherr E, Slavotinek A. Case report: Y;6 translocation with deletion of 6p. Clin Dysmorphol. 2005 Apr; 14(2):93-6.
        View in: PubMed
      83. Klein OD, Cotter PD, Albertson DG, Pinkel D, Tidyman WE, Moore MW, Rauen KA. Prader-Willi syndrome resulting from an unbalanced translocation: characterization by array comparative genomic hybridization. Clin Genet. 2004 Jun; 65(6):477-82.
        View in: PubMed
      84. Raga F, Bonilla-Musoles F, Osborne NG, Casañ EM, Klein O, Bonilla F . The Ultrasound Review of Obstetrics and Gynecology. Congenital Müllerian anomalies: A review of currently available imaging modalities. 2002; 2(1):56-67.
      85. Klein O, Azzi AE. The strategic confirmation of meta-stereotypes: how group members attempt to tailor an out-group's representation of themselves. Br J Soc Psychol. 2001 Jun; 40(Pt 2):279-93.
        View in: PubMed
      86. Raga F, Bonilla-Musoles F, Casañ EM, Klein O, Bonilla F. Assessment of endometrial volume by three-dimensional ultrasound prior to embryo transfer: clues to endometrial receptivity. Hum Reprod. 1999 Nov; 14(11):2851-4.
        View in: PubMed
      87. Klein O, Kegler-Ebo D, Su J, Smith S, DiMaio D. The bovine papillomavirus E5 protein requires a juxtamembrane negative charge for activation of the platelet-derived growth factor beta receptor and transformation of C127 cells. J Virol. 1999 Apr; 73(4):3264-72.
        View in: PubMed PMC104090
      88. Surti T, Klein O, Aschheim K, DiMaio D, Smith SO. Structural models of the bovine papillomavirus E5 protein. Proteins. 1998 Dec 1; 33(4):601-12.
        View in: PubMed
      89. Klein O, Polack GW, Surti T, Kegler-Ebo D, Smith SO, DiMaio D. Role of glutamine 17 of the bovine papillomavirus E5 protein in platelet-derived growth factor beta receptor activation and cell transformation. J Virol. 1998 Nov; 72(11):8921-32.
        View in: PubMed PMC110309
      90. DiMaio D, Lai CC, Klein O. Virocrine transformation: the intersection between viral transforming proteins and cellular signal transduction pathways. Annu Rev Microbiol. 1998; 52:397-421.
        View in: PubMed
      91. Lee ME, Dyer DH, Klein OD, Bolduc JM, Stoddard BL, Koshland DE. Mutational analysis of the catalytic residues lysine 230 and tyrosine 160 in the NADP(+)-dependent isocitrate dehydrogenase from Escherichia coli. Biochemistry. 1995 Jan 10; 34(1):378-84.
        View in: PubMed
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