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    Ophir Klein, PhD, MD

    TitleProfessor
    SchoolUCSF School of Dentistry
    DepartmentOrofacial Sciences
    Address513 Parnassus Ave, HSE
    San Francisco CA 94143
    Phone415-476-4719
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      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoGenetics residencySchool of Medicine2007
      Yale UniversityPediatrics residencySchool of Medicine2003
      Yale UniversityM.D.School of Medicine2000
      Yale UniversityPh.D.School of Medicine 1999
      University of California, BerkeleyB.A.1993

      Collapse Overview 
      Collapse Overview
      Embryonic development is one of the most beautiful processes in nature. However, when developmental processes go awry, then birth defects, cancer and other diseases can result. Our research is centered on understanding how development and regeneration normally occur in the hope of one day treating diseases that result from abnormalities in these processes.

      A central focus in the lab is craniofacial and dental development, as malformations in these organs are among the most common congenital abnormalities and have profound impacts on the lives of patients and their families. The maintenance, repair and growth of many adult organs, such as the bone marrow, skin, brain, and gastrointestinal tract, depend on tissue-specific populations of stem cells. We use the rodent incisor as a model system to understand adult stem cells. Unlike human teeth, the rodent incisor grows continuously throughout the life of the animal. We are working to understand the molecular processes that regulate the behavior of these stem cells, including their capacity to self-renew as well as to differentiate into the various cellular components of the tooth. We intend to use the insights provided by our experiments in mice to guide us in the use of stem cells in regenerating dental and craniofacial tissues as a paradigm for developing replacement organs.

      Another major area of study is regeneration of the gastrointestinal tract. The amazing ability of the mammalian gastrointestinal epithelium to renew has long fascinated biologists. Our research aims to address fundamental questions in this field, including the identity, regulation and plasticity of intestinal stem cells.

      Finally, our laboratory is interested in how positive and negative modulators of signaling affect development, homeostasis and cancer. We are studying the roles of these molecules in the patterning and outgrowth of teeth, taste papillae, craniofacial and long bones, external genitalia, skin, and other organs. We are also examining the roles of these molecules in embryonic and adult stem cells.


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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Sun Z, Yu W, Navarro MS, Sweat M, Eliason S, Sharp T, Liu H, Seidel K, Zhang L, Moreno M, Lynch T, Holton NE, Rogers L, Neff T, Goodheart MJ, Michon F, Klein OD, Chai Y, Dupuy A, Engelhardt JF, Chen Z, Amendt BA. Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal. Development. 2016 Sep 22. PMID: 27660324.
        View in: PubMed
      2. Sharir A, Klein OD. Watching a deep dive: Live imaging provides lessons about tooth invagination. J Cell Biol. 2016 Sep 12; 214(6):645-7. PMID: 27621361; PMCID: PMC5021101 [Available on 03/12/17].
      3. Koledova Z, Zhang X, Streuli C, Clarke RB, Klein OD, Werb Z, Lu P. SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling. Proc Natl Acad Sci U S A. 2016 Sep 27; 113(39):E5731-40. PMID: 27621461.
        View in: PubMed
      4. Demidov VE, Evelt M, Bessonov V, Demokritov SO, Prieto JL, Muñoz M, Ben Youssef J, Naletov VV, de Loubens G, Klein O, Collet M, Bortolotti P, Cros V, Anane A. Direct observation of dynamic modes excited in a magnetic insulator by pure spin current. Sci Rep. 2016; 6:32781. PMID: 27608533.
        View in: PubMed
      5. Cole JB, Manyama M, Kimwaga E, Mathayo J, Larson JR, Liberton DK, Lukowiak K, Ferrara TM, Riccardi SL, Li M, Mio W, Prochazkova M, Williams T, Li H, Jones KL, Klein OD, Santorico SA, Hallgrimsson B, Spritz RA. Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape. PLoS Genet. 2016 Aug; 12(8):e1006174. PMID: 27560698.
        View in: PubMed
      6. Li CY, Hu J, Lu H, Lan J, Du W, Galicia N, Klein OD. aE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development. Nat Commun. 2016; 7:12133. PMID: 27405641.
        View in: PubMed
      7. Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley RM, Klein OD. . JCI insight. Dual epithelial and immune cell function of Dvl1 regulates gut mircobiota composition and intestinal homeostasis. 2016; 1(10):e85395.
      8. Neben CL, Roberts RR, Dipple KM, Merrill AE, Klein OD, et al. Modeling craniofacial and skeletal congenital birth defects to advance therapies. Hum Mol Genet. 2016 Jun 26. PMID: 27346519.
        View in: PubMed
      9. Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J, Chai Y, et al. The FaceBase Consortium: a comprehensive resource for craniofacial researchers. Development. 2016 Jul 15; 143(14):2677-88. PMID: 27287806.
        View in: PubMed
      10. Joo A, Long R, Cheng Z, Alexander C, Chang W, Klein OD. Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling. Bone. 2016 Jul; 88:170-9. PMID: 27130872.
        View in: PubMed
      11. Belinson H, Nakatani J, Babineau BA, Birnbaum RY, Ellegood J, Bershteyn M, McEvilly RJ, Long JM, Willert K, Klein OD, Ahituv N, Lerch JP, Rosenfeld MG, Wynshaw-Boris A, et al. Prenatal ß-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors. Mol Psychiatry. 2016 Feb 2. PMID: 26830142.
        View in: PubMed
      12. Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM. Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome. J Neurosci. 2016 Jan 6; 36(1):142-52. PMID: 26740656.
        View in: PubMed
      13. Du W, Prochazka J, Prochazkova M, Klein OD. Expression of FGFs during early mouse tongue development. Gene Expr Patterns. 2016 Mar; 20(2):81-7. PMID: 26748348.
        View in: PubMed
      14. Prochazka J, Prochazkova M, Du W, Spoutil F, Tureckova J, Hoch R, Shimogori T, Sedlacek R, Rubenstein JL, Wittmann T, Klein OD. Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis. Dev Cell. 2015 Dec 21; 35(6):713-24. PMID: 26702830.
        View in: PubMed
      15. Klein OD, Nör JE. Craniofacial Stem Cells in Health and Disease. J Dent Res. 2015 Nov; 94(11):1485-6. PMID: 26494794.
        View in: PubMed
      16. Goodwin AF, Kim R, Bush JO, Klein OD. From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models. Curr Top Dev Biol. 2015; 115:459-92. PMID: 26589935.
        View in: PubMed
      17. Jheon AH, Prochazkova M, Meng B, Wen T, Lim YJ, Naveau A, Espinoza R, Cox TC, Sone ED, Ganss B, Siebel CW, Klein OD. Inhibition of Notch Signaling During Mouse Incisor Renewal Leads to Enamel Defects. J Bone Miner Res. 2016 Jan; 31(1):152-62. PMID: 26179131.
        View in: PubMed
      18. Tapaltsyan V, Charles C, Hu J, Mindell D, Ahituv N, Wilson GM, Black BL, Viriot L, Klein OD. Identification of novel Fgf enhancers and their role in dental evolution. Evol Dev. 2016 Jan; 18(1):31-40. PMID: 26086993.
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      19. Finkbeiner SR, Hill DR, Altheim CH, Dedhia PH, Taylor MJ, Tsai YH, Chin AM, Mahe MM, Watson CL, Freeman JJ, Nattiv R, Thomson M, Klein OD, Shroyer NF, Helmrath MA, Teitelbaum DH, Dempsey PJ, Spence JR. Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo. Stem Cell Reports. 2015 Jun 3. PMID: 26050928.
        View in: PubMed
      20. Wu D, Mandal S, Choi A, Anderson A, Prochazkova M, Perry H, Gil-Da-Silva-Lopes VL, Lao R, Wan E, Tang PL, Kwok PY, Klein O, Zhuan B, Slavotinek AM. DLX4 is associated with orofacial clefting and abnormal jaw development. Hum Mol Genet. 2015 Aug 1; 24(15):4340-52. PMID: 25954033; PMCID: PMC4492397 [Available on 08/01/16].
      21. Zarate YA, Perry H, Ben-Omran T, Sellars EA, Stein Q, Almureikhi M, Simmons K, Klein O, Fish J, Feingold M, Douglas J, Kruer MC, Si Y, Mao R, McKnight D, Gibellini F, Retterer K, Slavotinek A. Further supporting evidence for the SATB2-associated syndrome found through whole exome sequencing. Am J Med Genet A. 2015 May; 167A(5):1026-32. PMID: 25885067.
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      22. Thys A, Vandenberghe P, Hague P, Klein OD, Erneux C, Vanderwinden JM. Hyperplasia of interstitial cells of cajal in sprouty homolog 4 deficient mice. PLoS One. 2015; 10(4):e0124861. PMID: 25923139; PMCID: PMC4414615.
      23. Tapaltsyan V, Eronen JT, Lawing AM, Sharir A, Janis C, Jernvall J, Klein OD. Continuously growing rodent molars result from a predictable quantitative evolutionary change over 50 million years. Cell Rep. 2015 May 5; 11(5):673-80. PMID: 25921530; PMCID: PMC4426059 [Available on 05/05/16].
      24. Tian H, Biehs B, Chiu C, Siebel CW, Wu Y, Costa M, de Sauvage FJ, Klein OD. Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis. Cell Rep. 2015 Apr 7; 11(1):33-42. PMID: 25818302; PMCID: PMC4394041.
      25. Dye BR, Hill DR, Ferguson MA, Tsai YH, Nagy MS, Dyal R, Wells JM, Mayhew CN, Nattiv R, Klein OD, White ES, Deutsch GH, Spence JR. In vitro generation of human pluripotent stem cell derived lung organoids. Elife. 2015; 4. PMID: 25803487; PMCID: PMC4370217.
      26. Jheon AH, Prochazkova M, Sherman M, Manoli DS, Shah NM, Carbone L, Klein O. Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles (Microtus ochrogaster). Int J Oral Sci. 2015 Mar; 7(1):23-6. PMID: 25634121.
        View in: PubMed
      27. Barlow LA, Klein OD. Developing and regenerating a sense of taste. Curr Top Dev Biol. 2015; 111:401-19. PMID: 25662267; PMCID: PMC4435577 [Available on 01/20/16].
      28. Harjunmaa E, Seidel K, Häkkinen T, Renvoisé E, Corfe IJ, Kallonen A, Zhang ZQ, Evans AR, Mikkola ML, Salazar-Ciudad I, Klein OD, Jernvall J. Replaying evolutionary transitions from the dental fossil record. Nature. 2014 Aug 7; 512(7512):44-8. PMID: 25079326; PMCID: PMC4252015.
      29. Castillo D, Seidel K, Salcedo E, Ahn C, de Sauvage FJ, Klein OD, Barlow LA. Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium. Development. 2014 Aug; 141(15):2993-3002. PMID: 24993944; PMCID: PMC4197660.
      30. Michailovici I, Harrington HA, Azogui HH, Yahalom-Ronen Y, Plotnikov A, Ching S, Stumpf MP, Klein OD, Seger R, Tzahor E. Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells. Development. 2014 Jul; 141(13):2611-20. PMID: 24924195; PMCID: PMC4067960.
      31. Goodwin AF, Larson JR, Jones KB, Liberton DK, Landan M, Wang Z, Boekelheide A, Langham M, Mushegyan V, Oberoi S, Brao R, Wen T, Johnson R, Huttner K, Grange DK, Spritz RA, Hallgrímsson B, Jheon AH, Klein OD. Craniofacial morphometric analysis of individuals with X-linked hypohidrotic ectodermal dysplasia. Mol Genet Genomic Med. 2014 Sep; 2(5):422-9. PMID: 25333067; PMCID: PMC4190877.
      32. Chavez MG, Hu J, Seidel K, Li C, Jheon A, Naveau A, Horst O, Klein OD. Isolation and culture of dental epithelial stem cells from the adult mouse incisor. J Vis Exp. 2014; (87). PMID: 24834972; PMCID: PMC4141628.
      33. Sun F, Wan M, Xu X, Gao B, Zhou Y, Sun J, Cheng L, Klein OD, Zhou X, Zheng L. Crosstalk between miR-34a and Notch Signaling Promotes Differentiation in Apical Papilla Stem Cells (SCAPs). J Dent Res. 2014 Jun; 93(6):589-95. PMID: 24710391.
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      34. Mues G, Bonds J, Xiang L, Vieira AR, Seymen F, Klein O, D'Souza RN. The WNT10A gene in ectodermal dysplasias and selective tooth agenesis. Am J Med Genet A. 2014 Oct; 164A(10):2455-60. PMID: 24700731; PMCID: PMC4167166.
      35. Mendelsohn BA, Jeng LL, Oberoi S, Klein OD. Dental findings in 14q terminal deletion syndrome. Clin Dysmorphol. 2014 Apr; 23(2):60-2. PMID: 24535103.
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      36. Goodwin AF, Oberoi S, Landan M, Charles C, Massie JC, Fairley C, Rauen KA, Klein OD. Craniofacial and dental development in Costello syndrome. Am J Med Genet A. 2014 Jun; 164A(6):1425-30. PMID: 24668879; PMCID: PMC4115793.
      37. Naveau A, Seidel K, Klein OD. Tooth, hair and claw: comparing epithelial stem cell niches of ectodermal appendages. Exp Cell Res. 2014 Jul 15; 325(2):96-103. PMID: 24530577; PMCID: PMC4072742.
      38. Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y. Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell. 2014 Feb 6; 14(2):160-73. PMID: 24506883; PMCID: PMC3951379.
      39. Ching ST, Cunha GR, Baskin LS, Basson MA, Klein OD. Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia. Dev Biol. 2014 Feb 1; 386(1):1-11. PMID: 24361260; PMCID: PMC3921686.
      40. Li CY, Prochazka J, Goodwin AF, Klein OD. Fibroblast growth factor signaling in mammalian tooth development. Odontology. 2014 Jan; 102(1):1-13. PMID: 24343791.
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      41. Kuang-Hsien Hu J, Mushegyan V, Klein OD. On the cutting edge of organ renewal: Identification, regulation, and evolution of incisor stem cells. Genesis. 2014 Feb; 52(2):79-92. PMID: 24307456; PMCID: PMC4252016.
      42. Yamada Y, Nakamura S, Klein OD, Ito K. Current trends in stem cell therapy for improvement of bone quality. Histol Histopathol. 2014 Jun; 29(6):691-7. PMID: 24327103.
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      43. Klein OD, Bush JO, Knox SM, Jheon AH, Cordero DR, Richtsmeier JT. . American Journal of Medical Genetics Part A. The society of craniofacial genetics and developmental biology 35th annual meeting. 2013; 161(12):2938-2952.
      44. Klein OD, Oberoi S, Huysseune A, Hovorakova M, Peterka M, Peterkova R. Developmental disorders of the dentition: an update. Am J Med Genet C Semin Med Genet. 2013 Nov; 163C(4):318-32. PMID: 24124058; PMCID: PMC3844689.
      45. Goodwin AF, Tidyman WE, Jheon AH, Sharir A, Zheng X, Charles C, Fagin JA, McMahon M, Diekwisch TG, Ganss B, Rauen KA, Klein OD. Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation. Hum Mol Genet. 2014 Feb 1; 23(3):682-92. PMID: 24057668; PMCID: PMC3888259.
      46. Oishi PE, Klein OD, Keller RL. Developing physician-scientists in the fields of neonatology and pediatric critical care medicine: an effort to formulate a departmental policy. J Pediatr. 2013 Sep; 163(3):616-7.e1. PMID: 23973233.
        View in: PubMed
      47. Zheng L, Warotayanont R, Stahl J, Kunimatsu R, Klein O, DenBesten PK, Zhang Y. Inductive ability of human developing and differentiated dental mesenchyme. Cells Tissues Organs. 2013; 198(2):99-110. PMID: 24192998.
        View in: PubMed
      48. Jones KB, Klein OD. Oral epithelial stem cells in tissue maintenance and disease: the first steps in a long journey. Int J Oral Sci. 2013 Sep; 5(3):121-9. PMID: 23887128; PMCID: PMC3967329.
      49. Cao H, Jheon A, Li X, Sun Z, Wang J, Florez S, Zhang Z, McManus MT, Klein OD, Amendt BA. The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation. Development. 2013 Aug; 140(16):3348-59. PMID: 23863486; PMCID: PMC3737717.
      50. Biehs B, Hu JK, Strauli NB, Sangiorgi E, Jung H, Heber RP, Ho S, Goodwin AF, Dasen JS, Capecchi MR, Klein OD. BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor. Nat Cell Biol. 2013 Jul; 15(7):846-52. PMID: 23728424; PMCID: PMC3735916.
      51. Jones KB, Goodwin AF, Landan M, Seidel K, Tran DK, Hogue J, Chavez M, Fete M, Yu W, Hussein T, Johnson R, Huttner K, Jheon AH, Klein OD. Characterization of X-linked hypohidrotic ectodermal dysplasia (XL-HED) hair and sweat gland phenotypes using phototrichogram analysis and live confocal imaging. Am J Med Genet A. 2013 Jul; 161A(7):1585-93. PMID: 23687000; PMCID: PMC4414120.
      52. Lagronova-Churava S, Spoutil F, Vojtechova S, Lesot H, Peterka M, Klein OD, Peterkova R. The dynamics of supernumerary tooth development are differentially regulated by Sprouty genes. J Exp Zool B Mol Dev Evol. 2013 Jul; 320(5):307-20. PMID: 23606267.
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      53. Nusse YM, Klein OD. If a stem cell dies in the crypt, and no one is around to see it…. Cell Stem Cell. 2013 Apr 4; 12(4):389-90. PMID: 23561439.
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      54. Juuri E, Jussila M, Seidel K, Holmes S, Wu P, Richman J, Heikinheimo K, Chuong CM, Arnold K, Hochedlinger K, Klein O, Michon F, Thesleff I. Sox2 marks epithelial competence to generate teeth in mammals and reptiles. Development. 2013 Apr; 140(7):1424-32. PMID: 23462476; PMCID: PMC3596986.
      55. Yamada Y, Nakamura S, Ito K, Umemura E, Hara K, Nagasaka T, Abe A, Baba S, Furuichi Y, Izumi Y, Klein OD, Wakabayashi T. Injectable bone tissue engineering using expanded mesenchymal stem cells. Stem Cells. 2013 Mar; 31(3):572-80. PMID: 23225744; PMCID: PMC4043220.
      56. Plaks V, Brenot A, Lawson DA, Linnemann JR, Van Kappel EC, Wong KC, de Sauvage F, Klein OD, Werb Z. Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep. 2013 Jan 31; 3(1):70-8. PMID: 23352663; PMCID: PMC3563842.
      57. Felfly H, Klein OD. Sprouty genes regulate proliferation and survival of human embryonic stem cells. Sci Rep. 2013; 3:2277. PMID: 23880645; PMCID: PMC3721083.
      58. Modesto A, Klein O, Tenuta LM, Gerlach RF, Vieira AR. Summary of the IADR Cariology Research, Craniofacial Biology, and Mineralized Tissue Groups Symposium, Iguaçu Falls, Brazil, June 2012: Gene-environment Interactions and Epigenetics in Oral Diseases: Enamel Formation and its Clinical Impact on Tooth Defects, Caries, and Erosion. Dent 3000. 2013; 1(1). PMID: 25392764.
        View in: PubMed
      59. Wan M, Gao B, Sun F, Tang Y, Ye L, Fan Y, Klein OD, Zhou X, Zheng L. microRNA miR-34a regulates cytodifferentiation and targets multi-signaling pathways in human dental papilla cells. PLoS One. 2012; 7(11):e50090. PMID: 23226240; PMCID: PMC3511455.
      60. Griffin JN, Compagnucci C, Hu D, Fish J, Klein O, Marcucio R, Depew MJ. Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules. Dev Biol. 2013 Feb 1; 374(1):185-97. PMID: 23201021; PMCID: PMC4086262.
      61. Justice CM, Yagnik G, Kim Y, Peter I, Jabs EW, Erazo M, Ye X, Ainehsazan E, Shi L, Cunningham ML, Kimonis V, Roscioli T, Wall SA, Wilkie AO, Stoler J, Richtsmeier JT, Heuzé Y, Sanchez-Lara PA, Buckley MF, Druschel CM, Mills JL, Caggana M, Romitti PA, Kay DM, Senders C, Taub PJ, Klein OD, Boggan J, Zwienenberg-Lee M, Naydenov C, Kim J, Wilson AF, Boyadjiev SA. A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9. Nat Genet. 2012 Dec; 44(12):1360-4. PMID: 23160099; PMCID: PMC3736322.
      62. Goodwin AF, Oberoi S, Landan M, Charles C, Groth J, Martinez A, Fairley C, Weiss LA, Tidyman WE, Klein OD, Rauen KA. Craniofacial and dental development in cardio-facio-cutaneous syndrome: the importance of Ras signaling homeostasis. Clin Genet. 2013 Jun; 83(6):539-44. PMID: 22946697; PMCID: PMC4115672.
      63. Chavez MG, Yu W, Biehs B, Harada H, Snead ML, Lee JS, Desai TA, Klein OD. Characterization of dental epithelial stem cells from the mouse incisor with two-dimensional and three-dimensional platforms. Tissue Eng Part C Methods. 2013 Jan; 19(1):15-24. PMID: 22742471; PMCID: PMC3522131.
      64. Juuri E, Saito K, Ahtiainen L, Seidel K, Tummers M, Hochedlinger K, Klein OD, Thesleff I, Michon F. Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors. Dev Cell. 2012 Aug 14; 23(2):317-28. PMID: 22819339; PMCID: PMC3690347.
      65. Horst OV, Chavez MG, Jheon AH, Desai T, Klein OD. Stem cell and biomaterials research in dental tissue engineering and regeneration. Dent Clin North Am. 2012 Jul; 56(3):495-520. PMID: 22835534; PMCID: PMC3494412.
      66. Kyrylkova K, Kyryachenko S, Biehs B, Klein O, Kioussi C, Leid M. BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor. PLoS One. 2012; 7(5):e37670. PMID: 22629441; PMCID: PMC3358280.
      67. Jheon AH, Seidel K, Biehs B, Klein OD. From molecules to mastication: the development and evolution of teeth. Wiley Interdiscip Rev Dev Biol. 2013 Mar-Apr; 2(2):165-82. PMID: 24009032; PMCID: PMC3632217.
      68. Li CY, Cha W, Luder HU, Charles RP, McMahon M, Mitsiadis TA, Klein OD. E-cadherin regulates the behavior and fate of epithelial stem cells and their progeny in the mouse incisor. Dev Biol. 2012 Jun 15; 366(2):357-66. PMID: 22537490; PMCID: PMC3690274.
      69. Purcell P, Jheon A, Vivero MP, Rahimi H, Joo A, Klein OD. Spry1 and spry2 are essential for development of the temporomandibular joint. J Dent Res. 2012 Apr; 91(4):387-93. PMID: 22328578; PMCID: PMC3310757.
      70. The genome architecture of the Collaborative Cross mouse genetic reference population. Genetics. 2012 Feb; 190(2):389-401. PMID: 22345608; PMCID: PMC3276630.
      71. Tian H, Biehs B, Warming S, Leong KG, Rangell L, Klein OD, de Sauvage FJ. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature. 2011 Oct 13; 478(7368):255-9. PMID: 21927002; PMCID: PMC4251967.
      72. Jheon AH, Li CY, Wen T, Michon F, Klein OD. Expression of microRNAs in the stem cell niche of the adult mouse incisor. PLoS One. 2011; 6(9):e24536. PMID: 21931743; PMCID: PMC3169592.
      73. Charles C, Hovorakova M, Ahn Y, Lyons DB, Marangoni P, Churava S, Biehs B, Jheon A, Lesot H, Balooch G, Krumlauf R, Viriot L, Peterkova R, Klein OD. Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling. Development. 2011 Sep; 138(18):4063-73. PMID: 21862563; PMCID: PMC3160100.
      74. Petersen CI, Jheon AH, Mostowfi P, Charles C, Ching S, Thirumangalathu S, Barlow LA, Klein OD. FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size. PLoS Genet. 2011 Jun; 7(6):e1002098. PMID: 21655085; PMCID: PMC3107195.
      75. Hochheiser H, Aronow BJ, Artinger K, Beaty TH, Brinkley JF, Chai Y, Clouthier D, Cunningham ML, Dixon M, Donahue LR, Fraser SE, Hallgrimsson B, Iwata J, Klein O, Marazita ML, Murray JC, Murray S, de Villena FP, Postlethwait J, Potter S, Shapiro L, Spritz R, Visel A, Weinberg SM, Trainor PA. The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol. 2011 Jul 15; 355(2):175-82. PMID: 21458441; PMCID: PMC3440302.
      76. Hovorakova M, Prochazka J, Lesot H, Smrckova L, Churava S, Boran T, Kozmik Z, Klein O, Peterkova R, Peterka M. Shh expression in a rudimentary tooth offers new insights into development of the mouse incisor. J Exp Zool B Mol Dev Evol. 2011 Jul 15; 316(5):347-58. PMID: 21455944.
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      77. Jheon AH, Mostowfi P, Snead ML, Ihrie RA, Sone E, Pramparo T, Attardi LD, Klein OD. PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. J Cell Sci. 2011 Mar 1; 124(Pt 5):745-54. PMID: 21285247; PMCID: PMC3039019.
      78. Milunsky JM, Maher TM, Zhao G, Wang Z, Mulliken JB, Chitayat D, Clemens M, Stalker HJ, Bauer M, Burch M, Chénier S, Cunningham ML, Drack AV, Janssens S, Karlea A, Klatt R, Kini U, Klein O, Lachmeijer AM, Megarbane A, Mendelsohn NJ, Meschino WS, Mortier GR, Parkash S, Ray CR, Roberts A, Roberts A, Reardon W, Schnur RE, Smith R, Splitt M, Tezcan K, Whiteford ML, Wong DA, Zori R, Lin AE. Genotype-phenotype analysis of the branchio-oculo-facial syndrome. Am J Med Genet A. 2011 Jan; 155A(1):22-32. PMID: 21204207.
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      79. Parsa S, Kuremoto K, Seidel K, Tabatabai R, Mackenzie B, Yamaza T, Akiyama K, Branch J, Koh CJ, Al Alam D, Klein OD, Bellusci S. Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors. Development. 2010 Nov; 137(22):3743-52. PMID: 20978072; PMCID: PMC3049274.
      80. Seidel K, Ahn CP, Lyons D, Nee A, Ting K, Brownell I, Cao T, Carano RA, Curran T, Schober M, Fuchs E, Joyner A, Martin GR, de Sauvage FJ, Klein OD. Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development. 2010 Nov; 137(22):3753-61. PMID: 20978073; PMCID: PMC3049275.
      81. Jelin A, Perry H, Hogue J, Oberoi S, Cotter PD, Klein OD. Clefting in trisomy 9p patients: genotype-phenotype correlation using microarray comparative genomic hybridization. J Craniofac Surg. 2010 Sep; 21(5):1376-9. PMID: 20856024.
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      82. Ahn Y, Sanderson BW, Klein OD, Krumlauf R. Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning. Development. 2010 Oct; 137(19):3221-31. PMID: 20724449.
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      83. Prochazka J, Pantalacci S, Churava S, Rothova M, Lambert A, Lesot H, Klein O, Peterka M, Laudet V, Peterkova R. Patterning by heritage in mouse molar row development. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15497-502. PMID: 20709958; PMCID: PMC2932592.
      84. Kettunen P, Kivimäe S, Keshari P, Klein OD, Cheyette BN, Luukko K. Dact1-3 mRNAs exhibit distinct expression domains during tooth development. Gene Expr Patterns. 2010 Feb-Mar; 10(2-3):140-3. PMID: 20170752; PMCID: PMC2849867.
      85. Charles C, Lazzari V, Tafforeau P, Schimmang T, Tekin M, Klein O, Viriot L. Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22364-8. PMID: 20018768; PMCID: PMC2799759.
      86. Boran T, Peterkova R, Lesot H, Lyons DB, Peterka M, Klein OD. Temporal analysis of ectopic enamel production in incisors from sprouty mutant mice. J Exp Zool B Mol Dev Evol. 2009 Jul 15; 312B(5):473-85. PMID: 19101957; PMCID: PMC2837846.
      87. Peterkova R, Churava S, Lesot H, Rothova M, Prochazka J, Peterka M, Klein OD. Revitalization of a diastemal tooth primordium in Spry2 null mice results from increased proliferation and decreased apoptosis. J Exp Zool B Mol Dev Evol. 2009 Jun 15; 312B(4):292-308. PMID: 19127536; PMCID: PMC2880865.
      88. Catón J, Luder HU, Zoupa M, Bradman M, Bluteau G, Tucker AS, Klein O, Mitsiadis TA. Enamel-free teeth: Tbx1 deletion affects amelogenesis in rodent incisors. Dev Biol. 2009 Apr 15; 328(2):493-505. PMID: 19233155; PMCID: PMC2880856.
      89. Kalfa N, Liu B, Klein O, Wang MH, Cao M, Baskin LS. Genomic variants of ATF3 in patients with hypospadias. J Urol. 2008 Nov; 180(5):2183-8; discussion 2188. PMID: 18804813.
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      90. Kalfa N, Liu B, Klein O, Ophir K, Audran F, Wang MH, Mei C, Sultan C, Baskin LS. Mutations of CXorf6 are associated with a range of severities of hypospadias. Eur J Endocrinol. 2008 Oct; 159(4):453-8. PMID: 18635673.
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      91. Klein OD, Kostiner DR, Weisiger K, Moffatt E, Lindeman N, Goodman S, Tuchman M, Packman S. Acute fatal presentation of ornithine transcarbamylase deficiency in a previously healthy male. Hepatol Int. 2008 Sep; 2(3):390-4. PMID: 19669271; PMCID: PMC2716892.
      92. Metzger RJ, Klein OD, Martin GR, Krasnow MA. The branching programme of mouse lung development. Nature. 2008 Jun 5; 453(7196):745-50. PMID: 18463632; PMCID: PMC2892995.
      93. Klein OD, Lyons DB, Balooch G, Marshall GW, Basson MA, Peterka M, Boran T, Peterkova R, Martin GR. An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors. Development. 2008 Jan; 135(2):377-85. PMID: 18077585; PMCID: PMC2555979.
      94. Klein OD, Cotter PD, Moore MW, Zanko A, Gilats M, Epstein CJ, Conte F, Rauen KA. Interstitial deletions of chromosome 6q: genotype-phenotype correlation utilizing array CGH. Clin Genet. 2007 Mar; 71(3):260-6. PMID: 17309649.
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      95. D'Souza RN, Klein OD. Unraveling the molecular mechanisms that lead to supernumerary teeth in mice and men: current concepts and novel approaches. Cells Tissues Organs. 2007; 186(1):60-9. PMID: 17627119.
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      96. Klein OD, Minowada G, Peterkova R, Kangas A, Yu BD, Lesot H, Peterka M, Jernvall J, Martin GR. Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling. Dev Cell. 2006 Aug; 11(2):181-90. PMID: 16890158; PMCID: PMC2847684.
      97. Klein OD, Cotter PD, Schmidt AM, Bick DP, Tidyman WE, Albertson DG, Pinkel D, Rauen KA. Interstitial deletion of chromosome 12q: genotype-phenotype correlation of two patients utilizing array comparative genomic hybridization. Am J Med Genet A. 2005 Nov 1; 138(4):349-54. PMID: 16200635.
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      98. Ahn CP, Lachman RS, Cox VA, Blumberg B, Klein OD. Brachydactylic multiple delta phalanges plus syndrome. Am J Med Genet A. 2005 Sep 15; 138(1):41-4. PMID: 16092122.
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      99. Klein OD, Backstrand K, Cotter PD, Marco E, Sherr E, Slavotinek A. Case report: Y;6 translocation with deletion of 6p. Clin Dysmorphol. 2005 Apr; 14(2):93-6. PMID: 15770132.
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      100. Klein OD, Cotter PD, Albertson DG, Pinkel D, Tidyman WE, Moore MW, Rauen KA. Prader-Willi syndrome resulting from an unbalanced translocation: characterization by array comparative genomic hybridization. Clin Genet. 2004 Jun; 65(6):477-82. PMID: 15151506.
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      101. Raga F, Bonilla-Musoles F, Osborne NG, Casañ EM, Klein O, Bonilla F . . The Ultrasound Review of Obstetrics and Gynecology. Congenital Müllerian anomalies: A review of currently available imaging modalities. 2002; 2(1):56-67.
      102. Reichert H, Klein O, Dosch H, Denk M, Honkimäki V, Lippmann T, Reiter G. Observation of five-fold local symmetry in liquid lead. Nature. 2000 Dec 14; 408(6814):839-41. PMID: 11130718.
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      103. Raga F, Bonilla-Musoles F, Casañ EM, Klein O, Bonilla F. Assessment of endometrial volume by three-dimensional ultrasound prior to embryo transfer: clues to endometrial receptivity. Hum Reprod. 1999 Nov; 14(11):2851-4. PMID: 10548635.
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      104. Klein O, Kegler-Ebo D, Su J, Smith S, DiMaio D. The bovine papillomavirus E5 protein requires a juxtamembrane negative charge for activation of the platelet-derived growth factor beta receptor and transformation of C127 cells. J Virol. 1999 Apr; 73(4):3264-72. PMID: 10074180; PMCID: PMC104090.
      105. Surti T, Klein O, Aschheim K, DiMaio D, Smith SO. Structural models of the bovine papillomavirus E5 protein. Proteins. 1998 Dec 1; 33(4):601-12. PMID: 9849943.
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      106. Klein O, Polack GW, Surti T, Kegler-Ebo D, Smith SO, DiMaio D. Role of glutamine 17 of the bovine papillomavirus E5 protein in platelet-derived growth factor beta receptor activation and cell transformation. J Virol. 1998 Nov; 72(11):8921-32. PMID: 9765437; PMCID: PMC110309.
      107. DiMaio D, Lai CC, Klein O. Virocrine transformation: the intersection between viral transforming proteins and cellular signal transduction pathways. Annu Rev Microbiol. 1998; 52:397-421. PMID: 9891803.
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      108. Lee ME, Dyer DH, Klein OD, Bolduc JM, Stoddard BL, Koshland DE. Mutational analysis of the catalytic residues lysine 230 and tyrosine 160 in the NADP(+)-dependent isocitrate dehydrogenase from Escherichia coli. Biochemistry. 1995 Jan 10; 34(1):378-84. PMID: 7819221.
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      109. KLEIN O. Mesons and nucleons. Nature. 1948 Jun 5; 161(4101):897-9. PMID: 18864000.
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