Ophir Klein, PhD, MD
|School||UCSF School of Dentistry|
|Address||513 Parnassus Ave|
San Francisco CA 94143
|University of California, San Francisco||Genetics residency||2007||School of Medicine|
|Yale University||Pediatrics residency||2003||School of Medicine|
|Yale University||M.D.||2000||School of Medicine|
|Yale University||Ph.D.||1999||School of Medicine |
|University of California, Berkeley||B.A.||1993|
|2016||Charles J. Epstein Professor of Human Genetics|
|UCSF School of Dentistry||2015||Faculty Research Lecturer Award|
|Society for Pediatric Research||2015||E. Mead Johnson Award|
|American Association for the Advancement of Science (AAAS)||2014||Fellow|
|2014||Larry L. Hillblom Distinguished Professor in Craniofacial Anomalies|
|UCSF Graduate Students' Association||2013||Outstanding Faculty Mentorship Award|
|American Society for Clinical Investigation||2013||Elected Member|
|California Institute of Regenerative Medicine||2013||Physician Scientist Award|
|National Institutes of Health||2010||New Innovator Award|
|American Society for Bone and Mineral Research||2009||Harold M. Frost Young Investigator Award|
|Western Society for Pediatric Research||2009||Elected Member|
|March of Dimes||2009||Basil O'Connor Award|
|Society for Pediatric Research||2008||Elected Member|
|California Institute of Regenerative Medicine||2008||New Faculty Award|
|Goldman Philanthropic Partnerships||2008||Charles E. Culpeper Scholar|
|United States Bone and Joint Decade||2008||Young Investigator|
|American Academy of Pediatrics Section on Genetics and Birth Defects||2005||Young Investigator Research Grant Award|
|Society for Pediatric Research||2005||Fellow Research Award|
|Western Society for Pediatric Research||2005||David W. Smith Research Award|
|Pediatric Scientist Development Program, NICHD||2004||Fellow|
|American Academy of Pediatrics||2004||Fellow|
|Yale University Graduate School||1999||Dean's Distinguished Thesis Commendation|
|National Institutes of Health||1993||Medical Scientist Training Program|
|University of California, Berkeley||1989||Chancellor's Scholarship|
Ophir Klein is Professor of Orofacial Sciences and Pediatrics, the Larry L. Hillblom Distinguished Professor in Craniofacial Anomalies, and the Charles J. Epstein Professor of Human Genetics at the University of California, San Francisco (UCSF). He serves as Chief of the Division of Medical Genetics, Chair of the Division of Craniofacial Anomalies, Medical Director of the Craniofacial Center, and Director of the Program in Craniofacial Biology.
The Klein laboratory focuses on understanding how organs form in developing embryos and how they regenerate in adults. When developmental and regenerative processes go awry, then birth defects, cancer and other diseases can result. The group's research is centered on understanding how development and regeneration normally occur in the hope of one day treating diseases that result from abnormalities in these processes.
A central focus in the lab is craniofacial and dental development, as malformations in these organs are among the most common congenital abnormalities and have profound impacts on the lives of patients and their families. The maintenance, repair and growth of many adult organs, such as the bone marrow, skin, brain, and gastrointestinal tract, depend on tissue-specific populations of stem cells. The lab uses the rodent incisor as a model system to understand adult stem cells. Unlike human teeth, the rodent incisor grows continuously throughout the life of the animal. We are working to understand the molecular processes that regulate the behavior of these stem cells, including their capacity to self-renew as well as to differentiate into the various cellular components of the tooth. We intend to use the insights provided by our experiments in mice to guide us in the use of stem cells in regenerating dental and craniofacial tissues as a paradigm for developing replacement organs.
Another major area of study is regeneration of the gastrointestinal tract. The amazing ability of the mammalian gastrointestinal epithelium to renew has long fascinated biologists. Our research aims to address fundamental questions in this field, including the identity, regulation and plasticity of intestinal stem cells.
Finally, the laboratory is interested in how positive and negative modulators of signaling affect development, homeostasis and cancer. We are studying the roles of these molecules in the patterning and outgrowth of teeth, taste papillae, craniofacial and long bones, external genitalia, skin, and other organs. We are also examining the roles of these molecules in embryonic and adult stem cells.
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