Loading...

Ophir Klein, PhD, MD

TitleProfessor
SchoolUCSF School of Dentistry
DepartmentOrofacial Sciences
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-4719
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoGenetics residency2007School of Medicine
    Yale UniversityPediatrics residency2003School of Medicine
    Yale UniversityM.D.2000School of Medicine
    Yale UniversityPh.D.1999School of Medicine
    University of California, BerkeleyB.A.1993
    Collapse Awards and Honors
    2017Lawrence A. Tabak Lecturership, University of Rochester
    2017Craniofacial Biology Distinguished Scientist Award, International Association for Dental Research
    2016Inaugural Sustaining Outstanding Achievement in Research (SOAR) R35 Award, National Institute of Den
    2016Charles J. Epstein Professor of Human Genetics
    2015Faculty Research Lecturer Award, UCSF School of Dentistry
    2015E. Mead Johnson Award, Society for Pediatric Research
    2014Fellow, American Association for the Advancement of Science (AAAS)
    2014Larry L. Hillblom Distinguished Professor in Craniofacial Anomalies
    2013Outstanding Faculty Mentorship Award, UCSF Graduate Students' Association
    2013Elected Member, American Society for Clinical Investigation
    2013Physician Scientist Award, California Institute of Regenerative Medicine
    2010New Innovator Award, National Institutes of Health
    2009Harold M. Frost Young Investigator Award, American Society for Bone and Mineral Research
    2009Elected Member, Western Society for Pediatric Research
    2009Basil O'Connor Award, March of Dimes
    2008Elected Member, Society for Pediatric Research
    2008New Faculty Award, California Institute of Regenerative Medicine
    2008Charles E. Culpeper Scholar, Goldman Philanthropic Partnerships
    2008Young Investigator, United States Bone and Joint Decade
    2005Young Investigator Research Grant Award, American Academy of Pediatrics Section on Genetics and Birt
    2005Fellow Research Award, Society for Pediatric Research
    2005David W. Smith Research Award, Western Society for Pediatric Research
    2004Fellow, Pediatric Scientist Development Program, NICHD
    2004Fellow, American Academy of Pediatrics
    1999Dean's Distinguished Thesis Commendation, Yale University Graduate School
    1993Medical Scientist Training Program, National Institutes of Health
    1989Chancellor's Scholarship, University of California, Berkeley

    Collapse Overview 
    Collapse Overview
    Ophir Klein is Professor of Orofacial Sciences and Pediatrics, the Larry L. Hillblom Distinguished Professor in Craniofacial Anomalies, and the Charles J. Epstein Professor of Human Genetics at the University of California, San Francisco (UCSF). He serves as Chief of the Division of Medical Genetics, Chair of the Division of Craniofacial Anomalies, Medical Director of the Craniofacial Center, and Director of the Program in Craniofacial Biology.

    The Klein laboratory focuses on understanding how organs form in developing embryos and how they regenerate in adults. When developmental and regenerative processes go awry, then birth defects, cancer and other diseases can result. The group's research is centered on understanding how development and regeneration normally occur in the hope of one day treating diseases that result from abnormalities in these processes.

    A central focus in the lab is craniofacial and dental development, as malformations in these organs are among the most common congenital abnormalities and have profound impacts on the lives of patients and their families. The maintenance, repair and growth of many adult organs, such as the bone marrow, skin, brain, and gastrointestinal tract, depend on tissue-specific populations of stem cells. The lab uses the rodent incisor as a model system to understand adult stem cells. Unlike human teeth, the rodent incisor grows continuously throughout the life of the animal. We are working to understand the molecular processes that regulate the behavior of these stem cells, including their capacity to self-renew as well as to differentiate into the various cellular components of the tooth. We intend to use the insights provided by our experiments in mice to guide us in the use of stem cells in regenerating dental and craniofacial tissues as a paradigm for developing replacement organs.

    Another major area of study is regeneration of the gastrointestinal tract. The amazing ability of the mammalian gastrointestinal epithelium to renew has long fascinated biologists. Our research aims to address fundamental questions in this field, including the identity, regulation and plasticity of intestinal stem cells.

    Finally, the laboratory is interested in how positive and negative modulators of signaling affect development, homeostasis and cancer. We are studying the roles of these molecules in the patterning and outgrowth of teeth, taste papillae, craniofacial and long bones, external genitalia, skin, and other organs. We are also examining the roles of these molecules in embryonic and adult stem cells.


    Collapse Research 
    Collapse Research Activities and Funding
    Using human intestinal organoids to model IBD pathogenesis
    The Kenneth Rainin Foundation Innovator Award 2017-281Oct 1, 2017 - Sep 30, 2018
    Role: Principal Investigator
    Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)
    NIH/NIDCR U24DE026914Mar 1, 2017 - Feb 28, 2020
    Role: Co-Principal Investigator
    The role of stem cell competition in precancerous field formation
    UCSF UCSF Resource Allocation ProgramJan 1, 2017 - Dec 31, 2017
    Role: Principal Investigator
    Harnessing natural stem cell-based strategies for mammalian dental renewal
    NIH/NIDCR R35DE026602Sep 22, 2016 - Jun 30, 2024
    Role: Principal Investigator
    2016 Craniofacial Morphogenesis and Tissue Regeneration Gordon Research Conference and Gordon Research Seminar
    NIH/NIDCR R13DE025777Jan 19, 2016 - Jan 18, 2017
    Role: Principal Investigator
    Systems morphogenesis of tooth development
    The Royal Society IE150381Nov 1, 2015 - Oct 31, 2017
    Role: Principal Investigator
    University of California Tissue Regeneration Resource Center (UCTRRC)
    NIH/NIDCR R34DE025592Sep 8, 2015 - Aug 31, 2016
    Role: Co-Principal Investigator
    The role of Hippo and YAP/TAZ in dental renewal
    NIH R01DE024988Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Regulation of distinct pools of intestinal stem cells
    NIH/NIDDK U01DK103147Sep 5, 2014 - Aug 31, 2019
    Role: Principal Investigator
    Developing 3D Craniofacial Morphometry Data and Tools to Transform Dysmorphology
    NIH/NIDCR U01DE024440May 16, 2014 - Apr 30, 2019
    Role: Co-Principal Investigator
    Stem cell therapy for inflammatory bowel disease
    California Institute of Rgenerative Medicine RN3-06525Apr 1, 2013 - Mar 31, 2018
    Role: Principal Investigator
    The role of Sprouty genes in development of mammalian external genitalia
    NIH/NIDDK R01DK095002Sep 18, 2012 - Aug 31, 2014
    Role: Principal Investigator
    The role of Bmi1 in regulation of dental stem cells
    NIH/NIDCR R01DE021420Apr 1, 2011 - Mar 31, 2016
    Role: Principal Investigator
    An evolutionary-developmental approach to stem cells using teeth as a model
    NIH DP2OD007191Sep 30, 2010 - Jun 30, 2015
    Role: Principal Investigator
    The role of Sprouty genes in development of the circumvallate papilla
    NIH/NIDCD R21DC011108Jul 6, 2010 - Jun 30, 2012
    Role: Principal Investigator
    The role of Spry2 in regulation of bone formation
    NIH/NIAMS R03AR057121Apr 1, 2010 - Jan 31, 2013
    Role: Principal Investigator
    The Role of microRNAs in Tooth Regeneration using the Mouse Incisor Model
    NIH/NIDCR R21DE019958Jul 1, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Analysis of the Role of Sprouty Genes in Tooth Development
    NIH/NIDCR K08DE017654Jul 1, 2007 - Jun 30, 2012
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Faculty Mentoring
    Collapse Clinical Trials
    Collapse Global Health
    Collapse Twitter
    Collapse Featured Videos
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Du W, Hu JK, Du W, Klein O. Lineage tracing of epithelial cells in developing teeth reveals two strategies for building signaling centers. J Biol Chem. 2017 Sep 08; 292(36):15062-15069. PMID: 28733464.
      View in: PubMed
    2. Kousa YA, Roushangar R, Patel N, Walter A, Marangoni P, Krumlauf R, Klein OD, Schutte BC. IRF6 and SPRY4 Signaling Interact in Periderm Development. J Dent Res. 2017 Oct; 96(11):1306-1313. PMID: 28732181.
      View in: PubMed
    3. El Shahawy M, Reibring CG, Neben CL, Hallberg K, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A. Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid. PLoS Genet. 2017 Jul; 13(7):e1006914. PMID: 28715412.
      View in: PubMed
    4. Hadj-Rabia S, Schneider H, Navarro E, Klein O, Kirby N, Huttner K, Wolf L, Orin M, Wohlfart S, Bodemer C, Grange DK. Automatic recognition of the XLHED phenotype from facial images. Am J Med Genet A. 2017 Sep; 173(9):2408-2414. PMID: 28691769.
      View in: PubMed
    5. Naveau A, Zhang B, Meng B, Sutherland MT, Prochazkova M, Wen T, Marangoni P, Jones KB, Cox TC, Ganss B, Jheon AH, Klein OD. Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor. J Bone Miner Res. 2017 Jun 26. PMID: 28650075.
      View in: PubMed
    6. Zheng X, Goodwin AF, Tian H, Jheon AH, Klein OD. Ras Signaling Regulates Stem Cells and Amelogenesis in the Mouse Incisor. J Dent Res. 2017 Jun 01; 22034517717255. PMID: 28644741.
      View in: PubMed
    7. Cao H, Alrejaye N, Klein OD, Goodwin AF, Oberoi S. A review of craniofacial and dental findings of the RASopathies. Orthod Craniofac Res. 2017 Jun; 20 Suppl 1:32-38. PMID: 28643916.
      View in: PubMed
    8. Prochazkova M, Häkkinen TJ, Prochazka J, Spoutil F, Jheon AH, Ahn Y, Krumlauf R, Jernvall J, Klein OD. FGF signaling refines Wnt gradients to regulate the patterning of taste papillae. Development. 2017 Jun 15; 144(12):2212-2221. PMID: 28506989.
      View in: PubMed
    9. Percival CJ, Marangoni P, Tapaltsyan V, Klein O, Hallgrímsson B. The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape. G3 (Bethesda). 2017 May 05; 7(5):1439-1450. PMID: 28280213.
      View in: PubMed
    10. Hu JK, Du W, Shelton SJ, Oldham MC, DiPersio CM, Klein O. An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice. Cell Stem Cell. 2017 Jul 06; 21(1):91-106.e6. PMID: 28457749.
      View in: PubMed
    11. Kim R, Green JBA, Klein OD. From snapshots to movies: Understanding early tooth development in four dimensions. Dev Dyn. 2017 Jun; 246(6):442-450. PMID: 28324646.
      View in: PubMed
    12. Niethamer TK, Larson AR, O'Neill AK, Bershteyn M, Hsiao EC, Klein OD, Pomerantz JH, Bush JO. EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells. Stem Cell Reports. 2017 Mar 14; 8(3):529-537. PMID: 28238796.
      View in: PubMed
    13. Wald T, Spoutil F, Osickova A, Prochazkova M, Benada O, Kasparek P, Bumba L, Klein O, Sedlacek R, Sebo P, Prochazka J, Osicka R. Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif. Proc Natl Acad Sci U S A. 2017 Feb 28; 114(9):E1641-E1650. PMID: 28196895.
      View in: PubMed
    14. Cole JB, Manyama M, Larson JR, Liberton DK, Ferrara TM, Riccardi SL, Li M, Mio W, Klein OD, Santorico SA, Hallgrímsson B, Spritz RA. Human Facial Shape and Size Heritability and Genetic Correlations. Genetics. 2017 Feb; 205(2):967-978. PMID: 27974501.
      View in: PubMed
    15. Tsai YH, Nattiv R, Dedhia PH, Nagy MS, Chin AM, Thomson M, Klein O, Spence J. In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development. Development. 2017 Mar 15; 144(6):1045-1055. PMID: 27927684.
      View in: PubMed
    16. Sun Z, Yu W, Navarro MS, Sweat M, Eliason S, Sharp T, Liu H, Seidel K, Zhang L, Moreno M, Lynch T, Holton NE, Rogers L, Neff T, Goodheart MJ, Michon F, Klein OD, Chai Y, Dupuy A, Engelhardt JF, Chen Z, Amendt BA. Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal. Development. 2016 Nov 15; 143(22):4115-4126. PMID: 27660324.
      View in: PubMed
    17. Sharir A, Klein OD. Watching a deep dive: Live imaging provides lessons about tooth invagination. J Cell Biol. 2016 Sep 12; 214(6):645-7. PMID: 27621361; PMCID: PMC5021101 [Available on 03/12/17].
    18. Koledova Z, Zhang X, Streuli C, Clarke RB, Klein OD, Werb Z, Lu P. SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling. Proc Natl Acad Sci U S A. 2016 Sep 27; 113(39):E5731-40. PMID: 27621461.
      View in: PubMed
    19. Cole JB, Manyama M, Kimwaga E, Mathayo J, Larson JR, Liberton DK, Lukowiak K, Ferrara TM, Riccardi SL, Li M, Mio W, Prochazkova M, Williams T, Li H, Jones KL, Klein OD, Santorico SA, Hallgrimsson B, Spritz RA. Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape. PLoS Genet. 2016 Aug; 12(8):e1006174. PMID: 27560698; PMCID: PMC4999243.
    20. Shaffer JR, Orlova E, Lee MK, Leslie EJ, Raffensperger ZD, Heike CL, Cunningham ML, Hecht JT, Kau CH, Nidey NL, Moreno LM, Wehby GL, Murray JC, Laurie CA, Laurie CC, Cole J, Ferrara T, Santorico S, Klein O, Mio W, Feingold E, Hallgrimsson B, Spritz RA, Marazita ML, Weinberg SM. Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology. PLoS Genet. 2016 Aug; 12(8):e1006149. PMID: 27560520; PMCID: PMC4999139.
    21. Li CY, Hu J, Lu H, Lan J, Du W, Galicia N, Klein O. aE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development. Nat Commun. 2016 Jul 13; 7:12133. PMID: 27405641; PMCID: PMC4947177.
    22. Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley RM, Klein OD. Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis. JCI Insight. 2016 Jul 07; 1(10). PMID: 27525310.
      View in: PubMed
    23. Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley RM, Klein O . JCI insight. Dual epithelial and immune cell function of Dvl1 regulates gut mircobiota composition and intestinal homeostasis. 2016; 1(10):e85395.
    24. Neben CL, Roberts RR, Dipple KM, Merrill AE, Klein O, et al. Modeling craniofacial and skeletal congenital birth defects to advance therapies. Hum Mol Genet. 2016 Oct 01; 25(R2):R86-R93. PMID: 27346519.
      View in: PubMed
    25. Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein O, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J, Chai Y, et al. The FaceBase Consortium: a comprehensive resource for craniofacial researchers. Development. 2016 Jul 15; 143(14):2677-88. PMID: 27287806; PMCID: PMC4958338.
    26. Joo A, Long R, Cheng Z, Alexander C, Chang W, Klein O. Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling. Bone. 2016 Jul; 88:170-179. PMID: 27130872; PMCID: PMC4899137 [Available on 07/01/17].
    27. Belinson H, Nakatani J, Babineau BA, Birnbaum RY, Ellegood J, Bershteyn M, McEvilly RJ, Long JM, Willert K, Klein O, Ahituv N, Lerch JP, Rosenfeld MG, Wynshaw-Boris A, et al. Prenatal ß-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors. Mol Psychiatry. 2016 Oct; 21(10):1417-33. PMID: 26830142.
      View in: PubMed
    28. Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM. Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome. J Neurosci. 2016 Jan 06; 36(1):142-52. PMID: 26740656; PMCID: PMC4701956.
    29. Du W, Prochazka J, Prochazkova M, Klein OD. Expression of FGFs during early mouse tongue development. Gene Expr Patterns. 2016 Mar; 20(2):81-7. PMID: 26748348; PMCID: PMC4842327 [Available on 03/01/17].
    30. Prochazka J, Prochazkova M, Du W, Spoutil F, Tureckova J, Hoch R, Shimogori T, Sedlacek R, Rubenstein JL, Wittmann T, Klein OD. Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis. Dev Cell. 2015 Dec 21; 35(6):713-24. PMID: 26702830; PMCID: PMC4710359 [Available on 12/21/16].
    31. Carvalho de Moraes LO, Tedesco RC, Arraez-Aybar LA, Klein O, Mérida-Velasco JR, Alonso LG. Development of synovial membrane in the temporomandibular joint of the human fetus. Eur J Histochem. 2015 Nov 26; 59(4):2569. PMID: 26708184; PMCID: PMC4698616.
    32. Klein OD, Nör JE. Craniofacial Stem Cells in Health and Disease. J Dent Res. 2015 Nov; 94(11):1485-6. PMID: 26494794.
      View in: PubMed
    33. Goodwin AF, Kim R, Bush JO, Klein OD. From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models. Curr Top Dev Biol. 2015; 115:459-92. PMID: 26589935.
      View in: PubMed
    34. Jheon AH, Prochazkova M, Meng B, Wen T, Lim YJ, Naveau A, Espinoza R, Cox TC, Sone ED, Ganss B, Siebel CW, Klein OD. Inhibition of Notch Signaling During Mouse Incisor Renewal Leads to Enamel Defects. J Bone Miner Res. 2016 Jan; 31(1):152-62. PMID: 26179131; PMCID: PMC4840178 [Available on 01/01/17].
    35. Marangoni P, Charles C, Tafforeau P, Laugel-Haushalter V, Joo A, Bloch-Zupan A, Klein OD, Viriot L. Phenotypic and evolutionary implications of modulating the ERK-MAPK cascade using the dentition as a model. Sci Rep. 2015 Jun 30; 5:11658. PMID: 26123406; PMCID: PMC4485067.
    36. Tapaltsyan V, Charles C, Hu J, Mindell D, Ahituv N, Wilson GM, Black BL, Viriot L, Klein O. Identification of novel Fgf enhancers and their role in dental evolution. Evol Dev. 2016 Jan-Feb; 18(1):31-40. PMID: 26086993; PMCID: PMC4826035 [Available on 01/01/17].
    37. Finkbeiner SR, Hill DR, Altheim CH, Dedhia PH, Taylor MJ, Tsai YH, Chin AM, Mahe MM, Watson CL, Freeman JJ, Nattiv R, Thomson M, Klein O, Shroyer NF, Helmrath MA, Teitelbaum DH, Dempsey PJ, Spence JR. Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo. Stem Cell Reports. 2015 Jun 03. PMID: 26050928.
      View in: PubMed
    38. Wu D, Mandal S, Choi A, Anderson A, Prochazkova M, Perry H, Gil-Da-Silva-Lopes VL, Lao R, Wan E, Tang PL, Kwok PY, Klein O, Zhuan B, Slavotinek AM. DLX4 is associated with orofacial clefting and abnormal jaw development. Hum Mol Genet. 2015 Aug 01; 24(15):4340-52. PMID: 25954033; PMCID: PMC4492397.
    39. Zarate YA, Perry H, Ben-Omran T, Sellars EA, Stein Q, Almureikhi M, Simmons K, Klein O, Fish J, Feingold M, Douglas J, Kruer MC, Si Y, Mao R, McKnight D, Gibellini F, Retterer K, Slavotinek A. Further supporting evidence for the SATB2-associated syndrome found through whole exome sequencing. Am J Med Genet A. 2015 May; 167A(5):1026-32. PMID: 25885067.
      View in: PubMed
    40. Thys A, Vandenberghe P, Hague P, Klein OD, Erneux C, Vanderwinden JM. Hyperplasia of interstitial cells of cajal in sprouty homolog 4 deficient mice. PLoS One. 2015; 10(4):e0124861. PMID: 25923139; PMCID: PMC4414615.
    41. Tapaltsyan V, Eronen JT, Lawing AM, Sharir A, Janis C, Jernvall J, Klein OD. Continuously growing rodent molars result from a predictable quantitative evolutionary change over 50 million years. Cell Rep. 2015 May 05; 11(5):673-80. PMID: 25921530; PMCID: PMC4426059.
    42. Tian H, Biehs B, Chiu C, Siebel CW, Wu Y, Costa M, de Sauvage FJ, Klein OD. Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis. Cell Rep. 2015 Apr 07; 11(1):33-42. PMID: 25818302; PMCID: PMC4394041.
    43. Dye BR, Hill DR, Ferguson MA, Tsai YH, Nagy MS, Dyal R, Wells JM, Mayhew CN, Nattiv R, Klein OD, White ES, Deutsch GH, Spence JR. In vitro generation of human pluripotent stem cell derived lung organoids. Elife. 2015 Mar 24; 4. PMID: 25803487; PMCID: PMC4370217.
    44. Jheon AH, Prochazkova M, Sherman M, Manoli DS, Shah NM, Carbone L, Klein O. Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles (Microtus ochrogaster). Int J Oral Sci. 2015 Mar 23; 7(1):23-6. PMID: 25634121; PMCID: PMC4817538.
    45. Barlow LA, Klein OD. Developing and regenerating a sense of taste. Curr Top Dev Biol. 2015; 111:401-19. PMID: 25662267; PMCID: PMC4435577.
    46. Harjunmaa E, Seidel K, Häkkinen T, Renvoisé E, Corfe IJ, Kallonen A, Zhang ZQ, Evans AR, Mikkola ML, Salazar-Ciudad I, Klein OD, Jernvall J. Replaying evolutionary transitions from the dental fossil record. Nature. 2014 Aug 07; 512(7512):44-8. PMID: 25079326; PMCID: PMC4252015.
    47. Castillo D, Seidel K, Salcedo E, Ahn C, de Sauvage FJ, Klein OD, Barlow LA. Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium. Development. 2014 Aug; 141(15):2993-3002. PMID: 24993944; PMCID: PMC4197660.
    48. Michailovici I, Harrington HA, Azogui HH, Yahalom-Ronen Y, Plotnikov A, Ching S, Stumpf MP, Klein OD, Seger R, Tzahor E. Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells. Development. 2014 Jul; 141(13):2611-20. PMID: 24924195; PMCID: PMC4067960.
    49. Goodwin AF, Larson JR, Jones KB, Liberton DK, Landan M, Wang Z, Boekelheide A, Langham M, Mushegyan V, Oberoi S, Brao R, Wen T, Johnson R, Huttner K, Grange DK, Spritz RA, Hallgrímsson B, Jheon AH, Klein OD. Craniofacial morphometric analysis of individuals with X-linked hypohidrotic ectodermal dysplasia. Mol Genet Genomic Med. 2014 Sep; 2(5):422-9. PMID: 25333067; PMCID: PMC4190877.
    50. Chavez MG, Hu J, Seidel K, Li C, Jheon A, Naveau A, Horst O, Klein OD. Isolation and culture of dental epithelial stem cells from the adult mouse incisor. J Vis Exp. 2014 May 01; (87). PMID: 24834972; PMCID: PMC4141628.
    51. Sun F, Wan M, Xu X, Gao B, Zhou Y, Sun J, Cheng L, Klein O, Zhou X, Zheng L. Crosstalk between miR-34a and Notch Signaling Promotes Differentiation in Apical Papilla Stem Cells (SCAPs). J Dent Res. 2014 Jun; 93(6):589-95. PMID: 24710391.
      View in: PubMed
    52. Mues G, Bonds J, Xiang L, Vieira AR, Seymen F, Klein O, D'Souza RN. The WNT10A gene in ectodermal dysplasias and selective tooth agenesis. Am J Med Genet A. 2014 Oct; 164A(10):2455-60. PMID: 24700731; PMCID: PMC4167166.
    53. Mendelsohn BA, Jeng LL, Oberoi S, Klein OD. Dental findings in 14q terminal deletion syndrome. Clin Dysmorphol. 2014 Apr; 23(2):60-2. PMID: 24535103.
      View in: PubMed
    54. Goodwin AF, Oberoi S, Landan M, Charles C, Massie JC, Fairley C, Rauen KA, Klein OD. Craniofacial and dental development in Costello syndrome. Am J Med Genet A. 2014 Jun; 164A(6):1425-30. PMID: 24668879; PMCID: PMC4115793.
    55. Naveau A, Seidel K, Klein OD. Tooth, hair and claw: comparing epithelial stem cell niches of ectodermal appendages. Exp Cell Res. 2014 Jul 15; 325(2):96-103. PMID: 24530577; PMCID: PMC4072742.
    56. Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y. Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell. 2014 Feb 06; 14(2):160-73. PMID: 24506883; PMCID: PMC3951379.
    57. Ching ST, Cunha GR, Baskin LS, Basson MA, Klein OD. Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia. Dev Biol. 2014 Feb 01; 386(1):1-11. PMID: 24361260; PMCID: PMC3921686.
    58. Li CY, Prochazka J, Goodwin AF, Klein OD. Fibroblast growth factor signaling in mammalian tooth development. Odontology. 2014 Jan; 102(1):1-13. PMID: 24343791.
      View in: PubMed
    59. Kuang-Hsien Hu J, Mushegyan V, Klein OD. On the cutting edge of organ renewal: Identification, regulation, and evolution of incisor stem cells. Genesis. 2014 Feb; 52(2):79-92. PMID: 24307456; PMCID: PMC4252016.
    60. Yamada Y, Nakamura S, Klein OD, Ito K. Current trends in stem cell therapy for improvement of bone quality. Histol Histopathol. 2014 Jun; 29(6):691-7. PMID: 24327103.
      View in: PubMed
    61. Klein O, Bush JO, Knox SM, Jheon AH, Cordero DR, Richtsmeier JT. American Journal of Medical Genetics Part A. The society of craniofacial genetics and developmental biology 35th annual meeting. 2013; 161(12):2938-2952.
    62. Klein OD, Oberoi S, Huysseune A, Hovorakova M, Peterka M, Peterkova R. Developmental disorders of the dentition: an update. Am J Med Genet C Semin Med Genet. 2013 Nov; 163C(4):318-32. PMID: 24124058; PMCID: PMC3844689.
    63. Goodwin AF, Tidyman WE, Jheon AH, Sharir A, Zheng X, Charles C, Fagin JA, McMahon M, Diekwisch TG, Ganss B, Rauen KA, Klein OD. Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation. Hum Mol Genet. 2014 Feb 01; 23(3):682-92. PMID: 24057668; PMCID: PMC3888259.
    64. Oishi PE, Klein OD, Keller RL. Developing physician-scientists in the fields of neonatology and pediatric critical care medicine: an effort to formulate a departmental policy. J Pediatr. 2013 Sep; 163(3):616-7.e1. PMID: 23973233.
      View in: PubMed
    65. Zheng L, Warotayanont R, Stahl J, Kunimatsu R, Klein O, DenBesten PK, Zhang Y. Inductive ability of human developing and differentiated dental mesenchyme. Cells Tissues Organs. 2013; 198(2):99-110. PMID: 24192998.
      View in: PubMed
    66. Jones KB, Klein OD. Oral epithelial stem cells in tissue maintenance and disease: the first steps in a long journey. Int J Oral Sci. 2013 Sep; 5(3):121-9. PMID: 23887128; PMCID: PMC3967329.
    67. Cao H, Jheon A, Li X, Sun Z, Wang J, Florez S, Zhang Z, McManus MT, Klein OD, Amendt BA. The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation. Development. 2013 Aug; 140(16):3348-59. PMID: 23863486; PMCID: PMC3737717.
    68. Biehs B, Hu JK, Strauli NB, Sangiorgi E, Jung H, Heber RP, Ho S, Goodwin AF, Dasen JS, Capecchi MR, Klein OD. BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor. Nat Cell Biol. 2013 Jul; 15(7):846-52. PMID: 23728424; PMCID: PMC3735916.
    69. Jones KB, Goodwin AF, Landan M, Seidel K, Tran DK, Hogue J, Chavez M, Fete M, Yu W, Hussein T, Johnson R, Huttner K, Jheon AH, Klein OD. Characterization of X-linked hypohidrotic ectodermal dysplasia (XL-HED) hair and sweat gland phenotypes using phototrichogram analysis and live confocal imaging. Am J Med Genet A. 2013 Jul; 161A(7):1585-93. PMID: 23687000; PMCID: PMC4414120.
    70. Lagronova-Churava S, Spoutil F, Vojtechova S, Lesot H, Peterka M, Klein OD, Peterkova R. The dynamics of supernumerary tooth development are differentially regulated by Sprouty genes. J Exp Zool B Mol Dev Evol. 2013 Jul; 320(5):307-20. PMID: 23606267.
      View in: PubMed
    71. Nusse YM, Klein OD. If a stem cell dies in the crypt, and no one is around to see it…. Cell Stem Cell. 2013 Apr 04; 12(4):389-90. PMID: 23561439.
      View in: PubMed
    72. Juuri E, Jussila M, Seidel K, Holmes S, Wu P, Richman J, Heikinheimo K, Chuong CM, Arnold K, Hochedlinger K, Klein O, Michon F, Thesleff I. Sox2 marks epithelial competence to generate teeth in mammals and reptiles. Development. 2013 Apr; 140(7):1424-32. PMID: 23462476; PMCID: PMC3596986.
    73. Yamada Y, Nakamura S, Ito K, Umemura E, Hara K, Nagasaka T, Abe A, Baba S, Furuichi Y, Izumi Y, Klein OD, Wakabayashi T. Injectable bone tissue engineering using expanded mesenchymal stem cells. Stem Cells. 2013 Mar; 31(3):572-80. PMID: 23225744; PMCID: PMC4043220.
    74. Plaks V, Brenot A, Lawson DA, Linnemann JR, Van Kappel EC, Wong KC, de Sauvage F, Klein OD, Werb Z. Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep. 2013 Jan 31; 3(1):70-8. PMID: 23352663; PMCID: PMC3563842.
    75. Felfly H, Klein OD. Sprouty genes regulate proliferation and survival of human embryonic stem cells. Sci Rep. 2013; 3:2277. PMID: 23880645; PMCID: PMC3721083.
    76. Modesto A, Klein O, Tenuta LM, Gerlach RF, Vieira AR. Summary of the IADR Cariology Research, Craniofacial Biology, and Mineralized Tissue Groups Symposium, Iguaçu Falls, Brazil, June 2012: Gene-environment Interactions and Epigenetics in Oral Diseases: Enamel Formation and its Clinical Impact on Tooth Defects, Caries, and Erosion. Dent 3000. 2013; 1(1). PMID: 25392764.
      View in: PubMed
    77. Wan M, Gao B, Sun F, Tang Y, Ye L, Fan Y, Klein OD, Zhou X, Zheng L. microRNA miR-34a regulates cytodifferentiation and targets multi-signaling pathways in human dental papilla cells. PLoS One. 2012; 7(11):e50090. PMID: 23226240; PMCID: PMC3511455.
    78. Griffin JN, Compagnucci C, Hu D, Fish J, Klein O, Marcucio R, Depew MJ. Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules. Dev Biol. 2013 Feb 01; 374(1):185-97. PMID: 23201021; PMCID: PMC4086262.
    79. Justice CM, Yagnik G, Kim Y, Peter I, Jabs EW, Erazo M, Ye X, Ainehsazan E, Shi L, Cunningham ML, Kimonis V, Roscioli T, Wall SA, Wilkie AO, Stoler J, Richtsmeier JT, Heuzé Y, Sanchez-Lara PA, Buckley MF, Druschel CM, Mills JL, Caggana M, Romitti PA, Kay DM, Senders C, Taub PJ, Klein OD, Boggan J, Zwienenberg-Lee M, Naydenov C, Kim J, Wilson AF, Boyadjiev SA. A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9. Nat Genet. 2012 Dec; 44(12):1360-4. PMID: 23160099; PMCID: PMC3736322.
    80. Goodwin AF, Oberoi S, Landan M, Charles C, Groth J, Martinez A, Fairley C, Weiss LA, Tidyman WE, Klein OD, Rauen KA. Craniofacial and dental development in cardio-facio-cutaneous syndrome: the importance of Ras signaling homeostasis. Clin Genet. 2013 Jun; 83(6):539-44. PMID: 22946697; PMCID: PMC4115672.
    81. Chavez MG, Yu W, Biehs B, Harada H, Snead ML, Lee JS, Desai TA, Klein OD. Characterization of dental epithelial stem cells from the mouse incisor with two-dimensional and three-dimensional platforms. Tissue Eng Part C Methods. 2013 Jan; 19(1):15-24. PMID: 22742471; PMCID: PMC3522131.
    82. Juuri E, Saito K, Ahtiainen L, Seidel K, Tummers M, Hochedlinger K, Klein OD, Thesleff I, Michon F. Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors. Dev Cell. 2012 Aug 14; 23(2):317-28. PMID: 22819339; PMCID: PMC3690347.
    83. Horst OV, Chavez MG, Jheon AH, Desai T, Klein OD. Stem cell and biomaterials research in dental tissue engineering and regeneration. Dent Clin North Am. 2012 Jul; 56(3):495-520. PMID: 22835534; PMCID: PMC3494412.
    84. Kyrylkova K, Kyryachenko S, Biehs B, Klein O, Kioussi C, Leid M. BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor. PLoS One. 2012; 7(5):e37670. PMID: 22629441; PMCID: PMC3358280.
    85. Jheon AH, Seidel K, Biehs B, Klein OD. From molecules to mastication: the development and evolution of teeth. Wiley Interdiscip Rev Dev Biol. 2013 Mar-Apr; 2(2):165-82. PMID: 24009032; PMCID: PMC3632217.
    86. Li CY, Cha W, Luder HU, Charles RP, McMahon M, Mitsiadis TA, Klein OD. E-cadherin regulates the behavior and fate of epithelial stem cells and their progeny in the mouse incisor. Dev Biol. 2012 Jun 15; 366(2):357-66. PMID: 22537490; PMCID: PMC3690274.
    87. Purcell P, Jheon A, Vivero MP, Rahimi H, Joo A, Klein OD. Spry1 and spry2 are essential for development of the temporomandibular joint. J Dent Res. 2012 Apr; 91(4):387-93. PMID: 22328578; PMCID: PMC3310757.
    88. The genome architecture of the Collaborative Cross mouse genetic reference population. Genetics. 2012 Feb; 190(2):389-401. PMID: 22345608; PMCID: PMC3276630.
    89. Tian H, Biehs B, Warming S, Leong KG, Rangell L, Klein OD, de Sauvage FJ. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature. 2011 Sep 18; 478(7368):255-9. PMID: 21927002; PMCID: PMC4251967.
    90. Jheon AH, Li CY, Wen T, Michon F, Klein OD. Expression of microRNAs in the stem cell niche of the adult mouse incisor. PLoS One. 2011; 6(9):e24536. PMID: 21931743; PMCID: PMC3169592.
    91. Charles C, Hovorakova M, Ahn Y, Lyons DB, Marangoni P, Churava S, Biehs B, Jheon A, Lesot H, Balooch G, Krumlauf R, Viriot L, Peterkova R, Klein OD. Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling. Development. 2011 Sep; 138(18):4063-73. PMID: 21862563; PMCID: PMC3160100.
    92. Petersen CI, Jheon AH, Mostowfi P, Charles C, Ching S, Thirumangalathu S, Barlow LA, Klein OD. FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size. PLoS Genet. 2011 Jun; 7(6):e1002098. PMID: 21655085; PMCID: PMC3107195.
    93. Hochheiser H, Aronow BJ, Artinger K, Beaty TH, Brinkley JF, Chai Y, Clouthier D, Cunningham ML, Dixon M, Donahue LR, Fraser SE, Hallgrimsson B, Iwata J, Klein O, Marazita ML, Murray JC, Murray S, de Villena FP, Postlethwait J, Potter S, Shapiro L, Spritz R, Visel A, Weinberg SM, Trainor PA. The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol. 2011 Jul 15; 355(2):175-82. PMID: 21458441; PMCID: PMC3440302.
    94. Hovorakova M, Prochazka J, Lesot H, Smrckova L, Churava S, Boran T, Kozmik Z, Klein O, Peterkova R, Peterka M. Shh expression in a rudimentary tooth offers new insights into development of the mouse incisor. J Exp Zool B Mol Dev Evol. 2011 Jul 15; 316(5):347-58. PMID: 21455944.
      View in: PubMed
    95. Jheon AH, Mostowfi P, Snead ML, Ihrie RA, Sone E, Pramparo T, Attardi LD, Klein OD. PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. J Cell Sci. 2011 Mar 01; 124(Pt 5):745-54. PMID: 21285247; PMCID: PMC3039019.
    96. Milunsky JM, Maher TM, Zhao G, Wang Z, Mulliken JB, Chitayat D, Clemens M, Stalker HJ, Bauer M, Burch M, Chénier S, Cunningham ML, Drack AV, Janssens S, Karlea A, Klatt R, Kini U, Klein O, Lachmeijer AM, Megarbane A, Mendelsohn NJ, Meschino WS, Mortier GR, Parkash S, Ray CR, Roberts A, Roberts A, Reardon W, Schnur RE, Smith R, Splitt M, Tezcan K, Whiteford ML, Wong DA, Zori R, Lin AE. Genotype-phenotype analysis of the branchio-oculo-facial syndrome. Am J Med Genet A. 2011 Jan; 155A(1):22-32. PMID: 21204207.
      View in: PubMed
    97. Parsa S, Kuremoto K, Seidel K, Tabatabai R, Mackenzie B, Yamaza T, Akiyama K, Branch J, Koh CJ, Al Alam D, Klein OD, Bellusci S. Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors. Development. 2010 Nov; 137(22):3743-52. PMID: 20978072; PMCID: PMC3049274.
    98. Seidel K, Ahn CP, Lyons D, Nee A, Ting K, Brownell I, Cao T, Carano RA, Curran T, Schober M, Fuchs E, Joyner A, Martin GR, de Sauvage FJ, Klein OD. Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development. 2010 Nov; 137(22):3753-61. PMID: 20978073; PMCID: PMC3049275.
    99. Jelin A, Perry H, Hogue J, Oberoi S, Cotter PD, Klein OD. Clefting in trisomy 9p patients: genotype-phenotype correlation using microarray comparative genomic hybridization. J Craniofac Surg. 2010 Sep; 21(5):1376-9. PMID: 20856024.
      View in: PubMed
    100. Ahn Y, Sanderson BW, Klein OD, Krumlauf R. Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning. Development. 2010 Oct; 137(19):3221-31. PMID: 20724449.
      View in: PubMed
    101. Prochazka J, Pantalacci S, Churava S, Rothova M, Lambert A, Lesot H, Klein O, Peterka M, Laudet V, Peterkova R. Patterning by heritage in mouse molar row development. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15497-502. PMID: 20709958; PMCID: PMC2932592.
    102. Kettunen P, Kivimäe S, Keshari P, Klein OD, Cheyette BN, Luukko K. Dact1-3 mRNAs exhibit distinct expression domains during tooth development. Gene Expr Patterns. 2010 Feb-Mar; 10(2-3):140-3. PMID: 20170752; PMCID: PMC2849867.
    103. Charles C, Lazzari V, Tafforeau P, Schimmang T, Tekin M, Klein O, Viriot L. Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22364-8. PMID: 20018768; PMCID: PMC2799759.
    104. Boran T, Peterkova R, Lesot H, Lyons DB, Peterka M, Klein OD. Temporal analysis of ectopic enamel production in incisors from sprouty mutant mice. J Exp Zool B Mol Dev Evol. 2009 Jul 15; 312B(5):473-85. PMID: 19101957; PMCID: PMC2837846.
    105. Peterkova R, Churava S, Lesot H, Rothova M, Prochazka J, Peterka M, Klein OD. Revitalization of a diastemal tooth primordium in Spry2 null mice results from increased proliferation and decreased apoptosis. J Exp Zool B Mol Dev Evol. 2009 Jun 15; 312B(4):292-308. PMID: 19127536; PMCID: PMC2880865.
    106. Catón J, Luder HU, Zoupa M, Bradman M, Bluteau G, Tucker AS, Klein O, Mitsiadis TA. Enamel-free teeth: Tbx1 deletion affects amelogenesis in rodent incisors. Dev Biol. 2009 Apr 15; 328(2):493-505. PMID: 19233155; PMCID: PMC2880856.
    107. Kalfa N, Liu B, Klein O, Wang MH, Cao M, Baskin LS. Genomic variants of ATF3 in patients with hypospadias. J Urol. 2008 Nov; 180(5):2183-8; discussion 2188. PMID: 18804813.
      View in: PubMed
    108. Talmor Y, Bernheim J, Klein O, Green J, Rashid G. Calcitriol blunts pro-atherosclerotic parameters through NFkappaB and p38 in vitro. Eur J Clin Invest. 2008 Aug; 38(8):548-54. PMID: 18717824.
      View in: PubMed
    109. Kalfa N, Liu B, Klein O, Ophir K, Audran F, Wang MH, Mei C, Sultan C, Baskin LS. Mutations of CXorf6 are associated with a range of severities of hypospadias. Eur J Endocrinol. 2008 Oct; 159(4):453-8. PMID: 18635673.
      View in: PubMed
    110. Klein OD, Kostiner DR, Weisiger K, Moffatt E, Lindeman N, Goodman S, Tuchman M, Packman S. Acute fatal presentation of ornithine transcarbamylase deficiency in a previously healthy male. Hepatol Int. 2008 Sep; 2(3):390-4. PMID: 19669271; PMCID: PMC2716892.
    111. Metzger RJ, Klein OD, Martin GR, Krasnow MA. The branching programme of mouse lung development. Nature. 2008 Jun 05; 453(7196):745-50. PMID: 18463632; PMCID: PMC2892995.
    112. Klein OD, Lyons DB, Balooch G, Marshall GW, Basson MA, Peterka M, Boran T, Peterkova R, Martin GR. An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors. Development. 2008 Jan; 135(2):377-85. PMID: 18077585; PMCID: PMC2555979.
    113. Klein OD, Cotter PD, Moore MW, Zanko A, Gilats M, Epstein CJ, Conte F, Rauen KA. Interstitial deletions of chromosome 6q: genotype-phenotype correlation utilizing array CGH. Clin Genet. 2007 Mar; 71(3):260-6. PMID: 17309649.
      View in: PubMed
    114. D'Souza RN, Klein OD. Unraveling the molecular mechanisms that lead to supernumerary teeth in mice and men: current concepts and novel approaches. Cells Tissues Organs. 2007; 186(1):60-9. PMID: 17627119.
      View in: PubMed
    115. Klein OD, Minowada G, Peterkova R, Kangas A, Yu BD, Lesot H, Peterka M, Jernvall J, Martin GR. Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling. Dev Cell. 2006 Aug; 11(2):181-90. PMID: 16890158; PMCID: PMC2847684.
    116. Klein OD, Cotter PD, Schmidt AM, Bick DP, Tidyman WE, Albertson DG, Pinkel D, Rauen KA. Interstitial deletion of chromosome 12q: genotype-phenotype correlation of two patients utilizing array comparative genomic hybridization. Am J Med Genet A. 2005 Nov 01; 138(4):349-54. PMID: 16200635.
      View in: PubMed
    117. Ahn CP, Lachman RS, Cox VA, Blumberg B, Klein OD. Brachydactylic multiple delta phalanges plus syndrome. Am J Med Genet A. 2005 Sep 15; 138(1):41-4. PMID: 16092122.
      View in: PubMed
    118. Klein OD, Backstrand K, Cotter PD, Marco E, Sherr E, Slavotinek A. Case report: Y;6 translocation with deletion of 6p. Clin Dysmorphol. 2005 Apr; 14(2):93-6. PMID: 15770132.
      View in: PubMed
    119. Klein OD, Cotter PD, Albertson DG, Pinkel D, Tidyman WE, Moore MW, Rauen KA. Prader-Willi syndrome resulting from an unbalanced translocation: characterization by array comparative genomic hybridization. Clin Genet. 2004 Jun; 65(6):477-82. PMID: 15151506.
      View in: PubMed
    120. Raga F, Bonilla-Musoles F, Osborne NG, Casañ EM, Klein O, Bonilla F . The Ultrasound Review of Obstetrics and Gynecology. Congenital Müllerian anomalies: A review of currently available imaging modalities. 2002; 2(1):56-67.
    121. Raga F, Bonilla-Musoles F, Casañ EM, Klein O, Bonilla F. Assessment of endometrial volume by three-dimensional ultrasound prior to embryo transfer: clues to endometrial receptivity. Hum Reprod. 1999 Nov; 14(11):2851-4. PMID: 10548635.
      View in: PubMed
    122. Klein O, Lin S, Embon O, Sazbon A, Zidan J, Kook AI. An approach for high sensitivity detection of prostate cancer by analysis of changes in structuredness of the cytoplasmic matrix of lymphocytes specifically induced by PSA-ACT. J Urol. 1999 Jun; 161(6):1994-6. PMID: 10332488.
      View in: PubMed
    123. Klein O, Kegler-Ebo D, Su J, Smith S, DiMaio D. The bovine papillomavirus E5 protein requires a juxtamembrane negative charge for activation of the platelet-derived growth factor beta receptor and transformation of C127 cells. J Virol. 1999 Apr; 73(4):3264-72. PMID: 10074180; PMCID: PMC104090.
    124. Surti T, Klein O, Aschheim K, DiMaio D, Smith SO. Structural models of the bovine papillomavirus E5 protein. Proteins. 1998 Dec 01; 33(4):601-12. PMID: 9849943.
      View in: PubMed
    125. Klein O, Polack GW, Surti T, Kegler-Ebo D, Smith SO, DiMaio D. Role of glutamine 17 of the bovine papillomavirus E5 protein in platelet-derived growth factor beta receptor activation and cell transformation. J Virol. 1998 Nov; 72(11):8921-32. PMID: 9765437; PMCID: PMC110309.
    126. DiMaio D, Lai CC, Klein O. Virocrine transformation: the intersection between viral transforming proteins and cellular signal transduction pathways. Annu Rev Microbiol. 1998; 52:397-421. PMID: 9891803.
      View in: PubMed
    127. Lee ME, Dyer DH, Klein OD, Bolduc JM, Stoddard BL, Koshland DE. Mutational analysis of the catalytic residues lysine 230 and tyrosine 160 in the NADP(+)-dependent isocitrate dehydrogenase from Escherichia coli. Biochemistry. 1995 Jan 10; 34(1):378-84. PMID: 7819221.
      View in: PubMed
    Ophir's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _
    Back to TOP