Jonathan Weissman, PhD

Title(s)Professor, Cellular Molecular Pharmacology
SchoolSchool of Medicine
AddressLocation Required, #001
Phone415-502-8089
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    Title(s)Professor, School of Medicine


    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    The Cancer Target Discovery and Development Network at UCSF
    NIH U01CA217882Aug 10, 2017 - Jul 31, 2022
    Role: Co-Principal Investigator
    Harnessing CRISPR for Targeted and Inducible Epigenomic Reprogramming
    NIH R01DA036858Sep 30, 2013 - May 31, 2018
    Role: Principal Investigator
    Structural Basis of Protein Homeostasis
    NIH U01GM098254Sep 30, 2012 - Jul 31, 2016
    Role: Co-Principal Investigator
    Human Gene Knockdowns that May Extend Lifespan
    NIH R01AG041826May 1, 2012 - Apr 30, 2018
    Role: Principal Investigator
    Bay Area Cancer Target Discovery and Development Network
    NIH U01CA168370May 1, 2012 - Apr 30, 2017
    Role: Co-Principal Investigator
    MECHANISM OF CHAPERONE MEDIATED PROTEIN FOLDING
    NIH R01GM055595May 1, 1997 - Apr 30, 2002
    Role: Principal Investigator
    Molecular Pathogenesis of Age-Dependent CNS Regeneration
    NIH P01AG010770Apr 1, 1993 - Mar 31, 2016
    Role: Co-Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding. Nat Neurosci. 2024 Apr 08. Hacisuleyman E, Hale CR, Noble N, Luo JD, Fak JJ, Saito M, Chen J, Weissman JS, Darnell RB. PMID: 38589584.
      View in: PubMed   Mentions:
    2. Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology. Mol Cell. 2024 Feb 27. Muthukumar G, Stevens TA, Inglis AJ, Esantsi TK, Saunders RA, Schulte F, Voorhees RM, Guna A, Weissman JS. PMID: 38428433.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. CRISPR technologies for genome, epigenome and transcriptome editing. Nat Rev Mol Cell Biol. 2024 Feb 02. Villiger L, Joung J, Koblan L, Weissman J, Abudayyeh OO, Gootenberg JS. PMID: 38308006.
      View in: PubMed   Mentions:    Fields:    
    4. Deciphering cell states and genealogies of human haematopoiesis. Nature. 2024 Mar; 627(8003):389-398. Weng C, Yu F, Yang D, Poeschla M, Liggett LA, Jones MG, Qiu X, Wahlster L, Caulier A, Hussmann JA, Schnell A, Yost KE, Koblan LW, Martin-Rufino JD, Min J, Hammond A, Ssozi D, Bueno R, Mallidi H, Kreso A, Escabi J, Rideout WM, Jacks T, Hormoz S, van Galen P, Weissman JS, Sankaran VG. PMID: 38253266; PMCID: PMC10937407.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Author Correction: Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning. Nat Biotechnol. 2023 Nov; 41(11):1655. Koblan LW, Arbab M, Shen MW, Hussmann JA, Anzalone AV, Doman JL, Newby GA, Yang D, Mok B, Replogle JM, Xu A, Sisley TA, Weissman JS, Adamson B, Liu DR. PMID: 37853259.
      View in: PubMed   Mentions: 3     Fields:    
    6. A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens. BMC Genomics. 2023 Oct 30; 24(1):651. Guna A, Page KR, Replogle JM, Esantsi TK, Wang ML, Weissman JS, Voorhees RM. PMID: 37904134; PMCID: PMC10614335.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    7. Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq. Nat Commun. 2023 10 06; 14(1):6245. Sunshine S, Puschnik AS, Replogle JM, Laurie MT, Liu J, Zha BS, Nuñez JK, Byrum JR, McMorrow AH, Frieman MB, Winkler J, Qiu X, Rosenberg OS, Leonetti MD, Ye CJ, Weissman JS, DeRisi JL, Hein MY. PMID: 37803001; PMCID: PMC10558542.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology. bioRxiv. 2023 Aug 17. Muthukumar G, Stevens TA, Inglis AJ, Esantsi TK, Saunders RA, Schulte F, Voorhees RM, Guna A, Weissman JS. PMID: 37645817; PMCID: PMC10462106.
      View in: PubMed   Mentions:
    9. A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens. bioRxiv. 2023 Aug 14. Guna A, Page KR, Replogle JM, Esantsi TK, Wang ML, Weissman JS, Voorhees RM. PMID: 36711738; PMCID: PMC9882262.
      View in: PubMed   Mentions:
    10. Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity. Nucleic Acids Res. 2023 07 07; 51(12):6355-6369. She R, Luo J, Weissman JS. PMID: 37144468; PMCID: PMC10325891.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    11. Comparative landscape of genetic dependencies in human and chimpanzee stem cells. Cell. 2023 07 06; 186(14):2977-2994.e23. She R, Fair T, Schaefer NK, Saunders RA, Pavlovic BJ, Weissman JS, Pollen AA. PMID: 37343560; PMCID: PMC10461406.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    12. FET fusion oncoproteins disrupt physiologic DNA repair networks and induce ATR synthetic lethality in cancer. Res Sq. 2023 May 29. Menon S, Breese MR, Lin YP, Allegakoen H, Perati S, Heslin A, Horlbeck MA, Weissman J, Sweet-Cordero EA, Bivona TG, Tulpule A. PMID: 37398210; PMCID: PMC10312925.
      View in: PubMed   Mentions:
    13. FET fusion oncoproteins disrupt physiologic DNA repair networks in cancer. bioRxiv. 2023 May 16. Menon S, Breese MR, Lin YP, Allegakoen H, Perati S, Heslin A, Horlbeck MA, Weissman J, Sweet-Cordero EA, Bivona TG, Tulpule A. PMID: 37205599; PMCID: PMC10187251.
      View in: PubMed   Mentions:
    14. Coupled protein quality control during nonsense-mediated mRNA decay. J Cell Sci. 2023 05 15; 136(10). Inglis AJ, Guna A, Gálvez-Merchán Á, Pal A, Esantsi TK, Keys HR, Frenkel EM, Oania R, Weissman JS, Voorhees RM. PMID: 37218462; PMCID: PMC10234110.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. Comparative landscape of genetic dependencies in human and chimpanzee stem cells. bioRxiv. 2023 Mar 20. She R, Fair T, Schaefer NK, Saunders RA, Pavlovic BJ, Weissman JS, Pollen AA. PMID: 36993685; PMCID: PMC10055274.
      View in: PubMed   Mentions:
    16. Microfluidics-free single-cell genomics with templated emulsification. Nat Biotechnol. 2023 Nov; 41(11):1557-1566. Clark IC, Fontanez KM, Meltzer RH, Xue Y, Hayford C, May-Zhang A, D'Amato C, Osman A, Zhang JQ, Hettige P, Ishibashi JSA, Delley CL, Weisgerber DW, Replogle JM, Jost M, Phong KT, Kennedy VE, Peretz CAC, Kim EA, Song S, Karlon W, Weissman JS, Smith CC, Gartner ZJ, Abate AR. PMID: 36879006; PMCID: PMC10635830.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    17. Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors. Elife. 2022 Dec 28; 11. Replogle JM, Bonnar JL, Pogson AN, Liem CR, Maier NK, Ding Y, Russell BJ, Wang X, Leng K, Guna A, Norman TM, Pak RA, Ramos DM, Ward ME, Gilbert LA, Kampmann M, Weissman JS, Jost M. PMID: 36576240.
      View in: PubMed   Mentions: 15     Fields:    
    18. GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion-positive rhabdomyosarcoma. JCI Insight. 2022 12 08; 7(23). Morales J, Allegakoen DV, Garcia JA, Kwong K, Sahu PK, Fajardo DA, Pan Y, Horlbeck MA, Weissman JS, Gustafson WC, Bivona TG, Sabnis AJ. PMID: 36282590; PMCID: PMC9746907.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. MTCH2 is a mitochondrial outer membrane protein insertase. Science. 2022 10 21; 378(6617):317-322. Guna A, Stevens TA, Inglis AJ, Replogle JM, Esantsi TK, Muthukumar G, Shaffer KCL, Wang ML, Pogson AN, Jones JJ, Lomenick B, Chou TF, Weissman JS, Voorhees RM. PMID: 36264797; PMCID: PMC9674023.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    20. Cellular barcoding to decipher clonal dynamics in disease. Science. 2022 10 14; 378(6616):eabm5874. Sankaran VG, Weissman JS, Zon LI. PMID: 36227997; PMCID: PMC10111813.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    21. Dual genome-wide coding and lncRNA screens in neural induction of induced pluripotent stem cells. Cell Genom. 2022 Nov 09; 2(11). Wu D, Poddar A, Ninou E, Hwang E, Cole MA, Liu SJ, Horlbeck MA, Chen J, Replogle JM, Carosso GA, Eng NWL, Chang J, Shen Y, Weissman JS, Lim DA. PMID: 36381608; PMCID: PMC9648144.
      View in: PubMed   Mentions: 6  
    22. Adaptive exchange sustains cullin-RING ubiquitin ligase networks and proper licensing of DNA replication. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2205608119. Zhang Y, Jost M, Pak RA, Lu D, Li J, Lomenick B, Garbis SD, Li CM, Weissman JS, Lipford JR, Deshaies RJ. PMID: 36037385; PMCID: PMC9456757.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    23. Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice. Nat Biotechnol. 2022 12; 40(12):1834-1844. Tolani B, Celli A, Yao Y, Tan YZ, Fetter R, Liem CR, de Smith AJ, Vasanthakumar T, Bisignano P, Cotton AD, Seiple IB, Rubinstein JL, Jost M, Weissman JS. PMID: 35879364; PMCID: PMC9750872.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    24. A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities. Cell Chem Biol. 2022 08 18; 29(8):1303-1316.e3. Shao H, Taguwa S, Gilbert L, Shkedi A, Sannino S, Guerriero CJ, Gale-Day ZJ, Young ZT, Brodsky JL, Weissman J, Gestwicki JE, Frydman J. PMID: 35830852; PMCID: PMC9513760.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    25. Standardized annotation of translated open reading frames. Nat Biotechnol. 2022 07; 40(7):994-999. Mudge JM, Ruiz-Orera J, Prensner JR, Brunet MA, Calvet F, Jungreis I, Gonzalez JM, Magrane M, Martinez TF, Schulz JF, Yang YT, Albà MM, Aspden JL, Baranov PV, Bazzini AA, Bruford E, Martin MJ, Calviello L, Carvunis AR, Chen J, Couso JP, Deutsch EW, Flicek P, Frankish A, Gerstein M, Hubner N, Ingolia NT, Kellis M, Menschaert G, Moritz RL, Ohler U, Roucou X, Saghatelian A, Weissman JS, van Heesch S. PMID: 35831657; PMCID: PMC9757701.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    26. Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq. Cell. 2022 07 07; 185(14):2559-2575.e28. Replogle JM, Saunders RA, Pogson AN, Hussmann JA, Lenail A, Guna A, Mascibroda L, Wagner EJ, Adelman K, Lithwick-Yanai G, Iremadze N, Oberstrass F, Lipson D, Bonnar JL, Jost M, Norman TM, Weissman JS. PMID: 35688146; PMCID: PMC9380471.
      View in: PubMed   Mentions: 86     Fields:    
    27. Variant to function mapping at single-cell resolution through network propagation. Nat Biotechnol. 2022 11; 40(11):1644-1653. Yu F, Cato LD, Weng C, Liggett LA, Jeon S, Xu K, Chiang CWK, Wiemels JL, Wiemels JL, Weissman JS, de Smith AJ, Sankaran VG. PMID: 35668323; PMCID: PMC9646486.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    28. Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution. Cell. 2022 05 26; 185(11):1905-1923.e25. Yang D, Jones MG, Naranjo S, Rideout WM, Min KHJ, Ho R, Wu W, Replogle JM, Page JL, Quinn JJ, Horns F, Qiu X, Chen MZ, Freed-Pastor WA, McGinnis CS, Patterson DM, Gartner ZJ, Chow ED, Bivona TG, Chan MM, Yosef N, Jacks T, Weissman JS. PMID: 35523183; PMCID: PMC9452598.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    29. OpenCell: Endogenous tagging for the cartography of human cellular organization. Science. 2022 03 11; 375(6585):eabi6983. Cho NH, Cheveralls KC, Brunner AD, Kim K, Michaelis AC, Raghavan P, Kobayashi H, Savy L, Li JY, Canaj H, Kim JYS, Stewart EM, Gnann C, McCarthy F, Cabrera JP, Brunetti RM, Chhun BB, Dingle G, Hein MY, Huang B, Mehta SB, Weissman JS, Gómez-Sjöberg R, Itzhak DN, Royer LA, Mann M, Leonetti MD. PMID: 35271311; PMCID: PMC9119736.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    30. High-content CRISPR screening. Nat Rev Methods Primers. 2022; 2(1). Bock C, Datlinger P, Chardon F, Coelho MA, Dong MB, Lawson KA, Lu T, Maroc L, Norman TM, Song B, Stanley G, Chen S, Garnett M, Li W, Moffat J, Qi LS, Shapiro RS, Shendure J, Weissman JS, Zhuang X. PMID: 37214176; PMCID: PMC10200264.
      View in: PubMed   Mentions: 69  
    31. Mapping transcriptomic vector fields of single cells. Cell. 2022 02 17; 185(4):690-711.e45. Qiu X, Zhang Y, Martin-Rufino JD, Weng C, Hosseinzadeh S, Yang D, Pogson AN, Hein MY, Hoi Joseph Min K, Wang L, Grody EI, Shurtleff MJ, Yuan R, Xu S, Ma Y, Replogle JM, Lander ES, Darmanis S, Bahar I, Sankaran VG, Xing J, Weissman JS. PMID: 35108499; PMCID: PMC9332140.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    32. Variant to function mapping at single-cell resolution through network propagation. bioRxiv. 2022 Jan 24. Yu F, Cato LD, Weng C, Liggett LA, Jeon S, Xu K, Chiang CWK, Wiemels JL, Wiemels JL, Weissman JS, de Smith AJ, Sankaran VG. PMID: 35118467; PMCID: PMC8811900.
      View in: PubMed   Mentions:
    33. BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2. Nat Cell Biol. 2022 01; 24(1):24-34. Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Kain AM, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nuñez JK, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M. PMID: 35027731; PMCID: PMC8820466.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    34. Peroxisome function relies on organelle-associated mRNA translation. Sci Adv. 2022 Jan 14; 8(2):eabk2141. Dahan N, Bykov YS, Boydston EA, Fadel A, Gazi Z, Hochberg-Laufer H, Martenson J, Denic V, Shav-Tal Y, Weissman JS, Aviram N, Zalckvar E, Schuldiner M. PMID: 35020435; PMCID: PMC8754406.
      View in: PubMed   Mentions: 8     Fields:    
    35. The dark proteome: translation from noncanonical open reading frames. Trends Cell Biol. 2022 03; 32(3):243-258. Wright BW, Yi Z, Weissman JS, Chen J. PMID: 34844857; PMCID: PMC8934435.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    36. Functional single-cell genomics of human cytomegalovirus infection. Nat Biotechnol. 2022 03; 40(3):391-401. Hein MY, Weissman JS. PMID: 34697476.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    37. Mapping the genetic landscape of DNA double-strand break repair. Cell. 2021 Oct 28; 184(22):5653-5669.e25. Hussmann JA, Ling J, Ravisankar P, Yan J, Cirincione A, Xu A, Simpson D, Yang D, Bothmer A, Cotta-Ramusino C, Weissman JS, Adamson B. PMID: 34672952; PMCID: PMC9074467.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    38. Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Cell. 2021 10 28; 184(22):5635-5652.e29. Chen PJ, Hussmann JA, Yan J, Knipping F, Ravisankar P, Chen PF, Chen C, Nelson JW, Newby GA, Sahin M, Osborn MJ, Weissman JS, Adamson B, Liu DR. PMID: 34653350; PMCID: PMC8584034.
      View in: PubMed   Mentions: 189     Fields:    Translation:HumansCells
    39. BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2. bioRxiv. 2021 Sep 20. Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Mac Kain A, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nunez J, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M. PMID: 33501440; PMCID: PMC7836110.
      View in: PubMed   Mentions:
    40. Structured elements drive extensive circular RNA translation. Mol Cell. 2021 10 21; 81(20):4300-4318.e13. Chen CK, Cheng R, Demeter J, Chen J, Weingarten-Gabbay S, Jiang L, Snyder MP, Weissman JS, Segal E, Jackson PK, Chang HY. PMID: 34437836; PMCID: PMC8567535.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    41. An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens. Elife. 2021 08 20; 10. Coukos R, Yao D, Sanchez MI, Strand ET, Olive ME, Udeshi ND, Weissman JS, Carr SA, Bassik MC, Ting AY. PMID: 34414886; PMCID: PMC8423448.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    42. Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning. Nat Biotechnol. 2021 Nov; 39(11):1414-1425. Koblan LW, Arbab M, Shen MW, Hussmann JA, Anzalone AV, Doman JL, Newby GA, Yang D, Mok B, Replogle JM, Xu A, Sisley TA, Weissman JS, Adamson B, Liu DR. PMID: 34183861; PMCID: PMC8985520.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    43. Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells. Elife. 2021 05 26; 10. Le Vasseur M, Friedman J, Jost M, Xu J, Yamada J, Kampmann M, Horlbeck MA, Salemi MR, Phinney BS, Weissman JS, Nunnari J. PMID: 34034859; PMCID: PMC8154037.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    44. CRISPR-based functional genomics in human dendritic cells. Elife. 2021 04 27; 10. Jost M, Jacobson AN, Hussmann JA, Cirolia G, Fischbach MA, Weissman JS. PMID: 33904395; PMCID: PMC8104964.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    45. Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing. Cell. 2021 04 29; 184(9):2503-2519.e17. Nuñez JK, Chen J, Pommier GC, Cogan JZ, Replogle JM, Adriaens C, Ramadoss GN, Shi Q, Hung KL, Samelson AJ, Pogson AN, Kim JYS, Chung A, Leonetti MD, Chang HY, Kampmann M, Bernstein BE, Hovestadt V, Gilbert LA, Weissman JS. PMID: 33838111; PMCID: PMC8376083.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansCells
    46. Regulation of translation by methylation multiplicity of 18S rRNA. Cell Rep. 2021 03 09; 34(10):108825. Liu K, Santos DA, Hussmann JA, Wang Y, Sutter BM, Weissman JS, Tu BP. PMID: 33691096; PMCID: PMC8063911.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    47. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell. 2021 Feb 04; 184(3):844. Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA. PMID: 33545038.
      View in: PubMed   Mentions: 17     Fields:    
    48. High-content imaging-based pooled CRISPR screens in mammalian cells. J Cell Biol. 2021 02 01; 220(2). Yan X, Stuurman N, Ribeiro SA, Tanenbaum ME, Horlbeck MA, Liem CR, Jost M, Weissman JS, Vale RD. PMID: 33465779; PMCID: PMC7821101.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    49. Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts. Science. 2021 02 26; 371(6532). Quinn JJ, Jones MG, Okimoto RA, Nanjo S, Chan MM, Yosef N, Bivona TG, Weissman JS. PMID: 33479121; PMCID: PMC7983364.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    50. A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation. Cancer Discov. 2021 06; 11(6):1562-1581. Lo YH, Kolahi KS, Du Y, Chang CY, Krokhotin A, Nair A, Sobba WD, Karlsson K, Jones SJ, Longacre TA, Mah AT, Tercan B, Sockell A, Xu H, Seoane JA, Chen J, Shmulevich I, Weissman JS, Curtis C, Califano A, Fu H, Crabtree GR, Kuo CJ. PMID: 33451982; PMCID: PMC8346515.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    51. Genome-Scale Perturbation of Long Noncoding RNA Expression Using CRISPR Interference. Methods Mol Biol. 2021; 2254:323-338. Liu SJ, Horlbeck MA, Weissman JS, Lim DA. PMID: 33326085; PMCID: PMC7917014.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    52. Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. Elife. 2020 11 25; 9. Miller-Vedam LE, Bräuning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS. PMID: 33236988; PMCID: PMC7785296.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    53. Mismatch-CRISPRi Reveals the Co-varying Expression-Fitness Relationships of Essential Genes in Escherichia coli and Bacillus subtilis. Cell Syst. 2020 11 18; 11(5):523-535.e9. Hawkins JS, Silvis MR, Koo BM, Peters JM, Osadnik H, Jost M, Hearne CC, Weissman JS, Todor H, Gross CA. PMID: 33080209; PMCID: PMC7704046.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    54. Conserved Functions of Ether Lipids and Sphingolipids in the Early Secretory Pathway. Curr Biol. 2020 10 05; 30(19):3775-3787.e7. Jiménez-Rojo N, Leonetti MD, Zoni V, Colom A, Feng S, Iyengar NR, Matile S, Roux A, Vanni S, Weissman JS, Riezman H. PMID: 32857977.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    55. Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing. Cell. 2020 09 03; 182(5):1232-1251.e22. Maynard A, McCoach CE, Rotow JK, Harris L, Haderk F, Kerr DL, Yu EA, Schenk EL, Tan W, Zee A, Tan M, Gui P, Lea T, Wu W, Urisman A, Jones K, Sit R, Kolli PK, Seeley E, Gesthalter Y, Le DD, Yamauchi KA, Naeger DM, Bandyopadhyay S, Shah K, Cech L, Thomas NJ, Gupta A, Gonzalez M, Do H, Tan L, Bacaltos B, Gomez-Sjoberg R, Gubens M, Jahan T, Kratz JR, Jablons D, Neff N, Doebele RC, Weissman J, Blakely CM, Darmanis S, Bivona TG. PMID: 32822576; PMCID: PMC7484178.
      View in: PubMed   Mentions: 221     Fields:    Translation:HumansCells
    56. Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span. Sci Adv. 2020 08; 6(32):eaba1306. Zou K, Rouskin S, Dervishi K, McCormick MA, Sasikumar A, Deng C, Chen Z, Kaeberlein M, Brem RB, Polymenis M, Kennedy BK, Weissman JS, Zheng J, Ouyang Q, Li H. PMID: 32821821; PMCID: PMC7406366.
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    57. GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control. Mol Cell. 2020 09 17; 79(6):950-962.e6. Hickey KL, Dickson K, Cogan JZ, Replogle JM, Schoof M, D'Orazio KN, Sinha NK, Hussmann JA, Jost M, Frost A, Green R, Weissman JS, Kostova KK. PMID: 32726578; PMCID: PMC7891188.
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    58. Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent. Mol Cell. 2020 07 02; 79(1):191-198.e3. Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS. PMID: 32619469; PMCID: PMC7332992.
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    59. Polysomes Bypass a 50-Nucleotide Coding Gap Less Efficiently Than Monosomes Due to Attenuation of a 5' mRNA Stem-Loop and Enhanced Drop-off. J Mol Biol. 2020 07 24; 432(16):4369-4387. O'Loughlin S, Capece MC, Klimova M, Wills NM, Coakley A, Samatova E, O'Connor PBF, Loughran G, Weissman JS, Baranov PV, Rodnina MV, Puglisi JD, Atkins JF. PMID: 32454154; PMCID: PMC7245268.
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    60. Inference of single-cell phylogenies from lineage tracing data using Cassiopeia. Genome Biol. 2020 04 14; 21(1):92. Jones MG, Khodaverdian A, Quinn JJ, Chan MM, Hussmann JA, Wang R, Xu C, Weissman JS, Yosef N. PMID: 32290857; PMCID: PMC7155257.
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    61. CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma. Genome Biol. 2020 03 31; 21(1):83. Liu SJ, Malatesta M, Lien BV, Saha P, Thombare SS, Hong SJ, Pedraza L, Koontz M, Seo K, Horlbeck MA, He D, Birk HS, Jain M, Olsen HE, Akeson M, Weissman JS, Monje M, Gupta N, Raleigh DR, Ullian EM, Lim DA. PMID: 32234056; PMCID: PMC7110660.
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    62. Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing. Nat Biotechnol. 2020 Aug; 38(8):954-961. Replogle JM, Norman TM, Xu A, Hussmann JA, Chen J, Cogan JZ, Meer EJ, Terry JM, Riordan DP, Srinivas N, Fiddes IT, Arthur JG, Alvarado LJ, Pfeiffer KA, Mikkelsen TS, Weissman JS, Adamson B. PMID: 32231336; PMCID: PMC7416462.
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    63. Pervasive functional translation of noncanonical human open reading frames. Science. 2020 03 06; 367(6482):1140-1146. Chen J, Brunner AD, Cogan JZ, Nuñez JK, Fields AP, Adamson B, Itzhak DN, Li JY, Mann M, Leonetti MD, Weissman JS. PMID: 32139545; PMCID: PMC7289059.
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    64. Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes. Nat Biotechnol. 2020 May; 38(5):573-576. Horlbeck MA, Liu SJ, Chang HY, Lim DA, Weissman JS. PMID: 32094656; PMCID: PMC8128075.
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    65. Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs. Nat Biotechnol. 2020 Mar; 38(3):355-364. Jost M, Santos DA, Saunders RA, Horlbeck MA, Hawkins JS, Scaria SM, Norman TM, Hussmann JA, Liem CR, Gross CA, Weissman JS. PMID: 31932729; PMCID: PMC7065968.
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    66. The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regeneration. Genes Dev. 2020 02 01; 34(3-4):194-208. Vargas EJM, Matamoros AJ, Qiu J, Jan CH, Wang Q, Gorczyca D, Han TW, Weissman JS, Jan YN, Banerjee S, Song Y. PMID: 31919191; PMCID: PMC7000917.
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    67. Variation in expenditure for common, high cost surgical procedures in a working age population: implications for reimbursement reform. BMC Health Serv Res. 2019 Nov 21; 19(1):877. Wynn-Jones W, Koehlmoos TP, Tompkins C, Navathe A, Lipsitz S, Kwon NK, Learn PA, Madsen C, Schoenfeld A, Weissman JS. PMID: 31752866; PMCID: PMC6873455.
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    68. The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins. Elife. 2019 09 13; 8. Ngo AM, Shurtleff MJ, Popova KD, Kulsuptrakul J, Weissman JS, Puschnik AS. PMID: 31516121; PMCID: PMC6756788.
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    69. New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells. J Cell Biol. 2019 11 04; 218(11):3861-3879. Bassaganyas L, Popa SJ, Horlbeck M, Puri C, Stewart SE, Campelo F, Ashok A, Butnaru CM, Brouwers N, Heydari K, Ripoche J, Weissman J, Rubinsztein DC, Schekman R, Malhotra V, Moreau K, Villeneuve J. PMID: 31488582; PMCID: PMC6829651.
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    70. Exploring genetic interaction manifolds constructed from rich single-cell phenotypes. Science. 2019 08 23; 365(6455):786-793. Norman TM, Horlbeck MA, Replogle JM, Ge AY, Xu A, Jost M, Gilbert LA, Weissman JS. PMID: 31395745; PMCID: PMC6746554.
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    71. MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices. Nat Methods. 2019 07; 16(7):619-626. McGinnis CS, Patterson DM, Winkler J, Conrad DN, Hein MY, Srivastava V, Hu JL, Murrow LM, Weissman JS, Werb Z, Chow ED, Gartner ZJ. PMID: 31209384; PMCID: PMC6837808.
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    72. Cycloheximide can distort measurements of mRNA levels and translation efficiency. Nucleic Acids Res. 2019 06 04; 47(10):4974-4985. Santos DA, Shi L, Tu BP, Weissman JS. PMID: 30916348; PMCID: PMC6547433.
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    73. Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether. Elife. 2019 05 31; 8. Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P. PMID: 31149896; PMCID: PMC6588346.
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    74. Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress. Proc Natl Acad Sci U S A. 2019 06 04; 116(23):11291-11298. Igbaria A, Merksamer PI, Trusina A, Tilahun F, Johnson JR, Brandman O, Krogan NJ, Weissman JS, Papa FR. PMID: 31101715; PMCID: PMC6561268.
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    75. Molecular recording of mammalian embryogenesis. Nature. 2019 06; 570(7759):77-82. Chan MM, Smith ZD, Grosswendt S, Kretzmer H, Norman TM, Adamson B, Jost M, Quinn JJ, Yang D, Jones MG, Khodaverdian A, Yosef N, Meissner A, Weissman JS. PMID: 31086336; PMCID: PMC7229772.
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    76. Ribosome Profiling: Global Views of Translation. Cold Spring Harb Perspect Biol. 2019 05 01; 11(5). Ingolia NT, Hussmann JA, Weissman JS. PMID: 30037969; PMCID: PMC6496350.
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    77. Cellular response to small molecules that selectively stall protein synthesis by the ribosome. PLoS Genet. 2019 03; 15(3):e1008057. Liaud N, Horlbeck MA, Gilbert LA, Gjoni K, Weissman JS, Cate JHD. PMID: 30875366; PMCID: PMC6436758.
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    78. Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids. Mol Cell. 2019 04 04; 74(1):32-44.e8. Piccolis M, Bond LM, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai ZW, Gabriel KR, Elliott SD, Paulo JA, Harper JW, Weissman JS, Walther TC, Farese RV. PMID: 30846318; PMCID: PMC7696670.
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    79. Mapping the Genetic Landscape of Human Cells. Cell. 2018 08 09; 174(4):953-967.e22. Horlbeck MA, Xu A, Wang M, Bennett NK, Park CY, Bogdanoff D, Adamson B, Chow ED, Kampmann M, Peterson TR, Nakamura K, Fischbach MA, Weissman JS, Gilbert LA. PMID: 30033366; PMCID: PMC6426455.
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    80. Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70). J Med Chem. 2018 Jul 26; 61(14):6163-6177. Shao H, Li X, Moses MA, Gilbert LA, Kalyanaraman C, Young ZT, Chernova M, Journey SN, Weissman JS, Hann B, Jacobson MP, Neckers L, Gestwicki JE. PMID: 29953808; PMCID: PMC6104643.
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    81. Reprogramming human T cell function and specificity with non-viral genome targeting. Nature. 2018 07; 559(7714):405-409. Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta-Aranburu G, Del Gaudio D, Matsumoto H, Morell M, Mao Y, Cho M, Quadros RM, Gurumurthy CB, Smith B, Haugwitz M, Hughes SH, Weissman JS, Schumann K, Esensten JH, May AP, Ashworth A, Kupfer GM, Greeley SAW, Bacchetta R, Meffre E, Roncarolo MG, Romberg N, Herold KC, Ribas A, Leonetti MD, Marson A. PMID: 29995861; PMCID: PMC6239417.
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    82. Engineering ER-stress dependent non-conventional mRNA splicing. Elife. 2018 07 09; 7. Li W, Okreglak V, Peschek J, Kimmig P, Zubradt M, Weissman JS, Walter P. PMID: 29985129; PMCID: PMC6037481.
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    83. The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs. Nature. 2018 07; 559(7712):130-134. Guenther UP, Weinberg DE, Zubradt MM, Tedeschi FA, Stawicki BN, Zagore LL, Brar GA, Licatalosi DD, Bartel DP, Weissman JS, Jankowsky E. PMID: 29950728; PMCID: PMC6226265.
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    84. The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins. Elife. 2018 05 29; 7. Shurtleff MJ, Itzhak DN, Hussmann JA, Schirle Oakdale NT, Costa EA, Jonikas M, Weibezahn J, Popova KD, Jan CH, Sinitcyn P, Vembar SS, Hernandez H, Cox J, Burlingame AL, Brodsky JL, Frost A, Borner GH, Weissman JS. PMID: 29809151; PMCID: PMC5995541.
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    85. Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform. Hepatology. 2018 Aug; 68(2):663-676. Wangensteen KJ, Wang YJ, Dou Z, Wang AW, Mosleh-Shirazi E, Horlbeck MA, Gilbert LA, Weissman JS, Berger SL, Kaestner KH. PMID: 29091290; PMCID: PMC5930141.
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    86. Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. Elife. 2018 05 10; 7. Yu Z, Surface LE, Park CY, Horlbeck MA, Wyant GA, Abu-Remaileh M, Peterson TR, Sabatini DM, Weissman JS, O'Shea EK. PMID: 29745899; PMCID: PMC6021172.
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    87. Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. Cell. 2018 05 31; 173(6):1398-1412.e22. Cho SW, Xu J, Sun R, Mumbach MR, Carter AC, Chen YG, Yost KE, Kim J, He J, Nevins SA, Chin SF, Caldas C, Liu SJ, Horlbeck MA, Lim DA, Weissman JS, Curtis C, Chang HY. PMID: 29731168; PMCID: PMC5984165.
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    88. A Stress Response that Monitors and Regulates mRNA Structure Is Central to Cold Shock Adaptation. Mol Cell. 2018 04 19; 70(2):274-286.e7. Zhang Y, Burkhardt DH, Rouskin S, Li GW, Weissman JS, Gross CA. PMID: 29628307; PMCID: PMC5910227.
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    89. CRISPR Approaches to Small Molecule Target Identification. ACS Chem Biol. 2018 02 16; 13(2):366-375. Jost M, Weissman JS. PMID: 29261286; PMCID: PMC5834945.
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    90. Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins. Elife. 2018 01 23; 7. Martinko AJ, Truillet C, Julien O, Diaz JE, Horlbeck MA, Whiteley G, Blonder J, Weissman JS, Bandyopadhyay S, Evans MJ, Wells JA. PMID: 29359686; PMCID: PMC5796798.
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    91. Defining the physiological role of SRP in protein-targeting efficiency and specificity. Science. 2018 02 09; 359(6376):689-692. Costa EA, Subramanian K, Nunnari J, Weissman JS. PMID: 29348368; PMCID: PMC5970945.
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    92. Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER. Dev Cell. 2018 01 22; 44(2):261-270.e6. Friedman JR, Kannan M, Toulmay A, Jan CH, Weissman JS, Prinz WA, Nunnari J. PMID: 29290583; PMCID: PMC5975648.
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    93. The Human Cell Atlas. Elife. 2017 12 05; 6. Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell P, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, Enard W, Farmer A, Fugger L, Göttgens B, Hacohen N, Haniffa M, Hemberg M, Kim S, Klenerman P, Kriegstein A, Lein E, Linnarsson S, Lundberg E, Lundeberg J, Majumder P, Marioni JC, Merad M, Mhlanga M, Nawijn M, Netea M, Nolan G, Pe'er D, Phillipakis A, Ponting CP, Quake S, Reik W, Rozenblatt-Rosen O, Sanes J, Satija R, Schumacher TN, Shalek A, Shapiro E, Sharma P, Shin JW, Stegle O, Stratton M, Stubbington MJT, Theis FJ, Uhlen M, van Oudenaarden A, Wagner A, Watt F, Weissman J, Wold B, Xavier R, Yosef N, Human Cell Atlas Meeting Participants. PMID: 29206104; PMCID: PMC5762154.
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    94. Inducible and multiplex gene regulation using CRISPR-Cpf1-based transcription factors. Nat Methods. 2017 Dec; 14(12):1163-1166. Tak YE, Kleinstiver BP, Nuñez JK, Hsu JY, Horng JE, Gong J, Weissman JS, Joung JK. PMID: 29083402; PMCID: PMC5909187.
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    95. Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Mol Cell. 2017 Oct 05; 68(1):210-223.e6. Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS. PMID: 28985505; PMCID: PMC5640507.
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    96. CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides. Science. 2017 07 28; 357(6349):414-417. Kostova KK, Hickey KL, Osuna BA, Hussmann JA, Frost A, Weinberg DE, Weissman JS. PMID: 28751611; PMCID: PMC5673106.
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    97. Minimally invasive surgery and its impact on 30-day postoperative complications, unplanned readmissions and mortality. Br J Surg. 2017 Sep; 104(10):1372-1381. Sood A, Meyer CP, Abdollah F, Sammon JD, Sun M, Lipsitz SR, Hollis M, Weissman JS, Menon M, Trinh QD. PMID: 28632890.
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    98. Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia. Blood. 2017 06 01; 129(22):3000-3008. Kruth KA, Fang M, Shelton DN, Abu-Halawa O, Mahling R, Yang H, Weissman JS, Loh ML, Müschen M, Tasian SK, Bassik MC, Kampmann M, Pufall MA. PMID: 28424165; PMCID: PMC5454339.
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    99. Operon mRNAs are organized into ORF-centric structures that predict translation efficiency. Elife. 2017 01 31; 6. Burkhardt DH, Rouskin S, Zhang Y, Li GW, Weissman JS, Gross CA. PMID: 28139975; PMCID: PMC5318159.
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    100. Translation from unconventional 5' start sites drives tumour initiation. Nature. 2017 01 26; 541(7638):494-499. Sendoel A, Dunn JG, Rodriguez EH, Naik S, Gomez NC, Hurwitz B, Levorse J, Dill BD, Schramek D, Molina H, Weissman JS, Fuchs E. PMID: 28077873; PMCID: PMC5287289.
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    101. CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells. Science. 2017 01 06; 355(6320). Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, Weissman JS, Lim DA. PMID: 27980086; PMCID: PMC5394926.
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    102. A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response. Cell. 2016 Dec 15; 167(7):1867-1882.e21. Adamson B, Norman TM, Jost M, Cho MY, Nuñez JK, Chen Y, Villalta JE, Gilbert LA, Horlbeck MA, Hein MY, Pak RA, Gray AN, Gross CA, Dixit A, Parnas O, Regev A, Weissman JS. PMID: 27984733; PMCID: PMC5315571.
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    103. Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens. Cell. 2016 Dec 15; 167(7):1853-1866.e17. Dixit A, Parnas O, Li B, Chen J, Fulco CP, Jerby-Arnon L, Marjanovic ND, Dionne D, Burks T, Raychowdhury R, Adamson B, Norman TM, Lander ES, Weissman JS, Friedman N, Regev A. PMID: 27984732; PMCID: PMC5181115.
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    104. The mTOR Complex Controls HIV Latency. Cell Host Microbe. 2016 Dec 14; 20(6):785-797. Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E. PMID: 27978436; PMCID: PMC5354304.
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    105. The SND proteins constitute an alternative targeting route to the endoplasmic reticulum. Nature. 2016 11 30; 540(7631):134-138. Aviram N, Ast T, Costa EA, Arakel EC, Chuartzman SG, Jan CH, Haßdenteufel S, Dudek J, Jung M, Schorr S, Zimmermann R, Schwappach B, Weissman JS, Schuldiner M. PMID: 27905431; PMCID: PMC5513701.
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    106. Plastid: nucleotide-resolution analysis of next-generation sequencing and genomics data. BMC Genomics. 2016 11 22; 17(1):958. Dunn JG, Weissman JS. PMID: 27875984; PMCID: PMC5120557.
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    107. Model-guided optogenetic study of PKA signaling in budding yeast. Mol Biol Cell. 2017 01 01; 28(1):221-227. Stewart-Ornstein J, Chen S, Bhatnagar R, Weissman JS, El-Samad H. PMID: 28035051; PMCID: PMC5221627.
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    108. DMS-MaPseq for genome-wide or targeted RNA structure probing in vivo. Nat Methods. 2017 01; 14(1):75-82. Zubradt M, Gupta P, Persad S, Lambowitz AM, Weissman JS, Rouskin S. PMID: 27819661; PMCID: PMC5508988.
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    109. Dynamic translation regulation in Caulobacter cell cycle control. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):E6859-E6867. Schrader JM, Li GW, Childers WS, Perez AM, Weissman JS, Shapiro L, McAdams HH. PMID: 27791168; PMCID: PMC5098616.
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    110. Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation. Elife. 2016 Sep 23; 5. Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman JS. PMID: 27661255; PMCID: PMC5094855.
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    111. Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Proc Natl Acad Sci U S A. 2016 08 09; 113(32):9015-20. Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG. PMID: 27450084; PMCID: PMC4987817.
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    112. Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity. Nat Commun. 2016 07 01; 7:12009. Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman JS, Conklin BR, Wells JA. PMID: 27363581; PMCID: PMC4932181.
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    113. Htm1p-Pdi1p is a folding-sensitive mannosidase that marks N-glycoproteins for ER-associated protein degradation. Proc Natl Acad Sci U S A. 2016 07 12; 113(28):E4015-24. Liu YC, Fujimori DG, Weissman JS. PMID: 27357682; PMCID: PMC4948361.
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    114. Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3892-900. Braun CJ, Bruno PM, Horlbeck MA, Gilbert LA, Weissman JS, Hemann MT. PMID: 27325776; PMCID: PMC4941480.
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    115. A scalable strategy for high-throughput GFP tagging of endogenous human proteins. Proc Natl Acad Sci U S A. 2016 06 21; 113(25):E3501-8. Leonetti MD, Sekine S, Kamiyama D, Weissman JS, Huang B. PMID: 27274053; PMCID: PMC4922190.
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    116. A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria. Cell. 2016 Jun 02; 165(6):1493-1506. Peters JM, Colavin A, Shi H, Czarny TL, Larson MH, Wong S, Hawkins JS, Lu CHS, Koo BM, Marta E, Shiver AL, Whitehead EH, Weissman JS, Brown ED, Qi LS, Huang KC, Gross CA. PMID: 27238023; PMCID: PMC4894308.
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    117. Single-cell analysis of long non-coding RNAs in the developing human neocortex. Genome Biol. 2016 Apr 14; 17:67. Liu SJ, Nowakowski TJ, Pollen AA, Lui JH, Horlbeck MA, Attenello FJ, He D, Weissman JS, Kriegstein AR, Diaz AA, Lim DA. PMID: 27081004; PMCID: PMC4831157.
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    118. Versatile protein tagging in cells with split fluorescent protein. Nat Commun. 2016 Mar 18; 7:11046. Kamiyama D, Sekine S, Barsi-Rhyne B, Hu J, Chen B, Gilbert LA, Ishikawa H, Leonetti MD, Marshall WF, Weissman JS, Huang B. PMID: 26988139; PMCID: PMC4802074.
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    119. Nucleosomes impede Cas9 access to DNA in vivo and in vitro. Elife. 2016 03 17; 5. Horlbeck MA, Witkowsky LB, Guglielmi B, Replogle JM, Gilbert LA, Villalta JE, Torigoe SE, Tjian R, Weissman JS. PMID: 26987018; PMCID: PMC4861601.
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    120. CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs. Cell Stem Cell. 2016 Apr 07; 18(4):541-53. Mandegar MA, Huebsch N, Frolov EB, Shin E, Truong A, Olvera MP, Chan AH, Miyaoka Y, Holmes K, Spencer CI, Judge LM, Gordon DE, Eskildsen TV, Villalta JE, Horlbeck MA, Gilbert LA, Krogan NJ, Sheikh SP, Weissman JS, Qi LS, So PL, Conklin BR. PMID: 26971820; PMCID: PMC4830697.
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    121. A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation. Mol Cell. 2015 Dec 03; 60(5):816-827. Fields AP, Rodriguez EH, Jovanovic M, Stern-Ginossar N, Haas BJ, Mertins P, Raychowdhury R, Hacohen N, Carr SA, Ingolia NT, Regev A, Weissman JS. PMID: 26638175; PMCID: PMC4720255.
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    122. [KIL-d] Protein Element Confers Antiviral Activity via Catastrophic Viral Mutagenesis. Mol Cell. 2015 Nov 19; 60(4):651-60. Suzuki G, Weissman JS, Tanaka M. PMID: 26590718; PMCID: PMC5513702.
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    123. Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis. Cancer Cell. 2015 Nov 09; 28(5):653-665. Anderson DJ, Le Moigne R, Djakovic S, Kumar B, Rice J, Wong S, Wang J, Yao B, Valle E, Kiss von Soly S, Madriaga A, Soriano F, Menon MK, Wu ZY, Kampmann M, Chen Y, Weissman JS, Aftab BT, Yakes FM, Shawver L, Zhou HJ, Wustrow D, Rolfe M. PMID: 26555175; PMCID: PMC4941640.
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    124. Ribosome profiling reveals the what, when, where and how of protein synthesis. Nat Rev Mol Cell Biol. 2015 Nov; 16(11):651-64. Brar GA, Weissman JS. PMID: 26465719; PMCID: PMC5522010.
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    125. Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits. Elife. 2015 Sep 01; 4:e08153. Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M. PMID: 26327694; PMCID: PMC4602331.
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    126. Regulation of mRNA translation during mitosis. Elife. 2015 Aug 25; 4. Tanenbaum ME, Stern-Ginossar N, Weissman JS, Vale RD. PMID: 26305499; PMCID: PMC4548207.
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    127. Next-generation libraries for robust RNA interference-based genome-wide screens. Proc Natl Acad Sci U S A. 2015 Jun 30; 112(26):E3384-91. Kampmann M, Horlbeck MA, Chen Y, Tsai JC, Bassik MC, Gilbert LA, Villalta JE, Kwon SC, Chang H, Kim VN, Weissman JS. PMID: 26080438; PMCID: PMC4491794.
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    128. LOCAL TRANSLATION. Response to Comment on "Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling". Science. 2015 Jun 12; 348(6240):1217. Jan CH, Williams CC, Weissman JS. PMID: 26068842.
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    129. Oncogenic activation of the PI3-kinase p110β isoform via the tumor-derived PIK3Cβ(D1067V) kinase domain mutation. Oncogene. 2016 Mar 03; 35(9):1198-205. Pazarentzos E, Giannikopoulos P, Hrustanovic G, St John J, Olivas VR, Gubens MA, Balassanian R, Weissman J, Polkinghorn W, Bivona TG. PMID: 25982275.
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    130. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife. 2015 Apr 15; 4:e07314. Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. PMID: 25875391; PMCID: PMC4426669.
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    131. Corrigendum: functional genomics platform for pooled screening and generation of mammalian genetic interaction maps. Nat Protoc. 2015 Apr; 10(4):643. Kampmann M, Bassik MC, Weissman JS. PMID: 25811902.
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    132. Biotechnology. A prudent path forward for genomic engineering and germline gene modification. Science. 2015 Apr 03; 348(6230):36-8. Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR. PMID: 25791083; PMCID: PMC4394183.
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    133. Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens. Science. 2015 Mar 06; 347(6226):1259038. Jovanovic M, Rooney MS, Mertins P, Przybylski D, Chevrier N, Satija R, Rodriguez EH, Fields AP, Schwartz S, Raychowdhury R, Mumbach MR, Eisenhaure T, Rabani M, Gennert D, Lu D, Delorey T, Weissman JS, Carr SA, Hacohen N, Regev A. PMID: 25745177; PMCID: PMC4506746.
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    134. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar; 14(3):642-8. Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE. PMID: 25564440; PMCID: PMC4456214.
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    135. Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains. Science. 2015 Jan 02; 347(6217):75-8. Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O, Frost A. PMID: 25554787; PMCID: PMC4451101.
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    136. Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation. Mol Syst Biol. 2014 Dec 23; 10:770. Pop C, Rouskin S, Ingolia NT, Han L, Phizicky EM, Weissman JS, Koller D. PMID: 25538139; PMCID: PMC4300493.
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    137. Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds. Cell. 2015 Jan 15; 160(1-2):339-50. Zalatan JG, Lee ME, Almeida R, Gilbert LA, Whitehead EH, La Russa M, Tsai JC, Weissman JS, Dueber JE, Qi LS, Lim WA. PMID: 25533786; PMCID: PMC4297522.
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    138. Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling. Science. 2014 Nov 07; 346(6210):748-51. Williams CC, Jan CH, Weissman JS. PMID: 25378625; PMCID: PMC4263316.
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    139. Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling. Science. 2014 Nov 07; 346(6210):1257521. Jan CH, Williams CC, Weissman JS. PMID: 25378630; PMCID: PMC4285348.
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    140. The general mode of translation inhibition by macrolide antibiotics. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):15958-63. Kannan K, Kanabar P, Schryer D, Florin T, Oh E, Bahroos N, Tenson T, Weissman JS, Mankin AS. PMID: 25349425; PMCID: PMC4234590.
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    141. Genetic influences on translation in yeast. PLoS Genet. 2014 Oct; 10(10):e1004692. Albert FW, Muzzey D, Weissman JS, Kruglyak L. PMID: 25340754; PMCID: PMC4207643.
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    142. A protein-tagging system for signal amplification in gene expression and fluorescence imaging. Cell. 2014 Oct 23; 159(3):635-46. Tanenbaum ME, Gilbert LA, Qi LS, Weissman JS, Vale RD. PMID: 25307933; PMCID: PMC4252608.
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    143. Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation. Cell. 2014 Oct 23; 159(3):647-61. Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS. PMID: 25307932; PMCID: PMC4253859.
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    144. Unraveling the mechanism of cell death induced by chemical fibrils. Nat Chem Biol. 2014 Nov; 10(11):969-76. Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. PMID: 25262416; PMCID: PMC4201873.
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    145. Ribosome profiling reveals pervasive translation outside of annotated protein-coding genes. Cell Rep. 2014 Sep 11; 8(5):1365-79. Ingolia NT, Brar GA, Stern-Ginossar N, Harris MS, Talhouarne GJ, Jackson SE, Wills MR, Weissman JS. PMID: 25159147; PMCID: PMC4216110.
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    146. Misfolded proteins induce aggregation of the lectin Yos9. J Biol Chem. 2014 Sep 12; 289(37):25670-7. Smith MH, Rodriguez EH, Weissman JS. PMID: 25086047; PMCID: PMC4162170.
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    147. The coding and noncoding architecture of the Caulobacter crescentus genome. PLoS Genet. 2014 Jul; 10(7):e1004463. Schrader JM, Zhou B, Li GW, Lasker K, Childers WS, Williams B, Long T, Crosson S, McAdams HH, Weissman JS, Shapiro L. PMID: 25078267; PMCID: PMC4117421.
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    148. Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps. Nat Protoc. 2014 Aug; 9(8):1825-47. Kampmann M, Bassik MC, Weissman JS. PMID: 24992097; PMCID: PMC4144868.
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    149. A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation. Nat Commun. 2014 May 08; 5:3832. van de Weijer ML, Bassik MC, Luteijn RD, Voorburg CM, Lohuis MA, Kremmer E, Hoeben RC, LeProust EM, Chen S, Hoelen H, Ressing ME, Patena W, Weissman JS, McManus MT, Wiertz EJ, Lebbink RJ. PMID: 24807418; PMCID: PMC4024746.
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    150. A pause sequence enriched at translation start sites drives transcription dynamics in vivo. Science. 2014 May 30; 344(6187):1042-7. Larson MH, Mooney RA, Peters JM, Windgassen T, Nayak D, Gross CA, Block SM, Greenleaf WJ, Landick R, Weissman JS. PMID: 24789973; PMCID: PMC4108260.
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    151. Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources. Cell. 2014 Apr 24; 157(3):624-35. Li GW, Burkhardt D, Gross C, Weissman JS. PMID: 24766808; PMCID: PMC4006352.
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    152. Extensive and coordinated control of allele-specific expression by both transcription and translation in Candida albicans. Genome Res. 2014 Jun; 24(6):963-73. Muzzey D, Sherlock G, Weissman JS. PMID: 24732588; PMCID: PMC4032860.
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    153. Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol. 2014 Mar 31; 204(7):1083-6. Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, Park SK, Rehling P, Reichert AS, Sheikh MS, Taylor SS, Tsuchida N, van der Bliek AM, van der Klei IJ, Weissman JS, Westermann B, Zha J, Neupert W, Nunnari J. PMID: 24687277; PMCID: PMC3971754.
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    154. Differential scales of protein quality control. Cell. 2014 Mar 27; 157(1):52-64. Wolff S, Weissman JS, Dillin A. PMID: 24679526.
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    155. KSHV 2.0: a comprehensive annotation of the Kaposi's sarcoma-associated herpesvirus genome using next-generation sequencing reveals novel genomic and functional features. PLoS Pathog. 2014 Jan; 10(1):e1003847. Arias C, Weisburd B, Stern-Ginossar N, Mercier A, Madrid AS, Bellare P, Holdorf M, Weissman JS, Ganem D. PMID: 24453964; PMCID: PMC3894221.
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    156. Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system. Cell. 2013 Dec 19; 155(7):1479-91. Chen B, Gilbert LA, Cimini BA, Schnitzbauer J, Zhang W, Li GW, Park J, Blackburn EH, Weissman JS, Qi LS, Huang B. PMID: 24360272; PMCID: PMC3918502.
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    157. Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo. Nature. 2014 Jan 30; 505(7485):701-5. Rouskin S, Zubradt M, Washietl S, Kellis M, Weissman JS. PMID: 24336214; PMCID: PMC3966492.
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    158. Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster. Elife. 2013 Dec 03; 2:e01179. Dunn JG, Foo CK, Belletier NG, Gavis ER, Weissman JS. PMID: 24302569; PMCID: PMC3840789.
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    159. Msn2 coordinates a stoichiometric gene expression program. Curr Biol. 2013 Dec 02; 23(23):2336-45. Stewart-Ornstein J, Nelson C, DeRisi J, Weissman JS, El-Samad H. PMID: 24210615; PMCID: PMC4072881.
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    160. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol. 2013 Nov 21; 20(11):1352-63. Matheny CJ, Wei MC, Bassik MC, Donnelly AJ, Kampmann M, Iwasaki M, Piloto O, Solow-Cordero DE, Bouley DM, Rau R, Brown P, McManus MT, Weissman JS, Cleary ML. PMID: 24183972; PMCID: PMC3881547.
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    161. Global cellular response to chemotherapy-induced apoptosis. Elife. 2013 Oct 29; 2:e01236. Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA. PMID: 24171104; PMCID: PMC3808542.
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    162. Selective ribosome profiling as a tool for studying the interaction of chaperones and targeting factors with nascent polypeptide chains and ribosomes. Nat Protoc. 2013 Nov; 8(11):2212-39. Becker AH, Oh E, Weissman JS, Kramer G, Bukau B. PMID: 24136347; PMCID: PMC4001812.
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    163. CRISPR interference (CRISPRi) for sequence-specific control of gene expression. Nat Protoc. 2013 Nov; 8(11):2180-96. Larson MH, Gilbert LA, Wang X, Lim WA, Weissman JS, Qi LS. PMID: 24136345; PMCID: PMC3922765.
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    164. A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern. Genes Dev. 2013 Oct 01; 27(19):2147-63. Berchowitz LE, Gajadhar AS, van Werven FJ, De Rosa AA, Samoylova ML, Brar GA, Xu Y, Xiao C, Futcher B, Weissman JS, White FM, Amon A. PMID: 24115771; PMCID: PMC3850098.
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    165. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell. 2013 Jul 18; 154(2):442-51. Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman JS, Qi LS. PMID: 23849981; PMCID: PMC3770145.
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    166. Genome-wide annotation and quantitation of translation by ribosome profiling. Curr Protoc Mol Biol. 2013 Jul; Chapter 4:4.18.1-4.18.19. Ingolia NT, Brar GA, Rouskin S, McGeachy AM, Weissman JS. PMID: 23821443; PMCID: PMC3775365.
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    167. Ribosome profiling provides evidence that large noncoding RNAs do not encode proteins. Cell. 2013 Jul 03; 154(1):240-51. Guttman M, Russell P, Ingolia NT, Weissman JS, Lander ES. PMID: 23810193; PMCID: PMC3756563.
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    168. Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells. Proc Natl Acad Sci U S A. 2013 Jun 18; 110(25):E2317-26. Kampmann M, Bassik MC, Weissman JS. PMID: 23739767; PMCID: PMC3690882.
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    169. rRNA:mRNA pairing alters the length and the symmetry of mRNA-protected fragments in ribosome profiling experiments. Bioinformatics. 2013 Jun 15; 29(12):1488-91. O'Connor PB, Li GW, Weissman JS, Atkins JF, Baranov PV. PMID: 23603333; PMCID: PMC3673220.
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    170. Aneuploid yeast strains exhibit defects in cell growth and passage through START. Mol Biol Cell. 2013 May; 24(9):1274-89. Thorburn RR, Gonzalez C, Brar GA, Christen S, Carlile TM, Ingolia NT, Sauer U, Weissman JS, Amon A. PMID: 23468524; PMCID: PMC3639041.
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    171. The contribution of systematic approaches to characterizing the proteins and functions of the endoplasmic reticulum. Cold Spring Harb Perspect Biol. 2013 Mar 01; 5(3):a013284. Schuldiner M, Weissman JS. PMID: 23359093; PMCID: PMC3578357.
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    172. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell. 2013 Feb 28; 152(5):1173-83. Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA. PMID: 23452860; PMCID: PMC3664290.
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    173. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell. 2013 Feb 14; 152(4):909-22. Bassik MC, Kampmann M, Lebbink RJ, Wang S, Hein MY, Poser I, Weibezahn J, Horlbeck MA, Chen S, Mann M, Hyman AA, Leproust EM, McManus MT, Weissman JS. PMID: 23394947; PMCID: PMC3652613.
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    174. Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Genome Biol. 2013; 14(9):R97. Muzzey D, Schwartz K, Weissman JS, Sherlock G. PMID: 24025428; PMCID: PMC4054093.
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    175. Decoding human cytomegalovirus. Science. 2012 Nov 23; 338(6110):1088-93. Stern-Ginossar N, Weisburd B, Michalski A, Le VT, Hein MY, Huang SX, Ma M, Shen B, Qian SB, Hengel H, Mann M, Ingolia NT, Weissman JS. PMID: 23180859; PMCID: PMC3817102.
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    176. A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell. 2012 Nov 21; 151(5):1042-54. Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman JS. PMID: 23178123; PMCID: PMC3534965.
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    177. The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments. Nat Protoc. 2012 Jul 26; 7(8):1534-50. Ingolia NT, Brar GA, Rouskin S, McGeachy AM, Weissman JS. PMID: 22836135; PMCID: PMC3535016.
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    178. Proto-genes and de novo gene birth. Nature. 2012 Jul 19; 487(7407):370-4. Carvunis AR, Rolland T, Wapinski I, Calderwood MA, Yildirim MA, Simonis N, Charloteaux B, Hidalgo CA, Barbette J, Santhanam B, Brar GA, Weissman JS, Regev A, Thierry-Mieg N, Cusick ME, Vidal M. PMID: 22722833; PMCID: PMC3401362.
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    179. Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Cell. 2012 Jun 08; 149(6):1339-52. Frost A, Elgort MG, Brandman O, Ives C, Collins SR, Miller-Vedam L, Weibezahn J, Hein MY, Poser I, Mann M, Hyman AA, Weissman JS. PMID: 22682253; PMCID: PMC3613983.
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    180. Special issue: the molecular and cellular mechanisms of amyloidosis. J Mol Biol. 2012 Aug 10; 421(2-3):139-41. Radford SE, Weissman JS. PMID: 22664198.
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    181. Native elongating transcript sequencing (NET-seq). Curr Protoc Mol Biol. 2012 Apr; Chapter 4:Unit 4.14.1-17. Churchman LS, Weissman JS. PMID: 22470065.
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    182. The anti-Shine-Dalgarno sequence drives translational pausing and codon choice in bacteria. Nature. 2012 Mar 28; 484(7395):538-41. Li GW, Oh E, Weissman JS. PMID: 22456704; PMCID: PMC3338875.
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    183. Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae. Mol Cell. 2012 Feb 24; 45(4):483-93. Stewart-Ornstein J, Weissman JS, El-Samad H. PMID: 22365828; PMCID: PMC3327736.
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    184. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 2012 Feb 22; 485(7396):55-61. Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat KM, Rommel C, Ruggero D. PMID: 22367541; PMCID: PMC3663483.
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    185. High-resolution view of the yeast meiotic program revealed by ribosome profiling. Science. 2012 Feb 03; 335(6068):552-7. Brar GA, Yassour M, Friedman N, Regev A, Ingolia NT, Weissman JS. PMID: 22194413; PMCID: PMC3414261.
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    186. Selective ribosome profiling reveals the cotranslational chaperone action of trigger factor in vivo. Cell. 2011 Dec 09; 147(6):1295-308. Oh E, Becker AH, Sandikci A, Huber D, Chaba R, Gloge F, Nichols RJ, Typas A, Gross CA, Kramer G, Weissman JS, Bukau B. PMID: 22153074; PMCID: PMC3277850.
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    187. Genetics: Noise rules. Nature. 2011 Dec 07; 480(7376):188-9. El-Samad H, Weissman JS. PMID: 22158239.
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    188. Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science. 2011 Nov 25; 334(6059):1086-90. Smith MH, Ploegh HL, Weissman JS. PMID: 22116878; PMCID: PMC3864754.
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    189. Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19222-7. Roelants FM, Breslow DK, Muir A, Weissman JS, Thorner J. PMID: 22080611; PMCID: PMC3228448.
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    190. Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes. Cell. 2011 Nov 11; 147(4):789-802. Ingolia NT, Lareau LF, Weissman JS. PMID: 22056041; PMCID: PMC3225288.
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    191. A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol. 2011 Oct 17; 195(2):323-40. Hoppins S, Collins SR, Cassidy-Stone A, Hummel E, Devay RM, Lackner LL, Westermann B, Schuldiner M, Weissman JS, Nunnari J. PMID: 21987634; PMCID: PMC3198156.
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    192. Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats. Nature. 2011 Aug 03; 476(7358):88-91. Gracheva EO, Cordero-Morales JF, González-Carcacía JA, Ingolia NT, Manno C, Aranguren CI, Weissman JS, Julius D. PMID: 21814281; PMCID: PMC3535012.
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    193. H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway. Mol Cell Biol. 2011 Sep; 31(17):3569-83. Terzi N, Churchman LS, Vasiljeva L, Weissman J, Buratowski S. PMID: 21709022; PMCID: PMC3165552.
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    194. Strain conformation, primary structure and the propagation of the yeast prion [PSI+]. Nat Struct Mol Biol. 2011 Apr; 18(4):493-9. Verges KJ, Smith MH, Toyama BH, Weissman JS. PMID: 21423194; PMCID: PMC3490428.
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    195. Radically different amyloid conformations dictate the seeding specificity of a chimeric Sup35 prion. J Mol Biol. 2011 Apr 22; 408(1):1-8. Foo CK, Ohhashi Y, Kelly MJ, Tanaka M, Weissman JS. PMID: 21333653; PMCID: PMC3070826.
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    196. Nascent transcript sequencing visualizes transcription at nucleotide resolution. Nature. 2011 Jan 20; 469(7330):368-73. Churchman LS, Weissman JS. PMID: 21248844; PMCID: PMC3880149.
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    197. Amyloid structure: conformational diversity and consequences. Annu Rev Biochem. 2011; 80:557-85. Toyama BH, Weissman JS. PMID: 21456964; PMCID: PMC3817101.
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    198. Systematic screen of Schizosaccharomyces pombe deletion collection uncovers parallel evolution of the phosphate signal transduction pathway in yeasts. Eukaryot Cell. 2011 Feb; 10(2):198-206. Henry TC, Power JE, Kerwin CL, Mohammed A, Weissman JS, Cameron DM, Wykoff DD. PMID: 21169418; PMCID: PMC3067400.
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    199. The epistemology of cell biology. Mol Biol Cell. 2010 Nov 15; 21(22):3825. Weissman JS. PMID: 21079033; PMCID: PMC2982092.
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    200. Membranes in balance: mechanisms of sphingolipid homeostasis. Mol Cell. 2010 Oct 22; 40(2):267-79. Breslow DK, Weissman JS. PMID: 20965421; PMCID: PMC2987644.
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    201. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature. 2010 Aug 12; 466(7308):835-40. Guo H, Ingolia NT, Weissman JS, Bartel DP. PMID: 20703300; PMCID: PMC2990499.
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    202. Automated identification of pathways from quantitative genetic interaction data. Mol Syst Biol. 2010 Jun 08; 6:379. Battle A, Jonikas MC, Walter P, Weissman JS, Koller D. PMID: 20531408; PMCID: PMC2913392.
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    203. A general lack of compensation for gene dosage in yeast. Mol Syst Biol. 2010 May 11; 6:368. Springer M, Weissman JS, Kirschner MW. PMID: 20461075; PMCID: PMC2890323.
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    204. J domain co-chaperone specificity defines the role of BiP during protein translocation. J Biol Chem. 2010 Jul 16; 285(29):22484-94. Vembar SS, Jonikas MC, Hendershot LM, Weissman JS, Brodsky JL. PMID: 20430885; PMCID: PMC2903355.
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    205. Molecular basis of infrared detection by snakes. Nature. 2010 Apr 15; 464(7291):1006-11. Gracheva EO, Ingolia NT, Kelly YM, Cordero-Morales JF, Hollopeter G, Chesler AT, Sánchez EE, Perez JC, Weissman JS, Julius D. PMID: 20228791; PMCID: PMC2855400.
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    206. Orm family proteins mediate sphingolipid homeostasis. Nature. 2010 Feb 25; 463(7284):1048-53. Breslow DK, Collins SR, Bodenmiller B, Aebersold R, Simons K, Shevchenko A, Ejsing CS, Weissman JS. PMID: 20182505; PMCID: PMC2877384.
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    207. Differences in prion strain conformations result from non-native interactions in a nucleus. Nat Chem Biol. 2010 Mar; 6(3):225-230. Ohhashi Y, Ito K, Toyama BH, Weissman JS, Tanaka M. PMID: 20081853; PMCID: PMC3277852.
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    208. Journal club. A biochemist looks at how DNA sequencing can reveal more than just sequences. Nature. 2009 Oct 29; 461(7268):1177. Weissman J. PMID: 19865125.
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    209. From information to knowledge: new technologies for defining gene function. Nat Methods. 2009 Oct; 6(10):721-23. Collins SR, Weissman JS, Krogan NJ. PMID: 19953683; PMCID: PMC3066030.
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    210. Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol. 2009 Aug 10; 186(3):323-31. Hollien J, Lin JH, Li H, Stevens N, Walter P, Weissman JS. PMID: 19651891; PMCID: PMC2728407.
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    211. An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science. 2009 Jul 24; 325(5939):477-81. Kornmann B, Currie E, Collins SR, Schuldiner M, Nunnari J, Weissman JS, Walter P. PMID: 19556461; PMCID: PMC2933203.
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    212. Rapid creation and quantitative monitoring of high coverage shRNA libraries. Nat Methods. 2009 Jun; 6(6):443-5. Bassik MC, Lebbink RJ, Churchman LS, Ingolia NT, Patena W, LeProust EM, Schuldiner M, Weissman JS, McManus MT. PMID: 19448642; PMCID: PMC2783737.
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    213. Analysis of Dom34 and its function in no-go decay. Mol Biol Cell. 2009 Jul; 20(13):3025-32. Passos DO, Doma MK, Shoemaker CJ, Muhlrad D, Green R, Weissman J, Hollien J, Parker R. PMID: 19420139; PMCID: PMC2704154.
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    214. Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science. 2009 Mar 27; 323(5922):1693-7. Jonikas MC, Collins SR, Denic V, Oh E, Quan EM, Schmid V, Weibezahn J, Schwappach B, Walter P, Weissman JS, Schuldiner M. PMID: 19325107; PMCID: PMC2877488.
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    215. Functional organization of the S. cerevisiae phosphorylation network. Cell. 2009 Mar 06; 136(5):952-63. Fiedler D, Braberg H, Mehta M, Chechik G, Cagney G, Mukherjee P, Silva AC, Shales M, Collins SR, van Wageningen S, Kemmeren P, Holstege FC, Weissman JS, Keogh MC, Koller D, Shokat KM, Krogan NJ. PMID: 19269370; PMCID: PMC2856666.
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    216. Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling. Science. 2009 Apr 10; 324(5924):218-23. Ingolia NT, Ghaemmaghami S, Newman JR, Weissman JS. PMID: 19213877; PMCID: PMC2746483.
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    217. Defining the glycan destruction signal for endoplasmic reticulum-associated degradation. Mol Cell. 2008 Dec 26; 32(6):870-7. Quan EM, Kamiya Y, Kamiya D, Denic V, Weibezahn J, Kato K, Weissman JS. PMID: 19111666; PMCID: PMC2873636.
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    218. A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol Cell. 2008 Dec 05; 32(5):735-46. Wilmes GM, Bergkessel M, Bandyopadhyay S, Shales M, Braberg H, Cagney G, Collins SR, Whitworth GB, Kress TL, Weissman JS, Ideker T, Guthrie C, Krogan NJ. PMID: 19061648; PMCID: PMC2644724.
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    219. In vivo monitoring of the prion replication cycle reveals a critical role for Sis1 in delivering substrates to Hsp104. Mol Cell. 2008 Nov 21; 32(4):584-91. Tipton KA, Verges KJ, Weissman JS. PMID: 19026788; PMCID: PMC2875781.
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    220. Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network. Nat Biotechnol. 2008 Nov; 26(11):1251-9. Chechik G, Oh E, Rando O, Weissman J, Regev A, Koller D. PMID: 18953355; PMCID: PMC2651818.
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    221. Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Science. 2008 Oct 17; 322(5900):405-10. Roguev A, Bandyopadhyay S, Zofall M, Zhang K, Fischer T, Collins SR, Qu H, Shales M, Park HO, Hayles J, Hoe KL, Kim DU, Ideker T, Grewal SI, Weissman JS, Krogan NJ. PMID: 18818364; PMCID: PMC2753251.
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    222. High-throughput, quantitative analyses of genetic interactions in E. coli. Nat Methods. 2008 Sep; 5(9):781-7. Typas A, Nichols RJ, Siegele DA, Shales M, Collins SR, Lim B, Braberg H, Yamamoto N, Takeuchi R, Wanner BL, Mori H, Weissman JS, Krogan NJ, Gross CA. PMID: 19160513; PMCID: PMC2700713.
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    223. Systems biology: Reverse engineering the cell. Nature. 2008 Aug 28; 454(7208):1059-62. Ingolia NT, Weissman JS. PMID: 18756243.
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    224. The GET complex mediates insertion of tail-anchored proteins into the ER membrane. Cell. 2008 Aug 22; 134(4):634-45. Schuldiner M, Metz J, Schmid V, Denic V, Rakwalska M, Schmitt HD, Schwappach B, Weissman JS. PMID: 18724936; PMCID: PMC2572727.
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    225. A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods. 2008 Aug; 5(8):711-8. Breslow DK, Cameron DM, Collins SR, Schuldiner M, Stewart-Ornstein J, Newman HW, Braun S, Madhani HD, Krogan NJ, Weissman JS. PMID: 18622397; PMCID: PMC2756093.
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    226. Small-molecule aggregates inhibit amyloid polymerization. Nat Chem Biol. 2008 Mar; 4(3):197-9. Feng BY, Toyama BH, Wille H, Colby DW, Collins SR, May BC, Prusiner SB, Weissman J, Shoichet BK. PMID: 18223646; PMCID: PMC2730835.
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    227. Identification of yeast proteins necessary for cell-surface function of a potassium channel. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18079-84. Haass FA, Jonikas M, Walter P, Weissman JS, Jan YN, Jan LY, Schuldiner M. PMID: 17989219; PMCID: PMC2084299.
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    228. High-throughput genetic interaction mapping in the fission yeast Schizosaccharomyces pombe. Nat Methods. 2007 Oct; 4(10):861-6. Roguev A, Wiren M, Weissman JS, Krogan NJ. PMID: 17893680.
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    229. The structural basis of yeast prion strain variants. Nature. 2007 Sep 13; 449(7159):233-7. Toyama BH, Kelly MJ, Gross JD, Weissman JS. PMID: 17767153.
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    230. A molecular caliper mechanism for determining very long-chain fatty acid length. Cell. 2007 Aug 24; 130(4):663-77. Denic V, Weissman JS. PMID: 17719544.
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    231. Mec1/Tel1 phosphorylation of the INO80 chromatin remodeling complex influences DNA damage checkpoint responses. Cell. 2007 Aug 10; 130(3):499-511. Morrison AJ, Kim JA, Person MD, Highland J, Xiao J, Wehr TS, Hensley S, Bao Y, Shen J, Collins SR, Weissman JS, Delrow J, Krogan NJ, Haber JE, Shen X. PMID: 17693258.
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    232. Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss. Mol Syst Biol. 2007; 3:86. Ihmels J, Collins SR, Schuldiner M, Krogan NJ, Weissman JS. PMID: 17389874; PMCID: PMC1847942.
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    233. CCR4/NOT complex associates with the proteasome and regulates histone methylation. Proc Natl Acad Sci U S A. 2007 Apr 03; 104(14):5836-41. Laribee RN, Shibata Y, Mersman DP, Collins SR, Kemmeren P, Roguev A, Weissman JS, Briggs SD, Krogan NJ, Strahl BD. PMID: 17389396; PMCID: PMC1851578.
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    234. Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature. 2007 Apr 12; 446(7137):806-10. Collins SR, Miller KM, Maas NL, Roguev A, Fillingham J, Chu CS, Schuldiner M, Gebbia M, Recht J, Shales M, Ding H, Xu H, Han J, Ingvarsdottir K, Cheng B, Andrews B, Boone C, Berger SL, Hieter P, Zhang Z, Brown GW, Ingles CJ, Emili A, Allis CD, Toczyski DP, Weissman JS, Greenblatt JF, Krogan NJ. PMID: 17314980.
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    235. Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae. Mol Cell Proteomics. 2007 Mar; 6(3):439-50. Collins SR, Kemmeren P, Zhao XC, Greenblatt JF, Spencer F, Holstege FC, Weissman JS, Krogan NJ. PMID: 17200106.
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    236. Quantitative genetic analysis in Saccharomyces cerevisiae using epistatic miniarray profiles (E-MAPs) and its application to chromatin functions. Methods. 2006 Dec; 40(4):344-52. Schuldiner M, Collins SR, Weissman JS, Krogan NJ. PMID: 17101447.
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    237. Systems biology: many things from one. Nature. 2006 Nov 30; 444(7119):561-2. Newman JR, Weissman JS. PMID: 17122769.
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    238. A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation. Cell. 2006 Jul 28; 126(2):349-59. Denic V, Quan EM, Weissman JS. PMID: 16873065.
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    239. Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science. 2006 Jul 07; 313(5783):104-7. Hollien J, Weissman JS. PMID: 16825573.
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    240. The physical basis of how prion conformations determine strain phenotypes. Nature. 2006 Aug 03; 442(7102):585-9. Tanaka M, Collins SR, Toyama BH, Weissman JS. PMID: 16810177.
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    241. Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise. Nature. 2006 Jun 15; 441(7095):840-6. Newman JR, Ghaemmaghami S, Ihmels J, Breslow DK, Noble M, DeRisi JL, Weissman JS. PMID: 16699522.
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    242. Molecular chaperones and protein quality control. Cell. 2006 May 05; 125(3):443-51. Bukau B, Weissman J, Horwich A. PMID: 16678092.
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    243. Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30; 440(7084):637-43. Krogan NJ, Cagney G, Yu H, Zhong G, Guo X, Ignatchenko A, Li J, Pu S, Datta N, Tikuisis AP, Punna T, Peregrín-Alvarez JM, Shales M, Zhang X, Davey M, Robinson MD, Paccanaro A, Bray JE, Sheung A, Beattie B, Richards DP, Canadien V, Lalev A, Mena F, Wong P, Starostine A, Canete MM, Vlasblom J, Wu S, Orsi C, Collins SR, Chandran S, Haw R, Rilstone JJ, Gandi K, Thompson NJ, Musso G, St Onge P, Ghanny S, Lam MH, Butland G, Altaf-Ul AM, Kanaya S, Shilatifard A, O'Shea E, Weissman JS, Ingles CJ, Hughes TR, Parkinson J, Gerstein M, Wodak SJ, Emili A, Greenblatt JF. PMID: 16554755.
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    244. A strategy for extracting and analyzing large-scale quantitative epistatic interaction data. Genome Biol. 2006; 7(7):R63. Collins SR, Schuldiner M, Krogan NJ, Weissman JS. PMID: 16859555; PMCID: PMC1779568.
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    245. An efficient protein transformation protocol for introducing prions into yeast. Methods Enzymol. 2006; 412:185-200. Tanaka M, Weissman JS. PMID: 17046659.
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    246. Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell. 2005 Nov 18; 123(4):593-605. Keogh MC, Kurdistani SK, Morris SA, Ahn SH, Podolny V, Collins SR, Schuldiner M, Chin K, Punna T, Thompson NJ, Boone C, Emili A, Weissman JS, Hughes TR, Strahl BD, Grunstein M, Greenblatt JF, Buratowski S, Krogan NJ. PMID: 16286008.
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    247. Domain architecture of protein-disulfide isomerase facilitates its dual role as an oxidase and an isomerase in Ero1p-mediated disulfide formation. J Biol Chem. 2006 Jan 13; 281(2):876-84. Kulp MS, Frickel EM, Ellgaard L, Weissman JS. PMID: 16368681.
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    248. Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell. 2005 Nov 04; 123(3):507-19. Schuldiner M, Collins SR, Thompson NJ, Denic V, Bhamidipati A, Punna T, Ihmels J, Andrews B, Boone C, Greenblatt JF, Weissman JS, Krogan NJ. PMID: 16269340.
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    249. Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen. Mol Cell. 2005 Sep 16; 19(6):741-51. Bhamidipati A, Denic V, Quan EM, Weissman JS. PMID: 16168370.
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    250. Mechanism of cross-species prion transmission: an infectious conformation compatible with two highly divergent yeast prion proteins. Cell. 2005 Apr 08; 121(1):49-62. Tanaka M, Chien P, Yonekura K, Weissman JS. PMID: 15820678.
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    251. Construction, verification and experimental use of two epitope-tagged collections of budding yeast strains. Comp Funct Genomics. 2005; 6(1-2):2-16. Howson R, Huh WK, Ghaemmaghami S, Falvo JV, Bower K, Belle A, Dephoure N, Wykoff DD, Weissman JS, O'Shea EK. PMID: 18629296; PMCID: PMC2448600.
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    252. 2004 Irving Sigal Young Investigator Award. Protein Sci. 2004 Dec; 13(12):3333-5. Weissman JS, O'Shea EK. PMID: 15557272; PMCID: PMC2287319.
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    253. Mechanism of prion propagation: amyloid growth occurs by monomer addition. PLoS Biol. 2004 Oct; 2(10):e321. Collins SR, Douglass A, Vale RD, Weissman JS. PMID: 15383837; PMCID: PMC517824.
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    255. Conformational variations in an infectious protein determine prion strain differences. Nature. 2004 Mar 18; 428(6980):323-8. Tanaka M, Chien P, Naber N, Cooke R, Weissman JS. PMID: 15029196.
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    256. Oxidative protein folding in eukaryotes: mechanisms and consequences. J Cell Biol. 2004 Feb 02; 164(3):341-6. Tu BP, Weissman JS. PMID: 14757749; PMCID: PMC2172237.
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    257. Emerging principles of conformation-based prion inheritance. Annu Rev Biochem. 2004; 73:617-56. Chien P, Weissman JS, DePace AH. PMID: 15189155.
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    258. Global analysis of protein expression in yeast. Nature. 2003 Oct 16; 425(6959):737-41. Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS. PMID: 14562106.
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    259. Global analysis of protein localization in budding yeast. Nature. 2003 Oct 16; 425(6959):686-91. Huh WK, Falvo JV, Gerke LC, Carroll AS, Howson RW, Weissman JS, O'Shea EK. PMID: 14562095.
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    260. Generation of prion transmission barriers by mutational control of amyloid conformations. Nature. 2003 Aug 21; 424(6951):948-51. Chien P, DePace AH, Collins SR, Weissman JS. PMID: 12931190.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    261. Directed evolution of substrate-optimized GroEL/S chaperonins. Cell. 2002 Dec 27; 111(7):1027-39. Wang JD, Herman C, Tipton KA, Gross CA, Weissman JS. PMID: 12507429.
      View in: PubMed   Mentions: 62     Fields:    Translation:Cells
    262. Origins and kinetic consequences of diversity in Sup35 yeast prion fibers. Nat Struct Biol. 2002 May; 9(5):389-96. DePace AH, Weissman JS. PMID: 11938354.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    263. Prion diseases. A rogue protein. Lancet. 2001 Dec; 358 Suppl:S53. Weissman JS, Hood JK. PMID: 11784602.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    264. The relationship of market forces to the satisfaction of faculty at academic health centers. Am J Med. 2001 Sep; 111(4):333-40. Blumenthal D, Causino N, Campbell EG, Weissman JS. PMID: 11566469.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    265. Residents' preferences and preparation for caring for underserved populations. J Urban Health. 2001 Sep; 78(3):535-49. Weissman JS, Campbell EG, Gokhale M, Blumenthal D. PMID: 11564855; PMCID: PMC3455908.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    266. Conformational diversity in a yeast prion dictates its seeding specificity. Nature. 2001 Mar 08; 410(6825):223-7. Chien P, Weissman JS. PMID: 11242084.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    267. The Sar1 GTPase coordinates biosynthetic cargo selection with endoplasmic reticulum export site assembly. J Cell Biol. 2001 Jan 08; 152(1):213-29. Aridor M, Fish KN, Bannykh S, Weissman J, Roberts TH, Lippincott-Schwartz J, Balch WE. PMID: 11149932; PMCID: PMC2193666.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    268. Functional genomic approaches to understanding molecular chaperones and stress responses. Adv Protein Chem. 2001; 59:345-90. Travers KJ, Patil CK, Weissman JS. PMID: 11868277.
      View in: PubMed   Mentions: 4     Fields:    
    269. The action of molecular chaperones in the early secretory pathway. Annu Rev Genet. 2001; 35:149-91. Fewell SW, Travers KJ, Weissman JS, Brodsky JL. PMID: 11700281.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    270. Biochemical basis of oxidative protein folding in the endoplasmic reticulum. Science. 2000 Nov 24; 290(5496):1571-4. Tu BP, Ho-Schleyer SC, Travers KJ, Weissman JS. PMID: 11090354.
      View in: PubMed   Mentions: 154     Fields:    Translation:AnimalsCells
    271. Racial disparities in access to renal transplantation--clinically appropriate or due to underuse or overuse? N Engl J Med. 2000 Nov 23; 343(21):1537-44, 2 p preceding 1537. Epstein AM, Ayanian JZ, Keogh JH, Noonan SJ, Armistead N, Cleary PD, Weissman JS, David-Kasdan JA, Carlson D, Fuller J, Marsh D, Conti RM. PMID: 11087884; PMCID: PMC4598055.
      View in: PubMed   Mentions: 165     Fields:    Translation:Humans
    272. Unmet health needs of uninsured adults in the United States. JAMA. 2000 Oct 25; 284(16):2061-9. Ayanian JZ, Weissman JS, Schneider EC, Ginsburg JA, Zaslavsky AM. PMID: 11042754.
      View in: PubMed   Mentions: 235     Fields:    Translation:HumansPHPublic Health
    273. A census of glutamine/asparagine-rich regions: implications for their conserved function and the prediction of novel prions. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):11910-5. Michelitsch MD, Weissman JS. PMID: 11050225; PMCID: PMC17268.
      View in: PubMed   Mentions: 249     Fields:    Translation:HumansCells
    274. Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro- converted Sup35 protein. Science. 2000 Jul 28; 289(5479):595-9. Sparrer HE, Santoso A, Szoka FC, Weissman JS. PMID: 10915616.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    275. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell. 2000 Apr 28; 101(3):249-58. Travers KJ, Patil CK, Wodicka L, Lockhart DJ, Weissman JS, Walter P. PMID: 10847680.
      View in: PubMed   Mentions: 826     Fields:    Translation:AnimalsCells
    276. Stage-specific assays to study biosynthetic cargo selection and role of SNAREs in export from the endoplasmic reticulum and delivery to the Golgi. Methods. 2000 Apr; 20(4):411-6. Allan BB, Weissman J, Aridor M, Moyer B, Chen CD, Yoo JS, Balch WE. PMID: 10720462.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    277. Molecular basis of a yeast prion species barrier. Cell. 2000 Jan 21; 100(2):277-88. Santoso A, Chien P, Osherovich LZ, Weissman JS. PMID: 10660050.
      View in: PubMed   Mentions: 131     Fields:    Translation:AnimalsCells
    278. Quality of care by race and gender for congestive heart failure and pneumonia. Med Care. 1999 Dec; 37(12):1260-9. Ayanian JZ, Weissman JS, Chasan-Taber S, Epstein AM. PMID: 10599607.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    279. The effect of patients' preferences on racial differences in access to renal transplantation. N Engl J Med. 1999 Nov 25; 341(22):1661-9. Ayanian JZ, Cleary PD, Weissman JS, Epstein AM. PMID: 10572155.
      View in: PubMed   Mentions: 184     Fields:    Translation:Humans
    280. Academic health centers on the front lines: survival strategies in highly competitive markets. Acad Med. 1999 Sep; 74(9):1038-49. Blumenthal D, Weissman JS, Griner PF. PMID: 10498101.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    281. Thinking outside the box: new insights into the mechanism of GroEL-mediated protein folding. Nat Struct Biol. 1999 Jul; 6(7):597-600. Wang JD, Weissman JS. PMID: 10404205.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    282. Hospital readmissions and quality of care. Med Care. 1999 May; 37(5):490-501. Weissman JS, Ayanian JZ, Chasan-Taber S, Sherwood MJ, Roth C, Epstein AM. PMID: 10335751.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    283. Market forces and unsponsored research in academic health centers. JAMA. 1999 Mar 24-31; 281(12):1093-8. Weissman JS, Saglam D, Campbell EG, Causino N, Blumenthal D. PMID: 10188659.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    284. Termination from Medicaid: how does it affect access, continuity of care, and willingness to purchase insurance? J Health Care Poor Underserved. 1999 Feb; 10(1):122-37. Weissman JS, Witzburg R, Linov P, Campbell EG. PMID: 9989010.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    285. The stability of preferences for life-sustaining care among persons with AIDS in the Boston Health Study. Med Decis Making. 1999 Jan-Mar; 19(1):16-26. Weissman JS, Haas JS, Fowler FJ, Gatsonis C, Massagli MP, Seage GR, Cleary P. PMID: 9917016.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    286. GroEL-GroES-mediated protein folding requires an intact central cavity. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12163-8. Wang JD, Michelitsch MD, Weissman JS. PMID: 9770457; PMCID: PMC22802.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    287. A critical role for amino-terminal glutamine/asparagine repeats in the formation and propagation of a yeast prion. Cell. 1998 Jun 26; 93(7):1241-52. DePace AH, Santoso A, Hillner P, Weissman JS. PMID: 9657156.
      View in: PubMed   Mentions: 166     Fields:    Translation:AnimalsCells
    288. Costs and outcomes of AIDS care: comparing a health maintenance organization with fee-for-service systems in the Boston Health Study. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15; 17(5):424-32. Wilson IB, Sullivan LM, Weissman JS. PMID: 9562045.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    289. Cargo selection by the COPII budding machinery during export from the ER. J Cell Biol. 1998 Apr 06; 141(1):61-70. Aridor M, Weissman J, Bannykh S, Nuoffer C, Balch WE. PMID: 9531548; PMCID: PMC2132735.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    290. Ero1p: a novel and ubiquitous protein with an essential role in oxidative protein folding in the endoplasmic reticulum. Mol Cell. 1998 Jan; 1(2):171-82. Pollard MG, Travers KJ, Weissman JS. PMID: 9659914.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansAnimalsCells
    291. Construction of single-ring and two-ring hybrid versions of bacterial chaperonin GroEL. Methods Enzymol. 1998; 290:141-6. Horwich AL, Burston SG, Rye HS, Weissman JS, Fenton WA. PMID: 9534157.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    292. Commentary: economic transfers, the changing face of a familiar problem. Health Serv Res. 1997 Dec; 32(5):591-8. Weissman JS. PMID: 9402902; PMCID: PMC1070216.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    293. Deadly conformations--protein misfolding in prion disease. Cell. 1997 May 16; 89(4):499-510. Horwich AL, Weissman JS. PMID: 9160742.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    294. The influence of health-related quality of life and social characteristics on hospital use by patients with AIDS in the Boston Health Study. Med Care. 1996 Oct; 34(10):1037-56. Weissman JS, Cleary PD, Seage GR, Gatsonis C, Haas JS, Chasan-Taber S, Epstein AM. PMID: 8843929.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    295. Uncompensated hospital care. Will it be there if we need it? JAMA. 1996 Sep 11; 276(10):823-8. Weissman J. PMID: 8769594.
      View in: PubMed   Mentions: 6     Fields:    
    296. Release of both native and non-native proteins from a cis-only GroEL ternary complex. Nature. 1996 Sep 05; 383(6595):96-9. Burston SG, Weissman JS, Farr GW, Fenton WA, Horwich AL. PMID: 8779722.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    297. The validity of self-reported health-care utilization by AIDS patients. AIDS. 1996 Jun; 10(7):775-83. Weissman JS, Levin K, Chasan-Taber S, Massagli MP, Seage GR, Scampini L. PMID: 8805870.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    298. Putting a lid on protein folding: structure and function of the co-chaperonin, GroES. Chem Biol. 1996 Mar; 3(3):157-61. Fenton WA, Weissman JS, Horwich AL. PMID: 8807841.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    299. Characterization of the active intermediate of a GroEL-GroES-mediated protein folding reaction. Cell. 1996 Feb 09; 84(3):481-90. Weissman JS, Rye HS, Fenton WA, Beechem JM, Horwich AL. PMID: 8608602.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    300. A kinetic explanation for the rearrangement pathway of BPTI folding. Nat Struct Biol. 1995 Dec; 2(12):1123-30. Weissman JS, Kim PS. PMID: 8846225.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    301. Mechanism of GroEL action: productive release of polypeptide from a sequestered position under GroES. Cell. 1995 Nov 17; 83(4):577-87. Weissman JS, Hohl CM, Kovalenko O, Kashi Y, Chen S, Braig K, Saibil HR, Fenton WA, Horwich AL. PMID: 7585961.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    302. Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. J Mol Biol. 1995 Jun 02; 249(2):388-97. Yu MH, Weissman JS, Kim PS. PMID: 7540212.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    303. All roads lead to Rome? The multiple pathways of protein folding. Chem Biol. 1995 May; 2(5):255-60. Weissman JS. PMID: 9383427.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    304. From the cradle to the grave: ring complexes in the life of a protein. Science. 1995 Apr 28; 268(5210):523-4. Weissman JS, Sigler PB, Horwich AL. PMID: 7725096.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    305. Kinesis of polypeptide during GroEL-mediated folding. Cold Spring Harb Symp Quant Biol. 1995; 60:435-40. Horwich AL, Weissman JS, Fenton WA. PMID: 8824417.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    306. Costs of medical care and out-of-pocket expenditures for persons with AIDS in the Boston Health Study. Inquiry. 1995; 32(2):211-21. Epstein AM, Seage G, Weissman JS, Cleary PD, Fowler FJ, Gatsonis C, Massagli MP, Stone VE, Coltin K, Craven DE, et al. PMID: 7601519.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    307. GroEL-mediated protein folding proceeds by multiple rounds of binding and release of nonnative forms. Cell. 1994 Aug 26; 78(4):693-702. Weissman JS, Kashi Y, Fenton WA, Horwich AL. PMID: 7915201.
      View in: PubMed   Mentions: 95     Fields:    Translation:Cells
    308. Heat shock proteins and molecular chaperones: mediators of protein conformation and turnover in the cell. Cell. 1994 Aug 12; 78(3):365-72. Craig EA, Weissman JS, Horwich AL. PMID: 7914834.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    309. Utilization of formal and informal home care by AIDS patients in Boston: a comparison of intravenous drug users and homosexual males. Med Care. 1994 May; 32(5):459-70. Ettner SL, Weissman J. PMID: 8182974.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    310. Physician discretion and racial variation in the use of surgical procedures. Arch Intern Med. 1994 Apr 11; 154(7):761-7. Mort EA, Weissman JS, Epstein AM. PMID: 8147680.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    311. The impact of patient socioeconomic status and other social factors on readmission: a prospective study in four Massachusetts hospitals. Inquiry. 1994; 31(2):163-72. Weissman JS, Stern RS, Epstein AM. PMID: 8021022.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    312. Efficient catalysis of disulphide bond rearrangements by protein disulphide isomerase. Nature. 1993 Sep 09; 365(6442):185-8. Weissman JS, Kim PS. PMID: 7690463.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    313. Health-related quality of life in persons with acquired immune deficiency syndrome. Med Care. 1993 Jul; 31(7):569-80. Cleary PD, Fowler FJ, Weissman J, Massagli MP, Wilson I, Seage GR, Gatsonis C, Epstein A. PMID: 8326772.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    314. The pro region of BPTI facilitates folding. Cell. 1992 Nov 27; 71(5):841-51. Weissman JS, Kim PS. PMID: 1384990.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    315. Rates of avoidable hospitalization by insurance status in Massachusetts and Maryland. JAMA. 1992 Nov 04; 268(17):2388-94. Weissman JS, Gatsonis C, Epstein AM. PMID: 1404795.
      View in: PubMed   Mentions: 197     Fields:    Translation:Humans
    316. Kinetic role of nonnative species in the folding of bovine pancreatic trypsin inhibitor. Proc Natl Acad Sci U S A. 1992 Oct 15; 89(20):9900-4. Weissman JS, Kim PS. PMID: 1384063; PMCID: PMC50241.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    317. The emergency department as a pathway to admission for poor and high-cost patients. JAMA. 1991 Oct 23-30; 266(16):2238-43. Stern RS, Weissman JS, Epstein AM. PMID: 1920722.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    318. Reexamination of the folding of BPTI: predominance of native intermediates. Science. 1991 Sep 20; 253(5026):1386-93. Weissman JS, Kim PS. PMID: 1716783.
      View in: PubMed   Mentions: 115     Fields:    Translation:Cells
    319. Acute aortic thrombosis causing sudden paraplegia in a patient with known thoraco-lumbar spinal metastasis: the diagnostic usefulness of magnetic resonance imaging. Neurosurgery. 1989 Jul; 25(1):105-9. Moore MR, Blatter DD, Weissman J, Tyler HR. PMID: 2755568.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    320. Case mix and resource utilization by uninsured hospital patients in the Boston metropolitan area. JAMA. 1989 Jun 23-30; 261(24):3572-6. Weissman J, Epstein AM. PMID: 2498539.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    321. Risk factors of drug impairment in random samples of physicians and medical students. Int J Addict. 1987 Sep; 22(9):825-41. McAuliffe WE, Santangelo S, Magnuson E, Sobol A, Rohman M, Weissman J. PMID: 3679638.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    322. Metabolism of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by liver homogenate fractions. J Med Chem. 1985 Aug; 28(8):997-1001. Weissman J, Trevor A, Chiba K, Peterson LA, Caldera P, Castagnoli N, Baillie T. PMID: 3874963.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
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