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    Youngho Seo, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    Address185 Berry Street
    San Francisco CA 94143
    vCardDownload vCard

      Collapse Biography 
      Collapse Awards and Honors
      Korean Association of Medical Physicists in North America2015KAMPiNA Research Award for Best Science Paper
      Korean Association of Medical Physicists in North America2011KAMPiNA Physicist of the Year Award
      Frost & Sullivan2010Technology Innovation of the Year Award, Prostate Cancer Diagnosis North America
      National Cancer Institute2006 - 2011Mentored Quantitative Research Career Development Award
      American Physical Society2002Nomination for Mitsuyoshi Tanaka Dissertation Award in Experimental Particle Physics
      Korea Advanced Institute of Science and Technology, Daejeon, Korea1992 - 1995Government Scholarship

      Collapse Overview 
      Collapse Overview
      Youngho Seo, PhD, is an Associate Professor in Residence and Director of Nuclear Imaging Physics in the Department of Radiology and Biomedical Imaging, Associate Professor in Residence in the Department of Radiation Oncology at the University of California, San Francisco, and Physicist Faculty Scientist at Lawrence Berkeley National Laboratory. He received his bachelor's degree in Physics from Korea Advanced Institute of Science and Technology (KAIST). He completed two master's degrees in Physics at the University of Alabama in Huntsville, and at the University of California, Los Angeles (UCLA). Dr. Seo completed his PhD in Physics from UCLA under the supervision of Professor David Cline, followed by postdoctoral training at the same institution. He joined the UCSF Physics Research Laboratory (PRL) in 2003, and was trained under the supervision of Professor Bruce Hasegawa before joining the faculty in 2006.

      Dr. Seo leads a group of physicists and engineers working in the field of radionuclide and x-ray imaging instrumentation and physics, and directs the UCSF PRL. His primary research focus is to use quantitative SPECT/CT, PET/CT, and PET/MR molecular imaging for a broad range of research areas from small animal imaging using dedicated animal imaging systems and basic instrumentation development to physics analysis of clinical research data. Visit the UCSF PRL webpage to learn more about the current projects.

      Dr. Seo also directs the preclinical PET/SPECT/CT/Optical imaging core facility at the UCSF Center for Molecular and Functional Imaging at China Basin. If you are interested in using this core facility, or establishing a collaboration, please visit the core webpage, or contact Dr. Seo.

      Radionuclide and x-ray imaging physics and instrumentation

      PET/CT, SPECT/CT, PET/MR, CT, small animal PET/SPECT/CT

      Education and Training:
      • Bachelor of Science: Korea Advanced Institute of Science and Technology (KAIST) - Physics
      • Masters of Science: University of Alabama in Huntsville - Physics
      • Masters of Science: University of California, Los Angeles - Physics
      • Doctor of Philosophy: University of California, Los Angeles - Physics
      • Postdoctoral Training: UCLA and UCSF
      • American Board of Science in Nuclear Medicine (ABSNM) - Nuclear Medicine Physics and Instrumentation Specialty

      Collapse Interests
      Cancer imaging and therapy (prostate, pediatric, and liver), cardio-/cerebro- vascular imaging, novel ionizing radiation imaging technology development, image quantification.

      Collapse ORNG Applications 
      Collapse Websites
      Collapse NIH Awarded Grants
      Collapse Global Health

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Shrestha UM, Seo Y, Botvinick EH, Gullberg GT, et al. Image reconstruction in higher dimensions: myocardial perfusion imaging of tracer dynamics with cardiac motion due to deformation and respiration. Phys Med Biol. 2015 Oct 9; 60(21):8275-8301. PMID: 26450115.
        View in: PubMed
      2. Truitt ML, Conn CS, Shi Z, Pang X, Tokuyasu T, Coady AM, Seo Y, Barna M, Ruggero D. Differential Requirements for eIF4E Dose in Normal Development and Cancer. Cell. 2015 Jul 2; 162(1):59-71. PMID: 26095252.
        View in: PubMed
      3. Huang SY, Bolch WE, Lee C, Van Brocklin HF, Pampaloni MH, Hawkins RA, Sznewajs A, DuBois SG, Matthay KK, Seo Y. Patient-Specific Dosimetry Using Pretherapy [(124)I]m-iodobenzylguanidine ([ (124)I]mIBG) Dynamic PET/CT Imaging Before [ (131)I]mIBG Targeted Radionuclide Therapy for Neuroblastoma. Mol Imaging Biol. 2015 Apr; 17(2):284-94. PMID: 25145966.
        View in: PubMed
      4. Barajas RF, Pampaloni MH, Clarke JL, Seo Y, Savic D, Hawkins RA, Behr SC, Chang SM, Berger M, Dillon WP, Cha S. Assessing Biological Response to Bevacizumab Using 18F-Fluoromisonidazole PET/MR Imaging in a Patient with Recurrent Anaplastic Astrocytoma. Case Rep Radiol. 2015; 2015:731361. PMID: 25793136.
        View in: PubMed
      5. Lee TC, Ellin JR, Huang Q, Shrestha U, Gullberg GT, Seo Y. Multipinhole collimator with 20 apertures for a brain SPECT application. Med Phys. 2014 Nov; 41(11):112501. PMID: 25370660; PMCID: PMC4218691 [Available on 11/01/15].
      6. Bucknor MD, Rieke V, Seo Y, Horvai AE, Hawkins RA, Majumdar S, Link TM, Saeed M. Bone Remodeling after MR Imaging-guided High-Intensity Focused Ultrasound Ablation: Evaluation with MR Imaging, CT, Na(18)F-PET, and Histopathologic Examination in a Swine Model. Radiology. 2015 Feb; 274(2):387-94. PMID: 25302829.
        View in: PubMed
      7. Lee TC, Burghardt AJ, Yao W, Lane NE, Majumdar S, Gullberg GT, Seo Y. Improved trabecular bone structure of 20-month-old male spontaneously hypertensive rats. Calcif Tissue Int. 2014 Sep; 95(3):282-91. PMID: 25106873; PMCID: PMC4153466 [Available on 09/01/15].
      8. Jang AT, Lin JD, Seo Y, Etchin S, Merkle A, Fahey K, Ho SP. In situ compressive loading and correlative noninvasive imaging of the bone-periodontal ligament-tooth fibrous joint. J Vis Exp. 2014; (85). PMID: 24638035.
        View in: PubMed
      9. Alhassen F, Nguyen N, Bains S, Gould RG, Seo Y, Bacharach SL, Song X, Shao L, Gullberg GT, Aparici CM. Myocardial blood flow measurement with a conventional dual-head SPECT/CT with spatiotemporal iterative reconstructions - a clinical feasibility study. Am J Nucl Med Mol Imaging. 2013; 4(1):53-9. PMID: 24380045; PMCID: PMC3867729.
      10. Hernandez AM, Huber JS, Murphy ST, Janabi M, Zeng GL, Brennan KM, O'Neil JP, Seo Y, Gullberg GT. Longitudinal evaluation of left ventricular substrate metabolism, perfusion, and dysfunction in the spontaneously hypertensive rat model of hypertrophy using small-animal PET/CT imaging. J Nucl Med. 2013 Nov; 54(11):1938-45. PMID: 24092939; PMCID: PMC4000452.
      11. Weng F, Bagchi S, Huang Q, Seo Y, et al. Design Studies of a CZT-based Detector Combined with a Pixel-Geometry-Matching Collimator for SPECT Imaging. IEEE Nucl Sci Symp Conf Rec (1997). 2013 10; 2013:1-4. PMID: 25378898.
        View in: PubMed
      12. Bowen JD, Huang Q, Ellin JR, Lee TC, Shrestha U, Gullberg GT, Seo Y. Design and performance evaluation of a 20-aperture multipinhole collimator for myocardial perfusion imaging applications. Phys Med Biol. 2013 Oct 21; 58(20):7209-26. PMID: 24061162; PMCID: PMC3855225.
      13. Thuering T, Barber WC, Seo Y, Alhassen F, Stampanoni M. . Appl Phys Lett. Energy resolved x-ray grating interferometry. 2013; 102:191113.
      14. Seo Y, Jiang H, Franc BL. Preclinical SPECT and SPECT/CT. Recent Results Cancer Res. 2013; 187:193-220. PMID: 23179882.
        View in: PubMed
      15. Seo Y, Gustafson WC, Dannoon SF, Nekritz EA, Lee CL, Murphy ST, VanBrocklin HF, Hernandez-Pampaloni M, Haas-Kogan DA, Weiss WA, Matthay KK. Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft model. Mol Imaging Biol. 2012 Dec; 14(6):735-42. PMID: 22382618; PMCID: PMC3369020.
      16. Durack JC, Hope TA, Seo Y, Saeed M, He J, Wilson MW, Kerlan RK, Ring EJ. Intravenous vasopressin for the prevention of nontarget gastrointestinal embolization during liver-directed cancer treatment: experimental study in a porcine model. J Vasc Interv Radiol. 2012 Nov; 23(11):1505-12. PMID: 22974656.
        View in: PubMed
      17. Mari Aparici C, Seo Y. Functional imaging for prostate cancer: therapeutic implications. Semin Nucl Med. 2012 Sep; 42(5):328-42. PMID: 22840598; PMCID: PMC3408625.
      18. Carbone L, Carbone ET, Yi EM, Bauer DB, Lindstrom KA, Parker JM, Austin JA, Seo Y, Gandhi AD, Wilkerson JD. Assessing cervical dislocation as a humane euthanasia method in mice. J Am Assoc Lab Anim Sci. 2012 May; 51(3):352-6. PMID: 22776194; PMCID: PMC3358985.
      19. Yuneva MO, Fan TW, Allen TD, Higashi RM, Ferraris DV, Tsukamoto T, Matés JM, Alonso FJ, Wang C, Seo Y, Chen X, Bishop JM. The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metab. 2012 Feb 8; 15(2):157-70. PMID: 22326218; PMCID: PMC3282107.
      20. Yang J, Yamamoto T, Cho B, Seo Y, Keall PJ. The impact of audio-visual biofeedback on 4D PET images: results of a phantom study. Med Phys. 2012 Feb; 39(2):1046-57. PMID: 22320815; PMCID: PMC3281973.
      21. Harnish R, Streeper T, Saeed I, Schreck C, Dannoon S, Blecha J, VanBrocklin H, Hernandez-Pampaloni M, Hawkins R, Seo Y, Sayre G, Slater J, Lang T. . J Mol Imag Dynamic. Quantification of changes in skeletal muscle amino acid kinetics in adult humans in response to exercise via positron-emission tomography with L-[methyl-11C] methionine. 2012; 2:1000103.
      22. Aparici CM, Carlson D, Nguyen N, Hawkins RA, Seo Y, et al. Combined SPECT and Multidetector CT for Prostate Cancer Evaluations. Am J Nucl Med Mol Imaging. 2012; 2(1):48-54. PMID: 22267999.
        View in: PubMed
      23. Sayre GA, Bacharach SL, Dae MW, Seo Y. Combining dynamic and ECG-gated 8²Rb-PET for practical implementation in the clinic. Nucl Med Commun. 2012 Jan; 33(1):4-13. PMID: 21934541; PMCID: PMC3227790.
      24. Kim S, McClish M, Alhassen F, Seo Y, Shah KS, Gould RG, et al. Temperature dependent operation of PSAPD-based compact gamma camera for SPECT imaging. IEEE Trans Nucl Sci. 2011 Oct 10; 58(5):2169-2174. PMID: 24465051.
        View in: PubMed
      25. Sayre GA, Franc BL, Seo Y. Patient-Specific Method of Generating Parametric Maps of Patlak K(i) without Blood Sampling or Metabolite Correction: A Feasibility Study. Int J Mol Imaging. 2011; 2011:185083. PMID: 21912742; PMCID: PMC3168784.
      26. Seo Y, Aparici CM, Chen CP, Hsu C, Kased N, Schreck C, Costouros N, Hawkins R, Shinohara K, Roach Iii M. Mapping of lymphatic drainage from the prostate using filtered 99mTc-sulfur nanocolloid and SPECT/CT. J Nucl Med. 2011 Jul; 52(7):1068-72. PMID: 21680690; PMCID: PMC3129454.
      27. Alhassen F, Kudrolli H, Singh B, Kim S, Seo Y, Gould RG, Nagarkar VV, et al. Depth-of-Interaction Compensation Using a Focused-Cut Scintillator for a Pinhole Gamma Camera. IEEE Trans Nucl Sci. 2011 Jun 1; 58(3):634-638. PMID: 21731108.
        View in: PubMed
      28. Iyer AK, Lan X, Zhu X, Su Y, Feng J, Zhang X, Gao D, Seo Y, Vanbrocklin HF, Broaddus VC, Liu B, He J. Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas. Cancer Res. 2011 Apr 1; 71(7):2428-32. PMID: 21447742; PMCID: PMC3071798.
      29. More SS, Itsara M, Yang X, Geier EG, Tadano MK, Seo Y, Vanbrocklin HF, Weiss WA, Mueller S, Haas-Kogan DA, Dubois SG, Matthay KK, Giacomini KM. Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems. Clin Cancer Res. 2011 Apr 15; 17(8):2339-49. PMID: 21421857; PMCID: PMC3247296.
      30. Iyer AK, Su Y, Feng J, Lan X, Zhu X, Liu Y, Gao D, Seo Y, Vanbrocklin HF, Courtney Broaddus V, Liu B, He J. The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma. Biomaterials. 2011 Apr; 32(10):2605-13. PMID: 21255833; PMCID: PMC3040448.
      31. Kim S, Hernandez A, Alhassen F, Pivovaroff M, Cho HM, Gould RG, Seo Y, et al. Multi-Material Decomposition using Low-Current X-Ray and a Photon-Counting CZT Detector. IEEE Nucl Sci Symp Conf Rec (1997). 2011; 4735-4738. PMID: 23503709.
        View in: PubMed
      32. Kim S, McClish M, Alhassen F, Seo Y, Shah KS, Gould RG. . IEEE Trans Nucl Sci. Temperature dependent operation of PSAPD-based compact gamma camera for SPECT imaging. 2011; 58:2169-2174.
      33. Junttila MR, Karnezis AN, Garcia D, Madriles F, Kortlever RM, Rostker F, Brown Swigart L, Pham DM, Seo Y, Evan GI, Martins CP. Selective activation of p53-mediated tumour suppression in high-grade tumours. Nature. 2010 Nov 25; 468(7323):567-71. PMID: 21107427; PMCID: PMC3011233.
      34. Kim S, McClish M, Alhassen F, Seo Y, Shah KS, Gould RG, et al. Phantom experiments on a PSAPD-based compact gamma camera with submillimeter spatial resolution for small animal SPECT. IEEE Trans Nucl Sci. 2010 Oct; 57(5):2518-2523. PMID: 21278833.
        View in: PubMed
      35. Lee CL, Wahnishe H, Sayre GA, Cho HM, Kim HJ, Hernandez-Pampaloni M, Hawkins RA, Dannoon SF, VanBrocklin HF, Itsara M, Weiss WA, Yang X, Haas-Kogan DA, Matthay KK, Seo Y. Radiation dose estimation using preclinical imaging with 124I-metaiodobenzylguanidine (MIBG) PET. Med Phys. 2010 Sep; 37(9):4861-7. PMID: 20964203; PMCID: PMC2937055.
      36. He J, Wang Y, Feng J, Zhu X, Lan X, Iyer AK, Zhang N, Seo Y, VanBrocklin HF, Liu B. Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single-chain antibody fragment. J Nucl Med. 2010 Mar; 51(3):427-32. PMID: 20150269; PMCID: PMC2832590.
      37. Winant CD, Kim S, Seo Y. . Curr Med Imaging Rev. Functional imaging combined with multi-detector CT: A Radionuclide imaging perspective. 2010; 6:100-111.
      38. Seo Y, Aparici CM, Cooperberg MR, Konety BR, Hawkins RA. In vivo tumor grading of prostate cancer using quantitative 111In-capromab pendetide SPECT/CT. J Nucl Med. 2010 Jan; 51(1):31-6. PMID: 20008977; PMCID: PMC2821016.
      39. Pan MH, Gao DW, Feng J, He J, Seo Y, Tedesco J, Wolodzko JG, Hasegawa BH, Franc BL. Biodistributions of 177Lu- and 111In-labeled 7E11 antibodies to prostate-specific membrane antigen in xenograft model of prostate cancer and potential use of 111In-7E11 as a pre-therapeutic agent for 177Lu-7E11 radioimmunotherapy. Mol Imaging Biol. 2009 May-Jun; 11(3):159-66. PMID: 19034582; PMCID: PMC2841328.
      40. Seo Y, Teo BK, Hadi M, Schreck C, Bacharach SL, Hasegawa BH. Quantitative accuracy of PET/CT for image-based kinetic analysis. Med Phys. 2008 Jul; 35(7):3086-9. PMID: 18697532; PMCID: PMC2809714.
      41. Seo Y, Mari C, Hasegawa BH. Technological development and advances in single-photon emission computed tomography/computed tomography. Semin Nucl Med. 2008 May; 38(3):177-98. PMID: 18396178; PMCID: PMC3049175.
      42. Teo BK, Badiee S, Hadi M, Lam T, Johnson L, Seo Y, Bacharach SL, Hasegawa BH, Franc BL. Correcting tumour SUV for enhanced bone marrow uptake: retrospective 18F-FDG PET/CT studies. Nucl Med Commun. 2008 Apr; 29(4):359-66. PMID: 18317301.
        View in: PubMed
      43. Seo Y, Hashimoto T, Nuki Y, Hasegawa BH. In vivo microCT imaging of rodent cerebral vasculature. Phys Med Biol. 2008 Apr 7; 53(7):N99-107. PMID: 18364539; PMCID: PMC2593105.
      44. Seo Y . . Current Radiopharmaceuticals. Quantification of SPECT and PET for drug development. 2008; 1:17-21.
      45. He J, VanBrocklin HF, Franc BL, Seo Y, Jones EF. . Current Nanoscience. Nanoprobes for medical diagnosis: Current status of nanotechnology in molecular imaging. 2008; 4:17-29.
      46. Teo BK, Seo Y, Bacharach SL, Carrasquillo JA, Libutti SK, Shukla H, Hasegawa BH, Hawkins RA, Franc BL. Partial-volume correction in PET: validation of an iterative postreconstruction method with phantom and patient data. J Nucl Med. 2007 May; 48(5):802-10. PMID: 17475970.
        View in: PubMed
      47. Seo Y, Gao DW, Hasegawa BH, Dae MW, Franc BL. Rodent brain imaging with SPECT/CT. Med Phys. 2007 Apr; 34(4):1217-20. PMID: 17500453.
        View in: PubMed
      48. Seo Y, Franc BL, Hawkins RA, Wong KH, Hasegawa BH. Progress in SPECT/CT imaging of prostate cancer. Technol Cancer Res Treat. 2006 Aug; 5(4):329-36. PMID: 16866563.
        View in: PubMed
      49. Seo Y, Wong KH, Hasegawa BH. Calculation and validation of the use of effective attenuation coefficient for attenuation correction in In-111 SPECT. Med Phys. 2005 Dec; 32(12):3628-35. PMID: 16475761.
        View in: PubMed
      50. Seo Y, Wong KH, Sun M, Franc BL, Hawkins RA, Hasegawa BH. Correction of photon attenuation and collimator response for a body-contouring SPECT/CT imaging system. J Nucl Med. 2005 May; 46(5):868-77. PMID: 15872362.
        View in: PubMed
      51. Seo Y, Kurhanewicz J, Franc BL, Hawkins RA, Hasegawa BH. . IEEE Trans Nucl Sci. Improved prostate cancer imaging with SPECT/CT and MRI/MRSI. 2005; 52:1316-1320.
      52. Hasegawa BH, Barber WC, Funk T, Hwang AB, Sakdinawat AE, Taylor C, Sun M, Seo Y. . Nucl Instrum Meth A. Implementation and applications of dual-modality imaging. 2004; 525(1-2):236-241.
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