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Dean Sheppard, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
Address1550 4th Street, Bldg 19B
San Francisco CA 94158
Phone415-514-4269
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine
    SUNY, Stony BrookM.D.1975School of Medicine
    Collapse Awards and Honors
    ASCI1992Elected Member, American Society for Clinical Investigation
    AAP1995Elected Member, Association of American Physicians
    California Lung Association1995Clean Air Award
    American Thoracic Society1998Scientific Achievement Award
    NIH2004  - 2014NIH Merit Award
    American Thoracic Society2010Amberson Lecturer
    Nature Biotechnology2013Top 20 Translational Scientists
    UCSF2016UCSF Fraculty Research Lecture in Translational Science

    Collapse Overview 
    Collapse Overview
    Dean Sheppard is a Professor of Medicine, Chief of the Division of Pulmonary, Critical Care, Allergy and Sleep and director of the Lung Biology Center. His research focuses on the molecular mechanisms underlying pulmonary (and other organ) fibrosis, asthma and acute lung injury. One aim of the research is to identify new therapeutic targets to ultimately improve the treatment of each of these common diseases. The work begins with basic investigation of how cells use members of the integrin family to detect, modify and respond to spatially restricted extracellular clues and how these responses contribute to the development of common lung diseases. Utilizing mice with global or conditional knockouts of the epithelial-restricted integrin, avß6, and the widely expressed integrins, a5ß1, a9ß1, avß5 and avß8, the lab has identified important roles for these integrins in models of each common lung disease and key steps upstream and downstream of the integrins that provide potential therapeutic targets. His lab identified the unique roles that 3 integrins, avß1, avß6 and avß8 play in activation of the growth factor, latent transforming growth factor beta (TGFß) and has identified critical roles for this process in acute lung injury, pulmonary fibrosis, post-natal brain development and immunosuppression in the setting of cancer. The lab has partnered with academic colleagues, biotech and pharmaceutical companies to develop novel antibody and small molecule inhibitors of these integrins that are in various stages of pre-clinical and clinical development. Current work is also using single cell RNA sequencing to understand the heterogeneity of cells that contribute to tissue fibrosis in the lung, skin, kidney, liver and central nervous system and is exploring the potential of engineering T cells for local delivery of novel therapeutics to fibrotic organs.


    Collapse Research 
    Collapse Research Activities and Funding
    Treatment of pulmonary fibrosis with inhibitors of integrin alphavbeta1.
    NIH/NHLBI UH2HL123423Sep 1, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Treatment of pulmonary fibrosis with inhibitors of integrin alphavbeta1.
    NIH/NHLBI UH3HL123423Sep 1, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Targeting epithelial cells to treat pulmonary fibrosis
    NIH/NHLBI P01HL108794Aug 9, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Integrin-mediated Regulation of Airway Smooth Muscle
    NIH/NHLBI R01HL102292Dec 3, 2010 - Nov 30, 2015
    Role: Principal Investigator
    IL-13 and IL-17 dynamics in the asthmatic airway
    NIH/NIAID U19AI077439Apr 1, 2008 - Mar 31, 2018
    Role: Principal Investigator
    Regulation of Pulmonary Vascular Permeability by Integrin AlphaVBeta5
    NIH/NHLBI R01HL083950Apr 1, 2006 - Mar 31, 2011
    Role: Principal Investigator
    Conference on Fibronectin, Integrins &Related Molecules
    NIH/NCI R13CA097981Jan 17, 2003 - Dec 31, 2007
    Role: Principal Investigator
    The NHLBI-Bay Area Functional Genomics Consortium
    NIH/NHLBI U01HL066600Sep 30, 2000 - Jul 31, 2008
    Role: Principal Investigator
    Integrin-Mediated Development of the Thoracic Duct
    NIH/NHLBI R01HL064353Feb 1, 2000 - Nov 30, 2009
    Role: Principal Investigator
    Interactions of Lymphocytes, Cytokines and Airway Cells
    NIH/NHLBI P50HL056385Sep 30, 1996 - Aug 31, 2006
    Role: Principal Investigator
    MECHANISMS OF PERSISTENT AIRWAY INFLAMMATION IN ASTHMA
    NIH/NHLBI P01HL056385Sep 30, 1996 - Aug 31, 2001
    Role: Principal Investigator
    In Vivo Function of Pulmonary Integrins
    NIH/NHLBI R37HL053949Apr 1, 1995 - Mar 31, 2014
    Role: Principal Investigator
    In Vivo Function of Pulmonary Integrins
    NIH/NHLBI R01HL053949Apr 1, 1995 - Mar 31, 2009
    Role: Principal Investigator
    SCIENTIFIC REVIEW AND EVALUATION GRANT
    NIH/NHLBI U09HL053927Jun 1, 1994 - Jun 30, 2005
    Role: Co-Principal Investigator
    FUNCTION OF A NOVEL AIRWAY EPITHELIAL ADHESION RECEPTOR
    NIH/NHLBI R01HL047412Jan 23, 1992 - May 31, 2000
    Role: Principal Investigator
    Novel Leukocyte Integrins
    NIH/NIAID R01AI024674Sep 1, 1988 - Feb 28, 2010
    Role: Principal Investigator
    AIRWAY EPITHELIAL RECEPTORS FOR EXTRACELLULAR MATRIX
    NIH/NHLBI R01HL033259Sep 20, 1985 - Aug 31, 1998
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    Multidisciplinary Training Program in Lung Disease
    NIH/NHLBI T32HL007185Jul 1, 1976 - Jun 30, 2022
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Global Health
    Collapse Featured Publications
    Collapse Student Projects

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Tsujino K, Li JT, Tsukui T, Ren X, Bakiri L, Wagner EF, Sheppard D. Fra-2 negatively regulates postnatal alveolar septation by modulating myofibroblast function. Am J Physiol Lung Cell Mol Physiol. 2017 Aug 17; ajplung.00062.2017. PMID: 28818870.
      View in: PubMed
    2. Jenkins RG, Moore BB, Chambers RC, Eickelberg O, Königshoff M, Kolb M, Laurent GJ, Nanthakumar CB, Olman MA, Pardo A, Selman M, Sheppard D, Sime PJ, Tager AM, Tatler AL, Thannickal VJ, White ES. An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2017 May; 56(5):667-679. PMID: 28459387.
      View in: PubMed
    3. Sheppard DM, Li J, Henbest KB, Neil SR, Maeda K, Storey J, Schleicher E, Biskup T, Rodriguez R, Weber S, Hore PJ, Timmel CR, Mackenzie SR. Millitesla magnetic field effects on the photocycle of an animal cryptochrome. Sci Rep. 2017 Feb 08; 7:42228. PMID: 28176875.
      View in: PubMed
    4. Sundaram A, Chen C, Khalifeh-Soltani A, Atakilit A, Ren X, Qiu W, Jo H, DeGrado W, Huang X, Sheppard D. Targeting integrin a5ß1 ameliorates severe airway hyperresponsiveness in experimental asthma. J Clin Invest. 2017 Jan 03; 127(1):365-374. PMID: 27918306.
      View in: PubMed
    5. Tsujino K, Reed NI, Atakilit A, Ren X, Sheppard D. Transforming growth factor-ß plays divergent roles in modulating vascular remodeling, inflammation, and pulmonary fibrosis in a murine model of scleroderma. Am J Physiol Lung Cell Mol Physiol. 2017 Jan 01; 312(1):L22-L31. PMID: 27864286.
      View in: PubMed
    6. Reed NI, Tang YZ, McIntosh J, Wu Y, Molnar KS, Civitavecchia A, Sheppard D, DeGrado WF, Jo H. Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective avß1 Integrin Inhibitors. ACS Med Chem Lett. 2016 Oct 13; 7(10):902-907. PMID: 27774126.
      View in: PubMed
    7. Meliopoulos VA, Van de Velde LA, Van de Velde NC, Karlsson EA, Neale G, Vogel P, Guy C, Sharma S, Duan S, Surman SL, Jones BG, Johnson MD, Bosio C, Jolly L, Jenkins RG, Hurwitz JL, Rosch JW, Sheppard D, Thomas PG, Murray PJ, Schultz-Cherry S. An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens. PLoS Pathog. 2016 Aug; 12(8):e1005804. PMID: 27505057; PMCID: PMC4978498.
    8. McAleer JP, Nguyen NL, Chen K, Kumar P, Ricks DM, Binnie M, Armentrout RA, Pociask DA, Hein A, Yu A, Vikram A, Bibby K, Umesaki Y, Rivera A, Sheppard D, Ouyang W, Hooper LV, Kolls JK. Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome. J Immunol. 2016 Jul 01; 197(1):97-107. PMID: 27217583; PMCID: PMC4912941 [Available on 07/01/17].
    9. Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG. IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Science. 2016 May 13; 352(6287):aaf4822. PMID: 27174992; PMCID: PMC4890166 [Available on 11/13/16].
    10. Sun KH, Chang Y, Reed NI, Sheppard D. a-Smooth muscle actin is an inconsistent marker of fibroblasts responsible for force-dependent TGFß activation or collagen production across multiple models of organ fibrosis. Am J Physiol Lung Cell Mol Physiol. 2016 May 01; 310(9):L824-36. PMID: 26944089; PMCID: PMC4867351 [Available on 05/01/17].
    11. Mohammed J, Beura LK, Bobr A, Astry B, Chicoine B, Kashem SW, Welty NE, Igyártó BZ, Wijeyesinghe S, Thompson EA, Matte C, Bartholin L, Kaplan A, Sheppard D, Bridges AG, Shlomchik WD, Masopust D, Kaplan DH. Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-ß. Nat Immunol. 2016 Apr; 17(4):414-21. PMID: 26901152.
      View in: PubMed
    12. Tsujino K, Sheppard D. Critical Appraisal of the Utility and Limitations of Animal Models of Scleroderma. Curr Rheumatol Rep. 2016 Jan; 18(1):4. PMID: 26711695.
      View in: PubMed
    13. Peng ZW, Ikenaga N, Liu SB, Sverdlov DY, Vaid KA, Dixit R, Weinreb PH, Violette S, Sheppard D, Schuppan D, Popov Y. Integrin avß6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis. Hepatology. 2016 Jan; 63(1):217-32. PMID: 26448099.
      View in: PubMed
    14. Plaks V, Boldajipour B, Linnemann JR, Nguyen NH, Kersten K, Wolf Y, Casbon AJ, Kong N, van den Bijgaart RJ, Sheppard D, Melton AC, Krummel MF, Werb Z. Adaptive Immune Regulation of Mammary Postnatal Organogenesis. Dev Cell. 2015 Sep 14; 34(5):493-504. PMID: 26321127; PMCID: PMC4573906.
    15. Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Howard J, Fang X, Bhat S, Huynh KM, O'Kane CM, Ingram RJ, Muir RR, McAuley DF, Matthay MA, Sheppard D. Unexpected Role for Adaptive aßTh17 Cells in Acute Respiratory Distress Syndrome. J Immunol. 2015 Jul 01; 195(1):87-95. PMID: 26002979; PMCID: PMC4475475.
    16. Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D. The avß1 integrin plays a critical in vivo role in tissue fibrosis. Sci Transl Med. 2015 May 20; 7(288):288ra79. PMID: 25995225; PMCID: PMC4461057.
    17. Sheppard D. Epithelial-mesenchymal interactions in fibrosis and repair. Transforming growth factor-ß activation by epithelial cells and fibroblasts. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S21-3. PMID: 25830829; PMCID: PMC4430968.
    18. Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R. Innate antiviral host defense attenuates TGF-ß function through IRF3-mediated suppression of Smad signaling. Mol Cell. 2014 Dec 18; 56(6):723-37. PMID: 25526531; PMCID: PMC4273650 [Available on 12/18/15].
    19. Arnold TD, Niaudet C, Pang MF, Siegenthaler J, Gaengel K, Jung B, Ferrero GM, Mukouyama YS, Fuxe J, Akhurst R, Betsholtz C, Sheppard D, Reichardt LF. Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking aVß8-TGFß signaling in the brain. Development. 2014 Dec; 141(23):4489-99. PMID: 25406396; PMCID: PMC4302931.
    20. Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D. IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction. J Clin Invest. 2014 Nov; 124(11):4895-8. PMID: 25271629; PMCID: PMC4347230.
    21. Erle DJ, Sheppard D. The cell biology of asthma. J Cell Biol. 2014 Jun 09; 205(5):621-31. PMID: 24914235; PMCID: PMC4050726.
    22. Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Simmons S, Ishii M, Sheppard D, Takaoka A, Uede T. Integrin a9 on lymphatic endothelial cells regulates lymphocyte egress. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):3080-5. PMID: 24516133; PMCID: PMC3939877.
    23. Madala SK, Korfhagen TR, Schmidt S, Davidson C, Edukulla R, Ikegami M, Violette SM, Weinreb PH, Sheppard D, Hardie WD. Inhibition of the avß6 integrin leads to limited alteration of TGF-a-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15; 306(8):L726-35. PMID: 24508732; PMCID: PMC3989722.
    24. Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP. Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med. 2014 Jan 15; 189(2):214-22. PMID: 24160862; PMCID: PMC3983890.
    25. Travis MA, Sheppard D. TGF-ß activation and function in immunity. Annu Rev Immunol. 2014; 32:51-82. PMID: 24313777; PMCID: PMC4010192.
    26. Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. Targeting of av integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec; 19(12):1617-24. PMID: 24216753; PMCID: PMC3855865.
    27. Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley RM, Chawla A. Eosinophils secrete IL-4 to facilitate liver regeneration. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9914-9. PMID: 23716700; PMCID: PMC3683773.
    28. Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A. The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. J Clin Invest. 2013 May; 123(5):2037-48. PMID: 23543053; PMCID: PMC3635736.
    29. Sheppard D. ROCKing pulmonary fibrosis. J Clin Invest. 2013 Mar; 123(3):1005-6. PMID: 23434586; PMCID: PMC3582155.
    30. Su G, Atakilit A, Li JT, Wu N, Luong J, Chen R, Bhattacharya M, Sheppard D. Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin avß5. Crit Care Med. 2013 Feb; 41(2):546-53. PMID: 23263571.
      View in: PubMed
    31. Friedman SL, Sheppard D, Duffield JS, Violette S. Therapy for fibrotic diseases: nearing the starting line. Sci Transl Med. 2013 Jan 09; 5(167):167sr1. PMID: 23303606.
      View in: PubMed
    32. Freimuth J, Clermont FF, Huang X, DeSapio A, Tokuyasu TA, Sheppard D, Akhurst RJ. Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus. Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):18042-7. PMID: 23064636; PMCID: PMC3497801.
    33. Henderson NC, Sheppard D. Integrin-mediated regulation of TGFß in fibrosis. Biochim Biophys Acta. 2013 Jul; 1832(7):891-6. PMID: 23046811; PMCID: PMC3573259.
    34. Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR. Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16354-9. PMID: 22988107; PMCID: PMC3479591.
    35. Chen C, Kudo M, Rutaganira F, Takano H, Lee C, Atakilit A, Robinett KS, Uede T, Wolters PJ, Shokat KM, Huang X, Sheppard D. Integrin a9ß1 in airway smooth muscle suppresses exaggerated airway narrowing. J Clin Invest. 2012 Aug; 122(8):2916-27. PMID: 22772469; PMCID: PMC3448403.
    36. Sheppard D. Modulation of acute lung injury by integrins. Proc Am Thorac Soc. 2012 Jul; 9(3):126-9. PMID: 22802286.
      View in: PubMed
    37. Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF. Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med. 2012 Jun 04; 209(6):1183-99. PMID: 22585735; PMCID: PMC3371730.
    38. Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D. IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. Am J Physiol Lung Cell Mol Physiol. 2012 Jul 01; 303(1):L12-9. PMID: 22561460; PMCID: PMC3426434.
    39. Kudo M, Melton AC, Chen C, Engler MB, Huang KE, Ren X, Wang Y, Bernstein X, Li JT, Atabai K, Huang X, Sheppard D. IL-17A produced by aß T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction. Nat Med. 2012 Mar 04; 18(4):547-54. PMID: 22388091; PMCID: PMC3321096.
    40. Doherty TA, Khorram N, Sugimoto K, Sheppard D, Rosenthal P, Cho JY, Pham A, Miller M, Croft M, Broide DH. Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness. J Immunol. 2012 Mar 15; 188(6):2622-9. PMID: 22327070; PMCID: PMC3294141.
    41. Giacomini MM, Travis MA, Kudo M, Sheppard D. Epithelial cells utilize cortical actin/myosin to activate latent TGF-ß through integrin a(v)ß(6)-dependent physical force. Exp Cell Res. 2012 Apr 01; 318(6):716-22. PMID: 22309779; PMCID: PMC3294033.
    42. Sugimoto K, Kudo M, Sundaram A, Ren X, Huang K, Bernstein X, Wang Y, Raymond WW, Erle DJ, Abrink M, Caughey GH, Huang X, Sheppard D. The avß6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells. J Clin Invest. 2012 Feb; 122(2):748-58. PMID: 22232213; PMCID: PMC3266785.
    43. Su G, Atakilit A, Li JT, Wu N, Bhattacharya M, Zhu J, Shieh JE, Li E, Chen R, Sun S, Su CP, Sheppard D. Absence of integrin avß3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation. Am J Respir Crit Care Med. 2012 Jan 01; 185(1):58-66. PMID: 21980034; PMCID: PMC3262039.
    44. Munger JS, Sheppard D. Cross talk among TGF-ß signaling pathways, integrins, and the extracellular matrix. Cold Spring Harb Perspect Biol. 2011 Nov 01; 3(11):a005017. PMID: 21900405; PMCID: PMC3220354.
    45. Tatler AL, John AE, Jolly L, Habgood A, Porte J, Brightling C, Knox AJ, Pang L, Sheppard D, Huang X, Jenkins G. Integrin avß5-mediated TGF-ß activation by airway smooth muscle cells in asthma. J Immunol. 2011 Dec 01; 187(11):6094-107. PMID: 22025551; PMCID: PMC3242066.
    46. Katsumoto TR, Violette SM, Sheppard D. Blocking TGFß via Inhibition of the avß6 Integrin: A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease. Int J Rheumatol. 2011; 2011:208219. PMID: 22013449; PMCID: PMC3195527.
    47. Sheppard D. Aspen Lung Conference 2010: systems biology of lung diseases--progress in the omics era. Proc Am Thorac Soc. 2011 May; 8(2):199-202. PMID: 21543802; PMCID: PMC3159072.
    48. Kon S, Atakilit A, Sheppard D. Short form of a9 promotes a9ß1 integrin-dependent cell adhesion by modulating the function of the full-length a9 subunit. Exp Cell Res. 2011 Jul 15; 317(12):1774-84. PMID: 21515257; PMCID: PMC3118859.
    49. Nishimichi N, Hayashita-Kinoh H, Chen C, Matsuda H, Sheppard D, Yokosaki Y. Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrin alpha9beta1. J Biol Chem. 2011 Apr 01; 286(13):11170-8. PMID: 21321126; PMCID: PMC3064171.
    50. Spassov DS, Wong CH, Sergina N, Ahuja D, Fried M, Sheppard D, Moasser MM. Phosphorylation of Trask by Src kinases inhibits integrin clustering and functions in exclusion with focal adhesion signaling. Mol Cell Biol. 2011 Feb; 31(4):766-82. PMID: 21189288; PMCID: PMC3028653.
    51. Melton AC, Bailey-Bucktrout SL, Travis MA, Fife BT, Bluestone JA, Sheppard D. Expression of avß8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice. J Clin Invest. 2010 Dec; 120(12):4436-44. PMID: 21099117; PMCID: PMC2993595.
    52. Atabai K, Jame S, Azhar N, Kuo A, Lam M, McKleroy W, Dehart G, Rahman S, Xia DD, Melton AC, Wolters P, Emson CL, Turner SM, Werb Z, Sheppard D. Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. J Clin Invest. 2009 Dec; 119(12):3713-22. PMID: 19884654; PMCID: PMC2786804.
    53. Hogmalm A, Sheppard D, Lappalainen U, Bry K. beta6 Integrin subunit deficiency alleviates lung injury in a mouse model of bronchopulmonary dysplasia. Am J Respir Cell Mol Biol. 2010 Jul; 43(1):88-98. PMID: 19717813; PMCID: PMC2911573.
    54. Bazigou E, Xie S, Chen C, Weston A, Miura N, Sorokin L, Adams R, Muro AF, Sheppard D, Makinen T. Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Dev Cell. 2009 Aug; 17(2):175-86. PMID: 19686679; PMCID: PMC2747264.
    55. Seibold MA, Reese TA, Choudhry S, Salam MT, Beckman K, Eng C, Atakilit A, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Fahy JV, Rodriguez-Santana J, Rodriguez-Cintron W, Boot RG, Sheppard D, Gilliland FD, Locksley RM, Burchard EG. Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein. J Biol Chem. 2009 Jul 17; 284(29):19650-8. PMID: 19435888; PMCID: PMC2740590.
    56. Grassinger J, Haylock DN, Storan MJ, Haines GO, Williams B, Whitty GA, Vinson AR, Be CL, Li S, Sørensen ES, Tam PP, Denhardt DT, Sheppard D, Choong PF, Nilsson SK. Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins. Blood. 2009 Jul 02; 114(1):49-59. PMID: 19417209.
      View in: PubMed
    57. Xu MY, Porte J, Knox AJ, Weinreb PH, Maher TM, Violette SM, McAnulty RJ, Sheppard D, Jenkins G. Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q). Am J Pathol. 2009 Apr; 174(4):1264-79. PMID: 19147812; PMCID: PMC2671359.
    58. Singh P, Chen C, Pal-Ghosh S, Stepp MA, Sheppard D, Van De Water L. Loss of integrin alpha9beta1 results in defects in proliferation, causing poor re-epithelialization during cutaneous wound healing. J Invest Dermatol. 2009 Jan; 129(1):217-28. PMID: 18633440; PMCID: PMC3681306.
    59. deHart GW, Jin T, McCloskey DE, Pegg AE, Sheppard D. The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel. Proc Natl Acad Sci U S A. 2008 May 20; 105(20):7188-93. PMID: 18480266; PMCID: PMC2386075.
    60. Sheppard D. Dust mites' dirty dealings with dendritic cells. Nat Med. 2008 May; 14(5):487-8. PMID: 18463654.
      View in: PubMed
    61. Tabata T, Kawakatsu H, Maidji E, Sakai T, Sakai K, Fang-Hoover J, Aiba M, Sheppard D, Pereira L. Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production. Am J Pathol. 2008 Apr; 172(4):1127-40. PMID: 18349127; PMCID: PMC2276431.
    62. Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF. Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res. 2008 Apr 11; 102(7):804-12. PMID: 18276918; PMCID: PMC2739091.
    63. Muro AF, Moretti FA, Moore BB, Yan M, Atrasz RG, Wilke CA, Flaherty KR, Martinez FJ, Tsui JL, Sheppard D, Baralle FE, Toews GB, White ES. An essential role for fibronectin extra type III domain A in pulmonary fibrosis. Am J Respir Crit Care Med. 2008 Mar 15; 177(6):638-45. PMID: 18096707; PMCID: PMC2267338.
    64. Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL. Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest. 2007 Nov; 117(11):3551-62. PMID: 17965775; PMCID: PMC2040320.
    65. Horan GS, Wood S, Ona V, Li DJ, Lukashev ME, Weinreb PH, Simon KJ, Hahm K, Allaire NE, Rinaldi NJ, Goyal J, Feghali-Bostwick CA, Matteson EL, O'Hara C, Lafyatis R, Davis GS, Huang X, Sheppard D, Violette SM. Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med. 2008 Jan 01; 177(1):56-65. PMID: 17916809.
      View in: PubMed
    66. Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D. Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature. 2007 Sep 20; 449(7160):361-5. PMID: 17694047; PMCID: PMC2670239.
    67. Koth LL, Alex B, Hawgood S, Nead MA, Sheppard D, Erle DJ, Morris DG. Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1. Am J Respir Cell Mol Biol. 2007 Dec; 37(6):651-9. PMID: 17641300; PMCID: PMC2219547.
    68. Nandrot EF, Anand M, Almeida D, Atabai K, Sheppard D, Finnemann SC. Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12005-10. PMID: 17620600; PMCID: PMC1924559.
    69. Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA. Genomics and proteomics of lung disease: conference summary. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L45-51. PMID: 17468134; PMCID: PMC4212816.
    70. Vlahakis NE, Young BA, Atakilit A, Hawkridge AE, Issaka RB, Boudreau N, Sheppard D. Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis. J Biol Chem. 2007 May 18; 282(20):15187-96. PMID: 17363377.
      View in: PubMed
    71. Atabai K, Sheppard D, Werb Z. Roles of the innate immune system in mammary gland remodeling during involution. J Mammary Gland Biol Neoplasia. 2007 Mar; 12(1):37-45. PMID: 17286210; PMCID: PMC2574498.
    72. Chen C, Sheppard D. Identification and molecular characterization of multiple phenotypes in integrin knockout mice. Methods Enzymol. 2007; 426:291-305. PMID: 17697889.
      View in: PubMed
    73. Hahm K, Lukashev ME, Luo Y, Yang WJ, Dolinski BM, Weinreb PH, Simon KJ, Chun Wang L, Leone DR, Lobb RR, McCrann DJ, Allaire NE, Horan GS, Fogo A, Kalluri R, Shield CF, Sheppard D, Gardner HA, Violette SM. Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse. Am J Pathol. 2007 Jan; 170(1):110-25. PMID: 17200187; PMCID: PMC1762706.
    74. Morris DG, Sheppard D. Pulmonary emphysema: when more is less. Physiology (Bethesda). 2006 Dec; 21:396-403. PMID: 17119152.
      View in: PubMed
    75. Chen C, Huang X, Atakilit A, Zhu QS, Corey SJ, Sheppard D. The Integrin alpha9beta1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signaling. Immunity. 2006 Dec; 25(6):895-906. PMID: 17137800.
      View in: PubMed
    76. Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay MA, Sheppard D, Pittet JF. Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Am J Respir Cell Mol Biol. 2007 Mar; 36(3):377-86. PMID: 17079779; PMCID: PMC1899321.
    77. Rao H, Lu G, Kajiya H, Garcia-Palacios V, Kurihara N, Anderson J, Patrene K, Sheppard D, Blair HC, Windle JJ, Choi SJ, Roodman GD. Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function. J Bone Miner Res. 2006 Oct; 21(10):1657-65. PMID: 16995821; PMCID: PMC1937336.
    78. Chen C, Huang X, Sheppard D. ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice. Mol Cell Biol. 2006 Sep; 26(18):6950-6. PMID: 16943435; PMCID: PMC1592855.
    79. Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, Sheppard D, Chapman HA. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A. 2006 Aug 29; 103(35):13180-5. PMID: 16924102; PMCID: PMC1551904.
    80. Sheppard D. Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis. Proc Am Thorac Soc. 2006 Jul; 3(5):413-7. PMID: 16799084; PMCID: PMC2658705.
    81. Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D. Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest. 2006 Jun; 116(6):1606-14. PMID: 16710477; PMCID: PMC1462943.
    82. Neurohr C, Nishimura SL, Sheppard D. Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure. Am J Respir Cell Mol Biol. 2006 Aug; 35(2):252-9. PMID: 16574941; PMCID: PMC2643260.
    83. Choudhry S, Coyle NE, Tang H, Salari K, Lind D, Clark SL, Tsai HJ, Naqvi M, Phong A, Ung N, Matallana H, Avila PC, Casal J, Torres A, Nazario S, Castro R, Battle NC, Perez-Stable EJ, Kwok PY, Sheppard D, Shriver MD, Rodriguez-Cintron W, Risch N, Ziv E, Burchard EG. Population stratification confounds genetic association studies among Latinos. Hum Genet. 2006 Jan; 118(5):652-64. PMID: 16283388.
      View in: PubMed
    84. Atabai K, Fernandez R, Huang X, Ueki I, Kline A, Li Y, Sadatmansoori S, Smith-Steinhart C, Zhu W, Pytela R, Werb Z, Sheppard D. Mfge8 is critical for mammary gland remodeling during involution. Mol Biol Cell. 2005 Dec; 16(12):5528-37. PMID: 16195353; PMCID: PMC1289399.
    85. Sheppard D. Integrin-mediated activation of latent transforming growth factor beta. Cancer Metastasis Rev. 2005 Sep; 24(3):395-402. PMID: 16258727.
      View in: PubMed
    86. Salari K, Choudhry S, Tang H, Naqvi M, Lind D, Avila PC, Coyle NE, Ung N, Nazario S, Casal J, Torres-Palacios A, Clark S, Phong A, Gomez I, Matallana H, Pérez-Stable EJ, Shriver MD, Kwok PY, Sheppard D, Rodriguez-Cintron W, Risch NJ, Burchard EG, Ziv E. Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics. Genet Epidemiol. 2005 Jul; 29(1):76-86. PMID: 15918156.
      View in: PubMed
    87. Ludlow A, Yee KO, Lipman R, Bronson R, Weinreb P, Huang X, Sheppard D, Lawler J. Characterization of integrin beta6 and thrombospondin-1 double-null mice. J Cell Mol Med. 2005 Apr-Jun; 9(2):421-37. PMID: 15963261.
      View in: PubMed
    88. Bridges LC, Sheppard D, Bowditch RD. ADAM disintegrin-like domain recognition by the lymphocyte integrins alpha4beta1 and alpha4beta7. Biochem J. 2005 Apr 01; 387(Pt 1):101-8. PMID: 15504110; PMCID: PMC1134937.
    89. Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D, Matthay MA, Canessa CM, Pittet JF. Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. J Biol Chem. 2005 May 13; 280(19):18579-89. PMID: 15755725.
      View in: PubMed
    90. Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, Sheppard D, Oettgen P, Mercurio AM. Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest. 2005 Feb; 115(2):339-47. PMID: 15668738; PMCID: PMC544606.
    91. Nandrot EF, Kim Y, Brodie SE, Huang X, Sheppard D, Finnemann SC. Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin. J Exp Med. 2004 Dec 20; 200(12):1539-45. PMID: 15596525; PMCID: PMC2211990.
    92. Vlahakis NE, Young BA, Atakilit A, Sheppard D. The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1. J Biol Chem. 2005 Feb 11; 280(6):4544-52. PMID: 15590642; PMCID: PMC1368959.
    93. Choudhry S, Ung N, Avila PC, Ziv E, Nazario S, Casal J, Torres A, Gorman JD, Salari K, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Castro RA, Salazar M, Gomez I, Fagan JK, Salas J, Clark S, Lilly C, Matallana H, Selman M, Chapela R, Sheppard D, Weiss ST, Ford JG, Boushey HA, Drazen JM, Rodriguez-Cintron W, Silverman EK, Burchard EG. Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med. 2005 Mar 15; 171(6):563-70. PMID: 15557128.
      View in: PubMed
    94. Lane NE, Yao W, Nakamura MC, Humphrey MB, Kimmel D, Huang X, Sheppard D, Ross FP, Teitelbaum SL. Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state. J Bone Miner Res. 2005 Jan; 20(1):58-66. PMID: 15619670.
      View in: PubMed
    95. Sheppard D. Fishing in the bloodstream: insights into the mechanisms of pulmonary hypertension? Am J Respir Crit Care Med. 2004 Oct 15; 170(8):827-8. PMID: 15475403.
      View in: PubMed
    96. Chen C, Young BA, Coleman CS, Pegg AE, Sheppard D. Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration. J Cell Biol. 2004 Oct 11; 167(1):161-70. PMID: 15479742; PMCID: PMC2172529.
    97. Sheppard D. Roles of alphav integrins in vascular biology and pulmonary pathology. Curr Opin Cell Biol. 2004 Oct; 16(5):552-7. PMID: 15363806.
      View in: PubMed
    98. Williams CH, Kajander T, Hyypiä T, Jackson T, Sheppard D, Stanway G. Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9. J Virol. 2004 Jul; 78(13):6967-73. PMID: 15194773; PMCID: PMC421648.
    99. Bazan-Socha S, Kisiel DG, Young B, Theakston RD, Calvete JJ, Sheppard D, Marcinkiewicz C. Structural requirements of MLD-containing disintegrins for functional interaction with alpha 4 beta 1 and alpha 9 beta1 integrins. Biochemistry. 2004 Feb 17; 43(6):1639-47. PMID: 14769041.
      View in: PubMed
    100. Weinreb PH, Simon KJ, Rayhorn P, Yang WJ, Leone DR, Dolinski BM, Pearse BR, Yokota Y, Kawakatsu H, Atakilit A, Sheppard D, Violette SM. Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes. J Biol Chem. 2004 Apr 23; 279(17):17875-87. PMID: 14960589.
      View in: PubMed
    101. Burchard EG, Avila PC, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Salazar M, Gomez I, Fagan JK, Salas J, Lilly C, Matallana H, Ziv E, Castro R, Selman M, Chapela R, Sheppard D, Weiss ST, Ford JG, Boushey HA, Rodriguez-Cintron W, Drazen JM, Silverman EK. Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med. 2004 Feb 01; 169(3):386-92. PMID: 14617512.
      View in: PubMed
    102. Tomczuk M, Takahashi Y, Huang J, Murase S, Mistretta M, Klaffky E, Sutherland A, Bolling L, Coonrod S, Marcinkiewicz C, Sheppard D, Stepp MA, White JM. Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3. Exp Cell Res. 2003 Oct 15; 290(1):68-81. PMID: 14516789.
      View in: PubMed
    103. Ma LJ, Yang H, Gaspert A, Carlesso G, Barty MM, Davidson JM, Sheppard D, Fogo AB. Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice. Am J Pathol. 2003 Oct; 163(4):1261-73. PMID: 14507636; PMCID: PMC1868298.
    104. Wu W, Samet JM, Silbajoris R, Dailey LA, Sheppard D, Bromberg PA, Graves LM. Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation. Am J Respir Cell Mol Biol. 2004 Apr; 30(4):540-7. PMID: 12972402.
      View in: PubMed
    105. Lind DL, Choudhry S, Ung N, Ziv E, Avila PC, Salari K, Ha C, Lovins EG, Coyle NE, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Matallana H, Lilly CM, Salas J, Selman M, Boushey HA, Weiss ST, Chapela R, Ford JG, Rodriguez-Cintron W, Silverman EK, Sheppard D, Kwok PY, González Burchard E. ADAM33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med. 2003 Dec 01; 168(11):1312-6. PMID: 12958057.
      View in: PubMed
    106. Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay MA, Pittet JF. Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem. 2003 Nov 07; 278(45):43939-50. PMID: 12930837.
      View in: PubMed
    107. Sheppard D. Functions of pulmonary epithelial integrins: from development to disease. Physiol Rev. 2003 Jul; 83(3):673-86. PMID: 12843406.
      View in: PubMed
    108. Burchard EG, Ziv E, Coyle N, Gomez SL, Tang H, Karter AJ, Mountain JL, Pérez-Stable EJ, Sheppard D, Risch N. The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med. 2003 Mar 20; 348(12):1170-5. PMID: 12646676.
      View in: PubMed
    109. Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, Dolganov G, Glick A, Sheppard D. Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature. 2003 Mar 13; 422(6928):169-73. PMID: 12634787.
      View in: PubMed
    110. Sheppard D. Endothelial integrins and angiogenesis: not so simple anymore. J Clin Invest. 2002 Oct; 110(7):913-4. PMID: 12370267; PMCID: PMC151161.
    111. Knight PA, Wright SH, Brown JK, Huang X, Sheppard D, Miller HR. Enteric expression of the integrin alpha(v)beta(6) is essential for nematode-induced mucosal mast cell hyperplasia and expression of the granule chymase, mouse mast cell protease-1. Am J Pathol. 2002 Sep; 161(3):771-9. PMID: 12213704; PMCID: PMC1867270.
    112. Crystal RG, Bitterman PB, Mossman B, Schwarz MI, Sheppard D, Almasy L, Chapman HA, Friedman SL, King TE, Leinwand LA, Liotta L, Martin GR, Schwartz DA, Schultz GS, Wagner CR, Musson RA. Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med. 2002 Jul 15; 166(2):236-46. PMID: 12119236.
      View in: PubMed
    113. Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med. 2002 Aug; 8(8):885-9. PMID: 12091879.
      View in: PubMed
    114. Zuo F, Kaminski N, Eugui E, Allard J, Yakhini Z, Ben-Dor A, Lollini L, Morris D, Kim Y, DeLustro B, Sheppard D, Pardo A, Selman M, Heller RA. Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6292-7. PMID: 11983918; PMCID: PMC122942.
    115. Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, Sheppard D, Broaddus VC, Nishimura SL. The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. J Cell Biol. 2002 Apr 29; 157(3):493-507. PMID: 11970960; PMCID: PMC2173277.
    116. Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer DD, Huang XZ, Sheppard D, Cheresh DA. Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol. 2002 Apr 01; 157(1):149-60. PMID: 11927607; PMCID: PMC2173263.
    117. Sheppard D. Killed by leukocytes that don't know when to leave. Nat Immunol. 2002 Apr; 3(4):337-8. PMID: 11919573.
      View in: PubMed
    118. Eto K, Huet C, Tarui T, Kupriyanov S, Liu HZ, Puzon-McLaughlin W, Zhang XP, Sheppard D, Engvall E, Takada Y. Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. J Biol Chem. 2002 May 17; 277(20):17804-10. PMID: 11882657.
      View in: PubMed
    119. Sheppard D. Roger S. Mitchell lecture. Uses of expression microarrays in studies of pulmonary fibrosis, asthma, acute lung injury, and emphysema. Chest. 2002 Mar; 121(3 Suppl):21S-25S. PMID: 11893658.
      View in: PubMed
    120. Kaminski N, Zuo F, Cojocaro G, Yakhini Z, Ben-Dor A, Morris D, Sheppard D, Pardo A, Selman M, Heller RA. Use of oligonucleotide microarrays to analyze gene expression patterns in pulmonary fibrosis reveals distinct patterns of gene expression in mice and humans. Chest. 2002 Mar; 121(3 Suppl):31S-32S. PMID: 11893671.
      View in: PubMed
    121. Liao YF, Gotwals PJ, Koteliansky VE, Sheppard D, Van De Water L. The EIIIA segment of fibronectin is a ligand for integrins alpha 9beta 1 and alpha 4beta 1 providing a novel mechanism for regulating cell adhesion by alternative splicing. J Biol Chem. 2002 Apr 26; 277(17):14467-74. PMID: 11839764.
      View in: PubMed
    122. Jackson T, Mould AP, Sheppard D, King AM. Integrin alphavbeta1 is a receptor for foot-and-mouth disease virus. J Virol. 2002 Feb; 76(3):935-41. PMID: 11773368; PMCID: PMC135819.
    123. Reynolds LE, Wyder L, Lively JC, Taverna D, Robinson SD, Huang X, Sheppard D, Hynes RO, Hodivala-Dilke KM. Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat Med. 2002 Jan; 8(1):27-34. PMID: 11786903.
      View in: PubMed
    124. Ljubimov AV, Saghizadeh M, Pytela R, Sheppard D, Kenney MC. Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. J Histochem Cytochem. 2001 Nov; 49(11):1341-50. PMID: 11668187.
      View in: PubMed
    125. Young BA, Taooka Y, Liu S, Askins KJ, Yokosaki Y, Thomas SM, Sheppard D. The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner. Mol Biol Cell. 2001 Oct; 12(10):3214-25. PMID: 11598204; PMCID: PMC60168.
    126. Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle DJ, Sheppard D. Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types. Am J Respir Cell Mol Biol. 2001 Oct; 25(4):474-85. PMID: 11694453.
      View in: PubMed
    127. Thomas GJ, Lewis MP, Whawell SA, Russell A, Sheppard D, Hart IR, Speight PM, Marshall JF. Expression of the alphavbeta6 integrin promotes migration and invasion in squamous carcinoma cells. J Invest Dermatol. 2001 Jul; 117(1):67-73. PMID: 11442751.
      View in: PubMed
    128. Sheppard D. Integrin-mediated activation of transforming growth factor-beta(1) in pulmonary fibrosis. Chest. 2001 Jul; 120(1 Suppl):49S-53S. PMID: 11451914.
      View in: PubMed
    129. Sheppard D. Pulmonary fibrosis: a cellular overreaction or a failure of communication? J Clin Invest. 2001 Jun; 107(12):1501-2. PMID: 11413155; PMCID: PMC200201.
    130. Pittet JF, Griffiths MJ, Geiser T, Kaminski N, Dalton SL, Huang X, Brown LA, Gotwals PJ, Koteliansky VE, Matthay MA, Sheppard D. TGF-beta is a critical mediator of acute lung injury. J Clin Invest. 2001 Jun; 107(12):1537-44. PMID: 11413161; PMCID: PMC200192.
    131. Miller LC, Blakemore W, Sheppard D, Atakilit A, King AM, Jackson T. Role of the cytoplasmic domain of the beta-subunit of integrin alpha(v)beta6 in infection by foot-and-mouth disease virus. J Virol. 2001 May; 75(9):4158-64. PMID: 11287565; PMCID: PMC114161.
    132. Miller LA, Barnett NL, Sheppard D, Hyde DM. Expression of the beta6 integrin subunit is associated with sites of neutrophil influx in lung epithelium. J Histochem Cytochem. 2001 Jan; 49(1):41-8. PMID: 11118477.
      View in: PubMed
    133. Eto K, Puzon-McLaughlin W, Sheppard D, Sehara-Fujisawa A, Zhang XP, Takada Y. RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction. J Biol Chem. 2000 Nov 10; 275(45):34922-30. PMID: 10944520.
      View in: PubMed
    134. Marcinkiewicz C, Taooka Y, Yokosaki Y, Calvete JJ, Marcinkiewicz MM, Lobb RR, Niewiarowski S, Sheppard D. Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structural requirements for interaction of the integrin alpha 9beta 1 with VCAM-1, tenascin-C, and osteopontin. J Biol Chem. 2000 Oct 13; 275(41):31930-7. PMID: 10926928.
      View in: PubMed
    135. Davidson DJ, Kilanowski FM, Randell SH, Sheppard DN, Dorin JR. A primary culture model of differentiated murine tracheal epithelium. Am J Physiol Lung Cell Mol Physiol. 2000 Oct; 279(4):L766-78. PMID: 11000138.
      View in: PubMed
    136. Albelda SM, Sheppard D. Functional genomics and expression profiling: be there or be square. Am J Respir Cell Mol Biol. 2000 Sep; 23(3):265-9. PMID: 10970813.
      View in: PubMed
    137. Takahashi H, Isobe T, Horibe S, Takagi J, Yokosaki Y, Sheppard D, Saito Y. Tissue transglutaminase, coagulation factor XIII, and the pro-polypeptide of von Willebrand factor are all ligands for the integrins alpha 9beta 1 and alpha 4beta 1. J Biol Chem. 2000 Aug 04; 275(31):23589-95. PMID: 10816592.
      View in: PubMed
    138. Sheppard D. In vivo functions of integrins: lessons from null mutations in mice. Matrix Biol. 2000 Jul; 19(3):203-9. PMID: 10936445.
      View in: PubMed
    139. Huang XZ, Wu JF, Ferrando R, Lee JH, Wang YL, Farese RV, Sheppard D. Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1. Mol Cell Biol. 2000 Jul; 20(14):5208-15. PMID: 10866676; PMCID: PMC85969.
    140. Jackson T, Sheppard D, Denyer M, Blakemore W, King AM. The epithelial integrin alphavbeta6 is a receptor for foot-and-mouth disease virus. J Virol. 2000 Jun; 74(11):4949-56. PMID: 10799568; PMCID: PMC110846.
    141. Yokasaki Y, Sheppard D. Mapping of the cryptic integrin-binding site in osteopontin suggests a new mechanism by which thrombin can regulate inflammation and tissue repair. Trends Cardiovasc Med. 2000 May; 10(4):155-9. PMID: 11239795.
      View in: PubMed
    142. Lansdell KA, Cai Z, Kidd JF, Sheppard DN. Two mechanisms of genistein inhibition of cystic fibrosis transmembrane conductance regulator Cl- channels expressed in murine cell line. J Physiol. 2000 Apr 15; 524 Pt 2:317-30. PMID: 10766914; PMCID: PMC2269882.
    143. Kaminski N, Allard JD, Pittet JF, Zuo F, Griffiths MJ, Morris D, Huang X, Sheppard D, Heller RA. Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1778-83. PMID: 10677534; PMCID: PMC26512.
    144. Huang X, Griffiths M, Wu J, Farese RV, Sheppard D. Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice. Mol Cell Biol. 2000 Feb; 20(3):755-9. PMID: 10629031; PMCID: PMC85191.
    145. Yokosaki Y, Matsuura N, Sasaki T, Murakami I, Schneider H, Higashiyama S, Saitoh Y, Yamakido M, Taooka Y, Sheppard D. The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin. J Biol Chem. 1999 Dec 17; 274(51):36328-34. PMID: 10593924.
      View in: PubMed
    146. Milner R, Huang X, Wu J, Nishimura S, Pytela R, Sheppard D, ffrench-Constant C. Distinct roles for astrocyte alphavbeta5 and alphavbeta8 integrins in adhesion and migration. J Cell Sci. 1999 Dec; 112 ( Pt 23):4271-9. PMID: 10564645.
      View in: PubMed
    147. Spirin KS, Ljubimov AV, Castellon R, Wiedoeft O, Marano M, Sheppard D, Kenney MC, Brown DJ. Analysis of gene expression in human bullous keratopathy corneas containing limiting amounts of RNA. Invest Ophthalmol Vis Sci. 1999 Dec; 40(13):3108-15. PMID: 10586931.
      View in: PubMed
    148. Busse W, Elias J, Sheppard D, Banks-Schlegel S. Airway remodeling and repair. Am J Respir Crit Care Med. 1999 Sep; 160(3):1035-42. PMID: 10471638.
      View in: PubMed
    149. Cai Z, Lansdell KA, Sheppard DN. Inhibition of heterologously expressed cystic fibrosis transmembrane conductance regulator Cl- channels by non-sulphonylurea hypoglycaemic agents. Br J Pharmacol. 1999 Sep; 128(1):108-18. PMID: 10498841; PMCID: PMC1571594.
    150. Roger P, Puchelle E, Bajolet-Laudinat O, Tournier JM, Debordeaux C, Plotkowski MC, Cohen JH, Sheppard D, de Bentzmann S. Fibronectin and alpha5beta1 integrin mediate binding of Pseudomonas aeruginosa to repairing airway epithelium. Eur Respir J. 1999 Jun; 13(6):1301-9. PMID: 10445605.
      View in: PubMed
    151. Taooka Y, Chen J, Yednock T, Sheppard D. The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1. J Cell Biol. 1999 Apr 19; 145(2):413-20. PMID: 10209034; PMCID: PMC2133104.
    152. Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, Pittet JF, Kaminski N, Garat C, Matthay MA, Rifkin DB, Sheppard D. The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell. 1999 Feb 05; 96(3):319-28. PMID: 10025398.
      View in: PubMed
    153. Grünig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB. Requirement for IL-13 independently of IL-4 in experimental asthma. Science. 1998 Dec 18; 282(5397):2261-3. PMID: 9856950; PMCID: PMC3897229.
    154. Desloges N, Basora N, Perreault N, Bouatrouss Y, Sheppard D, Beaulieu JF. Regulated expression of the integrin alpha9beta1 in the epithelium of the developing human gut and in intestinal cell lines: relation with cell proliferation. J Cell Biochem. 1998 Dec 15; 71(4):536-45. PMID: 9827699.
      View in: PubMed
    155. Huang X, Wu J, Zhu W, Pytela R, Sheppard D. Expression of the human integrin beta6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in beta6 knockout mice. Am J Respir Cell Mol Biol. 1998 Oct; 19(4):636-42. PMID: 9761761.
      View in: PubMed
    156. Sheppard D. Airway epithelial integrins: why so many? Am J Respir Cell Mol Biol. 1998 Sep; 19(3):349-51. PMID: 9730861.
      View in: PubMed
    157. Huang X, Wu J, Spong S, Sheppard D. The integrin alphavbeta6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin. J Cell Sci. 1998 Aug; 111 ( Pt 15):2189-95. PMID: 9664040.
      View in: PubMed
    158. Schneider H, Harbottle RP, Yokosaki Y, Kunde J, Sheppard D, Coutelle C. A novel peptide, PLAEIDGIELTY, for the targeting of alpha9beta1-integrins. FEBS Lett. 1998 Jun 16; 429(3):269-73. PMID: 9662430.
      View in: PubMed
    159. Yokosaki Y, Matsuura N, Higashiyama S, Murakami I, Obara M, Yamakido M, Shigeto N, Chen J, Sheppard D. Identification of the ligand binding site for the integrin alpha9 beta1 in the third fibronectin type III repeat of tenascin-C. J Biol Chem. 1998 May 08; 273(19):11423-8. PMID: 9565552.
      View in: PubMed
    160. Corry DB, Grünig G, Hadeiba H, Kurup VP, Warnock ML, Sheppard D, Rennick DM, Locksley RM. Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice. Mol Med. 1998 May; 4(5):344-55. PMID: 9642684; PMCID: PMC2230383.
    161. Lansdell KA, Delaney SJ, Lunn DP, Thomson SA, Sheppard DN, Wainwright BJ. Comparison of the gating behaviour of human and murine cystic fibrosis transmembrane conductance regulator Cl- channels expressed in mammalian cells. J Physiol. 1998 Apr 15; 508 ( Pt 2):379-92. PMID: 9508803; PMCID: PMC2230885.
    162. Basora N, Desloges N, Chang Q, Bouatrouss Y, Gosselin J, Poisson J, Sheppard D, Beaulieu JF. Expression of the alpha9beta1 integrin in human colonic epithelial cells: resurgence of the fetal phenotype in a subset of colon cancers and adenocarcinoma cell lines. Int J Cancer. 1998 Mar 02; 75(5):738-43. PMID: 9495242.
      View in: PubMed
    163. Cass DL, Bullard KM, Sylvester KG, Yang EY, Sheppard D, Herlyn M, Adzick NS. Epidermal integrin expression is upregulated rapidly in human fetal wound repair. J Pediatr Surg. 1998 Feb; 33(2):312-6. PMID: 9498408.
      View in: PubMed
    164. Agrez MV, Shafren DR, Gu X, Cox K, Sheppard D, Barry RD. Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells. Virology. 1997 Dec 08; 239(1):71-7. PMID: 9426447.
      View in: PubMed
    165. Ramos DM, Chen BL, Boylen K, Stern M, Kramer RH, Sheppard D, Nishimura SL, Greenspan D, Zardi L, Pytela R. Stromal fibroblasts influence oral squamous-cell carcinoma cell interactions with tenascin-C. Int J Cancer. 1997 Jul 17; 72(2):369-76. PMID: 9219848.
      View in: PubMed
    166. Smith LL, Cheung HK, Ling LE, Chen J, Sheppard D, Pytela R, Giachelli CM. Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin. J Biol Chem. 1996 Nov 08; 271(45):28485-91. PMID: 8910476.
      View in: PubMed
    167. Hérard AL, Pierrot D, Hinnrasky J, Kaplan H, Sheppard D, Puchelle E, Zahm JM. Fibronectin and its alpha 5 beta 1-integrin receptor are involved in the wound-repair process of airway epithelium. Am J Physiol. 1996 Nov; 271(5 Pt 1):L726-33. PMID: 8944715.
      View in: PubMed
    168. Chen J, Maeda T, Sekiguchi K, Sheppard D. Distinct structural requirements for interaction of the integrins alpha 5 beta 1, alpha v beta 5, and alpha v beta 6 with the central cell binding domain in fibronectin. Cell Adhes Commun. 1996 Nov; 4(4-5):237-50. PMID: 9117344.
      View in: PubMed
    169. Wang A, Yokosaki Y, Ferrando R, Balmes J, Sheppard D. Differential regulation of airway epithelial integrins by growth factors. Am J Respir Cell Mol Biol. 1996 Nov; 15(5):664-72. PMID: 8918373.
      View in: PubMed
    170. Dixit RB, Chen A, Chen J, Sheppard D. Identification of a sequence within the integrin beta6 subunit cytoplasmic domain that is required to support the specific effect of alphavbeta6 on proliferation in three-dimensional culture. J Biol Chem. 1996 Oct 18; 271(42):25976-80. PMID: 8824234.
      View in: PubMed
    171. Yokosaki Y, Monis H, Chen J, Sheppard D. Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains. J Biol Chem. 1996 Sep 27; 271(39):24144-50. PMID: 8798654.
      View in: PubMed
    172. Sheppard D. Epithelial integrins. Bioessays. 1996 Aug; 18(8):655-60. PMID: 8760339.
      View in: PubMed
    173. Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, Farese RV, Sheppard D. Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J Cell Biol. 1996 May; 133(4):921-8. PMID: 8666675; PMCID: PMC2120829.
    174. Agrez MV, Bates RC, Mitchell D, Wilson N, Ferguson N, Anseline P, Sheppard D. Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer. Br J Cancer. 1996 Apr; 73(7):887-92. PMID: 8611401; PMCID: PMC2074269.
    175. Kumar NM, Sigurdson SL, Sheppard D, Lwebuga-Mukasa JS. Differential modulation of integrin receptors and extracellular matrix laminin by transforming growth factor-beta 1 in rat alveolar epithelial cells. Exp Cell Res. 1995 Dec; 221(2):385-94. PMID: 7493638.
      View in: PubMed
    176. Wang A, Patrone L, McDonald JA, Sheppard D. Expression of the integrin subunit alpha 9 in the murine embryo. Dev Dyn. 1995 Dec; 204(4):421-31. PMID: 8601035.
      View in: PubMed
    177. Boylan AM, Sanan DA, Sheppard D, Broaddus VC. Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin alpha v beta 5. J Clin Invest. 1995 Oct; 96(4):1987-2001. PMID: 7560092; PMCID: PMC185837.
    178. Schnapp LM, Hatch N, Ramos DM, Klimanskaya IV, Sheppard D, Pytela R. The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin. J Biol Chem. 1995 Sep 29; 270(39):23196-202. PMID: 7559467.
      View in: PubMed
    179. Huang XZ, Chen A, Agrez M, Sheppard D. A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts. Am J Respir Cell Mol Biol. 1995 Aug; 13(2):245-51. PMID: 7626292.
      View in: PubMed
    180. Weinacker A, Ferrando R, Elliott M, Hogg J, Balmes J, Sheppard D. Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways. Am J Respir Cell Mol Biol. 1995 May; 12(5):547-56. PMID: 7537970.
      View in: PubMed
    181. Stepp MA, Zhu L, Sheppard D, Cranfill RL. Localized distribution of alpha 9 integrin in the cornea and changes in expression during corneal epithelial cell differentiation. J Histochem Cytochem. 1995 Apr; 43(4):353-62. PMID: 7534781.
      View in: PubMed
    182. Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R. Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells. J Cell Sci. 1995 Feb; 108 ( Pt 2):537-44. PMID: 7768999.
      View in: PubMed
    183. Nikkari L, Haapasalmi K, Aho H, Torvinen A, Sheppard D, Larjava H, Heino J. Localization of the alpha v subfamily of integrins and their putative ligands in synovial lining cell layer. J Rheumatol. 1995 Jan; 22(1):16-23. PMID: 7535359.
      View in: PubMed
    184. Massion PP, Hébert CA, Leong S, Chan B, Inoue H, Grattan K, Sheppard D, Nadel JA. Staphylococcus aureus stimulates neutrophil recruitment by stimulating interleukin-8 production in dog trachea. Am J Physiol. 1995 Jan; 268(1 Pt 1):L85-94. PMID: 7840233.
      View in: PubMed
    185. Nishimura SL, Sheppard D, Pytela R. Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain. J Biol Chem. 1994 Nov 18; 269(46):28708-15. PMID: 7525578.
      View in: PubMed
    186. Yokosaki Y, Palmer EL, Prieto AL, Crossin KL, Bourdon MA, Pytela R, Sheppard D. The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin. J Biol Chem. 1994 Oct 28; 269(43):26691-6. PMID: 7523411.
      View in: PubMed
    187. Agrez M, Chen A, Cone RI, Pytela R, Sheppard D. The alpha v beta 6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain. J Cell Biol. 1994 Oct; 127(2):547-56. PMID: 7929593; PMCID: PMC2120218.
    188. Lukashev ME, Sheppard D, Pytela R. Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed beta 1 integrin cytoplasmic domain. J Biol Chem. 1994 Jul 15; 269(28):18311-4. PMID: 7518428.
      View in: PubMed
    189. Sheppard D. Dominant negative mutants: tools for the study of protein function in vitro and in vivo. Am J Respir Cell Mol Biol. 1994 Jul; 11(1):1-6. PMID: 8018332.
      View in: PubMed
    190. Cone RI, Weinacker A, Chen A, Sheppard D. Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin alpha v beta 6 to focal contacts. Cell Adhes Commun. 1994 Jun; 2(2):101-13. PMID: 8081887.
      View in: PubMed
    191. Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, Pytela R, Sheppard D. Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor. J Biol Chem. 1994 Mar 04; 269(9):6940-8. PMID: 8120056.
      View in: PubMed
    192. Pytela R, Suzuki S, Breuss J, Erle DJ, Sheppard D. Polymerase chain reaction cloning with degenerate primers: homology-based identification of adhesion molecules. Methods Enzymol. 1994; 245:420-51. PMID: 7760745.
      View in: PubMed
    193. Sheppard D. Identification and characterization of novel airway epithelial integrins. Am Rev Respir Dis. 1993 Dec; 148(6 Pt 2):S38-42. PMID: 8256923.
      View in: PubMed
    194. Palmer EL, Rüegg C, Ferrando R, Pytela R, Sheppard D. Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle. J Cell Biol. 1993 Dec; 123(5):1289-97. PMID: 8245132; PMCID: PMC2119880.
    195. Breuss JM, Gillett N, Lu L, Sheppard D, Pytela R. Restricted distribution of integrin beta 6 mRNA in primate epithelial tissues. J Histochem Cytochem. 1993 Oct; 41(10):1521-7. PMID: 8245410.
      View in: PubMed
    196. Royce S, Wald P, Sheppard D, Balmes J. Occupational asthma in a pesticides manufacturing worker. Chest. 1993 Jan; 103(1):295-6. PMID: 8417906.
      View in: PubMed
    197. Sheppard D, Cohen DS, Wang A, Busk M. Transforming growth factor beta differentially regulates expression of integrin subunits in guinea pig airway epithelial cells. J Biol Chem. 1992 Aug 25; 267(24):17409-14. PMID: 1512272.
      View in: PubMed
    198. Busk M, Pytela R, Sheppard D. Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein. J Biol Chem. 1992 Mar 25; 267(9):5790-6. PMID: 1532572.
      View in: PubMed
    199. Sheppard D, Erle D, Busk M, Pytela R. Identification of novel airway epithelial integrins using the homology-based polymerase chain reaction. Chest. 1992 Mar; 101(3 Suppl):49S. PMID: 1541204.
      View in: PubMed
    200. Gordon T, Balmes J, Fine J, Sheppard D. Airway oedema and obstruction in guinea pigs exposed to inhaled endotoxin. Br J Ind Med. 1991 Sep; 48(9):629-35. PMID: 1911406; PMCID: PMC1035436.
    201. Wang A, Cohen DS, Palmer E, Sheppard D. Polarized regulation of fibronectin secretion and alternative splicing by transforming growth factor. J Biol Chem. 1991 Aug 25; 266(24):15598-601. PMID: 1874718.
      View in: PubMed
    202. Cohen DS, Palmer E, Welch WJ, Sheppard D. The response of guinea pig airway epithelial cells and alveolar macrophages to environmental stress. Am J Respir Cell Mol Biol. 1991 Aug; 5(2):133-43. PMID: 1892643.
      View in: PubMed
    203. Erle DJ, Sheppard D, Breuss J, Rüegg C, Pytela R. Novel integrin alpha and beta subunit cDNAs identified in airway epithelial cells and lung leukocytes using the polymerase chain reaction. Am J Respir Cell Mol Biol. 1991 Aug; 5(2):170-7. PMID: 1892648.
      View in: PubMed
    204. Erle DJ, Rüegg C, Sheppard D, Pytela R. Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes. J Biol Chem. 1991 Jun 15; 266(17):11009-16. PMID: 2040616.
      View in: PubMed
    205. Aris R, Christian D, Sheppard D, Balmes JR. Lack of bronchoconstrictor response to sulfuric acid aerosols and fogs. Am Rev Respir Dis. 1991 Apr; 143(4 Pt 1):744-50. PMID: 2008986.
      View in: PubMed
    206. Aris R, Christian D, Sheppard D, Balmes JR. The effects of sequential exposure to acidic fog and ozone on pulmonary function in exercising subjects. Am Rev Respir Dis. 1991 Jan; 143(1):85-91. PMID: 1846067.
      View in: PubMed
    207. Sheppard D, Rozzo C, Starr L, Quaranta V, Erle DJ, Pytela R. Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction. J Biol Chem. 1990 Jul 15; 265(20):11502-7. PMID: 2365683.
      View in: PubMed
    208. Aris R, Christian D, Sheppard D, Balmes JR. Acid fog-induced bronchoconstriction. The role of hydroxymethanesulfonic acid. Am Rev Respir Dis. 1990 Mar; 141(3):546-51. PMID: 2155554.
      View in: PubMed
    209. Balmes JR, Fine JM, Gordon T, Sheppard D. Potential bronchoconstrictor stimuli in acid fog. Environ Health Perspect. 1989 Feb; 79:163-6. PMID: 2539989; PMCID: PMC1567583.
    210. Fine JM, Gordon T, Sheppard D. Epithelium removal alters responsiveness of guinea pig trachea to substance P. J Appl Physiol (1985). 1989 Jan; 66(1):232-7. PMID: 2465289.
      View in: PubMed
    211. Sheppard D. Sulfur dioxide and asthma--a double-edged sword? J Allergy Clin Immunol. 1988 Dec; 82(6):961-4. PMID: 3060513.
      View in: PubMed
    212. Sheppard D, Scypinski L. A tachykinin receptor antagonist inhibits and an inhibitor of tachykinin metabolism potentiates toluene diisocyanate-induced airway hyperresponsiveness in guinea pigs. Am Rev Respir Dis. 1988 Sep; 138(3):547-51. PMID: 2462379.
      View in: PubMed
    213. Balmes JR, Fine JM, Christian D, Gordon T, Sheppard D. Acidity potentiates bronchoconstriction induced by hypoosmolar aerosols. Am Rev Respir Dis. 1988 Jul; 138(1):35-9. PMID: 2849338.
      View in: PubMed
    214. Gordon T, Thompson JE, Sheppard D. Arachidonic acid metabolites do not mediate toluene diisocyanate-induced airway hyperresponsiveness in guinea pigs. Prostaglandins. 1988 May; 35(5):699-706. PMID: 2840688.
      View in: PubMed
    215. Gordon T, Sheppard D. Tumor necrosis factor inhibits a polymorphonuclear leukocyte-dependent airway edema in guinea pigs. J Appl Physiol (1985). 1988 Apr; 64(4):1688-92. PMID: 2837454.
      View in: PubMed
    216. Sheppard D, Thompson JE, Scypinski L, Dusser D, Nadel JA, Borson DB. Toluene diisocyanate increases airway responsiveness to substance P and decreases airway neutral endopeptidase. J Clin Invest. 1988 Apr; 81(4):1111-5. PMID: 2450892; PMCID: PMC329638.
    217. Turner JR, Corkery KJ, Eckman D, Gelb AM, Lipavsky A, Sheppard D. Equivalence of continuous flow nebulizer and metered-dose inhaler with reservoir bag for treatment of acute airflow obstruction. Chest. 1988 Mar; 93(3):476-81. PMID: 3342656.
      View in: PubMed
    218. Thompson JE, Sheppard D. Phosphoramidon potentiates the increase in lung resistance mediated by tachykinins in guinea pigs. Am Rev Respir Dis. 1988 Feb; 137(2):337-40. PMID: 2449105.
      View in: PubMed
    219. Sheppard D. Mechanisms of acute increases in airway responsiveness caused by environmental chemicals. J Allergy Clin Immunol. 1988 Jan; 81(1):128-32. PMID: 2828449.
      View in: PubMed
    220. Fine JM, Gordon T, Sheppard D. The roles of pH and ionic species in sulfur dioxide- and sulfite-induced bronchoconstriction. Am Rev Respir Dis. 1987 Nov; 136(5):1122-6. PMID: 3674574.
      View in: PubMed
    221. Balmes JR, Fine JM, Sheppard D. Symptomatic bronchoconstriction after short-term inhalation of sulfur dioxide. Am Rev Respir Dis. 1987 Nov; 136(5):1117-21. PMID: 3674573.
      View in: PubMed
    222. Sheppard D. What does exercise have to do with "exercise-induced" asthma? Am Rev Respir Dis. 1987 Sep; 136(3):547-9. PMID: 3631726.
      View in: PubMed
    223. Thompson JE, Scypinski LA, Gordon T, Sheppard D. Tachykinins mediate the acute increase in airway responsiveness caused by toluene diisocyanate in guinea pigs. Am Rev Respir Dis. 1987 Jul; 136(1):43-9. PMID: 2440357.
      View in: PubMed
    224. Gordon T, Milligan SA, Levin J, Thompson JE, Fine JM, Sheppard D. Apparent effect of catalase on airway edema in guinea pigs. Role of endotoxin contamination. Am Rev Respir Dis. 1987 Apr; 135(4):854-9. PMID: 3032030.
      View in: PubMed
    225. Fine JM, Gordon T, Thompson JE, Sheppard D. The role of titratable acidity in acid aerosol-induced bronchoconstriction. Am Rev Respir Dis. 1987 Apr; 135(4):826-30. PMID: 3551704.
      View in: PubMed
    226. Sheppard D. Physiology of the parasympathetic nervous system of the lung. Postgrad Med J. 1987; 63 Suppl 1:21-7. PMID: 3321011.
      View in: PubMed
    227. Thompson JE, Scypinski LA, Gordon T, Sheppard D. Hydroxyurea inhibits airway hyperresponsiveness in guinea pigs by a granulocyte-independent mechanism. Am Rev Respir Dis. 1986 Dec; 134(6):1213-8. PMID: 3024538.
      View in: PubMed
    228. Sheppard D. Mechanisms of bronchoconstriction from nonimmunologic environmental stimuli. Chest. 1986 Oct; 90(4):584-7. PMID: 3757569.
      View in: PubMed
    229. Myers DJ, Bigby BG, Calvayrac P, Sheppard D, Boushey HA. Interaction of cromolyn and a muscarinic antagonist in inhibiting bronchial reactivity to sulfur dioxide and to eucapnic hyperpnea alone. Am Rev Respir Dis. 1986 Jun; 133(6):1154-8. PMID: 2940953.
      View in: PubMed
    230. Bigby TD, Margolskee D, Curtis JL, Michael PF, Sheppard D, Hadley WK, Hopewell PC. The usefulness of induced sputum in the diagnosis of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. Am Rev Respir Dis. 1986 Apr; 133(4):515-8. PMID: 3485945.
      View in: PubMed
    231. Sheppard D, Scypinski L, Horn J, Gordon T, Thompson JE. Granulocyte-mediated airway edema in guinea pigs. J Appl Physiol (1985). 1986 Apr; 60(4):1213-20. PMID: 3009387.
      View in: PubMed
    232. Sheppard D, DiStefano S, Byrd RC, Eschenbacher WL, Bell V, Steck J, Laddu A. Effects of esmolol on airway function in patients with asthma. J Clin Pharmacol. 1986 Mar; 26(3):169-74. PMID: 2870080.
      View in: PubMed
    233. Sheppard D, Distefano S, Morse L, Becker C. Acute effects of routine firefighting on lung function. Am J Ind Med. 1986; 9(4):333-40. PMID: 3518426.
      View in: PubMed
    234. Gordon T, Sheppard D, McDonald DM, Distefano S, Scypinski L. Airway hyperresponsiveness and inflammation induced by toluene diisocyanate in guinea pigs. Am Rev Respir Dis. 1985 Nov; 132(5):1106-12. PMID: 2998244.
      View in: PubMed
    235. Tam EK, Geffroy BA, Myers DJ, Seltzer J, Sheppard D, Boushey HA. Effect of eucapnic hypoxia on bronchomotor tone and on the bronchomotor response to dry air in asthmatic subjects. Am Rev Respir Dis. 1985 Sep; 132(3):690-3. PMID: 3929659.
      View in: PubMed
    236. Siegel D, Sheppard D, Gelb A, Weinberg PF. Aminophylline increases the toxicity but not the efficacy of an inhaled beta-adrenergic agonist in the treatment of acute exacerbations of asthma. Am Rev Respir Dis. 1985 Aug; 132(2):283-6. PMID: 2862819.
      View in: PubMed
    237. Eschenbacher WL, Sheppard D. Respiratory heat loss is not the sole stimulus for bronchoconstriction induced by isocapnic hyperpnea with dry air. Am Rev Respir Dis. 1985 Jun; 131(6):894-901. PMID: 3923883.
      View in: PubMed
    238. Sheppard D. Pharmacotherapy of asthma. West J Med. 1985 May; 142(5):700-2. PMID: 2861694; PMCID: PMC1306164.
    239. Bethel RA, Sheppard D, Geffroy B, Tam E, Nadel JA, Boushey HA. Effect of 0.25 ppm sulfur dioxide on airway resistance in freely breathing, heavily exercising, asthmatic subjects. Am Rev Respir Dis. 1985 Apr; 131(4):659-61. PMID: 3994163.
      View in: PubMed
    240. Sheppard D, Eschenbacher WL, Epstein J. Lack of bronchomotor response to up to 3 ppm formaldehyde in subjects with asthma. Environ Res. 1984 Oct; 35(1):133-9. PMID: 6489284.
      View in: PubMed
    241. Eschenbacher WL, Bethel RA, Boushey HA, Sheppard D. Morphine sulfate inhibits bronchoconstriction in subjects with mild asthma whose responses are inhibited by atropine. Am Rev Respir Dis. 1984 Sep; 130(3):363-7. PMID: 6476586.
      View in: PubMed
    242. Bethel RA, Sheppard D, Epstein J, Tam E, Nadel JA, Boushey HA. Interaction of sulfur dioxide and dry cold air in causing bronchoconstriction in asthmatic subjects. J Appl Physiol Respir Environ Exerc Physiol. 1984 Aug; 57(2):419-23. PMID: 6469811.
      View in: PubMed
    243. Sheppard D, Eschenbacher WL, Boushey HA, Bethel RA. Magnitude of the interaction between the bronchomotor effects of sulfur dioxide and those of dry (cold) air. Am Rev Respir Dis. 1984 Jul; 130(1):52-5. PMID: 6742611.
      View in: PubMed
    244. Sheppard D, Eschenbacher WL. Respiratory water loss as a stimulus to exercise-induced bronchoconstriction. J Allergy Clin Immunol. 1984 May; 73(5 Pt 2):640-2. PMID: 6715729.
      View in: PubMed
    245. Eschenbacher WL, Boushey HA, Sheppard D. Alteration in osmolarity of inhaled aerosols cause bronchoconstriction and cough, but absence of a permeant anion causes cough alone. Am Rev Respir Dis. 1984 Feb; 129(2):211-5. PMID: 6696320.
      View in: PubMed
    246. Sheppard D, Epstein J, Skoogh BE, Bethel RA, Nadel JA, Boushey HA. Variable inhibition of histamine-induced bronchoconstriction by atropine in subjects with asthma. J Allergy Clin Immunol. 1984 Jan; 73(1 Pt 1):82-7. PMID: 6363488.
      View in: PubMed
    247. Bethel RA, Epstein J, Sheppard D, Nadel JA, Boushey HA. Sulfur dioxide-induced bronchoconstriction in freely breathing, exercising, asthmatic subjects. Am Rev Respir Dis. 1983 Dec; 128(6):987-90. PMID: 6650990.
      View in: PubMed
    248. Bethel RA, Erle DJ, Epstein J, Sheppard D, Nadel JA, Boushey HA. Effect of exercise rate and route of inhalation on sulfur-dioxide-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis. 1983 Oct; 128(4):592-6. PMID: 6354021.
      View in: PubMed
    249. Skoogh BE, Nadel JA, Fabbri LM, Sheppard D, Holtzman MJ. Antihistaminic versus anticholinergic effects of atropine on canine trachealis muscle. Am Rev Respir Dis. 1983 Oct; 128(4):603-6. PMID: 6137986.
      View in: PubMed
    250. Woo OF, Healey KM, Sheppard D, Tong TG. Chest pain and hypoxemia from inhalation of a trichloroethane aerosol product. J Toxicol Clin Toxicol. 1983 Jun; 20(4):333-41. PMID: 6689182.
      View in: PubMed
    251. Sheppard D, Rizk NW, Boushey HA, Bethel RA. Mechanism of cough and bronchoconstriction induced by distilled water aerosol. Am Rev Respir Dis. 1983 Jun; 127(6):691-4. PMID: 6407371.
      View in: PubMed
    252. Sheppard D, Epstein J, Bethel RA, Nadel JA, Boushey HA. Tolerance to sulfur dioxide-induced bronchoconstriction in subjects with asthma. Environ Res. 1983 Apr; 30(2):412-9. PMID: 6832125.
      View in: PubMed
    253. Sheppard D, Epstein J, Holtzman MJ, Nadel JA, Boushey HA. Effect of route of atropine delivery on bronchospasm from cold air and methacholine. J Appl Physiol Respir Environ Exerc Physiol. 1983 Jan; 54(1):130-3. PMID: 6337982.
      View in: PubMed
    254. Holtzman MJ, McNamara MP, Sheppard D, Fabbri LM, Hahn HL, Graf PD, Nadel JA. Intravenous versus inhaled atropine for inhibiting bronchoconstrictor responses in dogs. J Appl Physiol Respir Environ Exerc Physiol. 1983 Jan; 54(1):134-9. PMID: 6826397.
      View in: PubMed
    255. Sheppard D. Occupational asthma. West J Med. 1982 Dec; 137(6):480-5. PMID: 7164429; PMCID: PMC1274218.
    256. Kirkpatrick MB, Sheppard D, Nadel JA, Boushey HA. Effect of the oronasal breathing route on sulfur dioxide-induced bronchoconstriction in exercising asthmatic subjects. Am Rev Respir Dis. 1982 Jun; 125(6):627-31. PMID: 7091868.
      View in: PubMed
    257. Sheppard D, Nadel JA, Boushey HA. Inhibition of sulfur dioxide-induced bronchoconstriction by disodium cromoglycate in asthmatic subjects. Am Rev Respir Dis. 1981 Sep; 124(3):257-9. PMID: 6792956.
      View in: PubMed
    258. Sheppard D, Saisho A, Nadel JA, Boushey HA. Exercise increases sulfur dioxide-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis. 1981 May; 123(5):486-91. PMID: 7235370.
      View in: PubMed
    259. Sheppard D, Wong WS, Uehara CF, Nadel JA, Boushey HA. Lower threshold and greater bronchomotor responsiveness of asthmatic subjects to sulfur dioxide. Am Rev Respir Dis. 1980 Dec; 122(6):873-8. PMID: 7458061.
      View in: PubMed
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