Mark Anderson, MD, PhD

Title(s)Professor, Diabetes Center
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW
San Francisco CA 94143
Phone415-502-8052
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    Collapse Biography 
    Collapse Education and Training
    University of ChicagoM.D.1994Pritzker School of Medicine
    University of ChicagoPhD1992Immunology
    Collapse Awards and Honors
    2004Pew Scholar
    2009Robert B. Friend and Michelle M. Friend Endowed Chair in Diabetes Research
    2009American Society of Clinical Investigation
    UCSF2012Byers Award in Basic Science
    2016American Association of Physicians
    University of Chicago2019Distinguished Alumni Award
    2020National Academy of Medicine

    Collapse Overview 
    Collapse Overview
    EDUCATION/CLINICAL TRAINING
    MD: MD, PhD, University of Chicago, 1994
    Residency: University of Minnesota, MD, Internal Medicine, 1994-1997
    Chief Resident, University of Minnesota 1997-1998
    Fellowship: Massachusetts General Hospital, Adult Endocrinology, 1998-2001
    Board Certification: Endocrinology and Metabolism, 2001, Renewed 2012

    ACADEMIC INTERESTS
    The main research interest of our laboratory group is to examine the genetic control of autoimmune diseases to gain a better understanding of the mechanisms by which immune tolerance is broken. A major focus of our lab group is a human autoimmune syndrome called Autoimmune Polyglandular Syndrome Type 1 (APS1 or APECED), which is classically manifested by an autoimmune attack directed at multiple endocrine organs. This disease is inherited in a monogenic autosomal recessive fashion and the defective gene has been identified and is called Aire (for autoimmune regulator). Aire knockout mice, like their human counterparts, develop an autoimmune disease that is targeted to multiple organs. Through the use of the mouse model we, along with others, have determined that Aire plays an important role in immune tolerance by promoting the expression of many self proteins in specialized antigen presenting cells in the thymus called medullary epithelial cells (mTEC’s).

    Recently, we have determined that this process is not only critical in the thymus, but also in peripheral lymphoid organs. Current studies in the lab are directed at further understanding the relative contribution of specialized Aire-expressing cells to immune tolerance in multiple autoimmune disease models. In addition to these ongoing studies, our laboratory is also interested the pathogenesis of autoimmune diabetes and in developing other models of autoimmune disease by using transgenic, knockout, and knock-in approaches.



    CLINICAL INTERESTS:
    Type 1 diabetes and associated autoimmune disorders

    Appointments: 415-353-2350

    Collapse Research 
    Collapse Research Activities and Funding
    Medical Scientist Training Program (T32 NRSA Training Grant)
    NIH T32GM141323Jul 1, 2021 - Jun 30, 2026
    Role: Principal Investigator
    Modeling autoimmune pathogenesis and beta cell destruction by T1D immune systems
    NIH U01DK123559Sep 20, 2019 - May 31, 2023
    Role: Co-Principal Investigator
    Using human stem cell-derived thymic epithelium to remodel T1D immune tolerance
    NIH U01DK107383Jul 1, 2016 - Dec 31, 2020
    Role: Principal Investigator
    Using human stem cell-derived thymic epithelium to remodel T1D immune tolerance
    NIH/NIDDK R01DK107383Jul 1, 2016 - Jun 30, 2020
    Role: Principal Investigator
    Disruption of T cell tolerance in type 1 diabetes
    NIH P01AI118688Jun 8, 2016 - May 31, 2021
    Role: Principal Investigator
    Developing eTACs as a Novel Method of Tolerance in Type 1 Diabetes
    NIH R01DK101622Apr 2, 2014 - Mar 31, 2019
    Role: Principal Investigator
    Thymic medullary epithelial cell turnover and control of immune tolerance
    NIH R37AI097457Dec 1, 2011 - Jun 30, 2022
    Role: Principal Investigator
    Thymic medullary epithelial cell turnover and control of immune tolerance
    NIH R01AI097457Dec 1, 2011 - Jul 20, 2017
    Role: Principal Investigator
    Aire-defieciency as a novel model of uveitis
    NIH R01EY016408Jun 1, 2005 - Jun 30, 2015
    Role: Principal Investigator
    Role of the AIRE Gene in the Development of Autoimmunity
    NIH K08DK059958Sep 1, 2002 - Aug 31, 2008
    Role: Principal Investigator
    Immune Tolerance and Autoimmunity
    NIH P01AI035297Sep 1, 1997 - Jul 31, 2012
    Role: Co-Investigator
    Medical Scientist Training Program
    NIH T32GM007618Jul 1, 1978 - Jun 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Response to Comments on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections". Science. 2021 09 17; 373(6561):eabi8835. Break TJ, Oikonomou V, Dutzan N, Desai JV, Swidergall M, Freiwald T, Chauss D, Harrison OJ, Alejo J, Williams DW, Pittaluga S, Lee CR, Bouladoux N, Swamydas M, Hoffman KW, Greenwell-Wild T, Bruno VM, Rosen LB, Lwin W, Renteria A, Pontejo SM, Shannon JP, Myles IA, Olbrich P, Ferré EMN, Schmitt M, Martin D, Genomics and Computational Biology Core16 , Barber DL, Solis NV, Notarangelo LD, Serreze DV, Matsumoto M, Hickman HD, Murphy PM, Anderson MS, Lim JK, Holland SM, Filler SG, Afzali B, Belkaid Y, Moutsopoulos NM, Lionakis MS. PMID: 34529475.
      View in: PubMed   Mentions:    Fields:    
    2. Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19. Sci Transl Med. 2021 Aug 24. van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, Greenhouse B, Lionakis MS, Norris PJ, Dumont LJ, Kelly K, Zhang P, Zhang Q, Gervais A, Le Voyer T, Whatley A, Si Y, Byrne A, Combes AJ, Rao AA, Song YS, Fragiadakis GK, Kangelaris K, Calfee CS, Erle DJ, Hendrickson C, Krummel MF, Woodruff PG, Langelier CR, Casanova JL, Derisi JL, Anderson MS, Ye CJ, UCSF COMET consortium . PMID: 34429372.
      View in: PubMed   Mentions: 1     Fields:    
    3. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths. Sci Immunol. 2021 08 19; 6(62). Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, Manry J, Michailidis E, Hoffmann HH, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Haljasmägi L, Migaud M, Särekannu K, Maslovskaja J, de Prost N, Tandjaoui-Lambiotte Y, Luyt CE, Amador-Borrero B, Gaudet A, Poissy J, Morel P, Richard P, Cognasse F, Troya J, Trouillet-Assant S, Belot A, Saker K, Garçon P, Rivière JG, Lagier JC, Gentile S, Rosen LB, Shaw E, Morio T, Tanaka J, Dalmau D, Tharaux PL, Sene D, Stepanian A, Megarbane B, Triantafyllia V, Fekkar A, Heath JR, Franco JL, Anaya JM, Solé-Violán J, Imberti L, Biondi A, Bonfanti P, Castagnoli R, Delmonte OM, Zhang Y, Snow AL, Holland SM, Biggs C, Moncada-Vélez M, Arias AA, Lorenzo L, Boucherit S, Coulibaly B, Anglicheau D, Planas AM, Haerynck F, Duvlis S, Nussbaum RL, Ozcelik T, Keles S, Bousfiha AA, El Bakkouri J, Ramirez-Santana C, Paul S, Pan-Hammarström Q, Hammarström L, Dupont A, Kurolap A, Metz CN, Aiuti A, Casari G, Lampasona V, Ciceri F, Barreiros LA, Dominguez-Garrido E, Vidigal M, Zatz M, van de Beek D, Sahanic S, Tancevski I, Stepanovskyy Y, Boyarchuk O, Nukui Y, Tsumura M, Vidaur L, Tangye SG, Burrel S, Duffy D, Quintana-Murci L, Klocperk A, Kann NY, Shcherbina A, Lau YL, Leung D, Coulongeat M, Marlet J, Koning R, Reyes LF, Chauvineau-Grenier A, Venet F, Monneret G, Nussenzweig MC, Arrestier R, Boudhabhay I, Baris-Feldman H, Hagin D, Wauters J, Meyts I, Dyer AH, Kennelly SP, Bourke NM, Halwani R, Sharif-Askari NS, Dorgham K, Sallette J, Sedkaoui SM, AlKhater S, Rigo-Bonnin R, Morandeira F, Roussel L, Vinh DC, Ostrowski SR, Condino-Neto A, Prando C, Bonradenko A, Spaan AN, Gilardin L, Fellay J, Lyonnet S, Bilguvar K, Lifton RP, Mane S, HGID Lab , COVID Clinicians , COVID-STORM Clinicians , NIAID Immune Response to COVID Group , NH-COVAIR Study Group , Danish CHGE , Danish Blood Donor Study , St. James's Hospital , SARS CoV2 Interest group , French COVID Cohort Study Group , Imagine COVID-Group , Milieu Intérieur Consortium , CoV-Contact Cohort , Amsterdam UMC Covid-19 , Biobank Investigators , COVID Human Genetic Effort , CONSTANCES cohort , 3C-Dijon Study , Cerba Health-Care , Etablissement du Sang study group , Anderson MS, Boisson B, Béziat V, Zhang SY, Vandreakos E, Hermine O, Pujol A, Peterson P, Mogensen TH, Rowen L, Mond J, Debette S, de Lamballerie X, Duval X, Mentré F, Zins M, Soler-Palacin P, Colobran R, Gorochov G, Solanich X, Susen S, Martinez-Picado J, Raoult D, Vasse M, Gregersen PK, Piemonti L, Rodríguez-Gallego C, Notarangelo LD, Su HC, Kisand K, Okada S, Puel A, Jouanguy E, Rice CM, Tiberghien P, Zhang Q, Cobat A, Abel L, Casanova JL. PMID: 34413139.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Extrathymic Aire-expressing cells support maternal-fetal tolerance. Sci Immunol. 2021 Jul 16; 6(61). Gillis-Buck E, Miller H, Sirota M, Sanders SJ, Ntranos V, Anderson MS, Gardner JM, MacKenzie TC. PMID: 34272228.
      View in: PubMed   Mentions:    Fields:    
    5. Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1. J Exp Med. 2021 07 05; 218(7). Bastard P, Orlova E, Sozaeva L, Lévy R, James A, Schmitt MM, Ochoa S, Kareva M, Rodina Y, Gervais A, Le Voyer T, Rosain J, Philippot Q, Neehus AL, Shaw E, Migaud M, Bizien L, Ekwall O, Berg S, Beccuti G, Ghizzoni L, Thiriez G, Pavot A, Goujard C, Frémond ML, Carter E, Rothenbuhler A, Linglart A, Mignot B, Comte A, Cheikh N, Hermine O, Breivik L, Husebye ES, Humbert S, Rohrlich P, Coaquette A, Vuoto F, Faure K, Mahlaoui N, Kotnik P, Battelino T, Trebušak Podkrajšek K, Kisand K, Ferré EMN, DiMaggio T, Rosen LB, Burbelo PD, McIntyre M, Kann NY, Shcherbina A, Pavlova M, Kolodkina A, Holland SM, Zhang SY, Crow YJ, Notarangelo LD, Su HC, Abel L, Anderson MS, Jouanguy E, Neven B, Puel A, Casanova JL, Lionakis MS. PMID: 33890986.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    6. Diabetes With Multiple Autoimmune and Inflammatory Conditions Linked to an Activating SKAP2 Mutation. Diabetes Care. 2021 Aug; 44(8):1816-1825. Rutsch N, Chamberlain CE, Dixon W, Spector L, Letourneau-Freiberg LR, Lwin WW, Philipson LH, Zarbock A, Saintus K, Wang J, German MS, Anderson MS, Lowell CA. PMID: 34172489.
      View in: PubMed   Mentions:    Fields:    
    7. A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance. J Exp Med. 2021 Aug 02; 218(8). Warshauer JT, Belk JA, Chan AY, Wang J, Gupta AR, Shi Q, Skartsis N, Peng Y, Phipps JD, Acenas D, Smith JA, Tamaki SJ, Tang Q, Gardner JM, Satpathy AT, Anderson MS. PMID: 34115115.
      View in: PubMed   Mentions: 1     Fields:    
    8. Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree. Elife. 2021 May 19; 10. Hendley AM, Rao AA, Leonhardt L, Ashe S, Smith JA, Giacometti S, Peng XL, Jiang H, Berrios DI, Pawlak M, Li LY, Lee J, Collisson EA, Anderson MS, Fragiadakis GK, Yeh JJ, Ye CJ, Kim GE, Weaver VM, Hebrok M. PMID: 34009124.
      View in: PubMed   Mentions:    Fields:    
    9. Neutralizing Autoantibodies to Type I Interferons in COVID-19 Convalescent Donor Plasma. J Clin Immunol. 2021 08; 41(6):1169-1171. Vazquez SE, Bastard P, Kelly K, Gervais A, Norris PJ, Dumont LJ, Casanova JL, Anderson MS, DeRisi JL. PMID: 34009544.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19. bioRxiv. 2021 Mar 10. van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, Greenhouse B, Lionakis MS, Norris PJ, Dumont LJ, Kelly K, Zhang P, Zhang Q, Gervais A, Voyer TL, Whatley A, Si Y, Byrne A, Combes AJ, Rao AA, Song YS, UCSF COMET consortium , Fragiadakis GK, Kangelaris K, Calfee CS, Erle DJ, Hendrickson C, Krummel MF, Woodruff PG, Langelier CR, Casanova JL, Derisi JL, Anderson MS, Ye CJ. PMID: 33758859.
      View in: PubMed   Mentions:
    11. Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla. Nat Commun. 2021 02 17; 12(1):1096. Bautista JL, Cramer NT, Miller CN, Chavez J, Berrios DI, Byrnes LE, Germino J, Ntranos V, Sneddon JB, Burt TD, Gardner JM, Ye CJ, Anderson MS, Parent AV. PMID: 33597545.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. Aberrant type 1 immunity drives susceptibility to mucosal fungal infections. Science. 2021 01 15; 371(6526). Break TJ, Oikonomou V, Dutzan N, Desai JV, Swidergall M, Freiwald T, Chauss D, Harrison OJ, Alejo J, Williams DW, Pittaluga S, Lee CR, Bouladoux N, Swamydas M, Hoffman KW, Greenwell-Wild T, Bruno VM, Rosen LB, Lwin W, Renteria A, Pontejo SM, Shannon JP, Myles IA, Olbrich P, Ferré EMN, Schmitt M, Martin D, Genomics and Computational Biology Core , Barber DL, Solis NV, Notarangelo LD, Serreze DV, Matsumoto M, Hickman HD, Murphy PM, Anderson MS, Lim JK, Holland SM, Filler SG, Afzali B, Belkaid Y, Moutsopoulos NM, Lionakis MS. PMID: 33446526.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    13. More on STAT1 Gain of Function, Type 1 Diabetes, and JAK Inhibition. Reply. N Engl J Med. 2021 01 07; 384(1):93-94. Anderson MS, Chaimowitz NS, Forbes LR. PMID: 33406352.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Combined transient ablation and single-cell RNA-sequencing reveals the development of medullary thymic epithelial cells. Elife. 2020 11 23; 9. Wells KL, Miller CN, Gschwind AR, Wei W, Phipps JD, Anderson MS, Steinmetz LM. PMID: 33226342.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    15. STAT1 Gain of Function, Type 1 Diabetes, and Reversal with JAK Inhibition. N Engl J Med. 2020 10 08; 383(15):1494-1496. Chaimowitz NS, Ebenezer SJ, Hanson IC, Anderson M, Forbes LR. PMID: 33027576.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020 10 23; 370(6515). Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V, Manry J, Shaw E, Haljasmägi L, Peterson P, Lorenzo L, Bizien L, Trouillet-Assant S, Dobbs K, de Jesus AA, Belot A, Kallaste A, Catherinot E, Tandjaoui-Lambiotte Y, Le Pen J, Kerner G, Bigio B, Seeleuthner Y, Yang R, Bolze A, Spaan AN, Delmonte OM, Abers MS, Aiuti A, Casari G, Lampasona V, Piemonti L, Ciceri F, Bilguvar K, Lifton RP, Vasse M, Smadja DM, Migaud M, Hadjadj J, Terrier B, Duffy D, Quintana-Murci L, van de Beek D, Roussel L, Vinh DC, Tangye SG, Haerynck F, Dalmau D, Martinez-Picado J, Brodin P, Nussenzweig MC, Boisson-Dupuis S, Rodríguez-Gallego C, Vogt G, Mogensen TH, Oler AJ, Gu J, Burbelo PD, Cohen JI, Biondi A, Bettini LR, D'Angio M, Bonfanti P, Rossignol P, Mayaux J, Rieux-Laucat F, Husebye ES, Fusco F, Ursini MV, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Castagnoli R, Montagna D, Licari A, Marseglia GL, Duval X, Ghosn J, HGID Lab , NIAID-USUHS Immune Response to COVID Group , COVID Clinicians , COVID-STORM Clinicians , Imagine COVID Group , French COVID Cohort Study Group , Milieu Intérieur Consortium , CoV-Contact Cohort , Amsterdam UMC Covid-19 Biobank , COVID Human Genetic Effort , Tsang JS, Goldbach-Mansky R, Kisand K, Lionakis MS, Puel A, Zhang SY, Holland SM, Gorochov G, Jouanguy E, Rice CM, Cobat A, Notarangelo LD, Abel L, Su HC, Casanova JL. PMID: 32972996.
      View in: PubMed   Mentions: 425     Fields:    Translation:HumansCellsPHPublic Health
    17. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science. 2020 10 23; 370(6515). Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C, Rosain J, Bilguvar K, Ye J, Bolze A, Bigio B, Yang R, Arias AA, Zhou Q, Zhang Y, Onodi F, Korniotis S, Karpf L, Philippot Q, Chbihi M, Bonnet-Madin L, Dorgham K, Smith N, Schneider WM, Razooky BS, Hoffmann HH, Michailidis E, Moens L, Han JE, Lorenzo L, Bizien L, Meade P, Neehus AL, Ugurbil AC, Corneau A, Kerner G, Zhang P, Rapaport F, Seeleuthner Y, Manry J, Masson C, Schmitt Y, Schlüter A, Le Voyer T, Khan T, Li J, Fellay J, Roussel L, Shahrooei M, Alosaimi MF, Mansouri D, Al-Saud H, Al-Mulla F, Almourfi F, Al-Muhsen SZ, Alsohime F, Al Turki S, Hasanato R, van de Beek D, Biondi A, Bettini LR, D'Angio' M, Bonfanti P, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Oler AJ, Tompkins MF, Alba C, Vandernoot I, Goffard JC, Smits G, Migeotte I, Haerynck F, Soler-Palacin P, Martin-Nalda A, Colobran R, Morange PE, Keles S, Çölkesen F, Ozcelik T, Yasar KK, Senoglu S, Karabela SN, Rodríguez-Gallego C, Novelli G, Hraiech S, Tandjaoui-Lambiotte Y, Duval X, Laouénan C, COVID-STORM Clinicians , COVID Clinicians , Imagine COVID Group , French COVID Cohort Study Group , CoV-Contact Cohort , Amsterdam UMC Covid-19 Biobank , COVID Human Genetic Effort , NIAID-USUHS/TAGC COVID Immunity Group , Snow AL, Dalgard CL, Milner JD, Vinh DC, Mogensen TH, Marr N, Spaan AN, Boisson B, Boisson-Dupuis S, Bustamante J, Puel A, Ciancanelli MJ, Meyts I, Maniatis T, Soumelis V, Amara A, Nussenzweig M, García-Sastre A, Krammer F, Pujol A, Duffy D, Lifton RP, Zhang SY, Gorochov G, Béziat V, Jouanguy E, Sancho-Shimizu V, Rice CM, Abel L, Notarangelo LD, Cobat A, Su HC, Casanova JL. PMID: 32972995.
      View in: PubMed   Mentions: 380     Fields:    Translation:HumansCellsPHPublic Health
    18. Tolerance in the Age of Immunotherapy. N Engl J Med. 2020 09 17; 383(12):1156-1166. Bluestone JA, Anderson M. PMID: 32937048.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    19. Autoimmune Endocrinopathies: An Emerging Complication of Immune Checkpoint Inhibitors. Annu Rev Med. 2021 01 27; 72:313-330. Quandt Z, Young A, Perdigoto AL, Herold KC, Anderson MS. PMID: 32886542.
      View in: PubMed   Mentions: 2     Fields:    
    20. Evaluation of SARS-CoV-2 serology assays reveals a range of test performance. Nat Biotechnol. 2020 10; 38(10):1174-1183. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk RP, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. PMID: 32855547.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCellsPHPublic Health
    21. High-resolution epitope mapping of anti-Hu and anti-Yo autoimmunity by programmable phage display. Brain Commun. 2020; 2(2):fcaa059. O'Donovan B, Mandel-Brehm C, Vazquez SE, Liu J, Parent AV, Anderson MS, Kassimatis T, Zekeridou A, Hauser SL, Pittock SJ, Chow E, Wilson MR, DeRisi JL. PMID: 32954318.
      View in: PubMed   Mentions:
    22. Test performance evaluation of SARS-CoV-2 serological assays. medRxiv. 2020 May 17. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk R, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. PMID: 32511497.
      View in: PubMed   Mentions:
    23. Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq. Elife. 2020 05 15; 9. Vazquez SE, Ferré EM, Scheel DW, Sunshine S, Miao B, Mandel-Brehm C, Quandt Z, Chan AY, Cheng M, German M, Lionakis M, DeRisi JL, Anderson MS. PMID: 32410729.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    24. GILT in Thymic Epithelial Cells Facilitates Central CD4 T Cell Tolerance to a Tissue-Restricted, Melanoma-Associated Self-Antigen. J Immunol. 2020 06 01; 204(11):2877-2886. Rausch MP, Meador LR, Metzger TC, Li H, Qiu S, Anderson MS, Hastings KT. PMID: 32269095.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    25. The Molecular Medicine Investigation Unit: Linking Patient Care and Scientific Inquiry in Physician-Scientist Training. J Grad Med Educ. 2020 Feb; 12(1):92-97. Berger A, Matloubian M, Shah NP, Wachter RM, DeRisi JL, Anderson M. PMID: 32089799.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. New Frontiers in the Treatment of Type 1 Diabetes. Cell Metab. 2020 01 07; 31(1):46-61. Warshauer JT, Bluestone JA, Anderson MS. PMID: 31839487.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    27. Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes. Diabetes Care. 2020 01; 43(1):5-12. Battaglia M, Ahmed S, Anderson MS, Atkinson MA, Becker D, Bingley PJ, Bosi E, Brusko TM, DiMeglio LA, Evans-Molina C, Gitelman SE, Greenbaum CJ, Gottlieb PA, Herold KC, Hessner MJ, Knip M, Jacobsen L, Krischer JP, Long SA, Lundgren M, McKinney EF, Morgan NG, Oram RA, Pastinen T, Peters MC, Petrelli A, Qian X, Redondo MJ, Roep BO, Schatz D, Skibinski D, Peakman M. PMID: 31753960.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    28. Landscape of stimulation-responsive chromatin across diverse human immune cells. Nat Genet. 2019 10; 51(10):1494-1505. Calderon D, Nguyen MLT, Mezger A, Kathiria A, Müller F, Nguyen V, Lescano N, Wu B, Trombetta J, Ribado JV, Knowles DA, Gao Z, Blaeschke F, Parent AV, Burt TD, Anderson MS, Criswell LA, Greenleaf WJ, Marson A, Pritchard JK. PMID: 31570894.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
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    98. An autoimmune response to odorant binding protein 1a is associated with dry eye in the Aire-deficient mouse. J Immunol. 2010 Apr 15; 184(8):4236-46. DeVoss JJ, LeClair NP, Hou Y, Grewal NK, Johannes KP, Lu W, Yang T, Meagher C, Fong L, Strauss EC, Anderson MS. PMID: 20237294.
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    99. Acquired autoimmune polyglandular syndrome, thymoma, and an AIRE defect. N Engl J Med. 2010 Feb 25; 362(8):764-6. Cheng MH, Fan U, Grewal N, Barnes M, Mehta A, Taylor S, Husebye ES, Murphy EJ, Anderson MS. PMID: 20181983.
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    100. Identification of an autoantigen demonstrates a link between interstitial lung disease and a defect in central tolerance. Sci Transl Med. 2009 Dec 02; 1(9):9ra20. Shum AK, DeVoss J, Tan CL, Hou Y, Johannes K, O'Gorman CS, Jones KD, Sochett EB, Fong L, Anderson MS. PMID: 20368189.
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    101. AIRE in the thymus and beyond. Curr Opin Immunol. 2009 Dec; 21(6):582-9. Gardner JM, Fletcher AL, Anderson MS, Turley SJ. PMID: 19833494.
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    102. The sickness unto Deaf. Nat Immunol. 2009 Sep; 10(9):934-6. Gardner JM, Anderson MS. PMID: 19692991.
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    103. An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans. J Clin Invest. 2009 Jul; 119(7):2031-41. Hou Y, DeVoss J, Dao V, Kwek S, Simko JP, McNeel DG, Anderson MS, Fong L. PMID: 19603556.
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    104. Monogenic autoimmune diseases: insights into self-tolerance. Pediatr Res. 2009 May; 65(5 Pt 2):20R-25R. Su MA, Anderson MS. PMID: 19190526.
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    105. A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy. J Exp Med. 2009 Mar 16; 206(3):507-14. Louvet C, Kabre BG, Davini DW, Martinier N, Su MA, DeVoss JJ, Rosenthal WL, Anderson MS, Bour-Jordan H, Bluestone JA. PMID: 19221395.
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    106. The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patients. Clin Immunol. 2009 Apr; 131(1):139-44. Su MA, Stenerson M, Liu W, Putnam A, Conte F, Bluestone JA, Anderson MS. PMID: 19150256.
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    107. Update in endocrine autoimmunity. J Clin Endocrinol Metab. 2008 Oct; 93(10):3663-70. Anderson MS. PMID: 18842982.
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    108. Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1. J Immunol. 2008 Sep 15; 181(6):4072-9. Devoss JJ, Shum AK, Johannes KP, Lu W, Krawisz AK, Wang P, Yang T, Leclair NP, Austin C, Strauss EC, Anderson MS. PMID: 18768863.
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    109. Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med. 2008 Sep 01; 205(9):1983-91. Zhou X, Jeker LT, Fife BT, Zhu S, Anderson MS, McManus MT, Bluestone JA. PMID: 18725525.
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    110. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science. 2008 Aug 08; 321(5890):843-7. Gardner JM, Devoss JJ, Friedman RS, Wong DJ, Tan YX, Zhou X, Johannes KP, Su MA, Chang HY, Krummel MF, Anderson MS. PMID: 18687966.
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    111. Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire. J Clin Invest. 2008 May; 118(5):1712-26. Su MA, Giang K, Zumer K, Jiang H, Oven I, Rinn JL, Devoss JJ, Johannes KP, Lu W, Gardner J, Chang A, Bubulya P, Chang HY, Peterlin BM, Anderson MS. PMID: 18414681.
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    112. Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease. Invest Ophthalmol Vis Sci. 2008 Jan; 49(1):34-41. Li S, Nikulina K, DeVoss J, Wu AJ, Strauss EC, Anderson MS, McNamara NA. PMID: 18172072.
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    113. A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1. Clin Immunol. 2007 Nov; 125(2):131-7. Zhang L, Barker JM, Babu S, Su M, Stenerson M, Cheng M, Shum A, Zamir E, Badolato R, Law A, Eisenbarth GS, Anderson MS. PMID: 17825626.
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    114. What's new in the Aire? Trends Immunol. 2007 Jul; 28(7):321-7. Cheng MH, Shum AK, Anderson MS. PMID: 17556019.
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    115. Lessons on immune tolerance from the monogenic disease APS1. Curr Opin Genet Dev. 2007 Jun; 17(3):193-200. DeVoss JJ, Anderson MS. PMID: 17466510.
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    116. Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J Exp Med. 2006 Nov 27; 203(12):2727-35. DeVoss J, Hou Y, Johannes K, Lu W, Liou GI, Rinn J, Chang H, Caspi RR, Caspi R, Fong L, Anderson MS. PMID: 17116738.
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    117. Modifier loci condition autoimmunity provoked by Aire deficiency. J Exp Med. 2005 Sep 19; 202(6):805-15. Jiang W, Anderson MS, Bronson R, Mathis D, Benoist C. PMID: 16172259.
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    118. The cellular mechanism of Aire control of T cell tolerance. Immunity. 2005 Aug; 23(2):227-39. Anderson MS, Venanzi ES, Chen Z, Berzins SP, Benoist C, Mathis D. PMID: 16111640.
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    119. The NOD mouse: a model of immune dysregulation. Annu Rev Immunol. 2005; 23:447-85. Anderson MS, Bluestone JA. PMID: 15771578.
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    120. Aire: an update. Curr Opin Immunol. 2004 Dec; 16(6):746-52. Su MA, Anderson MS. PMID: 15511668.
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    121. Autoimmune endocrine disease. Curr Opin Immunol. 2002 Dec; 14(6):760-4. Anderson MS. PMID: 12413526.
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    122. Projection of an immunological self shadow within the thymus by the aire protein. Science. 2002 Nov 15; 298(5597):1395-401. Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ, von Boehmer H, Bronson R, Dierich A, Benoist C, Mathis D. PMID: 12376594.
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    123. Enhanced antigen presentation in the absence of the invariant chain endosomal localization signal. J Exp Med. 1993 Dec 01; 178(6):1959-69. Anderson MS, Swier K, Arneson L, Miller J. PMID: 7902408.
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    124. Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2282-6. Anderson MS, Miller J. PMID: 1549594.
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