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    Mark Anderson, MD, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentDiabetes Center
    Address513 Parnassus Ave
    San Francisco CA 94143
    Phone415-502-8052

       Biography 
       Awards and Honors
      2004Pew Scholar
      2009Robert B. Friend and Michelle M. Friend Endowed Chair in Diabetes Research
      UCSF2012Byers Award in Basic Science

       Overview 
       Overview
      EDUCATION/CLINICAL TRAINING
      MD: MD, PhD, University of Chicago, 1994
      Residency: University of Minnesota, MD, Internal Medicine, 1994-1997
      Chief Resident, University of Minnesota 1997-1998
      Fellowship: Massachusetts General Hospital, Adult Endocrinology, 1998-2001
      Board Certification: Endocrinology and Metabolism, 2001, Renewed 2012

      ACADEMIC INTERESTS
      The main research interest of our laboratory group is to examine the genetic control of autoimmune diseases to gain a better understanding of the mechanisms by which immune tolerance is broken. A major focus of our lab group is a human autoimmune syndrome called Autoimmune Polyglandular Syndrome Type 1 (APS1 or APECED), which is classically manifested by an autoimmune attack directed at multiple endocrine organs. This disease is inherited in a monogenic autosomal recessive fashion and the defective gene has been identified and is called Aire (for autoimmune regulator). Aire knockout mice, like their human counterparts, develop an autoimmune disease that is targeted to multiple organs. Through the use of the mouse model we, along with others, have determined that Aire plays an important role in immune tolerance by promoting the expression of many self proteins in specialized antigen presenting cells in the thymus called medullary epithelial cells (mTEC’s).

      Recently, we have determined that this process is not only critical in the thymus, but also in peripheral lymphoid organs. Current studies in the lab are directed at further understanding the relative contribution of specialized Aire-expressing cells to immune tolerance in multiple autoimmune disease models. In addition to these ongoing studies, our laboratory is also interested the pathogenesis of autoimmune diabetes and in developing other models of autoimmune disease by using transgenic, knockout, and knock-in approaches.



      CLINICAL INTERESTS:
      Type 1 diabetes and associated autoimmune disorders

      Appointments: 415-353-2350


       ORNG Applications 
       Websites
       Global Health
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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Khan IS, Mouchess ML, Zhu ML, Conley B, Fasano KJ, Hou Y, Fong L, Su MA, Anderson MS. Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance. J Exp Med. 2014 May 5; 211(5):761-8.
        View in: PubMed
      2. Chen YF, Zhou D, Metzger T, Gallup M, Jeanne M, Gould DB, Anderson MS, McNamara NA. Spontaneous Development of Autoimmune Uveitis Is CCR2 Dependent. Am J Pathol. 2014 Jun; 184(6):1695-705.
        View in: PubMed
      3. Schafer AL, Mumm S, El-Sayed I, McAlister WH, Horvai AE, Tom AM, Hsiao EC, Schaefer FV, Collins MT, Anderson MS, Whyte MP, Shoback DM. Panostotic Expansile Bone Disease With Massive Jaw Tumor Formation and a Novel Mutation in the Signal Peptide of RANK. J Bone Miner Res. 2014 Apr; 29(4):911-21.
        View in: PubMed
      4. Khan IS, Taniguchi RT, Fasano KJ, Anderson MS, Jeker LT. Canonical microRNAs in thymic epithelial cells promote central tolerance. Eur J Immunol. 2014 May; 44(5):1313-9.
        View in: PubMed
      5. Waterfield M, Khan IS, Cortez JT, Fan U, Metzger T, Greer A, Fasano K, Martinez-Llordella M, Pollack JL, Erle DJ, Su M, Anderson MS. The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance. Nat Immunol. 2014 Mar; 15(3):258-65.
        View in: PubMed
      6. Price JV, Haddon DJ, Kemmer D, Delepine G, Mandelbaum G, Jarrell JA, Gupta R, Balboni I, Chakravarty EF, Sokolove J, Shum AK, Anderson MS, Cheng MH, Robinson WH, Browne SK, Holland SM, Baechler EC, Utz PJ. Protein microarray analysis reveals BAFF-binding autoantibodies in systemic lupus erythematosus. J Clin Invest. 2013 Dec 2; 123(12):5135-45.
        View in: PubMed
      7. Mohan JF, Calderon B, Anderson MS, Unanue ER. Pathogenic CD4? T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes. J Exp Med. 2013 Oct 21; 210(11):2403-14.
        View in: PubMed
      8. Shum AK, Alimohammadi M, Tan CL, Cheng MH, Metzger TC, Law CS, Lwin W, Perheentupa J, Bour-Jordan H, Carel JC, Husebye ES, De Luca F, Janson C, Sargur R, Dubois N, Kajosaari M, Wolters PJ, Chapman HA, Kämpe O, Anderson MS. BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease. Sci Transl Med. 2013 Oct 9; 5(206):206ra139.
        View in: PubMed
      9. Metzger TC, Khan IS, Gardner JM, Mouchess ML, Johannes KP, Krawisz AK, Skrzypczynska KM, Anderson MS. Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population. Cell Rep. 2013 Oct 17; 5(1):166-79.
        View in: PubMed
      10. Gardner JM, Metzger TC, McMahon EJ, Au-Yeung BB, Krawisz AK, Lu W, Price JD, Johannes KP, Satpathy AT, Murphy KM, Tarbell KV, Weiss A, Anderson MS. Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4? T cells. Immunity. 2013 Sep 19; 39(3):560-72.
        View in: PubMed
      11. Cheng MH, Anderson MS. Insights into type 1 diabetes from the autoimmune polyendocrine syndromes. Curr Opin Endocrinol Diabetes Obes. 2013 Aug; 20(4):271-8.
        View in: PubMed
      12. Parent AV, Russ HA, Khan IS, LaFlam TN, Metzger TC, Anderson MS, Hebrok M. Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development. Cell Stem Cell. 2013 Aug 1; 13(2):219-29.
        View in: PubMed
      13. Breunig A, Lee MS, Miller BS, Binstadt BA, Anderson MS, Montezuma S. Autoimmune retinopathy in a patient with autoimmune polyendocrine syndrome type I. Ocul Immunol Inflamm. 2013 Apr; 21(2):153-7.
        View in: PubMed
      14. Gerstein NS, Carey MC, Braude DA, Tawil I, Petersen TR, Deriy L, Anderson MS. Efficacy of facemask ventilation techniques in novice providers. J Clin Anesth. 2013 May; 25(3):193-7.
        View in: PubMed
      15. Taniguchi RT, DeVoss JJ, Moon JJ, Sidney J, Sette A, Jenkins MK, Anderson MS. Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7847-52.
        View in: PubMed
      16. Su MA, Davini D, Cheng P, Giang K, Fan U, DeVoss JJ, Johannes KP, Taylor L, Shum AK, Valenzise M, Meloni A, Bour-Jordan H, Anderson MS. Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy. J Immunol. 2012 May 15; 188(10):4906-12.
        View in: PubMed
      17. Cheng MH, Anderson MS. Monogenic autoimmunity. Annu Rev Immunol. 2012; 30:393-427.
        View in: PubMed
      18. Waterfield M, Anderson MS. Autoimmunity's collateral damage: Immunodeficiency hints at autoreactivity to cytokines. Nat Med. 2011 Sep; 17(9):1054-5.
        View in: PubMed
      19. Metzger TC, Anderson MS. Control of central and peripheral tolerance by Aire. Immunol Rev. 2011 May; 241(1):89-103.
        View in: PubMed
      20. Metzger TC, Anderson MS. Myocarditis: a defect in central immune tolerance? J Clin Invest. 2011 Apr; 121(4):1251-3.
        View in: PubMed
      21. Anderson MS, Su MA. Aire and T cell development. Curr Opin Immunol. 2011 Apr; 23(2):198-206.
        View in: PubMed
      22. Taniguchi RT, Anderson MS. The role of Aire in clonal selection. Immunol Cell Biol. 2011 Jan; 89(1):40-4.
        View in: PubMed
      23. Waterfield M, Anderson MS. Clues to immune tolerance: the monogenic autoimmune syndromes. Ann N Y Acad Sci. 2010 Dec; 1214:138-55.
        View in: PubMed
      24. Husebye ES, Anderson MS. Autoimmune polyendocrine syndromes: clues to type 1 diabetes pathogenesis. Immunity. 2010 Apr 23; 32(4):479-87.
        View in: PubMed
      25. DeVoss JJ, LeClair NP, Hou Y, Grewal NK, Johannes KP, Lu W, Yang T, Meagher C, Fong L, Strauss EC, Anderson MS. An autoimmune response to odorant binding protein 1a is associated with dry eye in the Aire-deficient mouse. J Immunol. 2010 Apr 15; 184(8):4236-46.
        View in: PubMed
      26. Cheng MH, Fan U, Grewal N, Barnes M, Mehta A, Taylor S, Husebye ES, Murphy EJ, Anderson MS. Acquired autoimmune polyglandular syndrome, thymoma, and an AIRE defect. N Engl J Med. 2010 Feb 25; 362(8):764-6.
        View in: PubMed
      27. Shum AK, DeVoss J, Tan CL, Hou Y, Johannes K, O'Gorman CS, Jones KD, Sochett EB, Fong L, Anderson MS. Identification of an autoantigen demonstrates a link between interstitial lung disease and a defect in central tolerance. Sci Transl Med. 2009 Dec 2; 1(9):9ra20.
        View in: PubMed
      28. Gardner JM, Fletcher AL, Anderson MS, Turley SJ. AIRE in the thymus and beyond. Curr Opin Immunol. 2009 Dec; 21(6):582-9.
        View in: PubMed
      29. Gardner JM, Anderson MS. The sickness unto Deaf. Nat Immunol. 2009 Sep; 10(9):934-6.
        View in: PubMed
      30. Hou Y, DeVoss J, Dao V, Kwek S, Simko JP, McNeel DG, Anderson MS, Fong L. An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans. J Clin Invest. 2009 Jul; 119(7):2031-41.
        View in: PubMed
      31. Su MA, Anderson MS. Monogenic autoimmune diseases: insights into self-tolerance. Pediatr Res. 2009 May; 65(5 Pt 2):20R-25R.
        View in: PubMed
      32. Louvet C, Kabre BG, Davini DW, Martinier N, Su MA, DeVoss JJ, Rosenthal WL, Anderson MS, Bour-Jordan H, Bluestone JA. A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy. J Exp Med. 2009 Mar 16; 206(3):507-14.
        View in: PubMed
      33. Su MA, Stenerson M, Liu W, Putnam A, Conte F, Bluestone JA, Anderson MS. The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patients. Clin Immunol. 2009 Apr; 131(1):139-44.
        View in: PubMed
      34. Anderson MS. Update in endocrine autoimmunity. J Clin Endocrinol Metab. 2008 Oct; 93(10):3663-70.
        View in: PubMed
      35. Devoss JJ, Shum AK, Johannes KP, Lu W, Krawisz AK, Wang P, Yang T, Leclair NP, Austin C, Strauss EC, Anderson MS. Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1. J Immunol. 2008 Sep 15; 181(6):4072-9.
        View in: PubMed
      36. Zhou X, Jeker LT, Fife BT, Zhu S, Anderson MS, McManus MT, Bluestone JA. Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med. 2008 Sep 1; 205(9):1983-91.
        View in: PubMed
      37. Gardner JM, Devoss JJ, Friedman RS, Wong DJ, Tan YX, Zhou X, Johannes KP, Su MA, Chang HY, Krummel MF, Anderson MS. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science. 2008 Aug 8; 321(5890):843-7.
        View in: PubMed
      38. Su MA, Giang K, Zumer K, Jiang H, Oven I, Rinn JL, Devoss JJ, Johannes KP, Lu W, Gardner J, Chang A, Bubulya P, Chang HY, Peterlin BM, Anderson MS. Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire. J Clin Invest. 2008 May; 118(5):1712-26.
        View in: PubMed
      39. Schaller CE, Wang CL, Beck-Engeser G, Goss L, Scott HS, Anderson MS, Wabl M. Expression of Aire and the early wave of apoptosis in spermatogenesis. J Immunol. 2008 Feb 1; 180(3):1338-43.
        View in: PubMed
      40. Li S, Nikulina K, DeVoss J, Wu AJ, Strauss EC, Anderson MS, McNamara NA. Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease. Invest Ophthalmol Vis Sci. 2008 Jan; 49(1):34-41.
        View in: PubMed
      41. Zhang L, Barker JM, Babu S, Su M, Stenerson M, Cheng M, Shum A, Zamir E, Badolato R, Law A, Eisenbarth GS, Anderson MS. A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1. Clin Immunol. 2007 Nov; 125(2):131-7.
        View in: PubMed
      42. Cheng MH, Shum AK, Anderson MS. What's new in the Aire? Trends Immunol. 2007 Jul; 28(7):321-7.
        View in: PubMed
      43. DeVoss JJ, Anderson MS. Lessons on immune tolerance from the monogenic disease APS1. Curr Opin Genet Dev. 2007 Jun; 17(3):193-200.
        View in: PubMed
      44. DeVoss J, Hou Y, Johannes K, Lu W, Liou GI, Rinn J, Chang H, Caspi RR, Caspi R, Fong L, Anderson MS. Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J Exp Med. 2006 Nov 27; 203(12):2727-35.
        View in: PubMed
      45. Jiang W, Anderson MS, Bronson R, Mathis D, Benoist C. Modifier loci condition autoimmunity provoked by Aire deficiency. J Exp Med. 2005 Sep 19; 202(6):805-15.
        View in: PubMed
      46. Anderson MS, Venanzi ES, Chen Z, Berzins SP, Benoist C, Mathis D. The cellular mechanism of Aire control of T cell tolerance. Immunity. 2005 Aug; 23(2):227-39.
        View in: PubMed
      47. Anderson MS, Bluestone JA. The NOD mouse: a model of immune dysregulation. Annu Rev Immunol. 2005; 23:447-85.
        View in: PubMed
      48. Su MA, Anderson MS. Aire: an update. Curr Opin Immunol. 2004 Dec; 16(6):746-52.
        View in: PubMed
      49. Anderson MS. Autoimmune endocrine disease. Curr Opin Immunol. 2002 Dec; 14(6):760-4.
        View in: PubMed
      50. Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ, von Boehmer H, Bronson R, Dierich A, Benoist C, Mathis D. Projection of an immunological self shadow within the thymus by the aire protein. Science. 2002 Nov 15; 298(5597):1395-401.
        View in: PubMed
      51. Anderson MS, Swier K, Arneson L, Miller J. Enhanced antigen presentation in the absence of the invariant chain endosomal localization signal. J Exp Med. 1993 Dec 1; 178(6):1959-69.
        View in: PubMed
      52. Naujokas MF, Morin M, Anderson MS, Peterson M, Miller J. The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44. Cell. 1993 Jul 30; 74(2):257-68.
        View in: PubMed
      53. Anderson MS, Miller J. Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2282-6.
        View in: PubMed
      54. Lakey EK, Casten LA, Anderson MS, Smolenski LA, Smith JA, Margoliash E, Pierce SK. T cell activation by processed antigen is equally blocked by I-E and I-A-restricted immunodominant peptides. Eur J Immunol. 1987 Nov; 17(11):1605-9.
        View in: PubMed
      55. STAPLE TW, MCALISTER WH, ANDERSON MS. PLEXIFORM NEUROFIBROMATOSIS OF THE COLON SIMULATING HIRSCHSPRUNG'S DISEASE. Am J Roentgenol Radium Ther Nucl Med. 1964 Apr; 91:840-5.
        View in: PubMed
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