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Alexander Marson, MD, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentMicrobiology and Immunology
Address513 Parnassus Avenue
San Francisco CA 94117
Phone415-502-2611
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    Collapse Biography 
    Collapse Awards and Honors
    2016American Society of Clinical Investigation (ASCI) Young Physician-Scientist Award
    2016Burroughs Wellcome Foundation Career Award for Medical Scientists
    2016NIDA/NIH Avenir New Innovator Award
    2017Chan Zuckerberg Biohub Investigator

    Collapse Overview 
    Collapse Overview
    Our group employs an integrative genomics approach to decode the genetic programs governing CD4+ T-cell sub-specialization. We study the molecular circuitry that governs differentiation of pro-inflammatory and regulatory T cells, and the ways in which mutations affecting this circuitry contribute to immune dysregulation in human disease. We aim to connect the transcriptional regulatory circuitry of T cells to human genetic studies and functional genomic screens to advance understanding of specialized CD4+ T-cell functions and potentially generate novel therapeutic strategies for immune-mediated diseases.


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    Collapse Featured Publications

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H, Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, Hacohen N, Walker BD. A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Nat Genet. 2016 Dec 19. PMID: 27992415.
      View in: PubMed
    2. Hultquist JF, Schumann K, Woo JM, Manganaro L, McGregor MJ, Doudna J, Simon V, Krogan NJ, Marson A. A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells. Cell Rep. 2016 Oct 25; 17(5):1438-1452. PMID: 27783955.
      View in: PubMed
    3. Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM. A tissue checkpoint regulates type 2 immunity. Nat Immunol. 2016 Oct 17. PMID: 27749840.
      View in: PubMed
    4. Schumann K, Lin S, Boyer E, Simeonov DR, Subramaniam M, Gate RE, Haliburton GE, Ye CJ, Bluestone JA, Doudna JA, Marson A. Generation of knock-in primary human T cells using Cas9 ribonucleoproteins. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10437-42. PMID: 26216948; PMCID: PMC4547290.
    5. Marson A, Housley WJ, Hafler DA. Genetic basis of autoimmunity. J Clin Invest. 2015 Jun; 125(6):2234-41. PMID: 26030227; PMCID: PMC4497748 [Available on 06/01/16].
    6. DuPage M, Chopra G, Quiros J, Rosenthal WL, Morar MM, Holohan D, Zhang R, Turka L, Marson A, Bluestone JA. The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation. Immunity. 2015 Feb 17; 42(2):227-38. PMID: 25680271; PMCID: PMC4347854 [Available on 02/17/16].
    7. Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature. 2015 Feb 19; 518(7539):337-43. PMID: 25363779; PMCID: PMC4336207.
    8. Kofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA. Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. J Clin Invest. 2014 Jun; 124(6):2513-22. PMID: 24812667; PMCID: PMC4089462.
    9. Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Hafler DA, Regev A, Ghosh S, Marson A, Kuchroo VK. Small-molecule ROR?t antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity. 2014 Apr 17; 40(4):477-89. PMID: 24745332; PMCID: PMC4066874.
    10. Chow FC, Marson A, Liu C. Successful medical management of a Nocardia farcinica multiloculated pontine abscess. BMJ Case Rep. 2013; 2013. PMID: 24311420.
      View in: PubMed
    11. Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, Frampton GM, Cole MF, Odom DT, Odajima J, Geng Y, Zagozdzon A, Jecrois M, Young RA, Liu XS, Cepko CL, Gygi SP, Sicinski P. Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen. Nature. 2010 Jan 21; 463(7279):374-8. PMID: 20090754; PMCID: PMC2943587.
    12. Marson A, Levine SS, Cole MF, Frampton GM, Brambrink T, Johnstone S, Guenther MG, Johnston WK, Wernig M, Newman J, Calabrese JM, Dennis LM, Volkert TL, Gupta S, Love J, Hannett N, Sharp PA, Bartel DP, Jaenisch R, Young RA. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell. 2008 Aug 8; 134(3):521-33. PMID: 18692474; PMCID: PMC2586071.
    13. Marson A, Foreman R, Chevalier B, Bilodeau S, Kahn M, Young RA, Jaenisch R. Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell. 2008 Aug 7; 3(2):132-5. PMID: 18682236; PMCID: PMC3235673.
    14. Marson A, Kretschmer K, Frampton GM, Jacobsen ES, Polansky JK, MacIsaac KD, Levine SS, Fraenkel E, von Boehmer H, Young RA. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature. 2007 Feb 22; 445(7130):931-5. PMID: 17237765; PMCID: PMC3008159.
    15. Daniels MJ, Marson A, Venkitaraman AR. PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein. Nat Struct Mol Biol. 2004 Nov; 11(11):1114-21. PMID: 15467728.
      View in: PubMed
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