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    Max Krummel, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentPathology
    Address513 Parnassus Ave HSW 512
    San Francisco CA 94143
    Phone415-514-3130

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Li M, Wetzel-Strong SE, Hua X, Tilley SL, Oswald E, Krummel MF, Caron KM. Deficiency of RAMP1 Attenuates Antigen-Induced Airway Hyperresponsiveness in Mice. PLoS One. 2014; 9(7):e102356.
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      2. Friedman RS, Lindsay RS, Lilly JK, Nguyen V, Sorensen CM, Jacobelli J, Krummel MF. An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9223-8.
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      3. Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen SD. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med. 2014 Jun 30; 211(7):1281-8.
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      4. Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM. Chitin Activates Parallel Immune Modules that Direct Distinct Inflammatory Responses via Innate Lymphoid Type 2 and ?d T Cells. Immunity. 2014 Mar 20; 40(3):414-24.
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      5. Corbin K, Pinkard H, Peck S, Beemiller P, Krummel MF. Assessing and benchmarking multiphoton microscopes for biologists. Methods Cell Biol. 2014; 123:135-51.
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      6. Beemiller P, Krummel MF. Regulation of T-cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasm. Immunol Rev. 2013 Nov; 256(1):148-59.
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      7. Jacobelli J, Estin Matthews M, Chen S, Krummel MF. Activated T cell trans-endothelial migration relies on myosin-IIA contractility for squeezing the cell nucleus through endothelial cell barriers. PLoS One. 2013; 8(9):e75151.
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      8. Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10; 502(7470):245-8.
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      9. Gérard A, Khan O, Beemiller P, Oswald E, Hu J, Matloubian M, Krummel MF. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells. Nat Immunol. 2013 Apr; 14(4):356-63.
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      10. Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity. 2013 Jan 24; 38(1):166-75.
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      11. Gérard A, Beemiller P, Friedman RS, Jacobelli J, Krummel MF. Evolving immune circuits are generated by flexible, motile, and sequential immunological synapses. Immunol Rev. 2013 Jan; 251(1):80-96.
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      12. Zhang Y, Chen YC, Krummel MF, Rosen SD. Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells. J Immunol. 2012 Oct 15; 189(8):3914-24.
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      13. Beemiller P, Jacobelli J, Krummel MF. Integration of the movement of signaling microclusters with cellular motility in immunological synapses. Nat Immunol. 2012 Aug; 13(8):787-95.
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      14. Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF. Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med. 2012 Jun 4; 209(6):1183-99.
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      15. Thornton EE, Krummel MF, Looney MR. Live imaging of the lung. Curr Protoc Cytom. 2012 Apr; Chapter 12:Unit12.28.
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      16. Engelhardt JJ, Boldajipour B, Beemiller P, Pandurangi P, Sorensen C, Werb Z, Egeblad M, Krummel MF. Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell. 2012 Mar 20; 21(3):402-17.
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      17. Gilden JK, Peck S, Chen YC, Krummel MF. The septin cytoskeleton facilitates membrane retraction during motility and blebbing. J Cell Biol. 2012 Jan 9; 196(1):103-14.
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      18. Khan O, Headley M, Gerard A, Wei W, Liu L, Krummel MF. Regulation of T cell priming by lymphoid stroma. PLoS One. 2011; 6(11):e26138.
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      19. Krummel MF, Allison JP. Pillars article: CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. The journal of experimental medicine. 1995. 182: 459-465. J Immunol. 2011 Oct 1; 187(7):3459-65.
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      20. Looney MR, Thornton EE, Sen D, Lamm WJ, Glenny RW, Krummel MF. Stabilized imaging of immune surveillance in the mouse lung. Nat Methods. 2011 Jan; 8(1):91-6.
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      21. Friedman RS, Beemiller P, Sorensen CM, Jacobelli J, Krummel MF. Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics. J Exp Med. 2010 Nov 22; 207(12):2733-49.
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      22. Katzman SD, O'Gorman WE, Villarino AV, Gallo E, Friedman RS, Krummel MF, Nolan GP, Abbas AK. Duration of antigen receptor signaling determines T-cell tolerance or activation. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18085-90.
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      23. Jacobelli J, Friedman RS, Conti MA, Lennon-Dumenil AM, Piel M, Sorensen CM, Adelstein RS, Krummel MF. Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions. Nat Immunol. 2010 Oct; 11(10):953-61.
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      24. Beemiller P, Krummel MF. Mediation of T-cell activation by actin meshworks. Cold Spring Harb Perspect Biol. 2010 Sep; 2(9):a002444.
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      25. Gilden J, Krummel MF. Control of cortical rigidity by the cytoskeleton: emerging roles for septins. Cytoskeleton (Hoboken). 2010 Aug; 67(8):477-86.
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      26. Krummel MF. Illuminating emergent activity in the immune system by real-time imaging. Nat Immunol. 2010 Jul; 11(7):554-7.
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      27. Krummel MF, Cahalan MD. The immunological synapse: a dynamic platform for local signaling. J Clin Immunol. 2010 May; 30(3):364-72.
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      28. Doh J, Kim M, Krummel MF. Cell-laden microwells for the study of multicellularity in lymphocyte fate decisions. Biomaterials. 2010 Apr; 31(12):3422-8.
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      29. Doh J, Krummel MF. Immunological synapses within context: patterns of cell-cell communication and their application in T-T interactions. Curr Top Microbiol Immunol. 2010; 340:25-50.
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      30. Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nat Immunol. 2009 Nov; 10(11):1185-92.
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      31. Krummel M. Matthew Krummel: visions enumerated. Interview by Amy Maxmen. J Exp Med. 2009 Jun 8; 206(6):1212-3.
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      32. Melli K, Friedman RS, Martin AE, Finger EB, Miao G, Szot GL, Krummel MF, Tang Q. Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues. J Immunol. 2009 Mar 1; 182(5):2590-600.
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      33. Jacobelli J, Bennett FC, Pandurangi P, Tooley AJ, Krummel MF. Myosin-IIA and ICAM-1 regulate the interchange between two distinct modes of T cell migration. J Immunol. 2009 Feb 15; 182(4):2041-50.
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      34. Bullen A, Friedman RS, Krummel MF. Two-photon imaging of the immune system: a custom technology platform for high-speed, multicolor tissue imaging of immune responses. Curr Top Microbiol Immunol. 2009; 334:1-29.
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      35. Tooley AJ, Gilden J, Jacobelli J, Beemiller P, Trimble WS, Kinoshita M, Krummel MF. Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility. Nat Cell Biol. 2009 Jan; 11(1):17-26.
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      36. Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL. Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J Immunol. 2008 Oct 15; 181(8):5374-85.
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      37. Egeblad M, Ewald AJ, Askautrud HA, Truitt ML, Welm BE, Bainbridge E, Peeters G, Krummel MF, Werb Z. Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. Dis Model Mech. 2008 Sep-Oct; 1(2-3):155-67; discussion 165.
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      38. Gardner JM, Devoss JJ, Friedman RS, Wong DJ, Tan YX, Zhou X, Johannes KP, Su MA, Chang HY, Krummel MF, Anderson MS. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science. 2008 Aug 8; 321(5890):843-7.
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      39. Beemiller P, Krummel MF. Distinct functions for HS1 in chemosensory versus adhesive signaling. Nat Immunol. 2008 Aug; 9(8):833-4.
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      40. Sabatos CA, Doh J, Chakravarti S, Friedman RS, Pandurangi PG, Tooley AJ, Krummel MF. A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction. Immunity. 2008 Aug 15; 29(2):238-48.
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      41. Engelhardt JJ, Krummel MF. The importance of prolonged binding to antigen-presenting cells for T cell fate decisions. Immunity. 2008 Feb; 28(2):143-5.
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      42. Krummel MF. Testing the organization of the immunological synapse. Curr Opin Immunol. 2007 Aug; 19(4):460-2.
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      43. Krummel MF. Immunological synapses: breaking up may be good to do. Cell. 2007 May 18; 129(4):653-5.
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      44. Krummel MF, Macara I. Maintenance and modulation of T cell polarity. Nat Immunol. 2006 Nov; 7(11):1143-9.
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      45. Friedman RS, Jacobelli J, Krummel MF. Surface-bound chemokines capture and prime T cells for synapse formation. Nat Immunol. 2006 Oct; 7(10):1101-8.
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      46. Tang Q, Krummel MF. Imaging the function of regulatory T cells in vivo. Curr Opin Immunol. 2006 Aug; 18(4):496-502.
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      47. Moldovan MC, Sabbagh L, Breton G, Sékaly RP, Krummel MF. Triggering of T cell activation via CD4 dimers. J Immunol. 2006 May 1; 176(9):5438-45.
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      48. Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, Santamaria P, Locksley RM, Krummel MF, Bluestone JA. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol. 2006 Jan; 7(1):83-92.
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      49. Friedman RS, Jacobelli J, Krummel MF. Mechanisms of T cell motility and arrest: deciphering the relationship between intra- and extracellular determinants. Semin Immunol. 2005 Dec; 17(6):387-99.
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      50. Okada T, Miller MJ, Parker I, Krummel MF, Neighbors M, Hartley SB, O'Garra A, Cahalan MD, Cyster JG. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol. 2005 Jun; 3(6):e150.
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      51. Tooley AJ, Jacobelli J, Moldovan MC, Douglas A, Krummel MF. T cell synapse assembly: proteins, motors and the underlying cell biology. Semin Immunol. 2005 Feb; 17(1):65-75.
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      52. Boisvert J, Edmondson S, Krummel MF. Immunological synapse formation licenses CD40-CD40L accumulations at T-APC contact sites. J Immunol. 2004 Sep 15; 173(6):3647-52.
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      53. Jacobelli J, Andres PG, Boisvert J, Krummel MF. New views of the immunological synapse: variations in assembly and function. Curr Opin Immunol. 2004 Jun; 16(3):345-52.
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      54. Andres PG, Howland KC, Dresnek D, Edmondson S, Abbas AK, Krummel MF. CD28 signals in the immature immunological synapse. J Immunol. 2004 May 15; 172(10):5880-6.
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      55. Jacobelli J, Chmura SA, Buxton DB, Davis MM, Krummel MF. A single class II myosin modulates T cell motility and stopping, but not synapse formation. Nat Immunol. 2004 May; 5(5):531-8.
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      56. Ehrlich LI, Ebert PJ, Krummel MF, Weiss A, Davis MM. Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity. 2002 Dec; 17(6):809-22.
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      57. Moss WC, Irvine DJ, Davis MM, Krummel MF. Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formation. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):15024-9.
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      58. Richie LI, Ebert PJ, Wu LC, Krummel MF, Owen JJ, Davis MM. Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selection. Immunity. 2002 Apr; 16(4):595-606.
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      59. Krummel MF, Davis MM. Dynamics of the immunological synapse: finding, establishing and solidifying a connection. Curr Opin Immunol. 2002 Feb; 14(1):66-74.
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      60. Krummel M, Wülfing C, Sumen C, Davis MM. Thirty-six views of T-cell recognition. Philos Trans R Soc Lond B Biol Sci. 2000 Aug 29; 355(1400):1071-6.
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      61. Krummel MF, Sjaastad MD, Wülfing C, Davis MM. Differential clustering of CD4 and CD3zeta during T cell recognition. Science. 2000 Aug 25; 289(5483):1349-52.
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      62. Krummel MF, Heath WR, Allison J. Differential coupling of second signals for cytotoxicity and proliferation in CD8+ T cell effectors: amplification of the lytic potential by B7. J Immunol. 1999 Sep 15; 163(6):2999-3006.
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      63. Kurts C, Carbone FR, Krummel MF, Koch KM, Miller JF, Heath WR. Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells. Nature. 1999 Mar 25; 398(6725):341-4.
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      64. Davis MM, Wülfing C, Krummel MF, Savage PA, Xu J, Sumen C, Dustin ML, Chien YH. Visualizing T-cell recognition. Cold Spring Harb Symp Quant Biol. 1999; 64:243-51.
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      65. Allison J, Stephens LA, Kay TW, Kurts C, Heath WR, Miller JF, Krummel MF. The threshold for autoimmune T cell killing is influenced by B7-1. Eur J Immunol. 1998 Mar; 28(3):949-60.
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      66. Allison JP, Chambers C, Hurwitz A, Sullivan T, Boitel B, Fournier S, Brunner M, Krummel M. A role for CTLA-4-mediated inhibitory signals in peripheral T cell tolerance? Novartis Found Symp. 1998; 215:92-8; discussion 98-102, 186-90.
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      67. Winkel KD, Kronin V, Krummel MF, Shortman K. The nature of the signals regulating CD8 T cell proliferative responses to CD8alpha+ or CD8alpha- dendritic cells. Eur J Immunol. 1997 Dec; 27(12):3350-9.
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      68. Hurwitz AA, Sullivan TJ, Krummel MF, Sobel RA, Allison JP. Specific blockade of CTLA-4/B7 interactions results in exacerbated clinical and histologic disease in an actively-induced model of experimental allergic encephalomyelitis. J Neuroimmunol. 1997 Mar; 73(1-2):57-62.
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      69. Chambers CA, Krummel MF, Boitel B, Hurwitz A, Sullivan TJ, Fournier S, Cassell D, Brunner M, Allison JP. The role of CTLA-4 in the regulation and initiation of T-cell responses. Immunol Rev. 1996 Oct; 153:27-46.
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      70. Krummel MF, Allison JP. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med. 1996 Jun 1; 183(6):2533-40.
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      71. Krummel MF, Sullivan TJ, Allison JP. Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo. Int Immunol. 1996 Apr; 8(4):519-23.
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      72. Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science. 1996 Mar 22; 271(5256):1734-6.
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      73. Allison JP, Krummel MF. The Yin and Yang of T cell costimulation. Science. 1995 Nov 10; 270(5238):932-3.
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      74. Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med. 1995 Aug 1; 182(2):459-65.
        View in: PubMed
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