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    Michael Matthay, MD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address505 Parnassus Ave, Moffitt
    San Francisco CA 94143
    Phone415-353-1206

       Biography 
       Education and Training
      University of California, San FranciscoResidency School of Medicine

       Overview 
       Overview
      Michael A. Matthay, MD is a Professor of Medicine and Anesthesia at the University of California at San Francisco and a Senior Associate at the Cardiovascular Research Institute. He is Director of the Critical Care Medicine Training in the Department of Medicine and Associate Director of the Intensive Care Unit. He received his AB from Harvard University in 1969 and his MD from the University of Pennsylvania School of Medicine in 1973. Dr. Matthay received clinical training in Internal Medicine at the University of Colorado from 1973-76 and in Pulmonary and Critical Care Medicine from the University of California at San Francisco from 1977-78. He also received research training from the Cardiovascular Physiology Laboratory, University of Colorado in 1976 and the Cardiovascular Research Institute from 1978-79.

      Michael Matthay was selected in 2006 by the UCSF Academic Senate as the recipient of the Sixth Annual Distinguished Clinical Research Lectureshi, by the American Physiological Society and the Respiration Section for the Julius Comroe Jr Award in 2009, and by the University of Paris in 20011 with an Honorary Degree (Honora Causa).

      Dr. Matthay is currently the Principal Investigator of a NIH/NHLBI-sponsored phase 1/2 clinical trial of mesenchymal stem (stromal) cells for the treatment of Acute Respiratory Distress Syndrome (START). Details of the trial may be found at the following website: http://stemcellsards.ucsf.edu.


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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Beitler JR, Thompson BT, Matthay MA, Talmor D, Liu KD, Zhuo H, Hayden D, Spragg RG, Malhotra A. Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials. Crit Care Med. 2015 May; 43(5):1026-35.
        View in: PubMed
      2. Matthay MA. Therapeutic potential of mesenchymal stromal cells for acute respiratory distress syndrome. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S54-7.
        View in: PubMed
      3. Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA. Latent class models identify two subphenotypes in respiratory distress syndrome with differential response to positive end-expiratory pressure. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S77.
        View in: PubMed
      4. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA. Erratum to: Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):574.
        View in: PubMed
      5. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbot J, Matthay MA. Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):470-8.
        View in: PubMed
      6. Anderson WG, Cimino JW, Ernecoff NC, Ungar A, Shotsberger KJ, Pollice LA, Buddadhumaruk P, Carson SS, Curtis JR, Hough CL, Lo B, Matthay MA, Peterson MW, Steingrub JS, White DB. A Multicenter Study of Key Stakeholders' Perspectives on Communicating with Surrogates about Prognosis in Intensive Care Units. Ann Am Thorac Soc. 2015 Feb; 12(2):142-52.
        View in: PubMed
      7. Curley MA, Wypij D, Watson RS, Grant MJ, Asaro LA, Cheifetz IM, Dodson BL, Franck LS, Gedeit RG, Angus DC, Matthay MA. Protocolized sedation vs usual care in pediatric patients mechanically ventilated for acute respiratory failure: a randomized clinical trial. JAMA. 2015 Jan 27; 313(4):379-89.
        View in: PubMed
      8. Ji HL, Zhao R, Komissarov AA, Chang Y, Liu Y, Matthay MA. Proteolytic Regulation of Epithelial Sodium Channels by Urokinase Plasminogen Activator: CUTTING EDGE AND CLEAVAGE SITES. J Biol Chem. 2015 Feb 27; 290(9):5241-55.
        View in: PubMed
      9. Schell-Chaple HM, Puntillo KA, Matthay MA, Liu KD. Body temperature and mortality in patients with acute respiratory distress syndrome. Am J Crit Care. 2015 Jan; 24(1):15-23.
        View in: PubMed
      10. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature. 2015 Jan 29; 517(7536):621-5.
        View in: PubMed
      11. Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay MA. Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial. Lancet Respir Med. 2015 Jan; 3(1):24-32.
        View in: PubMed
      12. Hendrickson CM, Crestani B, Matthay MA. Biology and pathology of fibroproliferation following the acute respiratory distress syndrome. Intensive Care Med. 2015 Jan; 41(1):147-50.
        View in: PubMed
      13. Walter J, Ware LB, Matthay MA. Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis. Lancet Respir Med. 2014 Dec; 2(12):1016-26.
        View in: PubMed
      14. Matthay MA. Biomarkers to exclude the diagnosis of ventilator-associated pneumonia. Thorax. 2015 Jan; 70(1):5-6.
        View in: PubMed
      15. Gotts JE, Matthay MA. Endogenous and exogenous cell-based pathways for recovery from acute respiratory distress syndrome. Clin Chest Med. 2014 Dec; 35(4):797-809.
        View in: PubMed
      16. DePianto DJ, Chandriani S, Abbas AR, Jia G, N'Diaye EN, Caplazi P, Kauder SE, Biswas S, Karnik SK, Ha C, Modrusan Z, Matthay MA, Kukreja J, Collard HR, Egen JG, Wolters PJ, Arron JR. Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis. Thorax. 2015 Jan; 70(1):48-56.
        View in: PubMed
      17. Hsieh SJ, Zhuo H, Benowitz NL, Thompson BT, Liu KD, Matthay MA, Calfee CS. Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome. Crit Care Med. 2014 Sep; 42(9):2058-68.
        View in: PubMed PMC4134734
      18. Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eaton DC, Lucas R. A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation. Am J Respir Crit Care Med. 2014 Sep 1; 190(5):522-32.
        View in: PubMed
      19. Fitzgerald M, McAuley DF, Matthay M. Is there a need for emerging drugs for the acute respiratory distress syndrome? Expert Opin Emerg Drugs. 2014 Sep; 19(3):323-8.
        View in: PubMed
      20. Ware LB, Lee JW, Wickersham N, Nguyen J, Matthay MA, Calfee CS. Donor smoking is associated with pulmonary edema, inflammation and epithelial dysfunction in ex vivo human donor lungs. Am J Transplant. 2014 Oct; 14(10):2295-302.
        View in: PubMed PMC4169304
      21. Krupa A, Fol M, Rahman M, Stokes KY, Florence JM, Leskov IL, Khoretonenko MV, Matthay MA, Liu KD, Calfee CS, Tvinnereim A, Rosenfield GR, Kurdowska AK. Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15; 307(6):L435-48.
        View in: PubMed PMC4166786
      22. Gotts JE, Abbott J, Matthay MA. Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 1; 307(5):L395-406.
        View in: PubMed PMC4154253
      23. Czikora I, Sridhar S, Gorshkov B, Alieva IB, Kasa A, Gonzales J, Potapenko O, Umapathy NS, Pillich H, Rick FG, Block NL, Verin AD, Chakraborty T, Matthay MA, Schally AV, Lucas R. Protective effect of Growth Hormone-Releasing Hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction. Front Physiol. 2014; 5:259.
        View in: PubMed PMC4097355
      24. Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA. Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Ann Intensive Care. 2014; 4:22.
        View in: PubMed
      25. Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P. Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*. Crit Care Med. 2014 Jul; 42(7):1676-87.
        View in: PubMed
      26. Sakuma T, Matthay MA. Translational studies in the ex vivo human lung. Respir Investig. 2014 Jul; 52(4):219-20.
        View in: PubMed
      27. Shyamsundar M, McAuley DF, Ingram RJ, Gibson DS, O'Kane D, McKeown ST, Edwards A, Taggart C, Elborn JS, Calfee CS, Matthay MA, O'Kane CM. Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury. Am J Respir Crit Care Med. 2014 Jun 15; 189(12):1520-9.
        View in: PubMed PMC4226011
      28. Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters PJ, Woodruff PG, Fahy JV, Shin JS. Accumulation of BDCA1? dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma. PLoS One. 2014; 9(6):e99084.
        View in: PubMed PMC4051692
      29. Asmussen S, Ito H, Traber DL, Lee JW, Cox RA, Hawkins HK, McAuley DF, McKenna DH, Traber LD, Zhuo H, Wilson J, Herndon DN, Prough DS, Liu KD, Matthay MA, Enkhbaatar P. Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia. Thorax. 2014 Sep; 69(9):819-25.
        View in: PubMed
      30. Matthay MA. Resolution of pulmonary edema. Thirty years of progress. Am J Respir Crit Care Med. 2014 Jun 1; 189(11):1301-8.
        View in: PubMed PMC4098087
      31. McKenna D, Matthay MA, Pati S. Correspondence to: soliciting strategies for developing cell-based reference materials to advance mesenchymal stem/stromal cell research and clinical translation. Stem Cells Dev. 2014 Aug 1; 23(15):1717-8.
        View in: PubMed
      32. Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA. Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Lancet Respir Med. 2014 Aug; 2(8):611-20.
        View in: PubMed PMC4154544
      33. Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med. 2014 Jun 5; 370(23):2191-200.
        View in: PubMed
      34. Wilson JG, Matthay MA. Mechanical ventilation in acute hypoxemic respiratory failure: a review of new strategies for the practicing hospitalist. J Hosp Med. 2014 Jul; 9(7):469-75.
        View in: PubMed PMC4139286
      35. Rogers AJ, Matthay MA. Applying metabolomics to uncover novel biology in ARDS. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1; 306(11):L957-61.
        View in: PubMed PMC4042190
      36. Goolaerts A, Pellan-Randrianarison N, Larghero J, Vanneaux V, Uzunhan Y, Gille T, Dard N, Planès C, Matthay MA, Clerici C. Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1; 306(11):L975-85.
        View in: PubMed PMC4042188
      37. Ware LB, Landeck M, Koyama T, Zhao Z, Singer J, Kern R, Neidlinger N, Nguyen J, Johnson E, Janz DR, Bernard GR, Lee JW, Matthay MA. A randomized trial of the effects of nebulized albuterol on pulmonary edema in brain-dead organ donors. Am J Transplant. 2014 Mar; 14(3):621-8.
        View in: PubMed PMC3986821
      38. Kangelaris KN, Calfee CS, May AK, Zhuo H, Matthay MA, Ware LB. Is there still a role for the lung injury score in the era of the Berlin definition ARDS? Ann Intensive Care. 2014; 4(1):4.
        View in: PubMed PMC3931496
      39. McAuley DF, Curley GF, Hamid UI, Laffey JG, Abbott J, McKenna DH, Fang X, Matthay MA, Lee JW. Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation. Am J Physiol Lung Cell Mol Physiol. 2014 May 1; 306(9):L809-15.
        View in: PubMed PMC4010648
      40. Liles WC, Matthay MA, Dos Santos CC, Weiss DJ, Stewart DJ. Mesenchymal stromal (stem) cell therapy: an emerging immunomodulatory strategy for the adjunctive treatment of sepsis. Am J Respir Crit Care Med. 2014 Feb 1; 189(3):363-4.
        View in: PubMed
      41. Rogers AJ, McGeachie M, Baron RM, Gazourian L, Haspel JA, Nakahira K, Fredenburgh LE, Hunninghake GM, Raby BA, Matthay MA, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore S, Langley RJ, Choi AM. Metabolomic derangements are associated with mortality in critically ill adult patients. PLoS One. 2014; 9(1):e87538.
        View in: PubMed PMC3907548
      42. Asija R, Roth SJ, Hanley FL, Peng L, Liu K, Abbott J, Zhuo H, Matthay M. Reperfusion pulmonary edema in children with tetralogy of Fallot, pulmonary atresia, and major aortopulmonary collateral arteries undergoing unifocalization procedures: A pilot study examining potential pathophysiologic mechanisms and clinical significance. J Thorac Cardiovasc Surg. 2014 Oct; 148(4):1560-5.
        View in: PubMed
      43. Wang CY, Calfee CS, Paul DW, Janz DR, May AK, Zhuo H, Bernard GR, Matthay MA, Ware LB, Kangelaris KN. One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome. Intensive Care Med. 2014 Mar; 40(3):388-96.
        View in: PubMed PMC3943651
      44. Frank JA, Matthay MA. TGF-ß and lung fluid balance in ARDS. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):885-6.
        View in: PubMed PMC3903208
      45. Zhu YG, Feng XM, Abbott J, Fang XH, Hao Q, Monsel A, Qu JM, Matthay MA, Lee JW. Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice. Stem Cells. 2014 Jan; 32(1):116-25.
        View in: PubMed PMC3947321
      46. Kallet RH, Zhuo H, Liu KD, Calfee CS, Matthay MA. The Association Between Physiologic Dead-Space Fraction and Mortality in Subjects With ARDS Enrolled in a Prospective Multi-Center Clinical Trial. Respir Care. 2014 Nov; 59(11):1611-8.
        View in: PubMed PMC4077995
      47. Gotts JE, Matthay MA. Treating ARDS: new hope for a tough problem. Lancet Respir Med. 2014 Feb; 2(2):84-5.
        View in: PubMed
      48. Engel J, Matthay M. Cystic fibrosis epithelial cell and bacterial binding. Am J Physiol Lung Cell Mol Physiol. 2013 Dec; 305(11):L891.
        View in: PubMed
      49. Bajwa EK, Volk JA, Christiani DC, Harris RS, Matthay MA, Thompson BT, Januzzi JL. Prognostic and diagnostic value of plasma soluble suppression of tumorigenicity-2 concentrations in acute respiratory distress syndrome. Crit Care Med. 2013 Nov; 41(11):2521-31.
        View in: PubMed PMC3812317
      50. Ware LB, Koyama T, Zhao Z, Janz DR, Wickersham N, Bernard GR, May AK, Calfee CS, Matthay MA. Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Crit Care. 2013; 17(5):R253.
        View in: PubMed PMC4056313
      51. Brown LM, Calfee CS, Howard JP, Craig TR, Matthay MA, McAuley DF. Comparison of thermodilution measured extravascular lung water with chest radiographic assessment of pulmonary oedema in patients with acute lung injury. Ann Intensive Care. 2013; 3(1):25.
        View in: PubMed PMC3846630
      52. Hendrickson CM, Matthay MA. Viral pathogens and acute lung injury: investigations inspired by the SARS epidemic and the 2009 H1N1 influenza pandemic. Semin Respir Crit Care Med. 2013 Aug; 34(4):475-86.
        View in: PubMed PMC4045622
      53. Vieillard-Baron A, Price LC, Matthay MA. Acute cor pulmonale in ARDS. Intensive Care Med. 2013 Oct; 39(10):1836-8.
        View in: PubMed PMC3955086
      54. Matthay MA, Anversa P, Bhattacharya J, Burnett BK, Chapman HA, Hare JM, Hei DJ, Hoffman AM, Kourembanas S, McKenna DH, Ortiz LA, Ott HC, Tente W, Thébaud B, Trapnell BC, Weiss DJ, Yuan JX, Blaisdell CJ. Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012. Am J Respir Crit Care Med. 2013 Aug 1; 188(3):370-5.
        View in: PubMed PMC3778734
      55. Levitt JE, Calfee CS, Goldstein BA, Vojnik R, Matthay MA. Early acute lung injury: criteria for identifying lung injury prior to the need for positive pressure ventilation*. Crit Care Med. 2013 Aug; 41(8):1929-37.
        View in: PubMed PMC3748809
      56. Glassberg MK, Hare JM, Toonkel RL, Matthay MA. Reply: idiopathic pulmonary fibrosis: a degenerative disease requiring a regenerative approach. Am J Respir Crit Care Med. 2013 Jul 15; 188(2):253-4.
        View in: PubMed PMC3778759
      57. Toonkel RL, Hare JM, Matthay MA, Glassberg MK. Mesenchymal stem cells and idiopathic pulmonary fibrosis. Potential for clinical testing. Am J Respir Crit Care Med. 2013 Jul 15; 188(2):133-40.
        View in: PubMed
      58. Bucior I, Abbott J, Song Y, Matthay MA, Engel JN. Sugar administration is an effective adjunctive therapy in the treatment of Pseudomonas aeruginosa pneumonia. Am J Physiol Lung Cell Mol Physiol. 2013 Sep; 305(5):L352-63.
        View in: PubMed PMC3763031
      59. Gotts JE, Matthay MA. Cell therapy for lung disease: a step forward. Chest. 2013 Jun; 143(6):1525-7.
        View in: PubMed
      60. Pittet JF, Koh H, Fang X, Iles K, Christiaans S, Anjun N, Wagener BM, Park DW, Zmijewski JW, Matthay MA, Roux J. HMGB1 accelerates alveolar epithelial repair via an IL-1ß- and avß6 integrin-dependent activation of TGF-ß1. PLoS One. 2013; 8(5):e63907.
        View in: PubMed PMC3655948
      61. Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A. The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. J Clin Invest. 2013 May 1; 123(5):2037-48.
        View in: PubMed PMC3635736
      62. Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS. Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. Am J Respir Crit Care Med. 2013 Apr 1; 187(7):736-42.
        View in: PubMed PMC3678110
      63. Lee JW, Krasnodembskaya A, McKenna DH, Song Y, Abbott J, Matthay MA. Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria. Am J Respir Crit Care Med. 2013 Apr 1; 187(7):751-60.
        View in: PubMed PMC3678109
      64. Thompson BT, Matthay MA. The Berlin definition of ARDS versus pathological evidence of diffuse alveolar damage. Am J Respir Crit Care Med. 2013 Apr 1; 187(7):675-7.
        View in: PubMed
      65. Seeley EJ, Barry SS, Narala S, Matthay MA, Wolters PJ. Noradrenergic neurons regulate monocyte trafficking and mortality during gram-negative peritonitis in mice. J Immunol. 2013 May 1; 190(9):4717-24.
        View in: PubMed PMC3973442
      66. Seeley EJ, Rosenberg P, Matthay MA. Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy. J Clin Invest. 2013 Mar 1; 123(3):1015-8.
        View in: PubMed PMC3582152
      67. Cross LJ, O'Kane CM, McDowell C, Elborn JJ, Matthay MA, McAuley DF. Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction--a randomised placebo-controlled trial (KARE): study protocol. Trials. 2013; 14:51.
        View in: PubMed PMC3620926
      68. Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M. Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Mol Med. 2012; 18:1481-90.
        View in: PubMed PMC3576477
      69. Howard M, Roux J, Iles KE, Miyazawa B, Christiaans S, Anjum N, Dickinson DA, Goolaerts A, Matthay MA, Pittet JF. Activation of the heat shock response attenuates the interleukin 1ß-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transport. Shock. 2013 Feb; 39(2):189-96.
        View in: PubMed PMC3663580
      70. Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P. Risk factors and outcomes in transfusion-associated circulatory overload. Am J Med. 2013 Apr; 126(4):357.e29-38.
        View in: PubMed PMC3652681
      71. Schultz MJ, Juffermans NP, Matthay MA. From protective ventilation to super-protective ventilation for acute respiratory distress syndrome. Intensive Care Med. 2013 May; 39(5):963-5.
        View in: PubMed PMC3628414
      72. Bhattacharya J, Matthay MA. Regulation and repair of the alveolar-capillary barrier in acute lung injury. Annu Rev Physiol. 2013; 75:593-615.
        View in: PubMed
      73. Bastarache JA, Matthay MA. Cecal ligation model of sepsis in mice: new insights. Crit Care Med. 2013 Jan; 41(1):356-7.
        View in: PubMed PMC3734801
      74. Kallet RH, Matthay MA. Hyperoxic acute lung injury. Respir Care. 2013 Jan; 58(1):123-41.
        View in: PubMed PMC3915523
      75. Roux J, McNicholas CM, Carles M, Goolaerts A, Houseman BT, Dickinson DA, Iles KE, Ware LB, Matthay MA, Pittet JF. IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism. FASEB J. 2013 Mar; 27(3):1095-106.
        View in: PubMed PMC3574281
      76. Komissarov AA, Stankowska D, Krupa A, Fudala R, Florova G, Florence J, Fol M, Allen TC, Idell S, Matthay MA, Kurdowska AK. Novel aspects of urokinase function in the injured lung: role of a2-macroglobulin. Am J Physiol Lung Cell Mol Physiol. 2012 Dec 15; 303(12):L1037-45.
        View in: PubMed PMC3532585
      77. Khush KK, Pawlikowska L, Menza RL, Goldstein BA, Hayden V, Nguyen J, Kim H, Poon A, Sapru A, Matthay MA, Kwok PY, Young WL, Baxter-Lowe LA, Zaroff JG. Beta-adrenergic receptor polymorphisms and cardiac graft function in potential organ donors. Am J Transplant. 2012 Dec; 12(12):3377-86.
        View in: PubMed PMC3513582
      78. Agrawal A, Zhuo H, Brady S, Levitt J, Steingrub J, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Matthay MA, Liu KD. Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials. Am J Physiol Lung Cell Mol Physiol. 2012 Oct 15; 303(8):L634-9.
        View in: PubMed PMC3469636
      79. Matthay MA, Ware LB, Zimmerman GA. The acute respiratory distress syndrome. J Clin Invest. 2012 Aug 1; 122(8):2731-40.
        View in: PubMed PMC3408735
      80. Zeyed YF, Bastarache JA, Matthay MA, Ware LB. The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2012 Sep 15; 303(6):L550-5.
        View in: PubMed PMC3468480
      81. Rackley CR, Levitt JE, Zhuo H, Matthay MA, Calfee CS. Clinical evidence of early acute lung injury often precedes the diagnosis of ALI. J Intensive Care Med. 2013 Jul-Aug; 28(4):241-6.
        View in: PubMed PMC3482421
      82. Levitt JE, Matthay MA. Clinical review: Early treatment of acute lung injury--paradigm shift toward prevention and treatment prior to respiratory failure. Crit Care. 2012; 16(3):223.
        View in: PubMed PMC3580596
      83. Seeley EJ, Matthay MA, Wolters PJ. Inflection points in sepsis biology: from local defense to systemic organ injury. Am J Physiol Lung Cell Mol Physiol. 2012 Sep; 303(5):L355-63.
        View in: PubMed PMC3468422
      84. Calfee CS, Gallagher D, Abbott J, Thompson BT, Matthay MA. Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance. Crit Care Med. 2012 Jun; 40(6):1731-7.
        View in: PubMed PMC3601049
      85. Folkesson HG, Kuzenko SR, Lipson DA, Matthay MA, Simmons MA. The adenosine 2A receptor agonist GW328267C improves lung function after acute lung injury in rats. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 1; 303(3):L259-71.
        View in: PubMed
      86. Lee JW, Zhu Y, Matthay MA. Cell-based therapy for acute lung injury: are we there yet? Anesthesiology. 2012 Jun; 116(6):1189-91.
        View in: PubMed
      87. Lucas R, Yang G, Gorshkov BA, Zemskov EA, Sridhar S, Umapathy NS, Jezierska-Drutel A, Alieva IB, Leustik M, Hossain H, Fischer B, Catravas JD, Verin AD, Pittet JF, Caldwell RB, Mitchell TJ, Cederbaum SD, Fulton DJ, Matthay MA, Caldwell RW, Romero MJ, Chakraborty T. Protein kinase C-a and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability. Am J Respir Cell Mol Biol. 2012 Oct; 47(4):445-53.
        View in: PubMed PMC3488628
      88. Nazarov I, Lee JW, Soupene E, Etemad S, Knapik D, Green W, Bashkirova E, Fang X, Matthay MA, Kuypers FA, Serikov VB. Multipotent stromal stem cells from human placenta demonstrate high therapeutic potential. Stem Cells Transl Med. 2012 May; 1(5):359-72.
        View in: PubMed PMC3635148
      89. Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D. IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. Am J Physiol Lung Cell Mol Physiol. 2012 Jul 1; 303(1):L12-9.
        View in: PubMed PMC3426434
      90. Matthay MA, Howard JP. Progress in modelling acute lung injury in a pre-clinical mouse model. Eur Respir J. 2012 May; 39(5):1062-3.
        View in: PubMed
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      128. Yamakawa N, Uchida T, Matthay MA, Makita K. Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011 Apr; 300(4):L516-25.
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      154. Ballard PL, Lee JW, Fang X, Chapin C, Allen L, Segal MR, Fischer H, Illek B, Gonzales LW, Kolla V, Matthay MA. Regulated gene expression in cultured type II cells of adult human lung. Am J Physiol Lung Cell Mol Physiol. 2010 Jul; 299(1):L36-50.
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      166. Reel B, Oishi PE, Hsu JH, Gildengorin G, Matthay MA, Fineman JR, Flori H. Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury. Pediatr Pulmonol. 2009 Nov; 44(11):1118-24.
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      169. Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest. 2009 Nov; 119(11):3450-61.
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      171. Ware LB, Fremont RD, Bastarache JA, Calfee CS, Matthay MA. Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio. Eur Respir J. 2010 Feb; 35(2):331-7.
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      172. Lee JW, Fang X, Gupta N, Serikov V, Matthay MA. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16357-62.
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      193. Erickson SE, Shlipak MG, Martin GS, Wheeler AP, Ancukiewicz M, Matthay MA, Eisner MD. Racial and ethnic disparities in mortality from acute lung injury. Crit Care Med. 2009 Jan; 37(1):1-6.
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      194. Krupa A, Fudala R, Stankowska D, Loyd T, Allen TC, Matthay MA, Gryczynski Z, Gryczynski I, Mettikolla YV, Kurdowska AK. Anti-chemokine autoantibody:chemokine immune complexes activate endothelial cells via IgG receptors. Am J Respir Cell Mol Biol. 2009 Aug; 41(2):155-69.
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      195. Iles KE, Wright MM, Cole MP, Welty NE, Ware LB, Matthay MA, Schopfer FJ, Baker PR, Agarwal A, Freeman BA. Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway. Free Radic Biol Med. 2009 Apr 1; 46(7):866-75.
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      196. Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay MA. Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs. Chest. 2009 Feb; 135(2):269-75.
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      197. Ware LB, Matthay MA. Beyond fishing: the role of discovery proteomics in mechanistic lung research. Am J Physiol Lung Cell Mol Physiol. 2009 Jan; 296(1):L12-3.
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      198. Looney MR, Esmon CT, Matthay MA. Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury. Thorax. 2009 Feb; 64(2):114-20.
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      199. Glassberg AE, Luce JM, Matthay MA. Reasons for nonenrollment in a clinical trial of acute lung injury. Chest. 2008 Oct; 134(4):719-23.
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      200. Calfee CS, Eisner MD, Parsons PE, Thompson BT, Conner ER, Matthay MA, Ware LB. Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury. Intensive Care Med. 2009 Feb; 35(2):248-57.
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      201. Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA. Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury. Thorax. 2008 Dec; 63(12):1083-9.
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      202. Seeley E, McAuley DF, Eisner M, Miletin M, Matthay MA, Kallet RH. Predictors of mortality in acute lung injury during the era of lung protective ventilation. Thorax. 2008 Nov; 63(11):994-8.
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      203. Liu KD, Levitt J, Zhuo H, Kallet RH, Brady S, Steingrub J, Tidswell M, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Phillips C, Weinacker A, Thompson BT, Eisner MD, Matthay MA. Randomized clinical trial of activated protein C for the treatment of acute lung injury. Am J Respir Crit Care Med. 2008 Sep 15; 178(6):618-23.
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      204. Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay MA. Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion. Crit Care Med. 2008 Jun; 36(6):1846-54.
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      205. Su X, Johansen M, Looney MR, Brown EJ, Matthay MA. CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia. J Immunol. 2008 May 15; 180(10):6947-53.
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      206. Matthay MA, Berthiaume Y. Novel molecular strategy to prevent pulmonary edema. Crit Care Med. 2008 May; 36(5):1671-3.
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      207. Matthay MA. Measurement of extravascular lung water in patients with pulmonary edema. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1021-2.
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      208. Liu KD, Matthay MA. Protein C as a surrogate end-point for clinical trials of sepsis. Crit Care. 2008; 12(2):139.
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      209. Matthay MA. Treatment of acute lung injury: clinical and experimental studies. Proc Am Thorac Soc. 2008 Apr 15; 5(3):297-9.
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      210. Matthay MA, Calfee CS. Aerosolized beta-adrenergic agonist therapy reduces pulmonary edema following lung surgery. Chest. 2008 Apr; 133(4):833-5.
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      211. Serikov VB, Mikhaylov VM, Krasnodembskay AD, Matthay MA. Bone marrow-derived cells participate in stromal remodeling of the lung following acute bacterial pneumonia in mice. Lung. 2008 May-Jun; 186(3):179-90.
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      212. McClintock D, Zhuo H, Wickersham N, Matthay MA, Ware LB. Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury. Crit Care. 2008; 12(2):R41.
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      213. Hunt CA, Baranzini S, Matthay MA, Park S. A framework and mechanistically focused, in silico method for enabling rational translational research. Summit on Translat Bioinforma. 2008; 2008:46-50.
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      214. Matthay MA, Lee J. Beta2 adrenergic agonist therapy may enhance alveolar epithelial repair in patients with acute lung injury. Thorax. 2008 Mar; 63(3):189-90.
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      215. Bastarache JA, Wang L, Wang Z, Albertine KH, Matthay MA, Ware LB. Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity. Am J Physiol Lung Cell Mol Physiol. 2008 May; 294(5):L874-81.
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      216. Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF. Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res. 2008 Apr 11; 102(7):804-12.
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      217. Liu KD, Matthay MA. Advances in critical care for the nephrologist: acute lung injury/ARDS. Clin J Am Soc Nephrol. 2008 Mar; 3(2):578-86.
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      218. White KE, Ding Q, Moore BB, Peters-Golden M, Ware LB, Matthay MA, Olman MA. Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors. J Immunol. 2008 Jan 1; 180(1):637-46.
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      219. Liu KD, Glidden DV, Eisner MD, Parsons PE, Ware LB, Wheeler A, Korpak A, Thompson BT, Chertow GM, Matthay MA. Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med. 2007 Dec; 35(12):2755-61.
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      220. Calfee CS, Eisner MD, Ware LB, Thompson BT, Parsons PE, Wheeler AP, Korpak A, Matthay MA. Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Crit Care Med. 2007 Oct; 35(10):2243-50.
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      221. Popov BV, Serikov VB, Petrov NS, Izusova TV, Gupta N, Matthay MA. Lung epithelial cells induce endodermal differentiation in mouse mesenchymal bone marrow stem cells by paracrine mechanism. Tissue Eng. 2007 Oct; 13(10):2441-50.
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      222. Looney MR, Matthay MA. The role of protein C in sepsis. Curr Infect Dis Rep. 2007 Oct; 3(5):413-8.
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      223. Frank JA, Pittet JF, Wray C, Matthay MA. Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade. Thorax. 2008 Feb; 63(2):147-53.
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      224. Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE. Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1633-40.
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      225. Matthay MA, Taeusch W. Surfactant treatment of aspiration-induced lung injury in children. Pediatr Crit Care Med. 2007 Sep; 8(5):505-6.
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      226. Serikov VB, Popov B, Mikhailov VM, Gupta N, Matthay MA. Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice. Anat Rec (Hoboken). 2007 Sep; 290(9):1033-45.
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      227. Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA. Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol. 2007 Aug 1; 179(3):1855-63.
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      228. Pauluhn J, Carson A, Costa DL, Gordon T, Kodavanti U, Last JA, Matthay MA, Pinkerton KE, Sciuto AM. Workshop summary: phosgene-induced pulmonary toxicity revisited: appraisal of early and late markers of pulmonary injury from animal models with emphasis on human significance. Inhal Toxicol. 2007 Aug; 19(10):789-810.
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      229. Ware LB, Matthay MA, Parsons PE, Thompson BT, Januzzi JL, Eisner MD. Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome. Crit Care Med. 2007 Aug; 35(8):1821-8.
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      230. Matthay MA, Su X. Pulmonary barriers to pneumonia and sepsis. Nat Med. 2007 Jul; 13(7):780-1.
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      231. Calfee CS, Budev MM, Matthay MA, Church G, Brady S, Uchida T, Ishizaka A, Lara A, Ranes JL, deCamp MM, Arroliga AC. Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation. J Heart Lung Transplant. 2007 Jul; 26(7):675-80.
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      232. Lee JW, Fang X, Dolganov G, Fremont RD, Bastarache JA, Ware LB, Matthay MA. Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells. J Biol Chem. 2007 Aug 17; 282(33):24109-19.
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      233. Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Liu KD, Matthay MA. Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injury. Chest. 2007 Sep; 132(3):836-42.
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      234. Berthiaume Y, Matthay MA. Alveolar edema fluid clearance and acute lung injury. Respir Physiol Neurobiol. 2007 Dec 15; 159(3):350-9.
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      235. Fudala R, Krupa A, Matthay MA, Allen TC, Kurdowska AK. Anti-IL-8 autoantibody:IL-8 immune complexes suppress spontaneous apoptosis of neutrophils. Am J Physiol Lung Cell Mol Physiol. 2007 Aug; 293(2):L364-74.
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      236. Li CJ, Ning W, Matthay MA, Feghali-Bostwick CA, Choi AM. MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine production. Am J Physiol Lung Cell Mol Physiol. 2007 May; 292(5):L1297-303.
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      237. Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg. 2007 May; 245(5):812-8.
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      238. Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA. Genomics and proteomics of lung disease: conference summary. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L45-51.
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      239. Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA. Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats. Am J Respir Cell Mol Biol. 2007 Aug; 37(2):186-92.
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      240. Fremont RD, Kallet RH, Matthay MA, Ware LB. Postobstructive pulmonary edema: a case for hydrostatic mechanisms. Chest. 2007 Jun; 131(6):1742-6.
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      241. Hirsch J, Hansen KC, Sapru A, Frank JA, Chalkley RJ, Fang X, Trinidad JC, Baker P, Burlingame AL, Matthay MA. Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome. Am J Respir Crit Care Med. 2007 May 15; 175(10):1006-13.
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      242. Bastarache JA, Wang L, Geiser T, Wang Z, Albertine KH, Matthay MA, Ware LB. The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Thorax. 2007 Jul; 62(7):608-16.
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      243. Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA. Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L52-9.
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      244. Calfee CS, Matthay MA. Nonventilatory treatments for acute lung injury and ARDS. Chest. 2007 Mar; 131(3):913-20.
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      245. Flori HR, Ware LB, Milet M, Matthay MA. Early elevation of plasma von Willebrand factor antigen in pediatric acute lung injury is associated with an increased risk of death and prolonged mechanical ventilation. Pediatr Crit Care Med. 2007 Mar; 8(2):96-101.
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      246. Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay MA, Mostov K. Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. Mol Biol Cell. 2007 May; 18(5):1693-700.
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      247. Heresi GA, Arroliga AC, Wiedemann HP, Weidemann HP, Matthay MA. Pulmonary artery catheter and fluid management in acute lung injury and the acute respiratory distress syndrome. Clin Chest Med. 2006 Dec; 27(4):627-35; abstract ix.
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      248. Frank JA, Parsons PE, Matthay MA. Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies. Chest. 2006 Dec; 130(6):1906-14.
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      249. Ning W, Dong Y, Sun J, Li C, Matthay MA, Feghali-Bostwick CA, Choi AM. Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts. Am J Respir Cell Mol Biol. 2007 Apr; 36(4):480-90.
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      250. Wang L, Bastarache JA, Wickersham N, Fang X, Matthay MA, Ware LB. Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation. Am J Respir Cell Mol Biol. 2007 Apr; 36(4):497-503.
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      251. Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med. 2006 Nov; 12(11):1286-93.
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      252. McClintock DE, Ware LB, Eisner MD, Wickersham N, Thompson BT, Matthay MA. Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury. Am J Respir Crit Care Med. 2007 Feb 1; 175(3):256-62.
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      253. Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay MA, Sheppard D, Pittet JF. Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Am J Respir Cell Mol Biol. 2007 Mar; 36(3):377-86.
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      254. Lee JW, Matthay MA. Protein permeability in lung injury: now in real time again? J Appl Physiol (1985). 2007 Feb; 102(2):508-9.
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      255. Levitt JE, Matthay MA. Treatment of acute lung injury: historical perspective and potential future therapies. Semin Respir Crit Care Med. 2006 Aug; 27(4):426-37.
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      256. Frank JA, Wray CM, McAuley DF, Schwendener R, Matthay MA. Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Dec; 291(6):L1191-8.
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      257. Godzich M, Hodnett M, Frank JA, Su G, Pespeni M, Angel A, Howard MB, Matthay MA, Pittet JF. Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia-reperfusion injury in rats. FASEB J. 2006 Jul; 20(9):1519-21.
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      258. Sapru A, Wiemels JL, Witte JS, Ware LB, Matthay MA. Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways. Intensive Care Med. 2006 Sep; 32(9):1293-303.
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      259. Wiener-Kronish JP, Matthay MA. Beta-2-agonist treatment as a potential therapy for acute inhalational lung injury. Crit Care Med. 2006 Jun; 34(6):1841-2.
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      260. Gupta N, Matthay MA. Sepsis and stretch: synergistic effects on alveolar epithelial cell death? Crit Care Med. 2006 Jun; 34(6):1846-7.
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      261. Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA. Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest. 2006 Jun; 116(6):1615-23.
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      262. Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D. Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest. 2006 Jun; 116(6):1606-14.
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      263. Guidot DM, Folkesson HG, Jain L, Sznajder JI, Pittet JF, Matthay MA. Integrating acute lung injury and regulation of alveolar fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 291(3):L301-6.
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      264. McClintock DE, Starcher B, Eisner MD, Thompson BT, Hayden DL, Church GD, Matthay MA. Higher urine desmosine levels are associated with mortality in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Oct; 291(4):L566-71.
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      265. Liu KD, Matthay MA, Chertow GM. Evolving practices in critical care and potential implications for management of acute kidney injury. Clin J Am Soc Nephrol. 2006 Jul; 1(4):869-73.
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      266. Ganter MT, Ware LB, Howard M, Roux J, Gartland B, Matthay MA, Fleshner M, Pittet JF. Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 291(3):L354-61.
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      267. Looney MR, Matthay MA. Animal models of transfusion-related acute lung injury. Crit Care Med. 2006 May; 34(5 Suppl):S132-6.
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      268. Adler KB, Shapiro SD, Gallup M, Wu R, Randell SH, Holtzman MJ, Evans CM, Jacoby DB, Tesfaigzi Y, Rose MC, Mossman BT, Prince A, Reddy SP, Davis CW, Matthay MA. Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum. Am J Respir Cell Mol Biol. 2006 May; 34(5):523-6.
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      269. Cepkova M, Matthay MA. Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome. J Intensive Care Med. 2006 May-Jun; 21(3):119-43.
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      270. Ware LB, Camerer E, Welty-Wolf K, Schultz MJ, Matthay MA. Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 291(3):L307-11.
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      272. Folkesson HG, Matthay MA. Alveolar epithelial ion and fluid transport: recent progress. Am J Respir Cell Mol Biol. 2006 Jul; 35(1):10-9.
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      273. Curley MA, Arnold JH, Thompson JE, Fackler JC, Grant MJ, Fineman LD, Cvijanovich N, Barr FE, Molitor-Kirsch S, Steinhorn DM, Matthay MA, Hibberd PL. Clinical trial design--effect of prone positioning on clinical outcomes in infants and children with acute respiratory distress syndrome. J Crit Care. 2006 Mar; 21(1):23-32; discussion 32-7.
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      274. Sakuma T, Gu X, Wang Z, Maeda S, Sugita M, Sagawa M, Osanai K, Toga H, Ware LB, Folkesson G, Matthay MA. Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine. Crit Care Med. 2006 Mar; 34(3):676-81.
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      275. Hirsch J, Hansen KC, Choi S, Noh J, Hirose R, Roberts JP, Matthay MA, Burlingame AL, Maher JJ, Niemann CU. Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in rats. Mol Cell Proteomics. 2006 Jun; 5(6):979-86.
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      276. Uchida T, Shirasawa M, Ware LB, Kojima K, Hata Y, Makita K, Mednick G, Matthay ZA, Matthay MA. Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Am J Respir Crit Care Med. 2006 May 1; 173(9):1008-15.
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      280. Ware LB, Matthay MA. Clinical practice. Acute pulmonary edema. N Engl J Med. 2005 Dec 29; 353(26):2788-96.
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      281. Han B, Mura M, Andrade CF, Okutani D, Lodyga M, dos Santos CC, Keshavjee S, Matthay M, Liu M. TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK. J Immunol. 2005 Dec 15; 175(12):8303-11.
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      282. Su X, Robriquet L, Folkesson HG, Matthay MA. Protective effect of endogenous beta-adrenergic tone on lung fluid balance in acute bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2006 Apr; 290(4):L769-L776.
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      283. Matthay MA, Calfee CS. Therapeutic value of a lung protective ventilation strategy in acute lung injury. Chest. 2005 Nov; 128(5):3089-91.
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      284. Folkesson HG, Chapin CJ, Beard LL, Ertsey R, Matthay MA, Kitterman JA. Congenital diaphragmatic hernia prevents absorption of distal air space fluid in late-gestation rat fetuses. Am J Physiol Lung Cell Mol Physiol. 2006 Mar; 290(3):L478-84.
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      285. Matthay MA, Zimmerman GA. Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management. Am J Respir Cell Mol Biol. 2005 Oct; 33(4):319-27.
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      286. Ware LB, Fang X, Wang Y, Babcock WD, Jones K, Matthay MA. High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation. J Heart Lung Transplant. 2005 Oct; 24(10):1650-6.
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      287. Fang X, Song Y, Hirsch J, Galietta LJ, Pedemonte N, Zemans RL, Dolganov G, Verkman AS, Matthay MA. Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells. Am J Physiol Lung Cell Mol Physiol. 2006 Feb; 290(2):L242-9.
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      288. Su X, Camerer E, Hamilton JR, Coughlin SR, Matthay MA. Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. J Immunol. 2005 Aug 15; 175(4):2598-605.
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      289. Frank JA, Matthay MA. Leukotrienes in acute lung injury: a potential therapeutic target? Am J Respir Crit Care Med. 2005 Aug 1; 172(3):261-2.
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      291. Ware LB, Kaner RJ, Crystal RG, Schane R, Trivedi NN, McAuley D, Matthay MA. VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema. Eur Respir J. 2005 Jul; 26(1):101-5.
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      292. Calfee CS, Matthay MA. Recent advances in mechanical ventilation. Am J Med. 2005 Jun; 118(6):584-91.
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      294. Kallet RH, Daniel BM, Garcia O, Matthay MA. Accuracy of physiologic dead space measurements in patients with acute respiratory distress syndrome using volumetric capnography: comparison with the metabolic monitor method. Respir Care. 2005 Apr; 50(4):462-7.
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      296. Angus D, Ishizaka A, Matthay M, Lemaire F, Macnee W, Abraham E. Critical care in AJRCCM 2004. Am J Respir Crit Care Med. 2005 Mar 15; 171(6):537-44.
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      312. Su X, Looney M, Robriquet L, Fang X, Matthay MA. Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice. Exp Lung Res. 2004 Sep; 30(6):479-93.
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      313. Pugin J, Stern-Voeffray S, Daubeuf B, Matthay MA, Elson G, Dunn-Siegrist I. Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock. Blood. 2004 Dec 15; 104(13):4071-9.
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      314. Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med. 2004 Jul 22; 351(4):327-36.
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      315. Sue RD, Matthay MA, Ware LB. Hydrostatic mechanisms may contribute to the pathogenesis of human re-expansion pulmonary edema. Intensive Care Med. 2004 Oct; 30(10):1921-6.
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      317. Looney MR, Gropper MA, Matthay MA. Transfusion-related acute lung injury: a review. Chest. 2004 Jul; 126(1):249-58.
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      322. Matthay MA, Ware LB. Plasma protein C levels in patients with acute lung injury: prognostic significance. Crit Care Med. 2004 May; 32(5 Suppl):S229-32.
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      323. Geiser T, Ishigaki M, van Leer C, Matthay MA, Broaddus VC. H(2)O(2) inhibits alveolar epithelial wound repair in vitro by induction of apoptosis. Am J Physiol Lung Cell Mol Physiol. 2004 Aug; 287(2):L448-53.
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      324. Hastings RH, Folkesson HG, Matthay MA. Mechanisms of alveolar protein clearance in the intact lung. Am J Physiol Lung Cell Mol Physiol. 2004 Apr; 286(4):L679-89.
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      325. Zemans RL, Chatterjee K, Matthay MA. Diagnostic utility of B-type natriuretic peptide in patients with acute dyspnea or pleural effusions. Am J Med. 2004 Mar 15; 116(6):424-6.
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      327. Sakuma T, Zhao Y, Sugita M, Sagawa M, Toga H, Ishibashi T, Nishio M, Matthay MA. Malnutrition impairs alveolar fluid clearance in rat lungs. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1268-74.
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      330. Gropper MA, Matthay MA. Look before you leap: how do intensivists improve care for critically ill patients? Am J Med. 2004 Feb 1; 116(3):206-7.
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      415. Yost CS, Matthay MA, Gropper MA. Etiology of acute pulmonary edema during liver transplantation : a series of cases with analysis of the edema fluid. Chest. 2001 Jan; 119(1):219-23.
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      417. Song Y, Yang B, Matthay MA, Ma T, Verkman AS. Role of aquaporin water channels in pleural fluid dynamics. Am J Physiol Cell Physiol. 2000 Dec; 279(6):C1744-50.
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      419. Frank JA, Wang Y, Osorio O, Matthay MA. Beta-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats. J Appl Physiol (1985). 2000 Oct; 89(4):1255-65.
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      422. Frank JA, Nuckton TJ, Matthay MA. Diabetes mellitus: a negative predictor for the development of acute respiratory distress syndrome from septic shock. Crit Care Med. 2000 Jul; 28(7):2645-6.
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      425. Jasmer RM, Matthay MA. Cost-effectiveness of noninvasive ventilation for acute chronic obstructive pulmonary disease: cashing in too quickly. Crit Care Med. 2000 Jun; 28(6):2170-1.
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      426. Sakuma T, Tsukano C, Ishigaki M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Kurihara T, Nishio M, Matthay MA. Lung deflation impairs alveolar epithelial fluid transport in ischemic rabbit and rat lungs. Transplantation. 2000 May 15; 69(9):1785-93.
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      427. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 2000 May 4; 342(18):1334-49.
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      432. Newman V, Gonzalez RF, Matthay MA, Dobbs LG. A novel alveolar type I cell-specific biochemical marker of human acute lung injury. Am J Respir Crit Care Med. 2000 Mar; 161(3 Pt 1):990-5.
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      433. Pascual FE, Matthay MA, Bacchetti P, Wachter RM. Assessment of prognosis in patients with community-acquired pneumonia who require mechanical ventilation. Chest. 2000 Feb; 117(2):503-12.
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      434. Folkesson HG, Norlin A, Wang Y, Abedinpour P, Matthay MA. Dexamethasone and thyroid hormone pretreatment upregulate alveolar epithelial fluid clearance in adult rats. J Appl Physiol (1985). 2000 Feb; 88(2):416-24.
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      435. Yang B, Fukuda N, van Hoek A, Matthay MA, Ma T, Verkman AS. Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes. J Biol Chem. 2000 Jan 28; 275(4):2686-92.
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      436. Eberhard LW, Morabito DJ, Matthay MA, Mackersie RC, Campbell AR, Marks JD, Alonso JA, Pittet JF. Initial severity of metabolic acidosis predicts the development of acute lung injury in severely traumatized patients. Crit Care Med. 2000 Jan; 28(1):125-31.
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      439. Gaillard D, Hinnrasky J, Coscoy S, Hofman P, Matthay MA, Puchelle E, Barbry P. Early expression of beta- and gamma-subunits of epithelial sodium channel during human airway development. Am J Physiol Lung Cell Mol Physiol. 2000 Jan; 278(1):L177-84.
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      440. Song Y, Ma T, Matthay MA, Verkman AS. Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method. J Gen Physiol. 2000 Jan; 115(1):17-27.
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      442. Eisner MD, Matthay MA. Health-related quality of life after acute lung injury. Crit Care Med. 1999 Dec; 27(12):2825-6.
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      444. Rubenfeld GD, Caldwell E, Granton J, Hudson LD, Matthay MA. Interobserver variability in applying a radiographic definition for ARDS. Chest. 1999 Nov; 116(5):1347-53.
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      445. Wang Y, Folkesson HG, Jayr C, Ware LB, Matthay MA. Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta-agonist therapy. J Appl Physiol (1985). 1999 Nov; 87(5):1852-60.
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      446. Laffon M, Pittet JF, Modelska K, Matthay MA, Young DM. Interleukin-8 mediates injury from smoke inhalation to both the lung endothelial and the alveolar epithelial barriers in rabbits. Am J Respir Crit Care Med. 1999 Nov; 160(5 Pt 1):1443-9.
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      447. Modelska K, Pittet JF, Folkesson HG, Courtney Broaddus V, Matthay MA. Acid-induced lung injury. Protective effect of anti-interleukin-8 pretreatment on alveolar epithelial barrier function in rabbits. Am J Respir Crit Care Med. 1999 Nov; 160(5 Pt 1):1450-6.
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      448. Verghese GM, Ware LB, Matthay BA, Matthay MA. Alveolar epithelial fluid transport and the resolution of clinically severe hydrostatic pulmonary edema. J Appl Physiol (1985). 1999 Oct; 87(4):1301-12.
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      449. Laffon M, Lu LN, Modelska K, Matthay MA, Pittet JF. alpha-adrenergic blockade restores normal fluid transport capacity of alveolar epithelium after hemorrhagic shock. Am J Physiol. 1999 Oct; 277(4 Pt 1):L760-8.
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      450. Hribar M, Bloc A, van der Goot FG, Fransen L, De Baetselier P, Grau GE, Bluethmann H, Matthay MA, Dunant Y, Pugin J, Lucas R. The lectin-like domain of tumor necrosis factor-alpha increases membrane conductance in microvascular endothelial cells and peritoneal macrophages. Eur J Immunol. 1999 Oct; 29(10):3105-11.
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      451. Matthay MA, Geiser T, Matalon S, Ischiropoulos H. Oxidant-mediated lung injury in the acute respiratory distress syndrome. Crit Care Med. 1999 Sep; 27(9):2028-30.
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      452. Berthiaume Y, Folkesson HG, Matthay MA. Indomethacin does not influence alveolar liquid clearance in anesthetized sheep or rats. Exp Lung Res. 1999 Sep; 25(6):517-30.
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      453. Conner ER, Ware LB, Modin G, Matthay MA. Elevated pulmonary edema fluid concentrations of soluble intercellular adhesion molecule-1 in patients with acute lung injury: biological and clinical significance. Chest. 1999 Jul; 116(1 Suppl):83S-84S.
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      454. Wang Y, Jayr C, Folkesson HG, Matthay MA. Alveolar epithelial fluid transport can be upregulated simultaneously in rats by two different mechanisms. Chest. 1999 Jul; 116(1 Suppl):98S-100S.
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      455. Newman V, Gonzalez R, Matthay M, Dobbs L. HTI56, an integral apical membrane protein of the human alveolar type I cell, is a biochemical marker of acute lung injury. Chest. 1999 Jul; 116(1 Suppl):35S-36S.
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      456. Khan SU, Salloum J, O'Donovan PB, Mascha EJ, Mehta AC, Matthay MA, Arroliga AC. Acute pulmonary edema after lung transplantation: the pulmonary reimplantation response. Chest. 1999 Jul; 116(1):187-94.
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      457. Matthay MA. Conference summary: acute lung injury. Chest. 1999 Jul; 116(1 Suppl):119S-126S.
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      459. Ware LB, Golden JA, Finkbeiner WE, Matthay MA. Alveolar epithelial fluid transport capacity in reperfusion lung injury after lung transplantation. Am J Respir Crit Care Med. 1999 Mar; 159(3):980-8.
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      460. Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, Pittet JF, Kaminski N, Garat C, Matthay MA, Rifkin DB, Sheppard D. The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell. 1999 Feb 5; 96(3):319-28.
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      463. Planus E, Galiacy S, Matthay M, Laurent V, Gavrilovic J, Murphy G, Clérici C, Isabey D, Lafuma C, d'Ortho MP. Role of collagenase in mediating in vitro alveolar epithelial wound repair. J Cell Sci. 1999 Jan; 112 ( Pt 2):243-52.
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      464. Sakuma T, Takahashi K, Ohya N, Kajikawa O, Martin TR, Albertine KH, Matthay MA. Ischemia-reperfusion lung injury in rabbits: mechanisms of injury and protection. Am J Physiol. 1999 Jan; 276(1 Pt 1):L137-45.
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      465. Campbell AR, Folkesson HG, Berthiaume Y, Gutkowska J, Suzuki S, Matthay MA. Alveolar epithelial fluid clearance persists in the presence of moderate left atrial hypertension in sheep. J Appl Physiol (1985). 1999 Jan; 86(1):139-51.
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      466. Yang B, Folkesson HG, Yang J, Matthay MA, Ma T, Verkman AS. Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice. Am J Physiol. 1999 Jan; 276(1 Pt 1):C76-81.
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      467. Saint S, Matthay MA. Risk reduction in the intensive care unit. Am J Med. 1998 Dec; 105(6):515-23.
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      469. DiFederico EM, Burlingame JM, Kilpatrick SJ, Harrison M, Matthay MA. Pulmonary edema in obstetric patients is rapidly resolved except in the presence of infection or of nitroglycerin tocolysis after open fetal surgery. Am J Obstet Gynecol. 1998 Oct; 179(4):925-33.
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      470. Folkesson HG, Nitenberg G, Oliver BL, Jayr C, Albertine KH, Matthay MA. Upregulation of alveolar epithelial fluid transport after subacute lung injury in rats from bleomycin. Am J Physiol. 1998 Sep; 275(3 Pt 1):L478-90.
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      471. Verghese GM, McCormick-Shannon K, Mason RJ, Matthay MA. Hepatocyte growth factor and keratinocyte growth factor in the pulmonary edema fluid of patients with acute lung injury. Biologic and clinical significance. Am J Respir Crit Care Med. 1998 Aug; 158(2):386-94.
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      473. Bai C, Biwersi J, Verkman AS, Matthay MA. A mouse model to test the in vivo efficacy of chemical chaperones. J Pharmacol Toxicol Methods. 1998 Jul; 40(1):39-45.
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      474. Ma T, Yang B, Matthay MA, Verkman AS. Evidence against a role of mouse, rat, and two cloned human t1alpha isoforms as a water channel or a regulator of aquaporin-type water channels. Am J Respir Cell Mol Biol. 1998 Jul; 19(1):143-9.
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      475. Sakuma T, Takahashi K, Ohya N, Nakada T, Matthay MA. Effects of ATP-sensitive potassium channel opener on potassium transport and alveolar fluid clearance in the resected human lung. Pharmacol Toxicol. 1998 Jul; 83(1):16-22.
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      479. Carter EP, Olveczky BP, Matthay MA, Verkman AS. High microvascular endothelial water permeability in mouse lung measured by a pleural surface fluorescence method. Biophys J. 1998 Apr; 74(4):2121-8.
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      486. Folkesson HG, Matthay MA. Inhibition of CD18 or CD11b attenuates acute lung injury after acid instillation in rabbits. J Appl Physiol (1985). 1997 Jun; 82(6):1743-50.
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      487. Jasmer RM, Luce JM, Matthay MA. Noninvasive positive pressure ventilation for acute respiratory failure: underutilized or overrated? Chest. 1997 Jun; 111(6):1672-8.
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      489. Smith WS, Matthay MA. Evidence for a hydrostatic mechanism in human neurogenic pulmonary edema. Chest. 1997 May; 111(5):1326-33.
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      492. Chesnutt AN, Kheradmand F, Folkesson HG, Alberts M, Matthay MA. Soluble transforming growth factor-alpha is present in the pulmonary edema fluid of patients with acute lung injury. Chest. 1997 Mar; 111(3):652-6.
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      493. Sakuma T, Folkesson HG, Suzuki S, Okaniwa G, Fujimura S, Matthay MA. Beta-adrenergic agonist stimulated alveolar fluid clearance in ex vivo human and rat lungs. Am J Respir Crit Care Med. 1997 Feb; 155(2):506-12.
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      494. Rezaiguia S, Garat C, Delclaux C, Meignan M, Fleury J, Legrand P, Matthay MA, Jayr C. Acute bacterial pneumonia in rats increases alveolar epithelial fluid clearance by a tumor necrosis factor-alpha-dependent mechanism. J Clin Invest. 1997 Jan 15; 99(2):325-35.
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      495. Sakuma T, Usuda K, Handa M, Okaniwa G, Nakada T, Fujimura S, Matthay MA. Increased alveolar fluid clearance following thoracotomy: report of a case and results of an analysis. Surg Today. 1997; 27(8):762-5.
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      497. Garat C, Kheradmand F, Albertine KH, Folkesson HG, Matthay MA. Soluble and insoluble fibronectin increases alveolar epithelial wound healing in vitro. Am J Physiol. 1996 Nov; 271(5 Pt 1):L844-53.
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      498. Kurdowska A, Miller EJ, Noble JM, Baughman RP, Matthay MA, Brelsford WG, Cohen AB. Anti-IL-8 autoantibodies in alveolar fluid from patients with the adult respiratory distress syndrome. J Immunol. 1996 Sep 15; 157(6):2699-706.
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      500. Miller EJ, Cohen AB, Matthay MA. Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsis. Crit Care Med. 1996 Sep; 24(9):1448-54.
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      503. Matthay MA, Rosen GD. Acid aspiration induced lung injury. New insights and therapeutic options. Am J Respir Crit Care Med. 1996 Aug; 154(2 Pt 1):277-8.
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      504. Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 1996 May 30; 334(22):1469-70.
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      507. DiFederico EM, Harrison M, Matthay MA. Pulmonary edema in a woman following fetal surgery. Chest. 1996 Apr; 109(4):1114-7.
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      513. Hastings RH, Folkesson HG, Petersen V, Ciriales R, Matthay MA. Cellular uptake of albumin from lungs of anesthetized rabbits. Am J Physiol. 1995 Oct; 269(4 Pt 1):L453-62.
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      516. Rubenfeld GD, Doyle RL, Matthay MA. Evaluation of definitions of ARDS. Am J Respir Crit Care Med. 1995 Apr; 151(4):1270-1.
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      518. Schwartz DE, Matthay MA, Cohen NH. Death and other complications of emergency airway management in critically ill adults. A prospective investigation of 297 tracheal intubations. Anesthesiology. 1995 Feb; 82(2):367-76.
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      522. Pittet JF, Wiener-Kronish JP, McElroy MC, Folkesson HG, Matthay MA. Stimulation of lung epithelial liquid clearance by endogenous release of catecholamines in septic shock in anesthetized rats. J Clin Invest. 1994 Aug; 94(2):663-71.
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      523. Sakuma T, Okaniwa G, Nakada T, Nishimura T, Fujimura S, Matthay MA. Alveolar fluid clearance in the resected human lung. Am J Respir Crit Care Med. 1994 Aug; 150(2):305-10.
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      524. Jayr C, Garat C, Meignan M, Pittet JF, Zelter M, Matthay MA. Alveolar liquid and protein clearance in anesthetized ventilated rats. J Appl Physiol (1985). 1994 Jun; 76(6):2636-42.
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      525. Folkesson HG, Matthay MA, Hasegawa H, Kheradmand F, Verkman AS. Transcellular water transport in lung alveolar epithelium through mercury-sensitive water channels. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):4970-4.
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      526. Hastings RH, Wright JR, Albertine KH, Ciriales R, Matthay MA. Effect of endocytosis inhibitors on alveolar clearance of albumin, immunoglobulin G, and SP-A in rabbits. Am J Physiol. 1994 May; 266(5 Pt 1):L544-52.
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      527. Matthay MA. Function of the alveolar epithelial barrier under pathologic conditions. Chest. 1994 Mar; 105(3 Suppl):67S-74S.
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      528. Hasegawa H, Ma T, Skach W, Matthay MA, Verkman AS. Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. J Biol Chem. 1994 Feb 25; 269(8):5497-500.
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      529. Kelly BJ, Matthay MA. Prevalence and severity of neurologic dysfunction in critically ill patients. Influence on need for continued mechanical ventilation. Chest. 1993 Dec; 104(6):1818-24.
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      530. Matthay MA, Thiery JP, Lafont F, Stampfer F, Boyer B. Transient effect of epidermal growth factor on the motility of an immortalized mammary epithelial cell line. J Cell Sci. 1993 Nov; 106 ( Pt 3):869-78.
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      531. Matthay MA, Folkesson HG, Campagna A, Kheradmand F. Alveolar epithelial barrier and acute lung injury. New Horiz. 1993 Nov; 1(4):613-22.
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      532. Wiener-Kronish JP, Sakuma T, Kudoh I, Pittet JF, Frank D, Dobbs L, Vasil ML, Matthay MA. Alveolar epithelial injury and pleural empyema in acute P. aeruginosa pneumonia in anesthetized rabbits. J Appl Physiol (1985). 1993 Oct; 75(4):1661-9.
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      533. Pittet JF, Matthay MA, Pier G, Grady M, Wiener-Kronish JP. Pseudomonas aeruginosa-induced lung and pleural injury in sheep. Differential protective effect of circulating versus alveolar immunoglobulin G antibody. J Clin Invest. 1993 Sep; 92(3):1221-8.
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      534. Serikov VB, Grady M, Matthay MA. Effect of temperature on alveolar liquid and protein clearance in an in situ perfused goat lung. J Appl Physiol (1985). 1993 Aug; 75(2):940-7.
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      535. Cohen AB, Stevens MD, Miller EJ, Atkinson MA, Mullenbach G, Maunder RJ, Martin TR, Wiener-Kronish JP, Matthay MA. Neutrophil-activating peptide-2 in patients with pulmonary edema from congestive heart failure or ARDS. Am J Physiol. 1993 May; 264(5 Pt 1):L490-5.
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      536. Jayr C, Matthay MA, Goldstone J, Gold WM, Wiener-Kronish JP. Preoperative and intraoperative factors associated with prolonged mechanical ventilation. A study in patients following major abdominal vascular surgery. Chest. 1993 Apr; 103(4):1231-6.
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      537. Newman W, Beall LD, Carson CW, Hunder GG, Graben N, Randhawa ZI, Gopal TV, Wiener-Kronish J, Matthay MA. Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock. J Immunol. 1993 Jan 15; 150(2):644-54.
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      538. Sakuma T, Pittet JF, Jayr C, Matthay MA. Alveolar liquid and protein clearance in the absence of blood flow or ventilation in sheep. J Appl Physiol (1985). 1993 Jan; 74(1):176-85.
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      539. Espiritu RF, Pittet JF, Matthay MA, Goetzl EJ. Neuropeptides in pulmonary edema fluid of adult respiratory distress syndrome. Inflammation. 1992 Oct; 16(5):509-17.
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      540. Hastings RH, Grady M, Sakuma T, Matthay MA. Clearance of different-sized proteins from the alveolar space in humans and rabbits. J Appl Physiol (1985). 1992 Oct; 73(4):1310-6.
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      541. Cohen DS, Matthay MA, Cogan MG, Murray JF. Pulmonary edema associated with salt water near-drowning: new insights. Am Rev Respir Dis. 1992 Sep; 146(3):794-6.
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      542. Segredo V, Caldwell JE, Matthay MA, Sharma ML, Gruenke LD, Miller RD. Persistent paralysis in critically ill patients after long-term administration of vecuronium. N Engl J Med. 1992 Aug 20; 327(8):524-8.
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      543. Miller EJ, Cohen AB, Nagao S, Griffith D, Maunder RJ, Martin TR, Weiner-Kronish JP, Sticherling M, Christophers E, Matthay MA. Elevated levels of NAP-1/interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortality. Am Rev Respir Dis. 1992 Aug; 146(2):427-32.
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      544. Kilpatrick SJ, Matthay MA. Obstetric patients requiring critical care. A five-year review. Chest. 1992 May; 101(5):1407-12.
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      545. Callaham M, Barton C, Matthay M. Effect of epinephrine on the ability of end-tidal carbon dioxide readings to predict initial resuscitation from cardiac arrest. Crit Care Med. 1992 Mar; 20(3):337-43.
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      546. Jayr C, Matthay MA. Alveolar and lung liquid clearance in the absence of pulmonary blood flow in sheep. J Appl Physiol (1985). 1991 Nov; 71(5):1679-87.
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      547. Wiener-Kronish JP, Albertine KH, Matthay MA. Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin. J Clin Invest. 1991 Sep; 88(3):864-75.
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      548. Matthay MA, Matthay RA. Critical care medicine. JAMA. 1991 Jun 19; 265(23):3109-11.
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      549. Smedira N, Gates L, Hastings R, Jayr C, Sakuma T, Pittet JF, Matthay MA. Alveolar and lung liquid clearance in anesthetized rabbits. J Appl Physiol (1985). 1991 Apr; 70(4):1827-35.
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      550. Matthay MA. Resolution of pulmonary edema. New insights. West J Med. 1991 Mar; 154(3):315-21.
        View in: PubMed PMC1002752
      551. Chatterjee K, Matthay M. Right-heart catheterization is a diagnostic procedure not a therapeutic intervention. J Intensive Care Med. 1991 Mar-Apr; 6(2):101-4.
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      552. Matthay MA. The adult respiratory distress syndrome. Definition and prognosis. Clin Chest Med. 1990 Dec; 11(4):575-80.
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      553. Matthay MA, Wiener-Kronish JP. Intact epithelial barrier function is critical for the resolution of alveolar edema in humans. Am Rev Respir Dis. 1990 Dec; 142(6 Pt 1):1250-7.
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      554. Wiedemann HP, Matthay MA, Gillis CN. Pulmonary endothelial cell injury and altered lung metabolic function. Early detection of the adult respiratory distress syndrome and possible functional significance. Clin Chest Med. 1990 Dec; 11(4):723-36.
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      555. Rubin DB, Wiener-Kronish JP, Murray JF, Green DR, Turner J, Luce JM, Montgomery AB, Marks JD, Matthay MA. Elevated von Willebrand factor antigen is an early plasma predictor of acute lung injury in nonpulmonary sepsis syndrome. J Clin Invest. 1990 Aug; 86(2):474-80.
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      556. Wiener-Kronish JP, Gropper MA, Matthay MA. The adult respiratory distress syndrome: definition and prognosis, pathogenesis and treatment. Br J Anaesth. 1990 Jul; 65(1):107-29.
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      557. Urbanowicz JH, Shaaban MJ, Cohen NH, Cahalan MK, Botvinick EH, Chatterjee K, Schiller NB, Dae MW, Matthay MA. Comparison of transesophageal echocardiographic and scintigraphic estimates of left ventricular end-diastolic volume index and ejection fraction in patients following coronary artery bypass grafting. Anesthesiology. 1990 Apr; 72(4):607-12.
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      558. Heffner JE, Matthay MA. The case for oxidants in the adult respiratory distress syndrome--"elementary, Dr. Watson". J Lab Clin Med. 1990 Apr; 115(4):394-5.
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      559. Segredo V, Matthay MA, Sharma ML, Gruenke LD, Caldwell JE, Miller RD. Prolonged neuromuscular blockade after long-term administration of vecuronium in two critically ill patients. Anesthesiology. 1990 Mar; 72(3):566-70.
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      560. Brüssel T, Matthay MA, Chernow B. Pulmonary manifestations of endocrine and metabolic disorders. Clin Chest Med. 1989 Dec; 10(4):645-53.
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      561. Martin TR, Pistorese BP, Chi EY, Goodman RB, Matthay MA. Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability. J Clin Invest. 1989 Nov; 84(5):1609-19.
        View in: PubMed PMC304027
      562. Berthiaume Y, Albertine KH, Grady M, Fick G, Matthay MA. Protein clearance from the air spaces and lungs of unanesthetized sheep over 144 h. J Appl Physiol (1985). 1989 Nov; 67(5):1887-97.
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      563. Matthay MA. New modes of mechanical ventilation for ARDS. How should they be evaluated? Chest. 1989 Jun; 95(6):1175-7.
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      564. Baskin L, Mee S, Matthay M, Carroll PR. Ureteral obstruction caused by vasculitis. J Urol. 1989 Apr; 141(4):933-5.
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      565. Matthay MA. The adult respiratory distress syndrome. New insights into diagnosis, pathophysiology, and treatment. West J Med. 1989 Feb; 150(2):187-94.
        View in: PubMed PMC1026332
      566. Matthay MA, Wiener-Kronish JP. Respiratory management after cardiac surgery. Chest. 1989 Feb; 95(2):424-34.
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      567. Hubbard RC, Casolaro MA, Mitchell M, Sellers SE, Arabia F, Matthay MA, Crystal RG. Fate of aerosolized recombinant DNA-produced alpha 1-antitrypsin: use of the epithelial surface of the lower respiratory tract to administer proteins of therapeutic importance. Proc Natl Acad Sci U S A. 1989 Jan; 86(2):680-4.
        View in: PubMed PMC286537
      568. Matthay MA, Chatterjee K. Bedside catheterization of the pulmonary artery: risks compared with benefits. Ann Intern Med. 1988 Nov 15; 109(10):826-34.
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      569. Wiener-Kronish JP, Broaddus VC, Albertine KH, Gropper MA, Matthay MA, Staub NC. Relationship of pleural effusions to increased permeability pulmonary edema in anesthetized sheep. J Clin Invest. 1988 Oct; 82(4):1422-9.
        View in: PubMed PMC442700
      570. Murray JF, Matthay MA, Luce JM, Flick MR. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis. 1988 Sep; 138(3):720-3.
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      571. Berthiaume Y, Broaddus VC, Gropper MA, Tanita T, Matthay MA. Alveolar liquid and protein clearance from normal dog lungs. J Appl Physiol (1985). 1988 Aug; 65(2):585-93.
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      572. Aberle DR, Wiener-Kronish JP, Webb WR, Matthay MA. Hydrostatic versus increased permeability pulmonary edema: diagnosis based on radiographic criteria in critically ill patients. Radiology. 1988 Jul; 168(1):73-9.
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      573. Ratnoff WD, Matthay MA, Wong MY, Ito Y, Vu KH, Wiener-Kronish J, Goetzl EJ. Sulfidopeptide-leukotriene peptidases in pulmonary edema fluid from patients with the adult respiratory distress syndrome. J Clin Immunol. 1988 Jul; 8(4):250-8.
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      574. Wiener-Kronish JP, Matthay MA. Pleural effusions associated with hydrostatic and increased permeability pulmonary edema. Chest. 1988 Apr; 93(4):852-8.
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      575. Wiener-Kronish JP, Goldstein R, Matthay RA, Biondi JW, Broaddus VC, Chatterjee K, Matthay MA. Lack of association of pleural effusion with chronic pulmonary arterial and right atrial hypertension. Chest. 1987 Dec; 92(6):967-70.
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      576. Dean NC, Amend WC, Matthay MA. Adult respiratory distress syndrome related to antilymphocyte globulin therapy. Chest. 1987 Apr; 91(4):619-20.
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      577. Berthiaume Y, Staub NC, Matthay MA. Beta-adrenergic agonists increase lung liquid clearance in anesthetized sheep. J Clin Invest. 1987 Feb; 79(2):335-43.
        View in: PubMed PMC424066
      578. Biondi JW, Hines RL, Barash PG, Baker CC, Matthay MA, Matthay RA. The adult respiratory distress syndrome. Yale J Biol Med. 1986 Nov-Dec; 59(6):575-97.
        View in: PubMed PMC2590207
      579. Curtis JL, Mahlmeister M, Fink JB, Lampe G, Matthay MA, Stulbarg MS. Helium-oxygen gas therapy. Use and availability for the emergency treatment of inoperable airway obstruction. Chest. 1986 Sep; 90(3):455-7.
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      580. Gates LM, Matthay MA. Central intravascular pressure measurements: when should we believe them? J Thorac Imaging. 1986 Jul; 1(3):52-9.
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      581. Fein A, Wiener-Kronish JP, Niederman M, Matthay MA. Pathophysiology of the adult respiratory distress syndrome. What have we learned from human studies? Crit Care Clin. 1986 Jul; 2(3):429-53.
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      582. Hansen RM, Viquerat CE, Matthay MA, Wiener-Kronish JP, DeMarco T, Bahtia S, Marks JD, Botvinick EH, Chatterjee K. Poor correlation between pulmonary arterial wedge pressure and left ventricular end-diastolic volume after coronary artery bypass graft surgery. Anesthesiology. 1986 Jun; 64(6):764-70.
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      583. Bigby TD, Serota ML, Tierney LM, Matthay MA. Clinical spectrum of pulmonary mucormycosis. Chest. 1986 Mar; 89(3):435-9.
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      584. Broaddus C, Matthay MA. Pulmonary embolism. Guide to diagnosis, treatment, and prevention. Postgrad Med. 1986 Mar; 79(4):333-7, 340-3.
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      585. Swerdlow BN, Mihm FG, Goetzl EJ, Matthay MA. Leukotrienes in pulmonary edema fluid after cardiopulmonary bypass. Anesth Analg. 1986 Mar; 65(3):306-8.
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      586. Eisendrath SJ, Link N, Matthay M. Intensive care unit: how stressful for physicians? Crit Care Med. 1986 Feb; 14(2):95-8.
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      587. Wiener-Kronish JP, Matthay MA, Callen PW, Filly RA, Gamsu G, Staub NC. Relationship of pleural effusions to pulmonary hemodynamics in patients with congestive heart failure. Am Rev Respir Dis. 1985 Dec; 132(6):1253-6.
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      588. Matthay MA. Cellular basis for injury and repair in the adult respiratory distress syndrome. West J Med. 1985 Nov; 143(5):665-7.
        View in: PubMed PMC1306449
      589. Matthay MA. Pathophysiology of pulmonary edema. Clin Chest Med. 1985 Sep; 6(3):301-14.
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      590. Matthay MA, Berthiaume Y, Staub NC. Long-term clearance of liquid and protein from the lungs of unanesthetized sheep. J Appl Physiol (1985). 1985 Sep; 59(3):928-34.
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      591. Matthay MA. Resolution of pulmonary edema. Mechanisms of liquid, protein, and cellular clearance from the lung. Clin Chest Med. 1985 Sep; 6(3):521-45.
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      592. Viquerat CE, Hansen RM, Botvinick EH, Dae MW, Wiener-Kronish JP, Matthay MA. Undrained bloody pericardial effusion in the early postoperative period after coronary bypass surgery: a prospective blood pool study. Am Heart J. 1985 Aug; 110(2):335-41.
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      593. Matthay MA, Eschenbacher WL, Goetzl EJ. Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome. J Clin Immunol. 1984 Nov; 4(6):479-83.
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      594. Colice GL, Matthay MA, Bass E, Matthay RA. Neurogenic pulmonary edema. Am Rev Respir Dis. 1984 Nov; 130(5):941-8.
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      595. Weinberg PF, Matthay MA, Webster RO, Roskos KV, Goldstein IM, Murray JF. Biologically active products of complement and acute lung injury in patients with the sepsis syndrome. Am Rev Respir Dis. 1984 Nov; 130(5):791-6.
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      596. Bongard FS, Matthay M, Mackersie RC, Lewis FR. Morphologic and physiologic correlates of increased extravascular lung water. Surgery. 1984 Aug; 96(2):395-403.
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      597. Wiedemann HP, Matthay MA, Matthay RA. Cardiovascular-pulmonary monitoring in the intensive care unit (Part 2). Chest. 1984 May; 85(5):656-68.
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      598. Wiedemann HP, Matthay MA, Matthay RA. Cardiovascular-pulmonary monitoring in the intensive care unit (Part 1). Chest. 1984 Apr; 85(4):537-49.
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      599. Eisendrath SJ, Matthay MA, Dunkel JA, Zimmerman JK, Layzer RB. Guillain-Barré syndrome: psychosocial aspects of management. Psychosomatics. 1983 May; 24(5):465-75.
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      600. Matthay MA. Invasive hemodynamic monitoring in critically ill patients. Clin Chest Med. 1983 May; 4(2):233-49.
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      601. Prewitt RM, Matthay MA, Ghignone M. Hemodynamic management in the adult respiratory distress syndrome. Clin Chest Med. 1983 May; 4(2):251-68.
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      602. Landolt CC, Matthay MA, Albertine KH, Roos PJ, Wiener-Kronish JP, Staub NC. Overperfusion, hypoxia, and increased pressure cause only hydrostatic pulmonary edema in anesthetized sheep. Circ Res. 1983 Mar; 52(3):335-41.
        View in: PubMed
      603. Matthay MA, Landolt CC, Staub NC. Differential liquid and protein clearance from the alveoli of anesthetized sheep. J Appl Physiol Respir Environ Exerc Physiol. 1982 Jul; 53(1):96-104.
        View in: PubMed
      604. Russell J, Follansbee S, Matthay M. Adult respiratory distress syndrome complicating diabetic ketoacidosis. West J Med. 1981 Aug; 135(2):148-50.
        View in: PubMed PMC1273047
      605. Landolt CC, Matthay MA, Staub NC. Anatomic variations of efferent duct from caudal mediastinal lymph node in sheep. J Appl Physiol Respir Environ Exerc Physiol. 1981 Jun; 50(6):1372-4.
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      606. Matthay MA, Addison TE, Ellinger G, Choy SH, Kaltreider HB. Chest mass with pleurisy. Chest. 1979 Oct; 76(4):453-4.
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      607. Zwillich CW, Matthay M, Potts DE, Adler R, Hofeldt F, Weil JV. Thyrotoxicosis: comparison of effects of thyroid ablation and beta-adrenergic blockade on metabolic rate and ventilatory control. J Clin Endocrinol Metab. 1978 Mar; 46(3):491-500.
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      608. Matthay M, Lindamood M, Steigerwald JC, Solomons C. Acute pseudogout in the absence of synovial fluid Leukocytes. J Rheumatol. 1977; 4(3):303-6.
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      609. Matthay MA, Matthay RA, Mills DM, Lakshminarayan S, Cotton E. Hypertrophic osteoarthropathy in adults with cystic fibrosis. Thorax. 1976 Oct; 31(5):572-5.
        View in: PubMed PMC470477
      610. Matthay RA, Matthay MA, Weinberger MM. Grand mal seizure induced by oral theophylline. Thorax. 1976 Aug; 31(4):470-1.
        View in: PubMed PMC470462
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