Loading...
<'tr> 

Michael Matthay, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
Address505 Parnassus Avenue
San Francisco CA 94117
Phone415-353-1206
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Harvard UniversityA.B.1969English
    University of PennsylvaniaM.D.1973School of Medicine
    University of Colorado Medical CenterInternship and Residency1976Internal Medicine
    University of California, San FranciscoFellowship1978Pulmonary DIvision
    University of California, San FranciscoFellowship1979Cardiovascular Research Institute

    Collapse Overview 
    Collapse Overview
    Michael A. Matthay, MD is a Professor of Medicine and Anesthesia at the University of California at San Francisco and a Senior Associate at the Cardiovascular Research Institute. He is Director of the Critical Care Medicine Training in the Department of Medicine and Associate Director of the Intensive Care Unit. He received his AB from Harvard University in 1969 and his MD from the University of Pennsylvania School of Medicine in 1973. Dr. Matthay received clinical training in Internal Medicine at the University of Colorado from 1973-76 and in Pulmonary and Critical Care Medicine from the University of California at San Francisco from 1977-78. He also received research training from the Cardiovascular Physiology Laboratory, University of Colorado in 1976 and the Cardiovascular Research Institute from 1978-79.

    Michael Matthay was selected in 2006 by the UCSF Academic Senate as the recipient of the Sixth Annual Distinguished Clinical Research Lectureshi, by the American Physiological Society and the Respiration Section for the Julius Comroe Jr Award in 2009, and by the University of Paris in 20011 with an Honorary Degree (Honora Causa).

    Dr. Matthay is currently the Principal Investigator of a NIH/NHLBI-sponsored phase 1/2 clinical trial of mesenchymal stem (stromal) cells for the treatment of Acute Respiratory Distress Syndrome (START). Details of the trial may be found at the following website: http://stemcellsards.ucsf.edu.


    Collapse Research 
    Collapse Research Activities and Funding
    Prevention and Early Treatment of Acute Lung Injury
    NIH/NHLBI U01HL123004Jun 17, 2014 - Apr 30, 2021
    Role: Principal Investigator
    Allogeneic Human Mesenchymal Stem Cells for the Treatment of Acute Lung Injury
    NIH/NHLBI U01HL108713Sep 1, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH N01HR56166-16-0-1Sep 30, 2005 - Jul 15, 2013
    Role: Principal Investigator
    ARDS - SAILS Protocol
    NIH N01HR56166-16-0-4Sep 30, 2005 - Jul 15, 2013
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH/NHLBI N01HR56166-14-0-1Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH/NHLBI N01HR56166-14-0-1Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH/NHLBI N01HR56166-14-0-1Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH/NHLBI N01HR56166-14-0-1Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH/NHLBI N01HR56166-14-0-1Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH/NHLBI N01HR56166-14-0-1Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    ARDS - SAILS Protocol
    NIH/NHLBI N01HR56166-14-0-4Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    ARDS - SAILS Protocol
    NIH/NHLBI N01HR56166-14-0-4Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    ARDS - SAILS Protocol
    NIH/NHLBI N01HR56166-14-0-4Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    ARDS - SAILS Protocol
    NIH/NHLBI N01HR56166-14-0-4Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    ARDS - SAILS Protocol
    NIH/NHLBI N01HR56166-14-0-4Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    ARDS - SAILS Protocol
    NIH/NHLBI N01HR56166-14-0-4Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    ARDS - ALTA Protocol
    NIH/NHLBI N01HR56166Sep 30, 2005 - Sep 29, 2012
    Role: Co-Principal Investigator
    ARDS - EDEN Protocol
    NIH/NHLBI N01HR56166-6-0-3Sep 30, 2005 - Sep 29, 2012
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH/NHLBI N01HR56166-7-0-1Sep 30, 2005 - Sep 29, 2012
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH/NHLBI N01HR56166-9-0-1Sep 30, 2005 - Nov 30, 2011
    Role: Principal Investigator
    Transfusion and Lung Injury
    NIH/NHLBI P50HL081027Sep 30, 2005 - Aug 31, 2011
    Role: Co-Investigator
    SCCOR in translational research in Acute Lung Injury
    NIH/NHLBI P50HL074005Sep 30, 2003 - Jun 30, 2010
    Role: Principal Investigator
    Mucosal Immune Barrier in Infection and Immunity
    NIH/NIAID P01AI053194Sep 30, 2002 - Aug 31, 2014
    Role: Co-Investigator
    Resolution of Clinical Lung Injury
    NIH/NHLBI R37HL051856Apr 1, 1996 - Mar 31, 2016
    Role: Principal Investigator
    RESOLUTION OF CLINICAL LUNG INJURY
    NIH/NHLBI R01HL051856Apr 1, 1996 - Mar 31, 2006
    Role: Principal Investigator
    CCTG CLINICAL NETWORK FOR ARDS TREATMENT--CRITICAL CARE
    NIH/NHLBI N01HR046059Sep 30, 1994 - Dec 31, 2003
    Role: Principal Investigator
    Lung Fluid Balance and Mesenchymal Stem Cells
    NIH/NHLBI R01HL051854Apr 8, 1994 - Jun 30, 2013
    Role: Principal Investigator
    ALVEOLAR EPITHELIAL LIQUID AND PROTEIN CLEARANCE
    NIH/NHLBI R01HL040626Jun 1, 1988 - Nov 30, 1989
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    PATHOPHYSIOLOGY OF LUNG LIQUID &PROTEIN EXCHANGE
    NIH P01HL025816Jun 1, 1980 - May 31, 1994
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Featured Presentations
    Collapse Clinical Trials
    Collapse Global Health
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Schell-Chaple HM, Liu KD, Matthay M, Sessler DI, Puntillo KA. Effects of IV Acetaminophen on Core Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: A Randomized Controlled Trial. Crit Care Med. 2017 Mar 17. PMID: 28319467.
      View in: PubMed
    2. Zinter MS, Orwoll BE, Spicer AC, Alkhouli MF, Calfee CS, Matthay M, Sapru A. Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome. Crit Care Med. 2017 Feb 28. PMID: 28248715.
      View in: PubMed
    3. Hendrickson CM, Abbott J, Zhuo H, Liu KD, Calfee CS, Matthay M. Higher Mini-BAL Total Protein Concentration in Early ARDS Predicts Faster Resolution of Lung Injury Measured by More Ventilator Free Days. Am J Physiol Lung Cell Mol Physiol. 2017 Feb 17; ajplung.00381.2016. PMID: 28213470.
      View in: PubMed
    4. Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL. Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm. Vox Sang. 2016 Dec 21. PMID: 28001313.
      View in: PubMed
    5. Matthay M, Pati S, Lee JW. Mesenchymal Stem (Stromal) Cells: Biology and Preclinical Evidence for Therapeutic Potential for Organ Dysfunction following Trauma or Sepsis. Stem Cells. 2016 Nov 26. PMID: 27888550.
      View in: PubMed
    6. Bhatraju PK, Mukherjee P, Robinson-Cohen C, O'Keefe GE, Frank AJ, Christie JD, Meyer NJ, Liu KD, Matthay MA, Calfee CS, Christiani DC, Himmelfarb J, Wurfel MM. Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death. Crit Care. 2016 Nov 17; 20(1):372. PMID: 27852290.
      View in: PubMed
    7. Moore PK, Matthay MA. Overnight Extubation in Patients With Mechanical Ventilation: Is It Harmful? JAMA Intern Med. 2016 Nov 1; 176(11):1660-1661. PMID: 27599363.
      View in: PubMed
    8. Matthay MA, Beitler JR. Clinical, Radiographic, Physiologic, and Biologic Measurements to Facilitate Personalized Medicine for ARDS. Chest. 2016 Nov; 150(5):989-990. PMID: 27832890.
      View in: PubMed
    9. Xu X, Greenland JR, Gotts JE, Matthay MA, Caughey GH. Cathepsin L Helps to Defend Mice from Infection with Influenza A. PLoS One. 2016; 11(10):e0164501. PMID: 27716790.
      View in: PubMed
    10. Matthay MA. Challenges in predicting which patients will develop ARDS. Lancet Respir Med. 2016 Nov; 4(11):847-848. PMID: 27717862.
      View in: PubMed
    11. Ward SL, Quinn CM, Valentine SL, Sapru A, Curley MA, Willson DF, Liu KD, Matthay MA, Flori HR. Poor Adherence to Lung-Protective Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2016 Oct; 17(10):917-923. PMID: 27513687.
      View in: PubMed
    12. Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay M, Sheldon RT, Peters MC, Nocka KH, Fahy JV, Seibold MA. IL1RL1 asthma risk variants regulate airway type 2 inflammation. JCI Insight. 2016 Sep 8; 1(14):e87871. PMID: 27699235.
      View in: PubMed
    13. Alladina JW, Levy SD, Hibbert KA, Januzzi JL, Harris RS, Matthay MA, Thompson BT, Bajwa EK. Plasma Concentrations of Soluble Suppression of Tumorigenicity-2 and Interleukin-6 Are Predictive of Successful Liberation From Mechanical Ventilation in Patients With the Acute Respiratory Distress Syndrome. Crit Care Med. 2016 Sep; 44(9):1735-43. PMID: 27525994.
      View in: PubMed
    14. Spicer AC, Calfee CS, Zinter MS, Khemani RG, Lo VP, Alkhouli MF, Orwoll BE, Graciano AL, Boriosi JP, Howard JP, Flori HR, Matthay M, Sapru A, et al. A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2016 Aug 3. PMID: 27487912.
      View in: PubMed
    15. Kangelaris KN, Ware LB, Matthay MA, Calfee CS. The authors reply. Crit Care Med. 2016 Aug; 44(8):e771. PMID: 27428150.
      View in: PubMed
    16. Kangelaris KN, Ware LB, Matthay MA, Calfee CS. The authors reply. Crit Care Med. 2016 Aug; 44(8):e769-70. PMID: 27428148.
      View in: PubMed
    17. Disayabutr S, Kim EK, Cha SI, Green G, Naikawadi RP, Jones KD, Golden JA, Schroeder A, Matthay M, Kukreja J, Erle DJ, Collard HR, Wolters PJ. miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis. PLoS One. 2016; 11(6):e0158367. PMID: 27362652.
      View in: PubMed
    18. Beitler JR, Sands SA, Loring SH, Owens RL, Malhotra A, Spragg RG, Matthay MA, Thompson BT, Talmor D. Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria. Intensive Care Med. 2016 Sep; 42(9):1427-36. PMID: 27342819.
      View in: PubMed
    19. Puig F, Herrero R, Guillamat-Prats R, Gómez MN, Tijero J, Chimenti L, Stelmakh O, Blanch L, Serrano-Mollar A, Matthay MA, Artigas A. A new experimental model of acid- and endotoxin-induced acute lung injury in rats. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1; 311(2):L229-37. PMID: 27317688.
      View in: PubMed
    20. Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley GT, Matthay MA, Calfee CS, Cohen MJ. The acute respiratory distress syndrome following isolated severe traumatic brain injury. J Trauma Acute Care Surg. 2016 Jun; 80(6):989-97. PMID: 26881489.
      View in: PubMed
    21. Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA. Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome. Crit Care. 2016; 20(1):151. PMID: 27215212.
      View in: PubMed
    22. Gotts JE, Matthay MA. Sepsis: pathophysiology and clinical management. BMJ. 2016; 353:i1585. PMID: 27217054.
      View in: PubMed
    23. Ware LB, Zhao Z, Koyama T, May AK, Matthay MA, Lurmann FW, Balmes JR, Calfee CS. Long-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2016 May 15; 193(10):1143-50. PMID: 26681363.
      View in: PubMed
    24. Jackson MV, Morrison TJ, Doherty DF, McAuley DF, Matthay MA, Kissenpfennig A, O'Kane CM, Krasnodembskaya AD. Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS. Stem Cells. 2016 Aug; 34(8):2210-23. PMID: 27059413.
      View in: PubMed
    25. Bhattacharya M, Kallet RH, Ware LB, Matthay MA. Negative-Pressure Pulmonary Edema. Chest. 2016 Oct; 150(4):927-933. PMID: 27063348.
      View in: PubMed
    26. Vieillard-Baron A, Matthay M, Teboul JL, Bein T, Schultz M, Magder S, Marini JJ. Experts' opinion on management of hemodynamics in ARDS patients: focus on the effects of mechanical ventilation. Intensive Care Med. 2016 May; 42(5):739-49. PMID: 27038480.
      View in: PubMed
    27. Papazian L, Calfee CS, Chiumello D, Luyt CE, Meyer NJ, Sekiguchi H, Matthay MA, Meduri GU. Diagnostic workup for ARDS patients. Intensive Care Med. 2016 May; 42(5):674-85. PMID: 27007111.
      View in: PubMed
    28. Chan MC, Kuok DI, Leung CY, Hui KP, Valkenburg SA, Lau EH, Nicholls JM, Fang X, Guan Y, Lee JW, Chan RW, Webster RG, Matthay M, Peiris JS. Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):3621-6. PMID: 26976597.
      View in: PubMed
    29. Ernecoff NC, Witteman HO, Chon K, Chen YI, Buddadhumaruk P, Chiarchiaro J, Shotsberger KJ, Shields AM, Myers BA, Hough CL, Carson SS, Lo B, Matthay MA, Anderson WG, Peterson MW, Steingrub JS, Arnold RM, White DB. Key stakeholders' perceptions of the acceptability and usefulness of a tablet-based tool to improve communication and shared decision making in ICUs. J Crit Care. 2016 Jun; 33:19-25. PMID: 27037049.
      View in: PubMed
    30. Walter JM, Matthay MA, Gillespie CT, Corbridge T. Acute Hypoxemic Respiratory Failure after Large-Volume Thoracentesis. Mechanisms of Pleural Fluid Formation and Reexpansion Pulmonary Edema. Ann Am Thorac Soc. 2016 Mar; 13(3):438-43. PMID: 26963356.
      View in: PubMed
    31. Matthay MA, Liu KD. New Strategies for Effective Therapeutics in Critically Ill Patients. JAMA. 2016 Feb 23; 315(8):747-8. PMID: 26903328.
      View in: PubMed
    32. Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay M, McAuley DF, Calfee CS, et al. Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation. Thorax. 2016 Feb 2. PMID: 26839359.
      View in: PubMed
    33. Guérin C, Matthay MA. Acute cor pulmonale and the acute respiratory distress syndrome. Intensive Care Med. 2016 May; 42(5):934-6. PMID: 26759013.
      View in: PubMed
    34. Kangelaris KN, Ware LB, Wang CY, Janz DR, Zhuo H, Matthay M, Calfee CS. Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome. Crit Care Med. 2016 Jan; 44(1):120-9. PMID: 26474112.
      View in: PubMed
    35. Orwoll BE, Spicer AC, Zinter MS, Alkhouli MF, Khemani RG, Flori HR, Neuhaus JM, Calfee CS, Matthay MA, Sapru A. Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study. Crit Care. 2015; 19(1):435. PMID: 26652251.
      View in: PubMed
    36. Zinter MS, Spicer A, Orwoll BO, Alkhouli M, Dvorak CC, Calfee CS, Matthay M, Sapru A. Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality. Am J Physiol Lung Cell Mol Physiol. 2016 Feb 1; 310(3):L224-31. PMID: 26660787.
      View in: PubMed
    37. Calfee CS, Matthay MA, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB. Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome. Crit Care Med. 2015 Sep; 43(9):1790-7. PMID: 26010690.
      View in: PubMed
    38. Monsel A, Zhu YG, Gennai S, Hao Q, Hu S, Rouby JJ, Rosenzwajg M, Matthay MA, Lee JW. Therapeutic Effects of Human Mesenchymal Stem Cell-derived Microvesicles in Severe Pneumonia in Mice. Am J Respir Crit Care Med. 2015 Aug 1; 192(3):324-36. PMID: 26067592; PMCID: PMC4584251 [Available on 08/01/16].
    39. Matthay MA, Ware LB. Resolution of Alveolar Edema in Acute Respiratory Distress Syndrome. Physiology and Biology. Am J Respir Crit Care Med. 2015 Jul 15; 192(2):124-5. PMID: 26177166.
      View in: PubMed
    40. Fang X, Abbott J, Cheng L, Colby JK, Lee JW, Levy BD, Matthay MA. Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4. J Immunol. 2015 Aug 1; 195(3):875-81. PMID: 26116507.
      View in: PubMed
    41. Rajasekaran S, Tamatam CR, Potteti HR, Raman V, Lee JW, Matthay MA, Mehta D, Reddy NM, Reddy SP. Visualization of Fra-1/AP-1 activation during LPS-induced inflammatory lung injury using fluorescence optical imaging. Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15; 309(4):L414-24. PMID: 26071555; PMCID: PMC4538236 [Available on 08/15/16].
    42. Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay MA, Ware LB. Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies. Chest. 2015 Jun; 147(6):1539-48. PMID: 26033126; PMCID: PMC4451708 [Available on 06/01/16].
    43. Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Howard J, Fang X, Bhat S, Huynh KM, O'Kane CM, Ingram RJ, Muir RR, McAuley DF, Matthay MA, Sheppard D. Unexpected Role for Adaptive aßTh17 Cells in Acute Respiratory Distress Syndrome. J Immunol. 2015 Jul 1; 195(1):87-95. PMID: 26002979; PMCID: PMC4475475 [Available on 07/01/16].
    44. Matthay MA. Saving lives with high-flow nasal oxygen. N Engl J Med. 2015 Jun 4; 372(23):2225-6. PMID: 25982042.
      View in: PubMed
    45. Curley MA, Wypij D, Matthay MA. Sedation protocol for critically ill pediatric patients--reply. JAMA. 2015 May 5; 313(17):1754-5. PMID: 25942731.
      View in: PubMed
    46. Beitler JR, Thompson BT, Matthay MA, Talmor D, Liu KD, Zhuo H, Hayden D, Spragg RG, Malhotra A. Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials. Crit Care Med. 2015 May; 43(5):1026-35. PMID: 25738857; PMCID: PMC4400228 [Available on 05/01/16].
    47. Gennai S, Monsel A, Hao Q, Park J, Matthay MA, Lee JW. Microvesicles Derived From Human Mesenchymal Stem Cells Restore Alveolar Fluid Clearance in Human Lungs Rejected for Transplantation. Am J Transplant. 2015 Sep; 15(9):2404-12. PMID: 25847030.
      View in: PubMed
    48. Wilson J, McKenna D, Liu KD, Matthay MA. Mesenchymal stem (stromal) cells for treatment of acute respiratory distress syndrome - authors' reply. Lancet Respir Med. 2015 Apr; 3(4):e12-3. PMID: 25890655.
      View in: PubMed
    49. Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS. Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 1; 308(11):L1102-13. PMID: 25795726; PMCID: PMC4451399 [Available on 06/01/16].
    50. Matthay MA. Therapeutic potential of mesenchymal stromal cells for acute respiratory distress syndrome. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S54-7. PMID: 25830837.
      View in: PubMed
    51. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA. Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):574. PMID: 25708422.
      View in: PubMed
    52. Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL. Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Transfusion. 2015 Aug; 55(8):1838-46. PMID: 25702590; PMCID: PMC4536135 [Available on 08/01/16].
    53. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbot J, Matthay MA. Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):470-8. PMID: 25643902; PMCID: PMC4500527 [Available on 03/01/16].
    54. Anderson WG, Cimino JW, Ernecoff NC, Ungar A, Shotsberger KJ, Pollice LA, Buddadhumaruk P, Carson SS, Curtis JR, Hough CL, Lo B, Matthay MA, Peterson MW, Steingrub JS, White DB. A multicenter study of key stakeholders' perspectives on communicating with surrogates about prognosis in intensive care units. Ann Am Thorac Soc. 2015 Feb; 12(2):142-52. PMID: 25521191; PMCID: PMC4342839 [Available on 02/01/16].
    55. Curley MA, Wypij D, Watson RS, Grant MJ, Asaro LA, Cheifetz IM, Dodson BL, Franck LS, Gedeit RG, Angus DC, Matthay MA. Protocolized sedation vs usual care in pediatric patients mechanically ventilated for acute respiratory failure: a randomized clinical trial. JAMA. 2015 Jan 27; 313(4):379-89. PMID: 25602358.
      View in: PubMed
    56. Ji HL, Zhao R, Komissarov AA, Chang Y, Liu Y, Matthay MA. Proteolytic regulation of epithelial sodium channels by urokinase plasminogen activator: cutting edge and cleavage sites. J Biol Chem. 2015 Feb 27; 290(9):5241-55. PMID: 25555911; PMCID: PMC4342445 [Available on 02/27/16].
    57. Schell-Chaple HM, Puntillo KA, Matthay MA, Liu KD. Body temperature and mortality in patients with acute respiratory distress syndrome. Am J Crit Care. 2015 Jan; 24(1):15-23. PMID: 25554550; PMCID: PMC4464553 [Available on 01/01/16].
    58. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature. 2015 Jan 29; 517(7536):621-5. PMID: 25533958; PMCID: PMC4312207.
    59. Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay MA. Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial. Lancet Respir Med. 2015 Jan; 3(1):24-32. PMID: 25529339; PMCID: PMC4297579 [Available on 01/01/16].
    60. Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR. Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion. 2015 May; 55(5):947-52. PMID: 25488517; PMCID: PMC4428945 [Available on 05/01/16].
    61. Hendrickson CM, Crestani B, Matthay MA. Biology and pathology of fibroproliferation following the acute respiratory distress syndrome. Intensive Care Med. 2015 Jan; 41(1):147-50. PMID: 25480350; PMCID: PMC4284053 [Available on 01/01/16].
    62. Walter J, Ware LB, Matthay MA. Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis. Lancet Respir Med. 2014 Dec; 2(12):1016-26. PMID: 25465643.
      View in: PubMed
    63. Matthay MA. Biomarkers to exclude the diagnosis of ventilator-associated pneumonia. Thorax. 2015 Jan; 70(1):5-6. PMID: 25352532.
      View in: PubMed
    64. Gotts JE, Matthay MA. Endogenous and exogenous cell-based pathways for recovery from acute respiratory distress syndrome. Clin Chest Med. 2014 Dec; 35(4):797-809. PMID: 25453426; PMCID: PMC4254691 [Available on 12/01/15].
    65. DePianto DJ, Chandriani S, Abbas AR, Jia G, N'Diaye EN, Caplazi P, Kauder SE, Biswas S, Karnik SK, Ha C, Modrusan Z, Matthay MA, Kukreja J, Collard HR, Egen JG, Wolters PJ, Arron JR. Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis. Thorax. 2015 Jan; 70(1):48-56. PMID: 25217476; PMCID: PMC4472447 [Available on 01/01/16].
    66. Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eaton DC, Lucas R. A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation. Am J Respir Crit Care Med. 2014 Sep 1; 190(5):522-32. PMID: 25029038; PMCID: PMC4214088.
    67. Hsieh SJ, Zhuo H, Benowitz NL, Thompson BT, Liu KD, Matthay MA, Calfee CS. Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome. Crit Care Med. 2014 Sep; 42(9):2058-68. PMID: 24942512; PMCID: PMC4134734.
    68. Fitzgerald M, McAuley DF, Matthay M. Is there a need for emerging drugs for the acute respiratory distress syndrome? Expert Opin Emerg Drugs. 2014 Sep; 19(3):323-8. PMID: 25152048; PMCID: PMC4284055.
    69. Ware LB, Lee JW, Wickersham N, Nguyen J, Matthay MA, Calfee CS. Donor smoking is associated with pulmonary edema, inflammation and epithelial dysfunction in ex vivo human donor lungs. Am J Transplant. 2014 Oct; 14(10):2295-302. PMID: 25146497; PMCID: PMC4169304.
    70. Krupa A, Fol M, Rahman M, Stokes KY, Florence JM, Leskov IL, Khoretonenko MV, Matthay MA, Liu KD, Calfee CS, Tvinnereim A, Rosenfield GR, Kurdowska AK. Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15; 307(6):L435-48. PMID: 25085625; PMCID: PMC4166786.
    71. Gotts JE, Abbott J, Matthay MA. Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 1; 307(5):L395-406. PMID: 25038188; PMCID: PMC4154253.
    72. Czikora I, Sridhar S, Gorshkov B, Alieva IB, Kasa A, Gonzales J, Potapenko O, Umapathy NS, Pillich H, Rick FG, Block NL, Verin AD, Chakraborty T, Matthay MA, Schally AV, Lucas R. Protective effect of Growth Hormone-Releasing Hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction. Front Physiol. 2014; 5:259. PMID: 25076911; PMCID: PMC4097355.
    73. Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA. Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Ann Intensive Care. 2014; 4:22. PMID: 25593740; PMCID: PMC4273700.
    74. Moseson EM, Zhuo H, Chu J, Stein JC, Matthay MA, Kangelaris KN, Liu KD, Calfee CS. Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study. J Intensive Care. 2014; 2:40. PMID: 25960880; PMCID: PMC4424730.
    75. Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P. Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*. Crit Care Med. 2014 Jul; 42(7):1676-87. PMID: 24776608; PMCID: PMC4284060.
    76. Sakuma T, Matthay MA. Translational studies in the ex vivo human lung. Respir Investig. 2014 Jul; 52(4):219-20. PMID: 24998367.
      View in: PubMed
    77. Shyamsundar M, McAuley DF, Ingram RJ, Gibson DS, O'Kane D, McKeown ST, Edwards A, Taggart C, Elborn JS, Calfee CS, Matthay MA, O'Kane CM. Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury. Am J Respir Crit Care Med. 2014 Jun 15; 189(12):1520-9. PMID: 24716610; PMCID: PMC4226011.
    78. Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters PJ, Woodruff PG, Fahy JV, Shin JS. Accumulation of BDCA1? dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma. PLoS One. 2014; 9(6):e99084. PMID: 24915147; PMCID: PMC4051692.
    79. Asmussen S, Ito H, Traber DL, Lee JW, Cox RA, Hawkins HK, McAuley DF, McKenna DH, Traber LD, Zhuo H, Wilson J, Herndon DN, Prough DS, Liu KD, Matthay MA, Enkhbaatar P. Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia. Thorax. 2014 Sep; 69(9):819-25. PMID: 24891325; PMCID: PMC4284068.
    80. Matthay MA. Resolution of pulmonary edema. Thirty years of progress. Am J Respir Crit Care Med. 2014 Jun 1; 189(11):1301-8. PMID: 24881936; PMCID: PMC4098087.
    81. McKenna D, Matthay MA, Pati S. Correspondence to: soliciting strategies for developing cell-based reference materials to advance mesenchymal stem/stromal cell research and clinical translation. Stem Cells Dev. 2014 Aug 1; 23(15):1717-8. PMID: 24749526.
      View in: PubMed
    82. Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA. Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Lancet Respir Med. 2014 Aug; 2(8):611-20. PMID: 24853585; PMCID: PMC4154544.
    83. Truwit JD, Bernard GR, Steingrub J, Matthay MA, Liu KD, Albertson TE, Brower RG, Shanholtz C, Rock P, Douglas IS, deBoisblanc BP, Hough CL, Hite RD, Thompson BT. Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med. 2014 Jun 5; 370(23):2191-200. PMID: 24835849; PMCID: PMC4241052.
    84. Wilson JG, Matthay MA. Mechanical ventilation in acute hypoxemic respiratory failure: a review of new strategies for the practicing hospitalist. J Hosp Med. 2014 Jul; 9(7):469-75. PMID: 24733692; PMCID: PMC4139286.
    85. Rogers AJ, Matthay MA. Applying metabolomics to uncover novel biology in ARDS. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1; 306(11):L957-61. PMID: 24727586; PMCID: PMC4042190.
    86. Goolaerts A, Pellan-Randrianarison N, Larghero J, Vanneaux V, Uzunhan Y, Gille T, Dard N, Planès C, Matthay MA, Clerici C. Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1; 306(11):L975-85. PMID: 24682451; PMCID: PMC4042188.
    87. Ware LB, Landeck M, Koyama T, Zhao Z, Singer J, Kern R, Neidlinger N, Nguyen J, Johnson E, Janz DR, Bernard GR, Lee JW, Matthay MA. A randomized trial of the effects of nebulized albuterol on pulmonary edema in brain-dead organ donors. Am J Transplant. 2014 Mar; 14(3):621-8. PMID: 24730050; PMCID: PMC3986821.
    88. Kangelaris KN, Calfee CS, May AK, Zhuo H, Matthay MA, Ware LB. Is there still a role for the lung injury score in the era of the Berlin definition ARDS? Ann Intensive Care. 2014; 4(1):4. PMID: 24533450; PMCID: PMC3931496.
    89. McAuley DF, Curley GF, Hamid UI, Laffey JG, Abbott J, McKenna DH, Fang X, Matthay MA, Lee JW. Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation. Am J Physiol Lung Cell Mol Physiol. 2014 May 1; 306(9):L809-15. PMID: 24532289; PMCID: PMC4010648.
    90. Liles WC, Matthay MA, Dos Santos CC, Weiss DJ, Stewart DJ. Mesenchymal stromal (stem) cell therapy: an emerging immunomodulatory strategy for the adjunctive treatment of sepsis. Am J Respir Crit Care Med. 2014 Feb 1; 189(3):363-4. PMID: 24484339.
      View in: PubMed
    91. Rogers AJ, McGeachie M, Baron RM, Gazourian L, Haspel JA, Nakahira K, Fredenburgh LE, Hunninghake GM, Raby BA, Matthay MA, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore S, Langley RJ, Choi AM. Metabolomic derangements are associated with mortality in critically ill adult patients. PLoS One. 2014; 9(1):e87538. PMID: 24498130; PMCID: PMC3907548.
    92. Asija R, Roth SJ, Hanley FL, Peng L, Liu K, Abbott J, Zhuo H, Matthay M. Reperfusion pulmonary edema in children with tetralogy of Fallot, pulmonary atresia, and major aortopulmonary collateral arteries undergoing unifocalization procedures: A pilot study examining potential pathophysiologic mechanisms and clinical significance. J Thorac Cardiovasc Surg. 2014 Oct; 148(4):1560-5. PMID: 24534681.
      View in: PubMed
    93. Wang CY, Calfee CS, Paul DW, Janz DR, May AK, Zhuo H, Bernard GR, Matthay MA, Ware LB, Kangelaris KN. One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome. Intensive Care Med. 2014 Mar; 40(3):388-96. PMID: 24435201; PMCID: PMC3943651.
    94. Frank JA, Matthay MA. TGF-ß and lung fluid balance in ARDS. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):885-6. PMID: 24449829; PMCID: PMC3903208.
    95. Zhu YG, Feng XM, Abbott J, Fang XH, Hao Q, Monsel A, Qu JM, Matthay MA, Lee JW. Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice. Stem Cells. 2014 Jan; 32(1):116-25. PMID: 23939814; PMCID: PMC3947321.
    96. Kallet RH, Zhuo H, Liu KD, Calfee CS, Matthay MA. The association between physiologic dead-space fraction and mortality in subjects with ARDS enrolled in a prospective multi-center clinical trial. Respir Care. 2014 Nov; 59(11):1611-8. PMID: 24381187; PMCID: PMC4077995.
    97. Gotts JE, Matthay MA. Treating ARDS: new hope for a tough problem. Lancet Respir Med. 2014 Feb; 2(2):84-5. PMID: 24503258.
      View in: PubMed
    98. Engel J, Matthay M. Cystic fibrosis epithelial cell and bacterial binding. Am J Physiol Lung Cell Mol Physiol. 2013 Dec; 305(11):L891. PMID: 24310120.
      View in: PubMed
    99. Bajwa EK, Volk JA, Christiani DC, Harris RS, Matthay MA, Thompson BT, Januzzi JL. Prognostic and diagnostic value of plasma soluble suppression of tumorigenicity-2 concentrations in acute respiratory distress syndrome. Crit Care Med. 2013 Nov; 41(11):2521-31. PMID: 23939353; PMCID: PMC3812317.
    100. Ware LB, Koyama T, Zhao Z, Janz DR, Wickersham N, Bernard GR, May AK, Calfee CS, Matthay MA. Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Crit Care. 2013; 17(5):R253. PMID: 24156650; PMCID: PMC4056313.
    101. Brown LM, Calfee CS, Howard JP, Craig TR, Matthay MA, McAuley DF. Comparison of thermodilution measured extravascular lung water with chest radiographic assessment of pulmonary oedema in patients with acute lung injury. Ann Intensive Care. 2013; 3(1):25. PMID: 23937970; PMCID: PMC3846630.
    102. Hendrickson CM, Matthay MA. Viral pathogens and acute lung injury: investigations inspired by the SARS epidemic and the 2009 H1N1 influenza pandemic. Semin Respir Crit Care Med. 2013 Aug; 34(4):475-86. PMID: 23934716; PMCID: PMC4045622.
    103. Vieillard-Baron A, Price LC, Matthay MA. Acute cor pulmonale in ARDS. Intensive Care Med. 2013 Oct; 39(10):1836-8. PMID: 23907498; PMCID: PMC3955086.
    104. Levitt JE, Calfee CS, Goldstein BA, Vojnik R, Matthay MA. Early acute lung injury: criteria for identifying lung injury prior to the need for positive pressure ventilation*. Crit Care Med. 2013 Aug; 41(8):1929-37. PMID: 23782966; PMCID: PMC3748809.
    105. Matthay MA, Anversa P, Bhattacharya J, Burnett BK, Chapman HA, Hare JM, Hei DJ, Hoffman AM, Kourembanas S, McKenna DH, Ortiz LA, Ott HC, Tente W, Thébaud B, Trapnell BC, Weiss DJ, Yuan JX, Blaisdell CJ. Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012. Am J Respir Crit Care Med. 2013 Aug 1; 188(3):370-5. PMID: 23713908; PMCID: PMC3778734.
    106. Toonkel RL, Hare JM, Matthay MA, Glassberg MK. Mesenchymal stem cells and idiopathic pulmonary fibrosis. Potential for clinical testing. Am J Respir Crit Care Med. 2013 Jul 15; 188(2):133-40. PMID: 23306542.
      View in: PubMed
    107. Glassberg MK, Hare JM, Toonkel RL, Matthay MA. Reply: idiopathic pulmonary fibrosis: a degenerative disease requiring a regenerative approach. Am J Respir Crit Care Med. 2013 Jul 15; 188(2):253-4. PMID: 23855697; PMCID: PMC3778759.
    108. Bucior I, Abbott J, Song Y, Matthay MA, Engel JN. Sugar administration is an effective adjunctive therapy in the treatment of Pseudomonas aeruginosa pneumonia. Am J Physiol Lung Cell Mol Physiol. 2013 Sep; 305(5):L352-63. PMID: 23792737; PMCID: PMC3763031.
    109. Gotts JE, Matthay MA. Cell therapy for lung disease: a step forward. Chest. 2013 Jun; 143(6):1525-7. PMID: 23732575.
      View in: PubMed
    110. Matthay MA, Song Y, Bai C, Jones KD. The acute respiratory distress syndrome in 2013. Transl Respir Med. 2013 Dec; 1(1):10. PMID: 27234392.
      View in: PubMed
    111. Pittet JF, Koh H, Fang X, Iles K, Christiaans S, Anjun N, Wagener BM, Park DW, Zmijewski JW, Matthay MA, Roux J. HMGB1 accelerates alveolar epithelial repair via an IL-1ß- and avß6 integrin-dependent activation of TGF-ß1. PLoS One. 2013; 8(5):e63907. PMID: 23696858; PMCID: PMC3655948.
    112. Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A. The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. J Clin Invest. 2013 May; 123(5):2037-48. PMID: 23543053; PMCID: PMC3635736.
    113. Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS. Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. Am J Respir Crit Care Med. 2013 Apr 1; 187(7):736-42. PMID: 23328529; PMCID: PMC3678110.
    114. Lee JW, Krasnodembskaya A, McKenna DH, Song Y, Abbott J, Matthay MA. Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria. Am J Respir Crit Care Med. 2013 Apr 1; 187(7):751-60. PMID: 23292883; PMCID: PMC3678109.
    115. Thompson BT, Matthay MA. The Berlin definition of ARDS versus pathological evidence of diffuse alveolar damage. Am J Respir Crit Care Med. 2013 Apr 1; 187(7):675-7. PMID: 23540876.
      View in: PubMed
    116. Seeley EJ, Barry SS, Narala S, Matthay MA, Wolters PJ. Noradrenergic neurons regulate monocyte trafficking and mortality during gram-negative peritonitis in mice. J Immunol. 2013 May 1; 190(9):4717-24. PMID: 23543756; PMCID: PMC3973442.
    117. Seeley EJ, Rosenberg P, Matthay MA. Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy. J Clin Invest. 2013 Mar; 123(3):1015-8. PMID: 23434597; PMCID: PMC3582152.
    118. Cross LJ, O'Kane CM, McDowell C, Elborn JJ, Matthay MA, McAuley DF. Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction--a randomised placebo-controlled trial (KARE): study protocol. Trials. 2013; 14:51. PMID: 23419093; PMCID: PMC3620926.
    119. Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M. Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Mol Med. 2012; 18:1481-90. PMID: 23296426; PMCID: PMC3576477.
    120. Howard M, Roux J, Iles KE, Miyazawa B, Christiaans S, Anjum N, Dickinson DA, Goolaerts A, Matthay MA, Pittet JF. Activation of the heat shock response attenuates the interleukin 1ß-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transport. Shock. 2013 Feb; 39(2):189-96. PMID: 23324889; PMCID: PMC3663580.
    121. Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P. Risk factors and outcomes in transfusion-associated circulatory overload. Am J Med. 2013 Apr; 126(4):357.e29-38. PMID: 23357450; PMCID: PMC3652681.
    122. Schultz MJ, Juffermans NP, Matthay MA. From protective ventilation to super-protective ventilation for acute respiratory distress syndrome. Intensive Care Med. 2013 May; 39(5):963-5. PMID: 23306587; PMCID: PMC3628414.
    123. Bhattacharya J, Matthay MA. Regulation and repair of the alveolar-capillary barrier in acute lung injury. Annu Rev Physiol. 2013; 75:593-615. PMID: 23398155.
      View in: PubMed
    124. Bastarache JA, Matthay MA. Cecal ligation model of sepsis in mice: new insights. Crit Care Med. 2013 Jan; 41(1):356-7. PMID: 23269150; PMCID: PMC3734801.
    125. Kallet RH, Matthay MA. Hyperoxic acute lung injury. Respir Care. 2013 Jan; 58(1):123-41. PMID: 23271823; PMCID: PMC3915523.
    126. Roux J, McNicholas CM, Carles M, Goolaerts A, Houseman BT, Dickinson DA, Iles KE, Ware LB, Matthay MA, Pittet JF. IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism. FASEB J. 2013 Mar; 27(3):1095-106. PMID: 23221335; PMCID: PMC3574281.
    127. Komissarov AA, Stankowska D, Krupa A, Fudala R, Florova G, Florence J, Fol M, Allen TC, Idell S, Matthay MA, Kurdowska AK. Novel aspects of urokinase function in the injured lung: role of a2-macroglobulin. Am J Physiol Lung Cell Mol Physiol. 2012 Dec 15; 303(12):L1037-45. PMID: 23064953; PMCID: PMC3532585.
    128. Khush KK, Pawlikowska L, Menza RL, Goldstein BA, Hayden V, Nguyen J, Kim H, Poon A, Sapru A, Matthay MA, Kwok PY, Young WL, Baxter-Lowe LA, Zaroff JG. Beta-adrenergic receptor polymorphisms and cardiac graft function in potential organ donors. Am J Transplant. 2012 Dec; 12(12):3377-86. PMID: 22994654; PMCID: PMC3513582.
    129. Agrawal A, Zhuo H, Brady S, Levitt J, Steingrub J, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Matthay MA, Liu KD. Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials. Am J Physiol Lung Cell Mol Physiol. 2012 Oct 15; 303(8):L634-9. PMID: 22865551; PMCID: PMC3469636.
    130. Matthay MA, Ware LB, Zimmerman GA. The acute respiratory distress syndrome. J Clin Invest. 2012 Aug; 122(8):2731-40. PMID: 22850883; PMCID: PMC3408735.
    131. Zeyed YF, Bastarache JA, Matthay MA, Ware LB. The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2012 Sep 15; 303(6):L550-5. PMID: 22821995; PMCID: PMC3468480.
    132. Rackley CR, Levitt JE, Zhuo H, Matthay MA, Calfee CS. Clinical evidence of early acute lung injury often precedes the diagnosis of ALI. J Intensive Care Med. 2013 Jul-Aug; 28(4):241-6. PMID: 22733725; PMCID: PMC3482421.
    133. Levitt JE, Matthay MA. Clinical review: Early treatment of acute lung injury--paradigm shift toward prevention and treatment prior to respiratory failure. Crit Care. 2012; 16(3):223. PMID: 22713281; PMCID: PMC3580596.
    134. Seeley EJ, Matthay MA, Wolters PJ. Inflection points in sepsis biology: from local defense to systemic organ injury. Am J Physiol Lung Cell Mol Physiol. 2012 Sep; 303(5):L355-63. PMID: 22707617; PMCID: PMC3468422.
    135. Calfee CS, Gallagher D, Abbott J, Thompson BT, Matthay MA. Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance. Crit Care Med. 2012 Jun; 40(6):1731-7. PMID: 22610178; PMCID: PMC3601049.
    136. Folkesson HG, Kuzenko SR, Lipson DA, Matthay MA, Simmons MA. The adenosine 2A receptor agonist GW328267C improves lung function after acute lung injury in rats. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 1; 303(3):L259-71. PMID: 22659881.
      View in: PubMed
    137. Lee JW, Zhu Y, Matthay MA. Cell-based therapy for acute lung injury: are we there yet? Anesthesiology. 2012 Jun; 116(6):1189-91. PMID: 22531337.
      View in: PubMed
    138. Lucas R, Yang G, Gorshkov BA, Zemskov EA, Sridhar S, Umapathy NS, Jezierska-Drutel A, Alieva IB, Leustik M, Hossain H, Fischer B, Catravas JD, Verin AD, Pittet JF, Caldwell RB, Mitchell TJ, Cederbaum SD, Fulton DJ, Matthay MA, Caldwell RW, Romero MJ, Chakraborty T. Protein kinase C-a and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability. Am J Respir Cell Mol Biol. 2012 Oct; 47(4):445-53. PMID: 22582175; PMCID: PMC3488628.
    139. Nazarov I, Lee JW, Soupene E, Etemad S, Knapik D, Green W, Bashkirova E, Fang X, Matthay MA, Kuypers FA, Serikov VB. Multipotent stromal stem cells from human placenta demonstrate high therapeutic potential. Stem Cells Transl Med. 2012 May; 1(5):359-72. PMID: 23197815; PMCID: PMC3635148.
    140. Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D. IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. Am J Physiol Lung Cell Mol Physiol. 2012 Jul 1; 303(1):L12-9. PMID: 22561460; PMCID: PMC3426434.
    141. Matthay MA, Howard JP. Progress in modelling acute lung injury in a pre-clinical mouse model. Eur Respir J. 2012 May; 39(5):1062-3. PMID: 22547731.
      View in: PubMed
    142. Gotts JE, Matthay MA. Mesenchymal stem cells and the stem cell niche: a new chapter. Am J Physiol Lung Cell Mol Physiol. 2012 Jun 1; 302(11):L1147-9. PMID: 22505672.
      View in: PubMed
    143. Krasnodembskaya A, Samarani G, Song Y, Zhuo H, Su X, Lee JW, Gupta N, Petrini M, Matthay MA. Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes. Am J Physiol Lung Cell Mol Physiol. 2012 May 15; 302(10):L1003-13. PMID: 22427530; PMCID: PMC3362255.
    144. Cha SI, Chang CS, Kim EK, Lee JW, Matthay MA, Golden JA, Elicker BM, Jones K, Collard HR, Wolters PJ. Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis. Histopathology. 2012 Jul; 61(1):98-106. PMID: 22394225; PMCID: PMC3371307.
    145. Sapru A, Zaroff JG, Pawlikowska L, Liu KD, Khush KK, Baxter-Lowe LA, Hayden V, Menza RL, Convery M, Lo V, Poon A, Kim H, Young WL, Kukreja J, Matthay MA. The 4G/4G genotype of the PAI-1 (serpine-1) 4G/5G polymorphism is associated with decreased lung allograft utilization. Am J Transplant. 2012 Jul; 12(7):1848-54. PMID: 22390401; PMCID: PMC4018219.
    146. Kallet RH, Alonso JA, Matthay MA. Quantifying the severity of acute lung injury using dead-space ventilation: should the lung injury score be updated? Respir Care. 2012 Mar; 57(3):477-9. PMID: 22391272; PMCID: PMC3601047.
    147. Ware LB, Neyrinck A, O'Neal HR, Lee JW, Landeck M, Johnson E, Calfee CS, Matthay MA. Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors. Clin Transplant. 2012 Sep-Oct; 26(5):665-71. PMID: 22324977; PMCID: PMC3642873.
    148. Bosmann M, Grailer JJ, Zhu K, Matthay MA, Sarma JV, Zetoune FS, Ward PA. Anti-inflammatory effects of ß2 adrenergic receptor agonists in experimental acute lung injury. FASEB J. 2012 May; 26(5):2137-44. PMID: 22318967; PMCID: PMC3336792.
    149. Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay M, Meyer NJ, Kam C, Li M, Akey J, Barnes KC, Sevransky J, Lanken PN, May AK, Aplenc R, Ealoney JP, @akonarson H. Gefome wide association identifies PPFIA1 as a candidate gene for acute lung injurq risk following major trauma. PDoS One. 2012; 7 1):e28268. PMID2 22295056; PMCID: PMC3266233.
       View in: PubMed, PubMed Central
    150. 
    151.  Lucas R, Sridhar S, Rack FG, Gorshkov B, Umapathy NS, Yang G, Oseghale A, Verin AD, C`akraborty T, , Zemskov EA, White R, Block NL, Schally AV. Agonast of growth hormone-releasing `ormone reduces pneumolysin-induced pulmonary permeability edema& Proc Natl Acad Sci U S A. 2012 Feb 7; 109(6):2084-9. PMID: 22308467; PMCID: PMC3277580.
        
    152. 
    153. 
       Kafgelaris KN, Sapru A, Cadfee CS, Liu KD, Pawlikowska LWitte JS, Vittifghoff E, Zhuo H, Auerbach AD, Zav E, Matthay MA. The association between a Darc gene polymorphism and clinical outcoees in African Aeerican patients with acute lung injury. Chest. 2012 May; 141(5)21160-9. PMID: 22207676; PMCID: PMC3342784.
      
       View in: PubMed,
      
    154. 
    155. 
       Datar SA, Johnson EG, Oishi PE, Johengef M, Tang E, Araeburo A, Barton B, Kuo HC, Bennett S, Xoinis K, Reel B, Kalkan G$ Sajti E$ Osorio O, Raff GW<'a>, Matthay EA, Fineman JR. Altered lymphatics in an ovine model gf congenital heart disease with increased pulmofary blood flow. Am J Physiol Lufg Cell Mol Physaol. 2012 Mar 153 302(6):L530-40& PMID: 222075913 PMCID: PMC3311527. 
      View an: PubMed, PubMed Central 
      <'li> 
    156. , Thompson BT, Ancukiewicz M, Steingrub JS, Douglas IS, 4b>Matthay MAPeterson MW, Rock P, Hyzy RC, Anzueto A, Truwit JD. Acute kidney injury if patients with acute lung injurq: impact of fluad accumulation gn classificatiof of acute kidney injury and associated gutcomes. Crit Care Med. 2011 Dec; 39(12):2665-71. PMID: 21785346; PMCID: PMC3220741. 
      4div class="viewAn"> View in: PubMed$ PubMed Central 
    4/li> 
  • 4div> Brown LM, Cadfee CS, Eatthay MA, Brower RG, Thompson BT<'a>, Checkley W. A simple classification model fgr hospital mortality in patients with acute lung injury managed with lung protective ventilatiof. Crit Care Med& 2011 Dec; 39(12):2645-51. PMID2 21725235; PMCID: PMC3227537.
  •  View in: PubMed, PubMed Central 
  •  
  • 
    Matthay MA4/b>, Kallet RH. Prognostic value of pulmonary dead space in pataents with the acute respiratory distress syndroee. Crit Care. 2011; 15(5):185. PMID: 22067424; PMCID: PMC3334730. 4/div>
    PubMed, PubMed Central 
    Mac Sweeney R, McAuley DF, Matthay MA. Acute lung failure. Semin Respir Crat Care Med. 2011 Oct; 32(5):607%25. PMID: 21989697; PMCID: PMC3601050. 
    
    View in: PubMed, PubEed Central 
    
  • 
  • 
    Matthay MA, Brower RG$ Carson S, Douglas IS, Eisner M, Hite D, Holets S, Kallet RH$ Liu KD, MacIntyre N, Eoss M, Schoenfeld D, Steingrub J, Thompson BT  
  • 
  • 
     Pitt BR, Christman JW, Gunst SJ, Matthay MA, Stevefs T, Ware LB. P`ysiology, reductionism, and trafslational medicane: the right max. Am J Physiol Lung Cell Mol P`ysiol. 2011 Oct3 301(4):L389-90& PMID: 21856812& <'div>
     View in: PubMed 
    <'li> 
  • Matthay MA. Clanical review: T`inking outside the box--an icongclastic view of current practice. Crit Care. 2011; 15(4):225. PEID: 21888690; PECID: PMC3387582& <'div> <'li> 
  • Eatthay MA. Advancing donor eanagement research: design and amplementation of a large, randoeized, placebo-cgntrolled trial. Ann Intensive Care. 2011; 1(1):20. PMID: 21906362; PMCID: PMC3224478. 
     
  • 
  • 
    Cepkova M, Kapur V, Ren X, Quann T, Zhuo H, Fgster E, Eatthay MA, 4a href='http://profiles&ucsf.edu/kathleen.liu' target='Wblank'>Liu KD. Clinical sigfificance of elevated B-type natriuretic peptide in patients wit` acute lung injury with or withgut right ventricular dilatation2 an observational cohort study. Ann Intensive Care. 2011; 1(1):18. PMID: 21906356; PMCID: PMC3224453. 
     
  • 
  • 
    , Fang X, Krasnodembskaya A, Howard JP, Matthaq MA. Concise review: Mesenc`ymal stem cells for acute lung anjury: role of paracrine soluble factors. Stem Cells. 2011 Jun; 29(6):913-9. PMAD: 21506195; PMCID: PMC3293251.4/span>
     View in: 4a href='//www.ncbi.nlm.nih.gov/pubmed/21506195' target='_blank'6PubMed, PubMed Central <'div>
  • 
  • 
    4span id="ctl01_rpPublication_ctd166_lblPublicataon">Flori HR, Church G, Liu KD, Gildengorin G, Matt`ay MA. Positive fluid balance is associated with higher mortality and prolofged mechanical ventilation in pediatric patients with acute lung injury. Crit Care Res Pract. 2011; 2011:854142& PMID: 216875783 PMCID: PMC3114079. 
    View an: PubMed, PubMed Central 
    <'li> 
  • Gotts JE, 4b>Matthay MA
    
     View in: PubMed, PubMed Central
  • Matthay MA, Liu KD. Con: corticosteroids are not indicated for treatment of acute lung injury from H1N1 viral pneumonia. Am J Respir Crit Care Med. 2011 May 1; 183(9):1127-8. PMID: 21531953; PMCID: PMC3114049.
  • Matute-Bello G, Downey G, Moore BB, Groshong SD, Matthay MA, Slutsky AS, Kuebler WM. An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. Am J Respir Cell Mol Biol. 2011 May; 44(5):725-38. PMID: 21531958.
    View in: PubMed
  • Seeley EJ, McAuley DF, Eisner M, Miletin M, Zhuo H, Matthay MA, Kallet RH. Decreased respiratory system compliance on the sixth day of mechanical ventilation is a predictor of death in patients with established acute lung injury. Respir Res. 2011; 12:52. PMID: 21513532; PMCID: PMC3105946.
  • Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay MA, Chapman HA, Wolters PJ. Alveolar epithelial celds express mesenchymal proteins an patients with idiopathic pulmgnary fibrosis. Am J Physiol Lung Cell Mol Physigl. 2011 Jul; 301(1):L71-8. PMID2 21498628; PMCID: PMC3129898.
     View in: PubMed, PubMed Central
  • 
  •  Calfee CS, Ware LB, Glidden DV4/a>, Eisner MD, Parsons PE, Thompson BT, Matthaq MA. Use of risk reclassification with multaple biomarkers amproves mortality prediction in acute lung injury. Crit Care Med. 2011 Apr; 39(4):711-7. PMID: 21283009; PMCID: PMC3260884.
    
     View in: PubMed, PubMed Central 
    <'li> 
  • Matthay MA. Bigmarkers in acute lung injury: ifsights into the pathogenesis of acute lung injury. Crit Care Clan. 2011 Apr; 27 2):355-77. PMID2 21440206; PMCID: PMC3073651.
     View in: PubMed, PubMed Central
  • 
  •  Calfee CS, Matthay MA, Easner MD, Benowatz N, Call E, Pittet JF, Cohen MJ. Active and passive cigarette smokifg and acute lung injury after severe blunt trauea. Am J Respir Crit Care Med. 2011 Jun 15; 183(12):1660-5. PMID2 21471091; PMCID: PMC3136993. 
     
  • 
  • 
    Rice TW, Ware LB, , Chiles C, Wheeler AP, Bernard GR, Steingrub JS4/a>, Hite RD, Matthay MA$ Wright P, Ely EW. Vascular pedacle width in acute lung injury: correlation wit` intravascular pressures and abality to discrimanate fluid status. Crit Care. 2011; 15(2):R86. PMID: 21385351; PMCID: PMC3219344. 4/div>
    PubMed, PubMed Central 
    Su X, Looney MR, Su HE$ Dee JW, Song Y, Matthay MA. Role of CFTR expressed by neutrophils in eodulating acute lung inflammatign and injury in mice. Inflamm Res. 2011 Jul; 60 7):619-32. PMID2 21301926; PMCID: PMC3116128.
     View in: PubMed, PubMed Central
  • 
  •  Sapru A4/a>, Pawdikowska L, 4a href='http://profiles.ucsf.edu/kathleen.liu' target='_blank'>Diu KD, Khush KK$ Ann-Baxter-Lowe L, Hayden V, Menza RL, Convery M, Poon A, Landeck M, Zaroff JG$ Matthay MA<'b>. Single-nucleotide polymorphasms in the ß-adrenergic receptgr genes are assgciated with lung allograft utilazation. J Heart Lung Transplant& 2011 Feb; 30(2!:211-7. PMID: 20869266; PMCID: PMC3019270. 
    View if: PubMed, 4a href='//www.ncbi.nlm.nih.gov/pmc/articles/PMC3019270' target='_blank'>PubMed Central 
  • 4li id="ctl01_rpPublication_ctl178_liPublication" data-pmid="20975549"> Rey MM, Ware LB, Matthay MA, Bernard GR, 4a href='http://profiles.viictr.grg/profile/269908' target='_blafk'>McGuire AL, Caplan AL, Halpern SD. Inforeed consent in research to improve the number and quality of deceased donor orgafs. Crit Care Med. 2011 Feb; 39(2):280-3. PMID: 20975549; PMCID: PMC3717371.
    
     View in: PubEed, PubMed Central4/a> 
  • 
  • 
  •  Matthay MA4/b>, Zemans RL. The acute respiratorq distress syndrgme: pathogenesis and treatment. Annu Rev Pathol& 2011; 6:147-63& PMID: 209369363 PMCID: PMC3108259. 
    View an: PubMed, PubMed Central 
    <'li> 
  • Matthay EA, Benowitr NL, Calfee CS. Biomarkers increase detection of active smoking and secondhand smoke exposure in critacally ill patiefts. Crit Care Med. 2011 Jan; 39 1):40-5. PMID: 20935560; PMCID: PMC3148017.
    
  • Matthay MA, Martin GS. Stem cells in sepsis afd acute lung inbury. Crit Care Eed. 2010 Dec; 30(12):2379-85. PEID: 20838330; PECID: PMC3677751& <'div>
     View in: PubMed, PubMed Ceftral 4/div> Levitt JE, Matthaq MA. The utality of clinicad predictors of acute lung injurq: towards preveftion and earlier recognition. Eppert Rev Respir Med. 2010 Dec; 4(6):785-97. PMID: 21128753; PMCAD: PMC3044497.<'span>
     View in: PubMed, PubMed Central
  • 
  • Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay MA. Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Stem Cells. 2010 Dec; 28(12):2229-38. PMID: 20945332; PMCID: PMC3293245.
  • Lee JS, Su X, Rackley C, Matthay MA, Gupta N. Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury. Anat Rec (Hoboken). 2011 Jan; 294(1):165-72. PMID: 21157927; PMCID: PMC3072226.
  • Matthay MA, Goolaerts A, Howard JP, Lee JW. Mesenchymal stem cells for acute lung injury: preclinical evidence. Crit Care Med. 2010 Oct; 38(10 Suppl):S569-73. PMID: 21164399; PMCID: PMC3580946.
  • Singer M, Matthay MA. Thinking outside the box: Introduction. Crit Care Med. 2010 Oct; 38(10 Suppl):S511. PMID: 21164389.
    View in: PubMed
  • Matthay MA, Thompson BT, Read EJ, McKenna DH, Liu KD, Calfee CS, Lee JW. Therapeutic potential of mesenchymal stem cells for severe acute lung injury. Chest. 2010 Oct; 138(4):965-72. PMID: 20923800; PMCID: PMC2951759.
  • Brown LM, Kallet RH, Matthay MA, Dicker RA. The influence of race on the development of acute lung injury in trauma patients. Am J Surg. 2011 Apr; 201(4):486-91. PMID: 20832050; PMCID: PMC3006033.
  • Ong T, McClintock DE, Kallet RH, Ware LB, Matthay MA, Liu KD. Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients. Crit Care Med. 2010 Sep; 38(9):1845-51. PMID: 20581666; PMCID: PMC4009623.
  • Looney MR, Gilliss BM, Matthay MA. Pathophysiology of transfusion-related acute lung injury. Curr Opin Hematol. 2010 Sep; 17(5):418-23. PMID: 20601870.
    View in: PubMed
  • McAuley DF, Brown LM, Matthay MA. Assessing the quantity of pulmonary edema in critically ill children. Crit Care. 2010; 14(4):189. PMID: 20804574; PMCID: PMC2945115.
  • Bastarache JA, Ong T, Matthay MA, Ware LB. Alveolar fluid clearance is faster in women with acute lung injury compared to men. J Crit Care. 2011 Jun; 26(3):249-56. PMID: 20688464; PMCID: PMC2982881.
  • Matthay MA. Advances and challenges in translating stem cell therapies for clinical diseases. Transl Res. 2010 Sep; 156(3):107-11. PMID: 20801407.
    View in: PubMed
  • Johnson ER, Matthay MA. Acute lung injury: epidemiology, pathogenesis, and treatment. J Aerosol Med Pulm Drug Deliv. 2010 Aug; 23(4):243-52. PMID: 20073554; PMCID: PMC3133560.
  • Diaz JV, Brower R, Calfee CS, Matthay MA. Therapeutic strategies for severe acute lung injury. Crit Care Med. 2010 Aug; 38(8):1644-50. PMID: 20562704; PMCID: PMC4526259.
  • Matthay MA, Jayr C. Acute respiratory distress syndrome after surgery: can the risk be decreased? Anesth Analg. 2010 Aug; 111(2):268-9. PMID: 20664090.
    View in: PubMed
  • Fang X, Neyrinck AP, Matthay MA, Lee JW. Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1. J Biol Chem. 2010 Aug 20; 285(34):26211-22. PMID: 20554518; PMCID: PMC2924032.
  • Cooke CR, Erickson SE, Watkins TR, Matthay MA, Hudson LD, Rubenfeld GD. Age-, sex-, and race-based differences among patients enrolled versus not enrolled in acute lung injury clinical trials. Crit Care Med. 2010 Jun; 38(6):1450-7. PMID: 20386308; PMCID: PMC3799957.
  • Calfee CS, Thompson BT, Parsons PE, Ware LB, Matthay MA, Wong HR. Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock. Crit Care Med. 2010 Jun; 38(6):1436-41. PMID: 20386309; PMCID: PMC3348116.
  • Matthay MA, Idell S. Update on acute lung injury and critical care medicine 2009. Am J Respir Crit Care Med. 2010 May 15; 181(10):1027-32. PMID: 20460547; PMCID: PMC3269230.
  • Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR, Mitchell D, Wickersham N, Bernard GR, Matthay MA, May AK, Ware LB. Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma. 2010 May; 68(5):1121-7. PMID: 20038857; PMCID: PMC3347639.
  • Collard HR, Calfee CS, Wolters PJ, Song JW, Hong SB, Brady S, Ishizaka A, Jones KD, King TE, Matthay MA, Kim DS. Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2010 Jul; 299(1):L3-7. PMID: 20418386; PMCID: PMC2904092.
  • Ballard PL, Lee JW, Fang X, Chapin C, Allen L, Segal MR, Fischer H, Illek B, Gonzales LW, Kolla V, Matthay MA. Regulated gene expression in cultured type II cells of adult human lung. Am J Physiol Lung Cell Mol Physiol. 2010 Jul; 299(1):L36-50. PMID: 20382749; PMCID: PMC2904098.
  • Howard M, Roux J, Lee H, Miyazawa B, Lee JW, Gartland B, Howard AJ, Matthay MA, Carles M, Pittet JF. Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: role of Hsp90 and Hsp70. Thorax. 2010 Apr; 65(4):346-53. PMID: 20388761; PMCID: PMC3118552.
  • Kim SH, Matthay MA, Mostov K, Hunt CA. Simulation of lung alveolar epithelial wound healing in vitro. J R Soc Interface. 2010 Aug 6; 7(49):1157-70. PMID: 20236957; PMCID: PMC2894878.
  • Diep BA, Chan L, Tattevin P, Kajikawa O, Martin TR, Basuino L, Mai TT, Marbach H, Braughton KR, Whitney AR, Gardner DJ, Fan X, Tseng CW, Liu GY, Badiou C, Etienne J, Lina G, Matthay MA, DeLeo FR, Chambers HF. Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5587-92. PMID: 20231457; PMCID: PMC2851770.
  • Calfee CS, Matthay MA. Clinical immunology: Culprits with evolutionary ties. Nature. 2010 Mar 4; 464(7285):41-2. PMID: 20203598; PMCID: PMC2857339.
  • Matthay MA. Standards and recommendations for quantitative assessment of lung structure in research. Am J Physiol Lung Cell Mol Physiol. 2010 May; 298(5):L615. PMID: 20190035; PMCID: PMC2867400.
  • Vincent JL, Singer M, Marini JJ, Moreno R, Levy M, Matthay MA, Pinsky M, Rhodes A, Ferguson ND, Evans T, Annane D, Hall JB. Thirty years of critical care medicine. Crit Care. 2010; 14(3):311. PMID: 20550727; PMCID: PMC2911692.
  • Brown LM, Matthay MA. Measuring the quantity of pulmonary edema in clinical lung injury. Crit Care Med. 2010 Jan; 38(1):312-4. PMID: 20023478.
    View in: PubMed
  • Roux J, Carles M, Koh H, Goolaerts A, Ganter MT, Chesebro BB, Howard M, Houseman BT, Finkbeiner W, Shokat KM, Paquet AC, Matthay MA, Pittet JF. Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism. J Biol Chem. 2010 Feb 12; 285(7):4278-90. PMID: 19996317; PMCID: PMC2836032.
  • Abman SH, Matthay MA. Mesenchymal stem cells for the prevention of bronchopulmonary dysplasia: delivering the secretome. Am J Respir Crit Care Med. 2009 Dec 1; 180(11):1039-41. PMID: 19923401.
    View in: PubMed
  • Su X, Matthay MA, Malik AB. Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury. J Immunol. 2010 Jan 1; 184(1):401-10. PMID: 19949071; PMCID: PMC2877486.
  • Katayama M, Ishizaka A, Sakamoto M, Fujishima S, Sekiguchi K, Asano K, Betsuyaku T, Kotani T, Ware LB, Matthay MA, Hashimoto S. Laminin gamma2 fragments are increased in the circulation of patients with early phase acute lung injury. Intensive Care Med. 2010 Mar; 36(3):479-86. PMID: 19940975; PMCID: PMC2820224.
  • Reel B, Oishi PE, Hsu JH, Gildengorin G, Matthay MA, Fineman JR, Flori H. Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury. Pediatr Pulmonol. 2009 Nov; 44(11):1118-24. PMID: 19830720; PMCID: PMC4427345.
  • Ware LB, Koyama T, Billheimer DD, Wu W, Bernard GR, Thompson BT, Brower RG, Standiford TJ, Martin TR, Matthay MA. Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest. 2010 Feb; 137(2):288-96. PMID: 19858233; PMCID: PMC2816641.
  • Sapru A, Curley MA, Brady S, Matthay MA, Flori H. Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury. Intensive Care Med. 2010 Jan; 36(1):157-63. PMID: 19855955; PMCID: PMC2807603.
  • Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest. 2009 Nov; 119(11):3450-61. PMID: 19809160.
    View in: PubMed
  • Lee JW, Gupta N, Serikov V, Matthay MA. Potential application of mesenchymal stem cells in acute lung injury. Expert Opin Biol Ther. 2009 Oct; 9(10):1259-70. PMID: 19691441; PMCID: PMC2852252.
  • Ware LB, Fremont RD, Bastarache JA, Calfee CS, Matthay MA. Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio. Eur Respir J. 2010 Feb; 35(2):331-7. PMID: 19741024; PMCID: PMC2819058.
  • Lee JW, Fang X, Gupta N, Serikov V, Matthay MA. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16357-62. PMID: 19721001.
    View in: PubMed
  • Goolaerts A, Roux J, Ganter MT, Shlyonsky V, Chraibi A, Stéphane R, Mies F, Matthay MA, Naeije R, Sariban-Sohraby S, Howard M, Pittet JF. Serotonin decreases alveolar epithelial fluid transport via a direct inhibition of the epithelial sodium channel. Am J Respir Cell Mol Biol. 2010 Jul; 43(1):99-108. PMID: 19717814; PMCID: PMC2911574.
  • Colucci G, Domenighetti G, Della Bruna R, Bonilla J, Limoni C, Matthay MA, Martin TR. Comparison of two non-bronchoscopic methods for evaluating inflammation in patients with acute hypoxaemic respiratory failure. Crit Care. 2009; 13(4):R134. PMID: 19671148; PMCID: PMC2750192.
  • Carnesecchi S, Deffert C, Pagano A, Garrido-Urbani S, Métrailler-Ruchonnet I, Schäppi M, Donati Y, Matthay MA, Krause KH, Barazzone Argiroffo C. NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice. Am J Respir Crit Care Med. 2009 Nov 15; 180(10):972-81. PMID: 19661248; PMCID: PMC2778156.
  • Brown LM, Liu KD, Matthay MA. Measurement of extravascular lung water using the single indicator method in patients: research and potential clinical value. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L547-58. PMID: 19617309; PMCID: PMC2770794.
  • McAuley DF, Matthay MA. Clara cell protein CC16. A new lung epithelial biomarker for acute lung injury. Chest. 2009 Jun; 135(6):1408-10. PMID: 19497890.
    View in: PubMed
  • Liu KD, Looney MR, Matthay MA. Inhaled activated protein C: a novel therapy for acute lung injury? Crit Care. 2009; 13(3):150. PMID: 19519935; PMCID: PMC2717421.
  • Neyrinck AP, Liu KD, Howard JP, Matthay MA. Protective mechanisms of activated protein C in severe inflammatory disorders. Br J Pharmacol. 2009 Oct; 158(4):1034-47. PMID: 19466992; PMCID: PMC2785525.
  • Sapru A, Hansen H, Ajayi T, Brown R, Garcia O, Zhuo H, Wiemels J, Matthay MA, Wiener-Kronish J. 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia. Anesthesiology. 2009 May; 110(5):1086-91. PMID: 19387177; PMCID: PMC4127307.
  • Erickson SE, Martin GS, Davis JL, Matthay MA, Eisner MD. Recent trends in acute lung injury mortality: 1996-2005. Crit Care Med. 2009 May; 37(5):1574-9. PMID: 19325464; PMCID: PMC2696257.
  • Su X, Looney MR, Gupta N, Matthay MA. Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. Am J Physiol Lung Cell Mol Physiol. 2009 Jul; 297(1):L1-5. PMID: 19411309; PMCID: PMC2711813.
  • Ong T, Stuart-Killion RB, Daniel BM, Presnell LB, Zhuo H, Matthay MA, Liu KD. Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgery. Pediatr Pulmonol. 2009 May; 44(5):457-63. PMID: 19382217; PMCID: PMC2768264.
  • Church GD, Matthay MA, Liu K, Milet M, Flori HR. Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury. Pediatr Crit Care Med. 2009 May; 10(3):297-302. PMID: 19307809; PMCID: PMC3586190.
  • Matthay MA. Mesenchymally "stemming" angiogenesis. Blood. 2009 Apr 30; 113(18):4131-2. PMID: 19406996; PMCID: PMC2676079.
  • Su X, Matthay MA. Role of protease activated receptor 2 in experimental acute lung injury and lung fibrosis. Anat Rec (Hoboken). 2009 Apr; 292(4):580-6. PMID: 19226616; PMCID: PMC3092500.
  • Looney MR, Matthay MA. Neutrophil sandwiches injure the microcirculation. Nat Med. 2009 Apr; 15(4):364-6. PMID: 19350004; PMCID: PMC2719794.
  • Shyamsundar M, McKeown ST, O'Kane CM, Craig TR, Brown V, Thickett DR, Matthay MA, Taggart CC, Backman JT, Elborn JS, McAuley DF. Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers. Am J Respir Crit Care Med. 2009 Jun 15; 179(12):1107-14. PMID: 19324974; PMCID: PMC2695496.
  • Kim SH, Yu W, Mostov K, Matthay MA, Hunt CA. A computational approach to understand in vitro alveolar morphogenesis. PLoS One. 2009; 4(3):e4819. PMID: 19283073; PMCID: PMC2653231.
  • Levitt JE, Gould MK, Ware LB, Matthay MA. The pathogenetic and prognostic value of biologic markers in acute lung injury. J Intensive Care Med. 2009 May-Jun; 24(3):151-67. PMID: 19282296.
    View in: PubMed
  • Levitt JE, Bedi H, Calfee CS, Gould MK, Matthay MA. Identification of early acute lung injury at initial evaluation in an acute care setting prior to the onset of respiratory failure. Chest. 2009 Apr; 135(4):936-43. PMID: 19188549; PMCID: PMC2758305.
  • Neyrinck AP, Matthay MA. The role of angiotensin-converting enzyme inhibition in endotoxin-induced lung injury in rats. Crit Care Med. 2009 Feb; 37(2):776-7. PMID: 19325385.
    View in: PubMed
  • Erickson SE, Shlipak MG, Martin GS, Wheeler AP, Ancukiewicz M, Matthay MA, Eisner MD. Racial and ethnic disparities in mortality from acute lung injury. Crit Care Med. 2009 Jan; 37(1):1-6. PMID: 19050621; PMCID: PMC2696263.
  • Krupa A, Fudala R, Stankowska D, Loyd T, Allen TC, Matthay MA, Gryczynski Z, Gryczynski I, Mettikolla YV, Kurdowska AK. Anti-chemokine autoantibody:chemokine immune complexes activate endothelial cells via IgG receptors. Am J Respir Cell Mol Biol. 2009 Aug; 41(2):155-69. PMID: 19109244; PMCID: PMC2715905.
  • Iles KE, Wright MM, Cole MP, Welty NE, Ware LB, Matthay MA, Schopfer FJ, Baker PR, Agarwal A, Freeman BA. Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway. Free Radic Biol Med. 2009 Apr 1; 46(7):866-75. PMID: 19133325; PMCID: PMC3104854.
  • Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay MA. Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs. Chest. 2009 Feb; 135(2):269-75. PMID: 19017890; PMCID: PMC2714162.
  • Ware LB, Matthay MA. Beyond fishing: the role of discovery proteomics in mechanistic lung research. Am J Physiol Lung Cell Mol Physiol. 2009 Jan; 296(1):L12-3. PMID: 19011049; PMCID: PMC2636947.
  • Looney MR, Esmon CT, Matthay MA. Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury. Thorax. 2009 Feb; 64(2):114-20. PMID: 19008297; PMCID: PMC4459744.
  • Glassberg AE, Luce JM, Matthay MA. Reasons for nonenrollment in a clinical trial of acute lung injury. Chest. 2008 Oct; 134(4):719-23. PMID: 18689583; PMCID: PMC2789486.
  • Calfee CS, Eisner MD, Parsons PE, Thompson BT, Conner ER, Matthay MA, Ware LB. Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury. Intensive Care Med. 2009 Feb; 35(2):248-57. PMID: 18670758; PMCID: PMC2790376.
  • Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA. Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury. Thorax. 2008 Dec; 63(12):1083-9. PMID: 18566109; PMCID: PMC2764528.
  • Seeley E, McAuley DF, Eisner M, Miletin M, Matthay MA, Kallet RH. Predictors of mortality in acute lung injury during the era of lung protective ventilation. Thorax. 2008 Nov; 63(11):994-8. PMID: 18566110; PMCID: PMC2771451.
  • Liu KD, Levitt J, Zhuo H, Kallet RH, Brady S, Steingrub J, Tidswell M, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Phillips C, Weinacker A, Thompson BT, Eisner MD, Matthay MA. Randomized clinical trial of activated protein C for the treatment of acute lung injury. Am J Respir Crit Care Med. 2008 Sep 15; 178(6):618-23. PMID: 18565951; PMCID: PMC2542435.
  • Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay MA. Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion. Crit Care Med. 2008 Jun; 36(6):1846-54. PMID: 18496381; PMCID: PMC2442403.
  • Su X, Johansen M, Looney MR, Brown EJ, Matthay MA. CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia. J Immunol. 2008 May 15; 180(10):6947-53. PMID: 18453616; PMCID: PMC2771449.
  • Matthay MA, Berthiaume Y. Novel molecular strategy to prevent pulmonary edema. Crit Care Med. 2008 May; 36(5):1671-3. PMID: 18448936; PMCID: PMC2765326.
  • Matthay MA. Measurement of extravascular lung water in patients with pulmonary edema. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1021-2. PMID: 18441090.
    View in: PubMed
  • Liu KD, Matthay MA. Protein C as a surrogate end-point for clinical trials of sepsis. Crit Care. 2008; 12(2):139. PMID: 18492215; PMCID: PMC2447596.
  • Matthay MA. Treatment of acute lung injury: clinical and experimental studies. Proc Am Thorac Soc. 2008 Apr 15; 5(3):297-9. PMID: 18403322.
    View in: PubMed
  • Matthay MA, Calfee CS. Aerosolized beta-adrenergic agonist therapy reduces pulmonary edema following lung surgery. Chest. 2008 Apr; 133(4):833-5. PMID: 18398109.
    View in: PubMed
  • Serikov VB, Mikhaylov VM, Krasnodembskay AD, Matthay MA. Bone marrow-derived cells participate in stromal remodeling of the lung following acute bacterial pneumonia in mice. Lung. 2008 May-Jun; 186(3):179-90. PMID: 18357492; PMCID: PMC2863038.
  • McClintock D, Zhuo H, Wickersham N, Matthay MA, Ware LB. Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury. Crit Care. 2008; 12(2):R41. PMID: 18358078; PMCID: PMC2447583.
  • Hunt CA, Baranzini S, Matthay MA, Park S. A framework and mechanistically focused, in silico method for enabling rational translational research. Summit on Translat Bioinforma. 2008; 2008:46-50. PMID: 21347126; PMCID: PMC3041517.
  • Matthay MA, Lee J. Beta2 adrenergic agonist therapy may enhance alveolar epithelial repair in patients with acute lung injury. Thorax. 2008 Mar; 63(3):189-90. PMID: 18308954.
    View in: PubMed
  • Bastarache JA, Wang L, Wang Z, Albertine KH, Matthay MA, Ware LB. Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity. Am J Physiol Lung Cell Mol Physiol. 2008 May; 294(5):L874-81. PMID: 18310227; PMCID: PMC2764534.
  • Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF. Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res. 2008 Apr 11; 102(7):804-12. PMID: 18276918; PMCID: PMC2739091.
  • Liu KD, Matthay MA. Advances in critical care for the nephrologist: acute lung injury/ARDS. Clin J Am Soc Nephrol. 2008 Mar; 3(2):578-86. PMID: 18199848.
    View in: PubMed
  • White KE, Ding Q, Moore BB, Peters-Golden M, Ware LB, Matthay MA, Olman MA. Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors. J Immunol. 2008 Jan 1; 180(1):637-46. PMID: 18097066; PMCID: PMC2789491.
  • Liu KD, Glidden DV, Eisner MD, Parsons PE, Ware LB, Wheeler A, Korpak A, Thompson BT, Chertow GM, Matthay MA. Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med. 2007 Dec; 35(12):2755-61. PMID: 18074478; PMCID: PMC3293249.
  • Calfee CS, Eisner MD, Ware LB, Thompson BT, Parsons PE, Wheeler AP, Korpak A, Matthay MA. Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Crit Care Med. 2007 Oct; 35(10):2243-50. PMID: 17944012; PMCID: PMC2765812.
  • Looney MR, Matthay MA. The role of protein C in sepsis. Curr Infect Dis Rep. 2007 Oct; 3(5):413-8. PMID: 24395479.
    View in: PubMed
  • Popov BV, Serikov VB, Petrov NS, Izusova TV, Gupta N, Matthay MA. Lung epithelial cells induce endodermal differentiation in mouse mesenchymal bone marrow stem cells by paracrine mechanism. Tissue Eng. 2007 Oct; 13(10):2441-50. PMID: 17630877.
    View in: PubMed
  • Frank JA, Pittet JF, Wray C, Matthay MA. Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade. Thorax. 2008 Feb; 63(2):147-53. PMID: 17901159.
    View in: PubMed
  • Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE. Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1633-40. PMID: 17804488.
    View in: PubMed
  • Matthay MA, Taeusch W. Surfactant treatment of aspiration-induced lung injury in children. Pediatr Crit Care Med. 2007 Sep; 8(5):505-6. PMID: 17873790.
    View in: PubMed
  • Serikov VB, Popov B, Mikhailov VM, Gupta N, Matthay MA. Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice. Anat Rec (Hoboken). 2007 Sep; 290(9):1033-45. PMID: 17661377.
    View in: PubMed
  • Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA. Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol. 2007 Aug 1; 179(3):1855-63. PMID: 17641052.
    View in: PubMed
  • Pauluhn J, Carson A, Costa DL, Gordon T, Kodavanti U, Last JA, Matthay MA, Pinkerton KE, Sciuto AM. Workshop summary: phosgene-induced pulmonary toxicity revisited: appraisal of early and late markers of pulmonary injury from animal models with emphasis on human significance. Inhal Toxicol. 2007 Aug; 19(10):789-810. PMID: 17687713.
    View in: PubMed
  • Ware LB, Matthay MA, Parsons PE, Thompson BT, Januzzi JL, Eisner MD. Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome. Crit Care Med. 2007 Aug; 35(8):1821-8. PMID: 17667242; PMCID: PMC2764536.
  • Matthay MA, Su X. Pulmonary barriers to pneumonia and sepsis. Nat Med. 2007 Jul; 13(7):780-1. PMID: 17618264.
    View in: PubMed
  • Calfee CS, Budev MM, Matthay MA, Church G, Brady S, Uchida T, Ishizaka A, Lara A, Ranes JL, deCamp MM, Arroliga AC. Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation. J Heart Lung Transplant. 2007 Jul; 26(7):675-80. PMID: 17613396; PMCID: PMC2741136.
  • Lee JW, Fang X, Dolganov G, Fremont RD, Bastarache JA, Ware LB, Matthay MA. Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells. J Biol Chem. 2007 Aug 17; 282(33):24109-19. PMID: 17580309; PMCID: PMC2765119.
  • Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Liu KD, Matthay MA. Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injury. Chest. 2007 Sep; 132(3):836-42. PMID: 17573490.
    View in: PubMed
  • Berthiaume Y, Matthay MA. Alveolar edema fluid clearance and acute lung injury. Respir Physiol Neurobiol. 2007 Dec 15; 159(3):350-9. PMID: 17604701; PMCID: PMC2682357.
  • Fudala R, Krupa A, Matthay MA, Allen TC, Kurdowska AK. Anti-IL-8 autoantibody:IL-8 immune complexes suppress spontaneous apoptosis of neutrophils. Am J Physiol Lung Cell Mol Physiol. 2007 Aug; 293(2):L364-74. PMID: 17513455.
    View in: PubMed
  • Li CJ, Ning W, Matthay MA, Feghali-Bostwick CA, Choi AM. MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine production. Am J Physiol Lung Cell Mol Physiol. 2007 May; 292(5):L1297-303. PMID: 17494953.
    View in: PubMed
  • Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg. 2007 May; 245(5):812-8. PMID: 17457176; PMCID: PMC1877079.
  • Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA. Genomics and proteomics of lung disease: conference summary. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L45-51. PMID: 17468134; PMCID: PMC4212816.
  • Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA. Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats. Am J Respir Cell Mol Biol. 2007 Aug; 37(2):186-92. PMID: 17431097; PMCID: PMC1976545.
  • Fremont RD, Kallet RH, Matthay MA, Ware LB. Postobstructive pulmonary edema: a case for hydrostatic mechanisms. Chest. 2007 Jun; 131(6):1742-6. PMID: 17413051; PMCID: PMC2783608.
  • Hirsch J, Hansen KC, Sapru A, Frank JA, Chalkley RJ, Fang X, Trinidad JC, Baker P, Burlingame AL, Matthay MA. Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome. Am J Respir Crit Care Med. 2007 May 15; 175(10):1006-13. PMID: 17363773; PMCID: PMC1899270.
  • Bastarache JA, Wang L, Geiser T, Wang Z, Albertine KH, Matthay MA, Ware LB. The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Thorax. 2007 Jul; 62(7):608-16. PMID: 17356058; PMCID: PMC2117249.
  • Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA. Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L52-9. PMID: 17351061; PMCID: PMC2764531.
  • Calfee CS, Matthay MA. Nonventilatory treatments for acute lung injury and ARDS. Chest. 2007 Mar; 131(3):913-20. PMID: 17356114; PMCID: PMC2789489.
  • Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay MA, Mostov K. Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. Mol Biol Cell. 2007 May; 18(5):1693-700. PMID: 17332496; PMCID: PMC1855040.
  • Flori HR, Ware LB, Milet M, Matthay MA. Early elevation of plasma von Willebrand factor antigen in pediatric acute lung injury is associated with an increased risk of death and prolonged mechanical ventilation. Pediatr Crit Care Med. 2007 Mar; 8(2):96-101. PMID: 17273112; PMCID: PMC3586228.
  • Heresi GA, Arroliga AC, Wiedemann HP, Weidemann HP, Matthay MA. Pulmonary artery catheter and fluid management in acute lung injury and the acute respiratory distress syndrome. Clin Chest Med. 2006 Dec; 27(4):627-35; abstract ix. PMID: 17085251.
    View in: PubMed
  • Frank JA, Parsons PE, Matthay MA. Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies. Chest. 2006 Dec; 130(6):1906-14. PMID: 17167015; PMCID: PMC2764530.
  • Ning W, Dong Y, Sun J, Li C, Matthay MA, Feghali-Bostwick CA, Choi AM. Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts. Am J Respir Cell Mol Biol. 2007 Apr; 36(4):480-90. PMID: 17099140; PMCID: PMC1899323.
  • Wang L, Bastarache JA, Wickersham N, Fang X, Matthay MA, Ware LB. Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation. Am J Respir Cell Mol Biol. 2007 Apr; 36(4):497-503. PMID: 17099142; PMCID: PMC1899324.
  • Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med. 2006 Nov; 12(11):1286-93. PMID: 17086189; PMCID: PMC2768268.
  • McClintock DE, Ware LB, Eisner MD, Wickersham N, Thompson BT, Matthay MA. Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury. Am J Respir Crit Care Med. 2007 Feb 1; 175(3):256-62. PMID: 17082495; PMCID: PMC1899263.
  • Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay MA, Sheppard D, Pittet JF. Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Am J Respir Cell Mol Biol. 2007 Mar; 36(3):377-86. PMID: 17079779; PMCID: PMC1899321.
  • Lee JW, Matthay MA. Protein permeability in lung injury: now in real time again? J Appl Physiol (1985). 2007 Feb; 102(2):508-9. PMID: 17068211.
    View in: PubMed
  • Levitt JE, Matthay MA. Treatment of acute lung injury: historical perspective and potential future therapies. Semin Respir Crit Care Med. 2006 Aug; 27(4):426-37. PMID: 16909376.
    View in: PubMed
  • Frank JA, Wray CM, McAuley DF, Schwendener R, Matthay MA. Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Dec; 291(6):L1191-8. PMID: 16877636.
    View in: PubMed
  • Godzich M, Hodnett M, Frank JA, Su G, Pespeni M, Angel A, Howard MB, Matthay MA, Pittet JF. Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia-reperfusion injury in rats. FASEB J. 2006 Jul; 20(9):1519-21. PMID: 16793871.
    View in: PubMed
  • Sapru A, Wiemels JL, Witte JS, Ware LB, Matthay MA. Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways. Intensive Care Med. 2006 Sep; 32(9):1293-303. PMID: 16770611.
    View in: PubMed
  • Wiener-Kronish JP, Matthay MA. Beta-2-agonist treatment as a potential therapy for acute inhalational lung injury. Crit Care Med. 2006 Jun; 34(6):1841-2. PMID: 16714996.
    View in: PubMed
  • Gupta N, Matthay MA. Sepsis and stretch: synergistic effects on alveolar epithelial cell death? Crit Care Med. 2006 Jun; 34(6):1846-7. PMID: 16714999.
    View in: PubMed
  • Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA. Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest. 2006 Jun; 116(6):1615-23. PMID: 16710475; PMCID: PMC1462945.
  • Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D. Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest. 2006 Jun; 116(6):1606-14. PMID: 16710477; PMCID: PMC1462943.
  • Guidot DM, Folkesson HG, Jain L, Sznajder JI, Pittet JF, Matthay MA. Integrating acute lung injury and regulation of alveolar fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 291(3):L301-6. PMID: 16698856.
    View in: PubMed
  • McClintock DE, Starcher B, Eisner MD, Thompson BT, Hayden DL, Church GD, Matthay MA. Higher urine desmosine levels are associated with mortality in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Oct; 291(4):L566-71. PMID: 16698854; PMCID: PMC2765125.
  • Liu KD, Matthay MA, Chertow GM. Evolving practices in critical care and potential implications for management of acute kidney injury. Clin J Am Soc Nephrol. 2006 Jul; 1(4):869-73. PMID: 17699299.
    View in: PubMed
  • Ganter MT, Ware LB, Howard M, Roux J, Gartland B, Matthay MA, Fleshner M, Pittet JF. Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 291(3):L354-61. PMID: 16679378; PMCID: PMC2765126.
  • Looney MR, Matthay MA. Animal models of transfusion-related acute lung injury. Crit Care Med. 2006 May; 34(5 Suppl):S132-6. PMID: 16617257.
    View in: PubMed
  • Adler KB, Shapiro SD, Gallup M, Wu R, Randell SH, Holtzman MJ, Evans CM, Jacoby DB, Tesfaigzi Y, Rose MC, Mossman BT, Prince A, Reddy SP, Davis CW, Matthay MA. Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum. Am J Respir Cell Mol Biol. 2006 May; 34(5):523-6. PMID: 16618787.
    View in: PubMed
  • Cepkova M, Matthay MA. Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome. J Intensive Care Med. 2006 May-Jun; 21(3):119-43. PMID: 16672636; PMCID: PMC2765330.
  • Ware LB, Camerer E, Welty-Wolf K, Schultz MJ, Matthay MA. Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 291(3):L307-11. PMID: 16648240.
    View in: PubMed
  • Matthay MA, Christman JW, Pitt BR, Schwiebert LM, Stevens T, Ware LB. Perspectives, translational research, and letters to the editor. Am J Physiol Lung Cell Mol Physiol. 2006 Apr; 290(4):L621. PMID: 16531563.
    View in: PubMed
  • Folkesson HG, Matthay MA. Alveolar epithelial ion and fluid transport: recent progress. Am J Respir Cell Mol Biol. 2006 Jul; 35(1):10-9. PMID: 16514116; PMCID: PMC2658691.
  • Curley MA, Arnold JH, Thompson JE, Fackler JC, Grant MJ, Fineman LD, Cvijanovich N, Barr FE, Molitor-Kirsch S, Steinhorn DM, Matthay MA, Hibberd PL. Clinical trial design--effect of prone positioning on clinical outcomes in infants and children with acute respiratory distress syndrome. J Crit Care. 2006 Mar; 21(1):23-32; discussion 32-7. PMID: 16616620; PMCID: PMC1778462.
  • Sakuma T, Gu X, Wang Z, Maeda S, Sugita M, Sagawa M, Osanai K, Toga H, Ware LB, Folkesson G, Matthay MA. Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine. Crit Care Med. 2006 Mar; 34(3):676-81. PMID: 16505652; PMCID: PMC2765117.
  • Hirsch J, Hansen KC, Choi S, Noh J, Hirose R, Roberts JP, Matthay MA, Burlingame AL, Maher JJ, Niemann CU. Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in rats. Mol Cell Proteomics. 2006 Jun; 5(6):979-86. PMID: 16500929.
    View in: PubMed
  • Uchida T, Shirasawa M, Ware LB, Kojima K, Hata Y, Makita K, Mednick G, Matthay ZA, Matthay MA. Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Am J Respir Crit Care Med. 2006 May 1; 173(9):1008-15. PMID: 16456142; PMCID: PMC2662912.
  • Matthay MA, Abraham E. Beta-adrenergic agonist therapy as a potential treatment for acute lung injury. Am J Respir Crit Care Med. 2006 Feb 1; 173(3):254-5. PMID: 16436367.
    View in: PubMed
  • Looney MR, Matthay MA. Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury. Crit Care. 2006; 10(6):239. PMID: 17169139; PMCID: PMC1794467.
  • Cepkova M, Brady S, Sapru A, Matthay MA, Church G. Biological markers of lung injury before and after the institution of positive pressure ventilation in patients with acute lung injury. Crit Care. 2006; 10(5):R126. PMID: 16956410; PMCID: PMC1751077.
  • Ware LB, Matthay MA. Clinical practice. Acute pulmonary edema. N Engl J Med. 2005 Dec 29; 353(26):2788-96. PMID: 16382065.
    View in: PubMed
  • Han B, Mura M, Andrade CF, Okutani D, Lodyga M, dos Santos CC, Keshavjee S, Matthay M, Liu M. TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK. J Immunol. 2005 Dec 15; 175(12):8303-11. PMID: 16339571.
    View in: PubMed
  • Su X, Robriquet L, Folkesson HG, Matthay MA. Protective effect of endogenous beta-adrenergic tone on lung fluid balance in acute bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2006 Apr; 290(4):L769-L776. PMID: 16284214.
    View in: PubMed
  • Matthay MA, Calfee CS. Therapeutic value of a lung protective ventilation strategy in acute lung injury. Chest. 2005 Nov; 128(5):3089-91. PMID: 16304246.
    View in: PubMed
  • Folkesson HG, Chapin CJ, Beard LL, Ertsey R, Matthay MA, Kitterman JA. Congenital diaphragmatic hernia prevents absorption of distal air space fluid in late-gestation rat fetuses. Am J Physiol Lung Cell Mol Physiol. 2006 Mar; 290(3):L478-84. PMID: 16214817.
    View in: PubMed
  • Matthay MA, Zimmerman GA. Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management. Am J Respir Cell Mol Biol. 2005 Oct; 33(4):319-27. PMID: 16172252; PMCID: PMC2715340.
  • Ware LB, Fang X, Wang Y, Babcock WD, Jones K, Matthay MA. High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation. J Heart Lung Transplant. 2005 Oct; 24(10):1650-6. PMID: 16210143.
    View in: PubMed
  • Fang X, Song Y, Hirsch J, Galietta LJ, Pedemonte N, Zemans RL, Dolganov G, Verkman AS, Matthay MA. Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells. Am J Physiol Lung Cell Mol Physiol. 2006 Feb; 290(2):L242-9. PMID: 16143588.
    View in: PubMed
  • Su X, Camerer E, Hamilton JR, Coughlin SR, Matthay MA. Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. J Immunol. 2005 Aug 15; 175(4):2598-605. PMID: 16081834.
    View in: PubMed
  • Frank JA, Matthay MA. Leukotrienes in acute lung injury: a potential therapeutic target? Am J Respir Crit Care Med. 2005 Aug 1; 172(3):261-2. PMID: 16040787; PMCID: PMC2718469.
  • Curley MA, Hibberd PL, Fineman LD, Wypij D, Shih MC, Thompson JE, Grant MJ, Barr FE, Cvijanovich NZ, Sorce L, Luckett PM, Matthay MA, Arnold JH. Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial. JAMA. 2005 Jul 13; 294(2):229-37. PMID: 16014597; PMCID: PMC1237036.
  • Ware LB, Kaner RJ, Crystal RG, Schane R, Trivedi NN, McAuley D, Matthay MA. VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema. Eur Respir J. 2005 Jul; 26(1):101-5. PMID: 15994395; PMCID: PMC2757043.
  • Calfee CS, Matthay MA. Recent advances in mechanical ventilation. Am J Med. 2005 Jun; 118(6):584-91. PMID: 15922687.
    View in: PubMed
  • Suzuki T, Moraes TJ, Vachon E, Ginzberg HH, Huang TT, Matthay MA, Hollenberg MD, Marshall J, McCulloch CA, Abreu MT, Chow CW, Downey GP. Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells. Am J Respir Cell Mol Biol. 2005 Sep; 33(3):231-47. PMID: 15891109; PMCID: PMC2715314.
  • Kallet RH, Daniel BM, Garcia O, Matthay MA. Accuracy of physiologic dead space measurements in patients with acute respiratory distress syndrome using volumetric capnography: comparison with the metabolic monitor method. Respir Care. 2005 Apr; 50(4):462-7. PMID: 15807908.
    View in: PubMed
  • Looney MR, Sartori C, Chakraborty S, James PF, Lingrel JB, Matthay MA. Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2005 Jul; 289(1):L104-10. PMID: 15781423.
    View in: PubMed
  • Angus D, Ishizaka A, Matthay M, Lemaire F, Macnee W, Abraham E. Critical care in AJRCCM 2004. Am J Respir Crit Care Med. 2005 Mar 15; 171(6):537-44. PMID: 15753483.
    View in: PubMed
  • Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D, Matthay MA, Canessa CM, Pittet JF. Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. J Biol Chem. 2005 May 13; 280(19):18579-89. PMID: 15755725.
    View in: PubMed
  • Planès C, Leyvraz C, Uchida T, Angelova MA, Vuagniaux G, Hummler E, Matthay M, Clerici C, Rossier B. In vitro and in vivo regulation of transepithelial lung alveolar sodium transport by serine proteases. Am J Physiol Lung Cell Mol Physiol. 2005 Jun; 288(6):L1099-109. PMID: 15681398.
    View in: PubMed
  • Matthay MA, Robriquet L, Fang X. Alveolar epithelium: role in lung fluid balance and acute lung injury. Proc Am Thorac Soc. 2005; 2(3):206-13. PMID: 16222039.
    View in: PubMed
  • McAuley DF, Matthay MA. Is there a role for beta-adrenoceptor agonists in the management of acute lung injury and the acute respiratory distress syndrome? Treat Respir Med. 2005; 4(5):297-307. PMID: 16137187.
    View in: PubMed
  • Parsons PE, Eisner MD, Thompson BT, Matthay MA, Ancukiewicz M, Bernard GR, Wheeler AP. Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit Care Med. 2005 Jan; 33(1):1-6; discussion 230-2. PMID: 15644641.
    View in: PubMed
  • Frank JA, McAuley DF, Gutierrez JA, Daniel BM, Dobbs L, Matthay MA. Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury. Crit Care Med. 2005 Jan; 33(1):181-8; discussion 254-5. PMID: 15644667.
    View in: PubMed
  • Cheng IW, Eisner MD, Thompson BT, Ware LB, Matthay MA. Acute effects of tidal volume strategy on hemodynamics, fluid balance, and sedation in acute lung injury. Crit Care Med. 2005 Jan; 33(1):63-70; discussion 239-40. PMID: 15644650.
    View in: PubMed
  • Dezfulian C, Shojania K, Collard HR, Kim HM, Matthay MA, Saint S. Subglottic secretion drainage for preventing ventilator-associated pneumonia: a meta-analysis. Am J Med. 2005 Jan; 118(1):11-8. PMID: 15639202.
    View in: PubMed
  • Flori HR, Glidden DV, Rutherford GW, Matthay MA. Pediatric acute lung injury: prospective evaluation of risk factors associated with mortality. Am J Respir Crit Care Med. 2005 May 1; 171(9):995-1001. PMID: 15618461.
    View in: PubMed
  • Mehta D, Bhattacharya J, Matthay MA, Malik AB. Integrated control of lung fluid balance. Am J Physiol Lung Cell Mol Physiol. 2004 Dec; 287(6):L1081-90. PMID: 15531757.
    View in: PubMed
  • Lee H, Pespeni M, Roux J, Dennery PA, Matthay MA, Pittet JF. HO-1 induction restores c-AMP-dependent lung epithelial fluid transport following severe hemorrhage in rats. FASEB J. 2005 Feb; 19(2):287-9. PMID: 15550551.
    View in: PubMed
  • Matthay MA, Ware LB. Can nicotine treat sepsis? Nat Med. 2004 Nov; 10(11):1161-2. PMID: 15516907.
    View in: PubMed
  • Parsons PE, Matthay MA, Ware LB, Eisner MD. Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2005 Mar; 288(3):L426-31. PMID: 15516488.
    View in: PubMed
  • Bandi VD, Munnur U, Matthay MA. Acute lung injury and acute respiratory distress syndrome in pregnancy. Crit Care Clin. 2004 Oct; 20(4):577-607. PMID: 15388190.
    View in: PubMed
  • Kallet RH, Alonso JA, Pittet JF, Matthay MA. Prognostic value of the pulmonary dead-space fraction during the first 6 days of acute respiratory distress syndrome. Respir Care. 2004 Sep; 49(9):1008-14. PMID: 15329171.
    View in: PubMed
  • Su X, Looney M, Robriquet L, Fang X, Matthay MA. Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice. Exp Lung Res. 2004 Sep; 30(6):479-93. PMID: 15524406.
    View in: PubMed
  • Pugin J, Stern-Voeffray S, Daubeuf B, Matthay MA, Elson G, Dunn-Siegrist I. Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock. Blood. 2004 Dec 15; 104(13):4071-9. PMID: 15328161.
    View in: PubMed
  • Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med. 2004 Jul 22; 351(4):327-36. PMID: 15269312.
    View in: PubMed
  • Sue RD, Matthay MA, Ware LB. Hydrostatic mechanisms may contribute to the pathogenesis of human re-expansion pulmonary edema. Intensive Care Med. 2004 Oct; 30(10):1921-6. PMID: 15258730.
    View in: PubMed
  • Looney MR, Gropper MA, Matthay MA. Transfusion-related acute lung injury: a review. Chest. 2004 Jul; 126(1):249-58. PMID: 15249468.
    View in: PubMed
  • McAuley DF, Frank JA, Fang X, Matthay MA. Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury. Crit Care Med. 2004 Jul; 32(7):1470-6. PMID: 15241090.
    View in: PubMed
  • Matthay MA, Clements JA. Coagulation-dependent mechanisms and asthma. J Clin Invest. 2004 Jul; 114(1):20-3. PMID: 15232607; PMCID: PMC437975.
  • Hirsch J, Hansen KC, Burlingame AL, Matthay MA. Proteomics: current techniques and potential applications to lung disease. Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L1-23. PMID: 15187006.
    View in: PubMed
  • Zemans RL, Matthay MA. Bench-to-bedside review: the role of the alveolar epithelium in the resolution of pulmonary edema in acute lung injury. Crit Care. 2004 Dec; 8(6):469-77. PMID: 15566618; PMCID: PMC1065044.
  • Ware LB, Eisner MD, Thompson BT, Parsons PE, Matthay MA. Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury. Am J Respir Crit Care Med. 2004 Oct 1; 170(7):766-72. PMID: 15201135.
    View in: PubMed
  • Matthay MA, Ware LB. Plasma protein C levels in patients with acute lung injury: prognostic significance. Crit Care Med. 2004 May; 32(5 Suppl):S229-32. PMID: 15118523.
    View in: PubMed
  • Geiser T, Ishigaki M, van Leer C, Matthay MA, Broaddus VC. H(2)O(2) inhibits alveolar epithelial wound repair in vitro by induction of apoptosis. Am J Physiol Lung Cell Mol Physiol. 2004 Aug; 287(2):L448-53. PMID: 15121637.
    View in: PubMed
  • Hastings RH, Folkesson HG, Matthay MA. Mechanisms of alveolar protein clearance in the intact lung. Am J Physiol Lung Cell Mol Physiol. 2004 Apr; 286(4):L679-89. PMID: 15003932.
    View in: PubMed
  • Zemans RL, Chatterjee K, Matthay MA. Diagnostic utility of B-type natriuretic peptide in patients with acute dyspnea or pleural effusions. Am J Med. 2004 Mar 15; 116(6):424-6. PMID: 15006593.
    View in: PubMed
  • Fang X, Song Y, Zemans R, Hirsch J, Matthay MA. Fluid transport across cultured rat alveolar epithelial cells: a novel in vitro system. Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L104-10. PMID: 14990396.
    View in: PubMed
  • Sakuma T, Zhao Y, Sugita M, Sagawa M, Toga H, Ishibashi T, Nishio M, Matthay MA. Malnutrition impairs alveolar fluid clearance in rat lungs. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1268-74. PMID: 14977628.
    View in: PubMed
  • Olman MA, White KE, Ware LB, Simmons WL, Benveniste EN, Zhu S, Pugin J, Matthay MA. Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression. J Immunol. 2004 Feb 15; 172(4):2668-77. PMID: 14764742.
    View in: PubMed
  • Gropper MA, Matthay MA. Look before you leap: how do intensivists improve care for critically ill patients? Am J Med. 2004 Feb 1; 116(3):206-7. PMID: 14749169.
    View in: PubMed
  • McClintock DE, Matthay MA. Why does acute lung injury have no impact on mortality in patients with major trauma? Crit Care Med. 2004 Feb; 32(2):583-4. PMID: 14758183.
    View in: PubMed
  • Uchida T, Rossignol F, Matthay MA, Mounier R, Couette S, Clottes E, Clerici C. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. J Biol Chem. 2004 Apr 9; 279(15):14871-8. PMID: 14744852.
    View in: PubMed
  • Bowler RP, Duda B, Chan ED, Enghild JJ, Ware LB, Matthay MA, Duncan MW. Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1095-104. PMID: 14742308.
    View in: PubMed
  • Krupa A, Kato H, Matthay MA, Kurdowska AK. Proinflammatory activity of anti-IL-8 autoantibody:IL-8 complexes in alveolar edema fluid from patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1105-13. PMID: 14729508.
    View in: PubMed
  • Garrity-Ryan L, Shafikhani S, Balachandran P, Nguyen L, Oza J, Jakobsen T, Sargent J, Fang X, Cordwell S, Matthay MA, Engel JN. The ADP ribosyltransferase domain of Pseudomonas aeruginosa ExoT contributes to its biological activities. Infect Immun. 2004 Jan; 72(1):546-58. PMID: 14688136; PMCID: PMC343945.
  • Wang L, Zhu DM, Su X, Bai CX, Ware LB, Matthay MA. Acute cardiopulmonary effects of a dual-endothelin receptor antagonist on oleic acid-induced pulmonary arterial hypertension in dogs. Exp Lung Res. 2004 Jan-Feb; 30(1):31-42. PMID: 14967602.
    View in: PubMed
  • Pastor CM, Matthay MA, Frossard JL. Pancreatitis-associated acute lung injury: new insights. Chest. 2003 Dec; 124(6):2341-51. PMID: 14665518.
    View in: PubMed
  • Goodman RB, Pugin J, Lee JS, Matthay MA. Cytokine-mediated inflammation in acute lung injury. Cytokine Growth Factor Rev. 2003 Dec; 14(6):523-35. PMID: 14563354.
    View in: PubMed
  • Clerici C, Matthay MA. Transforming growth factor-beta 1 regulates lung epithelial barrier function and fluid transport. Am J Physiol Lung Cell Mol Physiol. 2003 Dec; 285(6):L1190-1. PMID: 14604849.
    View in: PubMed
  • Paine R, Wilcoxen SE, Morris SB, Sartori C, Baleeiro CE, Matthay MA, Christensen PJ. Transgenic overexpression of granulocyte macrophage-colony stimulating factor in the lung prevents hyperoxic lung injury. Am J Pathol. 2003 Dec; 163(6):2397-406. PMID: 14633611; PMCID: PMC1892382.
  • Eisner MD, Parsons P, Matthay MA, Ware L, Greene K. Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury. Thorax. 2003 Nov; 58(11):983-8. PMID: 14586055; PMCID: PMC1746524.
  • Brower RG, Morris A, MacIntyre N, Matthay MA, Hayden D, Thompson T, Clemmer T, Lanken PN, Schoenfeld D. Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure. Crit Care Med. 2003 Nov; 31(11):2592-7. PMID: 14605529.
    View in: PubMed
  • Su X, Bai C, Hong Q, Zhu D, He L, Wu J, Ding F, Fang X, Matthay MA. Effect of continuous hemofiltration on hemodynamics, lung inflammation and pulmonary edema in a canine model of acute lung injury. Intensive Care Med. 2003 Nov; 29(11):2034-42. PMID: 14557856.
    View in: PubMed
  • Cheng IW, Matthay MA. Acute lung injury and the acute respiratory distress syndrome. Crit Care Clin. 2003 Oct; 19(4):693-712. PMID: 14601715.
    View in: PubMed
  • Ishizaka A, Matsuda T, Albertine KH, Koh H, Tasaka S, Hasegawa N, Kohno N, Kotani T, Morisaki H, Takeda J, Nakamura M, Fang X, Martin TR, Matthay MA, Hashimoto S. Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1088-94. PMID: 12959931.
    View in: PubMed
  • Bowler RP, Velsor LW, Duda B, Chan ED, Abraham E, Ware LB, Matthay MA, Day BJ. Pulmonary edema fluid antioxidants are depressed in acute lung injury. Crit Care Med. 2003 Sep; 31(9):2309-15. PMID: 14501961.
    View in: PubMed
  • Olman MA, Matthay MA. Transforming growth factor-beta induces fibrosis in immune cell-depleted lungs. Am J Physiol Lung Cell Mol Physiol. 2003 Sep; 285(3):L522-6. PMID: 12902316.
    View in: PubMed
  • Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay MA, Pittet JF. Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem. 2003 Nov 7; 278(45):43939-50. PMID: 12930837.
    View in: PubMed
  • Elia N, Tapponnier M, Matthay MA, Hamacher J, Pache JC, Brundler MA, Totsch M, De Baetselier P, Fransen L, Fukuda N, Morel DR, Lucas R. Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha. Am J Respir Crit Care Med. 2003 Nov 1; 168(9):1043-50. PMID: 12842853.
    View in: PubMed
  • Flori HR, Ware LB, Glidden D, Matthay MA. Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation. Pediatr Crit Care Med. 2003 Jul; 4(3):315-21. PMID: 12831413.
    View in: PubMed
  • Ware LB, Fang X, Matthay MA. Protein C and thrombomodulin in human acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2003 Sep; 285(3):L514-21. PMID: 12754194.
    View in: PubMed
  • Prabhakaran P, Ware LB, White KE, Cross MT, Matthay MA, Olman MA. Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L20-8. PMID: 12730079.
    View in: PubMed
  • Matthay MA, Zimmerman GA, Esmon C, Bhattacharya J, Coller B, Doerschuk CM, Floros J, Gimbrone MA, Hoffman E, Hubmayr RD, Leppert M, Matalon S, Munford R, Parsons P, Slutsky AS, Tracey KJ, Ward P, Gail DB, Harabin AL. Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med. 2003 Apr 1; 167(7):1027-35. PMID: 12663342.
    View in: PubMed
  • Folkesson HG, Matthay MA. Therapeutic strategies to hasten the resolution of pulmonary edema. Crit Care Med. 2003 Apr; 31(4):1288-9. PMID: 12682513.
    View in: PubMed
  • Collard HR, Saint S, Matthay MA. Prevention of ventilator-associated pneumonia: an evidence-based systematic review. Ann Intern Med. 2003 Mar 18; 138(6):494-501. PMID: 12639084.
    View in: PubMed
  • Galiacy S, Planus E, Lepetit H, Féréol S, Laurent V, Ware L, Isabey D, Matthay M, Harf A, d'Ortho MP. Keratinocyte growth factor promotes cell motility during alveolar epithelial repair in vitro. Exp Cell Res. 2003 Feb 15; 283(2):215-29. PMID: 12581741.
    View in: PubMed
  • Frank JA, Pittet JF, Lee H, Godzich M, Matthay MA. High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2003 May; 284(5):L791-8. PMID: 12562562.
    View in: PubMed
  • Cheng IW, Ware LB, Greene KE, Nuckton TJ, Eisner MD, Matthay MA. Prognostic value of surfactant proteins A and D in patients with acute lung injury. Crit Care Med. 2003 Jan; 31(1):20-7. PMID: 12544988.
    View in: PubMed
  • Berthiaume Y, Folkesson HG, Matthay MA. Lung edema clearance: 20 years of progress: invited review: alveolar edema fluid clearance in the injured lung. J Appl Physiol (1985). 2002 Dec; 93(6):2207-13. PMID: 12433940.
    View in: PubMed
  • Matthay MA. Alveolar fluid clearance in patients with ARDS: does it make a difference? Chest. 2002 Dec; 122(6 Suppl):340S-343S. PMID: 12475812.
    View in: PubMed
  • Brower RG, Matthay M, Schoenfeld D. Meta-analysis of acute lung injury and acute respiratory distress syndrome trials. Am J Respir Crit Care Med. 2002 Dec 1; 166(11):1515-7. PMID: 12450936.
    View in: PubMed
  • Matthay MA. Clinical measurement of pulmonary edema. Chest. 2002 Dec; 122(6):1877-9. PMID: 12475816.
    View in: PubMed
  • Sartori C, Matthay MA. Alveolar epithelial fluid transport in acute lung injury: new insights. Eur Respir J. 2002 Nov; 20(5):1299-313. PMID: 12449188.
    View in: PubMed
  • Albertine KH, Soulier MF, Wang Z, Ishizaka A, Hashimoto S, Zimmerman GA, Matthay MA, Ware LB. Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome. Am J Pathol. 2002 Nov; 161(5):1783-96. PMID: 12414525; PMCID: PMC1850801.
  • Pham I, Uchida T, Planes C, Ware LB, Kaner R, Matthay MA, Clerici C. Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol. 2002 Nov; 283(5):L1133-42. PMID: 12376368.
    View in: PubMed
  • Sartori C, Fang X, McGraw DW, Koch P, Snider ME, Folkesson HG, Matthay MA. Selected contribution: long-term effects of beta(2)-adrenergic receptor stimulation on alveolar fluid clearance in mice. J Appl Physiol (1985). 2002 Nov; 93(5):1875-80. PMID: 12381778.
    View in: PubMed
  • Ware LB, Fang X, Wang Y, Sakuma T, Hall TS, Matthay MA. Selected contribution: mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lung. J Appl Physiol (1985). 2002 Nov; 93(5):1869-74. PMID: 12381777.
    View in: PubMed
  • Ware LB, Matthay MA. Measuring microvascular blood flow in sepsis--a continuing challenge. Lancet. 2002 Oct 19; 360(9341):1187-8. PMID: 12401242.
    View in: PubMed
  • Frank JA, Matthay MA. Science review: mechanisms of ventilator-induced injury. Crit Care. 2003 Jun; 7(3):233-41. PMID: 12793874; PMCID: PMC270664.
  • Planès C, Blot-Chabaud M, Matthay MA, Couette S, Uchida T, Clerici C. Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells. J Biol Chem. 2002 Dec 6; 277(49):47318-24. PMID: 12372821.
    View in: PubMed
  • Matthay MA, Bhattacharya S, Gaver D, Ware LB, Lim LH, Syrkina O, Eyal F, Hubmayr R. Ventilator-induced lung injury: in vivo and in vitro mechanisms. Am J Physiol Lung Cell Mol Physiol. 2002 Oct; 283(4):L678-82. PMID: 12225942.
    View in: PubMed
  • Lane RK, Matthay MA. Central line infections. Curr Opin Crit Care. 2002 Oct; 8(5):441-8. PMID: 12357113.
    View in: PubMed
  • Sakuma T, Sagawa M, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Matthay MA. Time-dependent effect of pneumonectomy on alveolar epithelial fluid clearance in rat lungs. J Thorac Cardiovasc Surg. 2002 Oct; 124(4):668-74. PMID: 12324723.
    View in: PubMed
  • Matthay MA, Clerici C, Saumon G. Invited review: Active fluid clearance from the distal air spaces of the lung. J Appl Physiol (1985). 2002 Oct; 93(4):1533-41. PMID: 12235056.
    View in: PubMed
  • Jiang J, Song Y, Bai C, Koller BH, Matthay MA, Verkman AS. Pleural surface fluorescence measurement of Na+ and Cl- transport across the air space-capillary barrier. J Appl Physiol (1985). 2003 Jan; 94(1):343-52. PMID: 12391048.
    View in: PubMed
  • Ware LB, Wang Y, Fang X, Warnock M, Sakuma T, Hall TS, Matthay M. Assessment of lungs rejected for transplantation and implications for donor selection. Lancet. 2002 Aug 24; 360(9333):619-20. PMID: 12241936.
    View in: PubMed
  • Matthay MA. The pulmonary epithelium is an important mediator of ventilator-induced lung injury. Crit Care Med. 2002 Aug; 30(8):1910-1. PMID: 12163818.
    View in: PubMed
  • Atabai K, Ishigaki M, Geiser T, Ueki I, Matthay MA, Ware LB. Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms. Am J Physiol Lung Cell Mol Physiol. 2002 Jul; 283(1):L163-9. PMID: 12060573.
    View in: PubMed
  • Fang X, Yang B, Matthay MA, Verkman AS. Evidence against aquaporin-1-dependent CO2 permeability in lung and kidney. J Physiol. 2002 Jul 1; 542(Pt 1):63-9. PMID: 12096051; PMCID: PMC2290384.
  • Matthay MA, Folkesson HG, Clerici C. Lung epithelial fluid transport and the resolution of pulmonary edema. Physiol Rev. 2002 Jul; 82(3):569-600. PMID: 12087129.
    View in: PubMed
  • Saint S, Savel RH, Matthay MA. Enhancing the safety of critically ill patients by reducing urinary and central venous catheter-related infections. Am J Respir Crit Care Med. 2002 Jun 1; 165(11):1475-9. PMID: 12045119.
    View in: PubMed
  • Atabai K, Ware LB, Snider ME, Koch P, Daniel B, Nuckton TJ, Matthay MA. Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure. Intensive Care Med. 2002 Jun; 28(6):705-11. PMID: 12107675.
    View in: PubMed
  • Atabai K, Matthay MA. The pulmonary physician in critical care. 5: Acute lung injury and the acute respiratory distress syndrome: definitions and epidemiology. Thorax. 2002 May; 57(5):452-8. PMID: 11978926; PMCID: PMC1746331.
  • Ware LB, Matthay MA. Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. Am J Physiol Lung Cell Mol Physiol. 2002 May; 282(5):L924-40. PMID: 11943656.
    View in: PubMed
  • Kurdowska AK, Geiser TK, Alden SM, Dziadek BR, Noble JM, Nuckton TJ, Matthay MA. Activity of pulmonary edema fluid interleukin-8 bound to alpha(2)-macroglobulin in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2002 May; 282(5):L1092-8. PMID: 11943675.
    View in: PubMed
  • Nuckton TJ, Alonso JA, Kallet RH, Daniel BM, Pittet JF, Eisner MD, Matthay MA. Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome. N Engl J Med. 2002 Apr 25; 346(17):1281-6. PMID: 11973365.
    View in: PubMed
  • Eisner MD, Thompson BT, Schoenfeld D, Anzueto A, Matthay MA. Airway pressures and early barotrauma in patients with acute lung injury and acute respiratory distress syndrome. Am J Respir Crit Care Med. 2002 Apr 1; 165(7):978-82. PMID: 11934725.
    View in: PubMed
  • Olman MA, White KE, Ware LB, Cross MT, Zhu S, Matthay MA. Microarray analysis indicates that pulmonary edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and fibroblast proliferation through bioactive interleukin-1. Chest. 2002 Mar; 121(3 Suppl):69S-70S. PMID: 11893691.
    View in: PubMed
  • Folkesson HG, Matthay MA, Chapin CJ, Porta NF, Kitterman JA. Distal air space epithelial fluid clearance in near-term rat fetuses is fast and requires endogenous catecholamines. Am J Physiol Lung Cell Mol Physiol. 2002 Mar; 282(3):L508-15. PMID: 11839545.
    View in: PubMed
  • Fang X, Fukuda N, Barbry P, Sartori C, Verkman AS, Matthay MA. Novel role for CFTR in fluid absorption from the distal airspaces of the lung. J Gen Physiol. 2002 Feb; 119(2):199-207. PMID: 11815669; PMCID: PMC2233804.
  • Laffon M, Jayr C, Barbry P, Wang Y, Folkesson HG, Pittet JF, Clerici C, Matthay MA. Lidocaine induces a reversible decrease in alveolar epithelial fluid clearance in rats. Anesthesiology. 2002 Feb; 96(2):392-9. PMID: 11818773.
    View in: PubMed
  • Pittet JF, Lu LN, Geiser T, Lee H, Matthay MA, Welch WJ. Stress preconditioning attenuates oxidative injury to the alveolar epithelium of the lung following haemorrhage in rats. J Physiol. 2002 Jan 15; 538(Pt 2):583-97. PMID: 11790821; PMCID: PMC2290060.
  • Frank JA, Gutierrez JA, Jones KD, Allen L, Dobbs L, Matthay MA. Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs. Am J Respir Crit Care Med. 2002 Jan 15; 165(2):242-9. PMID: 11790662.
    View in: PubMed
  • Ware LB, Conner ER, Matthay MA. von Willebrand factor antigen is an independent marker of poor outcome in patients with early acute lung injury. Crit Care Med. 2001 Dec; 29(12):2325-31. PMID: 11801836.
    View in: PubMed
  • Oswari J, Matthay MA, Margulies SS. Keratinocyte growth factor reduces alveolar epithelial susceptibility to in vitro mechanical deformation. Am J Physiol Lung Cell Mol Physiol. 2001 Nov; 281(5):L1068-77. PMID: 11597897.
    View in: PubMed
  • Vivona ML, Matthay M, Chabaud MB, Friedlander G, Clerici C. Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: reversal by beta-adrenergic agonist treatment. Am J Respir Cell Mol Biol. 2001 Nov; 25(5):554-61. PMID: 11713096.
    View in: PubMed
  • Thompson BT, Hayden D, Matthay MA, Brower R, Parsons PE. Clinicians' approaches to mechanical ventilation in acute lung injury and ARDS. Chest. 2001 Nov; 120(5):1622-7. PMID: 11713144.
    View in: PubMed
  • McGraw DW, Fukuda N, James PF, Forbes SL, Woo AL, Lingrel JB, Witte DP, Matthay MA, Liggett SB. Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2001 Oct; 281(4):L895-903. PMID: 11557593.
    View in: PubMed
  • Brower RG, Ware LB, Berthiaume Y, Matthay MA. Treatment of ARDS. Chest. 2001 Oct; 120(4):1347-67. PMID: 11591581.
    View in: PubMed
  • Eisner MD, Thompson T, Hudson LD, Luce JM, Hayden D, Schoenfeld D, Matthay MA. Efficacy of low tidal volume ventilation in patients with different clinical risk factors for acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med. 2001 Jul 15; 164(2):231-6. PMID: 11463593.
    View in: PubMed
  • Sakuma T, Tuchihara C, Ishigaki M, Osanai K, Nambu Y, Toga H, Takahashi K, Ohya N, Inoue M, Matthay MA. Beta1-adrenoceptor stimulation by high-dose terbutaline downregulates terbutaline-stimulated alveolar fluid clearance in ex vivo rat lung. Exp Lung Res. 2001 Jul-Aug; 27(5):453-68. PMID: 11480585.
    View in: PubMed
  • Fischer H, Fukuda N, Barbry P, Illek B, Sartori C, Matthay MA. Partial restoration of defective chloride conductance in DeltaF508 CF mice by trimethylamine oxide. Am J Physiol Lung Cell Mol Physiol. 2001 Jul; 281(1):L52-7. PMID: 11404245.
    View in: PubMed
  • Chesnutt MS, Nuckton TJ, Golden J, Folkesson HG, Matthay MA. Rapid alveolar epithelial fluid clearance following lung lavage in pulmonary alveolar proteinosis. Chest. 2001 Jul; 120(1):271-4. PMID: 11451848.
    View in: PubMed
  • Pittet JF, Griffiths MJ, Geiser T, Kaminski N, Dalton SL, Huang X, Brown LA, Gotwals PJ, Koteliansky VE, Matthay MA, Sheppard D. TGF-beta is a critical mediator of acute lung injury. J Clin Invest. 2001 Jun; 107(12):1537-44. PMID: 11413161; PMCID: PMC200192.
  • Song Y, Jayaraman S, Yang B, Matthay MA, Verkman AS. Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration. J Gen Physiol. 2001 Jun; 117(6):573-82. PMID: 11382807; PMCID: PMC2232398.
  • Fukuda N, Jayr C, Lazrak A, Wang Y, Lucas R, Matalon S, Matthay MA. Mechanisms of TNF-alpha stimulation of amiloride-sensitive sodium transport across alveolar epithelium. Am J Physiol Lung Cell Mol Physiol. 2001 Jun; 280(6):L1258-65. PMID: 11350806.
    View in: PubMed
  • Pittet JF, Lu LN, Morris DG, Modelska K, Welch WJ, Carey HV, Roux J, Matthay MA. Reactive nitrogen species inhibit alveolar epithelial fluid transport after hemorrhagic shock in rats. J Immunol. 2001 May 15; 166(10):6301-10. PMID: 11342654.
    View in: PubMed
  • Geiser T, Atabai K, Jarreau PH, Ware LB, Pugin J, Matthay MA. Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1beta-dependent mechanism. Am J Respir Crit Care Med. 2001 May; 163(6):1384-8. PMID: 11371405.
    View in: PubMed
  • Ware LB, Matthay MA. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med. 2001 May; 163(6):1376-83. PMID: 11371404.
    View in: PubMed
  • Norlin A, Lu LN, Guggino SE, Matthay MA, Folkesson HG. Contribution of amiloride-insensitive pathways to alveolar fluid clearance in adult rats. J Appl Physiol (1985). 2001 Apr; 90(4):1489-96. PMID: 11247951.
    View in: PubMed
  • Geiser TK, Kazmierczak BI, Garrity-Ryan LK, Matthay MA, Engel JN. Pseudomonas aeruginosa ExoT inhibits in vitro lung epithelial wound repair. Cell Microbiol. 2001 Apr; 3(4):223-36. PMID: 11298646.
    View in: PubMed
  • Matthay MA. Severe sepsis--a new treatment with both anticoagulant and antiinflammatory properties. N Engl J Med. 2001 Mar 8; 344(10):759-62. PMID: 11236781.
    View in: PubMed
  • Crandall ED, Matthay MA. Alveolar epithelial transport. Basic science to clinical medicine. Am J Respir Crit Care Med. 2001 Mar; 163(4):1021-9. PMID: 11282783.
    View in: PubMed
  • Sartori C, Matthay MA, Scherrer U. Transepithelial sodium and water transport in the lung. Major player and novel therapeutic target in pulmonary edema. Adv Exp Med Biol. 2001; 502:315-38. PMID: 11950147.
    View in: PubMed
  • Zhu S, Ware LB, Geiser T, Matthay MA, Matalon S. Increased levels of nitrate and surfactant protein a nitration in the pulmonary edema fluid of patients with acute lung injury. Am J Respir Crit Care Med. 2001 Jan; 163(1):166-72. PMID: 11208643.
    View in: PubMed
  • Yost CS, Matthay MA, Gropper MA. Etiology of acute pulmonary edema during liver transplantation : a series of cases with analysis of the edema fluid. Chest. 2001 Jan; 119(1):219-23. PMID: 11157607.
    View in: PubMed
  • Sakuma T, Tuchihara C, Ishigaki M, Osanai K, Nambu Y, Toga H, Takahashi K, Ohya N, Kurihara T, Matthay MA. Denopamine, a beta(1)-adrenergic agonist, increases alveolar fluid clearance in ex vivo rat and guinea pig lungs. J Appl Physiol (1985). 2001 Jan; 90(1):10-6. PMID: 11133887.
    View in: PubMed
  • Song Y, Yang B, Matthay MA, Ma T, Verkman AS. Role of aquaporin water channels in pleural fluid dynamics. Am J Physiol Cell Physiol. 2000 Dec; 279(6):C1744-50. PMID: 11078688.
    View in: PubMed
  • Geiser T, Jarreau PH, Atabai K, Matthay MA. Interleukin-1beta augments in vitro alveolar epithelial repair. Am J Physiol Lung Cell Mol Physiol. 2000 Dec; 279(6):L1184-90. PMID: 11076808.
    View in: PubMed
  • Frank JA, Wang Y, Osorio O, Matthay MA. Beta-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats. J Appl Physiol (1985). 2000 Oct; 89(4):1255-65. PMID: 11007557.
    View in: PubMed
  • Matthay MA, Fukuda N, Frank J, Kallet R, Daniel B, Sakuma T. Alveolar epithelial barrier. Role in lung fluid balance in clinical lung injury. Clin Chest Med. 2000 Sep; 21(3):477-90. PMID: 11019721.
    View in: PubMed
  • Fukuda N, Folkesson HG, Matthay MA. Relationship of interstitial fluid volume to alveolar fluid clearance in mice: ventilated vs. in situ studies. J Appl Physiol (1985). 2000 Aug; 89(2):672-9. PMID: 10926653.
    View in: PubMed
  • Frank JA, Nuckton TJ, Matthay MA. Diabetes mellitus: a negative predictor for the development of acute respiratory distress syndrome from septic shock. Crit Care Med. 2000 Jul; 28(7):2645-6. PMID: 10921610.
    View in: PubMed
  • Song Y, Fukuda N, Bai C, Ma T, Matthay MA, Verkman AS. Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice. J Physiol. 2000 Jun 15; 525 Pt 3:771-9. PMID: 10856128; PMCID: PMC2269974.
  • Kaner RJ, Ladetto JV, Singh R, Fukuda N, Matthay MA, Crystal RG. Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema. Am J Respir Cell Mol Biol. 2000 Jun; 22(6):657-64. PMID: 10837361.
    View in: PubMed
  • Jasmer RM, Matthay MA. Cost-effectiveness of noninvasive ventilation for acute chronic obstructive pulmonary disease: cashing in too quickly. Crit Care Med. 2000 Jun; 28(6):2170-1. PMID: 10890702.
    View in: PubMed
  • Sakuma T, Tsukano C, Ishigaki M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Kurihara T, Nishio M, Matthay MA. Lung deflation impairs alveolar epithelial fluid transport in ischemic rabbit and rat lungs. Transplantation. 2000 May 15; 69(9):1785-93. PMID: 10830212.
    View in: PubMed
  • Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 2000 May 4; 342(18):1334-49. PMID: 10793167.
    View in: PubMed
  • Coscoy S, de Weille J, Lingueglia E, Fukuda N, Matthay M, Lazdunski M, Barbry P. [Amiloride-sensitive sodium channel in the nephron and its activation by vasopressin]. Ann Endocrinol (Paris). 2000 May; 61(2):145-6. PMID: 10960333.
    View in: PubMed
  • Clerici C, Matthay MA. Hypoxia regulates gene expression of alveolar epithelial transport proteins. J Appl Physiol (1985). 2000 May; 88(5):1890-6. PMID: 10797154.
    View in: PubMed
  • Verkman AS, Matthay MA, Song Y. Aquaporin water channels and lung physiology. Am J Physiol Lung Cell Mol Physiol. 2000 May; 278(5):L867-79. PMID: 10781416.
    View in: PubMed
  • Ordoñez CL, Shaughnessy TE, Matthay MA, Fahy JV. Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance. Am J Respir Crit Care Med. 2000 Apr; 161(4 Pt 1):1185-90. PMID: 10764310.
    View in: PubMed
  • Newman V, Gonzalez RF, Matthay MA, Dobbs LG. A novel alveolar type I cell-specific biochemical marker of human acute lung injury. Am J Respir Crit Care Med. 2000 Mar; 161(3 Pt 1):990-5. PMID: 10712353.
    View in: PubMed
  • Pascual FE, Matthay MA, Bacchetti P, Wachter RM. Assessment of prognosis in patients with community-acquired pneumonia who require mechanical ventilation. Chest. 2000 Feb; 117(2):503-12. PMID: 10669697.
    View in: PubMed
  • Folkesson HG, Norlin A, Wang Y, Abedinpour P, Matthay MA. Dexamethasone and thyroid hormone pretreatment upregulate alveolar epithelial fluid clearance in adult rats. J Appl Physiol (1985). 2000 Feb; 88(2):416-24. PMID: 10658006.
    View in: PubMed
  • Yang B, Fukuda N, van Hoek A, Matthay MA, Ma T, Verkman AS. Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes. J Biol Chem. 2000 Jan 28; 275(4):2686-92. PMID: 10644730.
    View in: PubMed
  • Gaillard D, Hinnrasky J, Coscoy S, Hofman P, Matthay MA, Puchelle E, Barbry P. Early expression of beta- and gamma-subunits of epithelial sodium channel during human airway development. Am J Physiol Lung Cell Mol Physiol. 2000 Jan; 278(1):L177-84. PMID: 10645905.
    View in: PubMed
  • Song Y, Ma T, Matthay MA, Verkman AS. Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method. J Gen Physiol. 2000 Jan; 115(1):17-27. PMID: 10613915; PMCID: PMC1887782.
  • Eberhard LW, Morabito DJ, Matthay MA, Mackersie RC, Campbell AR, Marks JD, Alonso JA, Pittet JF. Initial severity of metabolic acidosis predicts the development of acute lung injury in severely traumatized patients. Crit Care Med. 2000 Jan; 28(1):125-31. PMID: 10667511.
    View in: PubMed
  • Ma T, Fukuda N, Song Y, Matthay MA, Verkman AS. Lung fluid transport in aquaporin-5 knockout mice. J Clin Invest. 2000 Jan; 105(1):93-100. PMID: 10619865; PMCID: PMC382590.
  • Abraham E, Matthay MA, Dinarello CA, Vincent JL, Cohen J, Opal SM, Glauser M, Parsons P, Fisher CJ, Repine JE. Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation. Crit Care Med. 2000 Jan; 28(1):232-5. PMID: 10667529.
    View in: PubMed
  • Jasmer RM, Matthay MA. Noninvasive ventilation for acute respiratory failure. J Clin Monit Comput. 2000; 16(5-6):403-8. PMID: 12580223.
    View in: PubMed
  • Kallet RH, Alonso JA, Luce JM, Matthay MA. Exacerbation of acute pulmonary edema during assisted mechanical ventilation using a low-tidal volume, lung-protective ventilator strategy. Chest. 1999 Dec; 116(6):1826-32. PMID: 10593817.
    View in: PubMed
  • Eisner MD, Matthay MA. Health-related quality of life after acute lung injury. Crit Care Med. 1999 Dec; 27(12):2825-6. PMID: 10628634.
    View in: PubMed
  • Wang Y, Folkesson HG, Jayr C, Ware LB, Matthay MA. Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta-agonist therapy. J Appl Physiol (1985). 1999 Nov; 87(5):1852-60. PMID: 10562630.
    View in: PubMed
  • Rubenfeld GD, Caldwell E, Granton J, Hudson LD, Matthay MA. Interobserver variability in applying a radiographic definition for ARDS. Chest. 1999 Nov; 116(5):1347-53. PMID: 10559098.
    View in: PubMed
  • Laffon M, Pittet JF, Modelska K, Matthay MA, Young DM. Interleukin-8 mediates injury from smoke inhalation to both the lung endothelial and the alveolar epithelial barriers in rabbits. Am J Respir Crit Care Med. 1999 Nov; 160(5 Pt 1):1443-9. PMID: 10556103.
    View in: PubMed
  • Modelska K, Pittet JF, Folkesson HG, Courtney Broaddus V, Matthay MA. Acid-induced lung injury. Protective effect of anti-interleukin-8 pretreatment on alveolar epithelial barrier function in rabbits. Am J Respir Crit Care Med. 1999 Nov; 160(5 Pt 1):1450-6. PMID: 10556104.
    View in: PubMed
  • Verghese GM, Ware LB, Matthay BA, Matthay MA. Alveolar epithelial fluid transport and the resolution of clinically severe hydrostatic pulmonary edema. J Appl Physiol (1985). 1999 Oct; 87(4):1301-12. PMID: 10517756.
    View in: PubMed
  • Hribar M, Bloc A, van der Goot FG, Fransen L, De Baetselier P, Grau GE, Bluethmann H, Matthay MA, Dunant Y, Pugin J, Lucas R. The lectin-like domain of tumor necrosis factor-alpha increases membrane conductance in microvascular endothelial cells and peritoneal macrophages. Eur J Immunol. 1999 Oct; 29(10):3105-11. PMID: 10540321.
    View in: PubMed
  • Laffon M, Lu LN, Modelska K, Matthay MA, Pittet JF. alpha-adrenergic blockade restores normal fluid transport capacity of alveolar epithelium after hemorrhagic shock. Am J Physiol. 1999 Oct; 277(4 Pt 1):L760-8. PMID: 10516217.
    View in: PubMed
  • Matthay MA, Geiser T, Matalon S, Ischiropoulos H. Oxidant-mediated lung injury in the acute respiratory distress syndrome. Crit Care Med. 1999 Sep; 27(9):2028-30. PMID: 10507639.
    View in: PubMed
  • Berthiaume Y, Folkesson HG, Matthay MA. Indomethacin does not influence alveolar liquid clearance in anesthetized sheep or rats. Exp Lung Res. 1999 Sep; 25(6):517-30. PMID: 10533677.
    View in: PubMed
  • Conner ER, Ware LB, Modin G, Matthay MA. Elevated pulmonary edema fluid concentrations of soluble intercellular adhesion molecule-1 in patients with acute lung injury: biological and clinical significance. Chest. 1999 Jul; 116(1 Suppl):83S-84S. PMID: 10424604.
    View in: PubMed
  • Wang Y, Jayr C, Folkesson HG, Matthay MA. Alveolar epithelial fluid transport can be upregulated simultaneously in rats by two different mechanisms. Chest. 1999 Jul; 116(1 Suppl):98S-100S. PMID: 10424619.
    View in: PubMed
  • Newman V, Gonzalez R, Matthay M, Dobbs L. HTI56, an integral apical membrane protein of the human alveolar type I cell, is a biochemical marker of acute lung injury. Chest. 1999 Jul; 116(1 Suppl):35S-36S. PMID: 10424584.
    View in: PubMed
  • Khan SU, Salloum J, O'Donovan PB, Mascha EJ, Mehta AC, Matthay MA, Arroliga AC. Acute pulmonary edema after lung transplantation: the pulmonary reimplantation response. Chest. 1999 Jul; 116(1):187-94. PMID: 10424524.
    View in: PubMed
  • Matthay MA. Conference summary: acute lung injury. Chest. 1999 Jul; 116(1 Suppl):119S-126S. PMID: 10424631.
    View in: PubMed
  • Modelska K, Matthay MA, Brown LA, Deutch E, Lu LN, Pittet JF. Inhibition of beta-adrenergic-dependent alveolar epithelial clearance by oxidant mechanisms after hemorrhagic shock. Am J Physiol. 1999 May; 276(5 Pt 1):L844-57. PMID: 10330041.
    View in: PubMed
  • Ware LB, Golden JA, Finkbeiner WE, Matthay MA. Alveolar epithelial fluid transport capacity in reperfusion lung injury after lung transplantation. Am J Respir Crit Care Med. 1999 Mar; 159(3):980-8. PMID: 10051282.
    View in: PubMed
  • Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, Pittet JF, Kaminski N, Garat C, Matthay MA, Rifkin DB, Sheppard D. The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell. 1999 Feb 5; 96(3):319-28. PMID: 10025398.
    View in: PubMed
  • Bai C, Fukuda N, Song Y, Ma T, Matthay MA, Verkman AS. Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. J Clin Invest. 1999 Feb; 103(4):555-61. PMID: 10021464; PMCID: PMC408096.
  • Pugin J, Verghese G, Widmer MC, Matthay MA. The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome. Crit Care Med. 1999 Feb; 27(2):304-12. PMID: 10075054.
    View in: PubMed
  • Planus E, Galiacy S, Matthay M, Laurent V, Gavrilovic J, Murphy G, Clérici C, Isabey D, Lafuma C, d'Ortho MP. Role of collagenase in mediating in vitro alveolar epithelial wound repair. J Cell Sci. 1999 Jan; 112 ( Pt 2):243-52. PMID: 9858477.
    View in: PubMed
  • Sakuma T, Takahashi K, Ohya N, Kajikawa O, Martin TR, Albertine KH, Matthay MA. Ischemia-reperfusion lung injury in rabbits: mechanisms of injury and protection. Am J Physiol. 1999 Jan; 276(1 Pt 1):L137-45. PMID: 9887066.
    View in: PubMed
  • Yang B, Folkesson HG, Yang J, Matthay MA, Ma T, Verkman AS. Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice. Am J Physiol. 1999 Jan; 276(1 Pt 1):C76-81. PMID: 9886922.
    View in: PubMed
  • Campbell AR, Folkesson HG, Berthiaume Y, Gutkowska J, Suzuki S, Matthay MA. Alveolar epithelial fluid clearance persists in the presence of moderate left atrial hypertension in sheep. J Appl Physiol (1985). 1999 Jan; 86(1):139-51. PMID: 9887124.
    View in: PubMed
  • Saint S, Matthay MA. Risk reduction in the intensive care unit. Am J Med. 1998 Dec; 105(6):515-23. PMID: 9870839.
    View in: PubMed
  • Matthay MA, Flori HR, Conner ER, Ware LB. Alveolar epithelial fluid transport: basic mechanisms and clinical relevance. Proc Assoc Am Physicians. 1998 Nov-Dec; 110(6):496-505. PMID: 9824532.
    View in: PubMed
  • DiFederico EM, Burlingame JM, Kilpatrick SJ, Harrison M, Matthay MA. Pulmonary edema in obstetric patients is rapidly resolved except in the presence of infection or of nitroglycerin tocolysis after open fetal surgery. Am J Obstet Gynecol. 1998 Oct; 179(4):925-33. PMID: 9790372.
    View in: PubMed
  • Folkesson HG, Nitenberg G, Oliver BL, Jayr C, Albertine KH, Matthay MA. Upregulation of alveolar epithelial fluid transport after subacute lung injury in rats from bleomycin. Am J Physiol. 1998 Sep; 275(3 Pt 1):L478-90. PMID: 9728042.
    View in: PubMed
  • Verghese GM, McCormick-Shannon K, Mason RJ, Matthay MA. Hepatocyte growth factor and keratinocyte growth factor in the pulmonary edema fluid of patients with acute lung injury. Biologic and clinical significance. Am J Respir Crit Care Med. 1998 Aug; 158(2):386-94. PMID: 9700111.
    View in: PubMed
  • Parsons PE, Matthay M. Protective ventilation for the acute respiratory distress syndrome. N Engl J Med. 1998 Jul 16; 339(3):197; author reply 198-9. PMID: 9669913.
    View in: PubMed
  • Bai C, Biwersi J, Verkman AS, Matthay MA. A mouse model to test the in vivo efficacy of chemical chaperones. J Pharmacol Toxicol Methods. 1998 Jul; 40(1):39-45. PMID: 9920533.
    View in: PubMed
  • Ma T, Yang B, Matthay MA, Verkman AS. Evidence against a role of mouse, rat, and two cloned human t1alpha isoforms as a water channel or a regulator of aquaporin-type water channels. Am J Respir Cell Mol Biol. 1998 Jul; 19(1):143-9. PMID: 9651190.
    View in: PubMed
  • Sakuma T, Takahashi K, Ohya N, Nakada T, Matthay MA. Effects of ATP-sensitive potassium channel opener on potassium transport and alveolar fluid clearance in the resected human lung. Pharmacol Toxicol. 1998 Jul; 83(1):16-22. PMID: 9764421.
    View in: PubMed
  • Garat C, Carter EP, Matthay MA. New in situ mouse model to quantify alveolar epithelial fluid clearance. J Appl Physiol (1985). 1998 May; 84(5):1763-7. PMID: 9572828.
    View in: PubMed
  • Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg R, Suter PM. The American-European Consensus Conference on ARDS, part 2. Ventilatory, pharmacologic, supportive therapy, study design strategies and issues related to recovery and remodeling. Intensive Care Med. 1998 Apr; 24(4):378-98. PMID: 9609420.
    View in: PubMed
  • Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg R, Suter PM. The American-European Consensus Conference on ARDS, part 2: Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory distress syndrome. Am J Respir Crit Care Med. 1998 Apr; 157(4 Pt 1):1332-47. PMID: 9563759.
    View in: PubMed
  • Carter EP, Olveczky BP, Matthay MA, Verkman AS. High microvascular endothelial water permeability in mouse lung measured by a pleural surface fluorescence method. Biophys J. 1998 Apr; 74(4):2121-8. PMID: 9545071; PMCID: PMC1299553.
  • Dobbs LG, Gonzalez R, Matthay MA, Carter EP, Allen L, Verkman AS. Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):2991-6. PMID: 9501203; PMCID: PMC19682.
  • Matthay MA, Pittet JF, Jayr C. Just say NO to inhaled nitric oxide for the acute respiratory distress syndrome. Crit Care Med. 1998 Jan; 26(1):1-2. PMID: 9428528.
    View in: PubMed
  • Chesnutt AN, Matthay MA, Tibayan FA, Clark JG. Early detection of type III procollagen peptide in acute lung injury. Pathogenetic and prognostic significance. Am J Respir Crit Care Med. 1997 Sep; 156(3 Pt 1):840-5. PMID: 9310002.
    View in: PubMed
  • Carter EP, Umenishi F, Matthay MA, Verkman AS. Developmental changes in water permeability across the alveolar barrier in perinatal rabbit lung. J Clin Invest. 1997 Sep 1; 100(5):1071-8. PMID: 9276723; PMCID: PMC508281.
  • Modelska K, Matthay MA, McElroy MC, Pittet JF. Upregulation of alveolar liquid clearance after fluid resuscitation for hemorrhagic shock in rats. Am J Physiol. 1997 Aug; 273(2 Pt 1):L305-14. PMID: 9277441.
    View in: PubMed
  • Tibayan FA, Chesnutt AN, Folkesson HG, Eandi J, Matthay MA. Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation. Am J Respir Crit Care Med. 1997 Aug; 156(2 Pt 1):438-44. PMID: 9279221.
    View in: PubMed
  • Folkesson HG, Matthay MA. Inhibition of CD18 or CD11b attenuates acute lung injury after acid instillation in rabbits. J Appl Physiol (1985). 1997 Jun; 82(6):1743-50. PMID: 9173936.
    View in: PubMed
  • Jasmer RM, Luce JM, Matthay MA. Noninvasive positive pressure ventilation for acute respiratory failure: underutilized or overrated? Chest. 1997 Jun; 111(6):1672-8. PMID: 9187192.
    View in: PubMed
  • Garat C, Meignan M, Matthay MA, Luo DF, Jayr C. Alveolar epithelial fluid clearance mechanisms are intact after moderate hyperoxic lung injury in rats. Chest. 1997 May; 111(5):1381-8. PMID: 9149598.
    View in: PubMed
  • Smith WS, Matthay MA. Evidence for a hydrostatic mechanism in human neurogenic pulmonary edema. Chest. 1997 May; 111(5):1326-33. PMID: 9149590.
    View in: PubMed
  • Oliver BL, Garat C, Pytela R, Matthay MA. Protein tyrosine phosphatases mediate cell readhesion in alveolar epithelial cells mechanically separated from in vitro matrix. Am J Respir Cell Mol Biol. 1997 May; 16(5):613-20. PMID: 9160844.
    View in: PubMed
  • Pittet JF, Mackersie RC, Martin TR, Matthay MA. Biological markers of acute lung injury: prognostic and pathogenetic significance. Am J Respir Crit Care Med. 1997 Apr; 155(4):1187-205. PMID: 9105054.
    View in: PubMed
  • Chesnutt AN, Kheradmand F, Folkesson HG, Alberts M, Matthay MA. Soluble transforming growth factor-alpha is present in the pulmonary edema fluid of patients with acute lung injury. Chest. 1997 Mar; 111(3):652-6. PMID: 9118703.
    View in: PubMed
  • Sakuma T, Folkesson HG, Suzuki S, Okaniwa G, Fujimura S, Matthay MA. Beta-adrenergic agonist stimulated alveolar fluid clearance in ex vivo human and rat lungs. Am J Respir Crit Care Med. 1997 Feb; 155(2):506-12. PMID: 9032186.
    View in: PubMed
  • Rezaiguia S, Garat C, Delclaux C, Meignan M, Fleury J, Legrand P, Matthay MA, Jayr C. Acute bacterial pneumonia in rats increases alveolar epithelial fluid clearance by a tumor necrosis factor-alpha-dependent mechanism. J Clin Invest. 1997 Jan 15; 99(2):325-35. PMID: 9006001; PMCID: PMC507800.
  • Sakuma T, Usuda K, Handa M, Okaniwa G, Nakada T, Fujimura S, Matthay MA. Increased alveolar fluid clearance following thoracotomy: report of a case and results of an analysis. Surg Today. 1997; 27(8):762-5. PMID: 9306595.
    View in: PubMed
  • Umenishi F, Carter EP, Yang B, Oliver B, Matthay MA, Verkman AS. Sharp increase in rat lung water channel expression in the perinatal period. Am J Respir Cell Mol Biol. 1996 Nov; 15(5):673-9. PMID: 8918374.
    View in: PubMed
  • Garat C, Kheradmand F, Albertine KH, Folkesson HG, Matthay MA. Soluble and insoluble fibronectin increases alveolar epithelial wound healing in vitro. Am J Physiol. 1996 Nov; 271(5 Pt 1):L844-53. PMID: 8944729.
    View in: PubMed
  • Kurdowska A, Miller EJ, Noble JM, Baughman RP, Matthay MA, Brelsford WG, Cohen AB. Anti-IL-8 autoantibodies in alveolar fluid from patients with the adult respiratory distress syndrome. J Immunol. 1996 Sep 15; 157(6):2699-706. PMID: 8805676.
    View in: PubMed
  • Miller EJ, Cohen AB, Matthay MA. Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsis. Crit Care Med. 1996 Sep; 24(9):1448-54. PMID: 8797614.
    View in: PubMed
  • Carter EP, Matthay MA, Farinas J, Verkman AS. Transalveolar osmotic and diffusional water permeability in intact mouse lung measured by a novel surface fluorescence method. J Gen Physiol. 1996 Sep; 108(3):133-42. PMID: 8882859; PMCID: PMC2229323.
  • Folkesson HG, Pittet JF, Nitenberg G, Matthay MA. Transforming growth factor-alpha increases alveolar liquid clearance in anesthetized ventilated rats. Am J Physiol. 1996 Aug; 271(2 Pt 1):L236-44. PMID: 8770062.
    View in: PubMed
  • Pittet JF, Brenner TJ, Modelska K, Matthay MA. Alveolar liquid clearance is increased by endogenous catecholamines in hemorrhagic shock in rats. J Appl Physiol (1985). 1996 Aug; 81(2):830-7. PMID: 8872653.
    View in: PubMed
  • Matthay MA, Rosen GD. Acid aspiration induced lung injury. New insights and therapeutic options. Am J Respir Crit Care Med. 1996 Aug; 154(2 Pt 1):277-8. PMID: 8756794.
    View in: PubMed
  • Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 1996 May 30; 334(22):1469-70. PMID: 8618587.
    View in: PubMed
  • Folkesson HG, Matthay MA, Weström BR, Kim KJ, Karlsson BW, Hastings RH. Alveolar epithelial clearance of protein. J Appl Physiol (1985). 1996 May; 80(5):1431-45. PMID: 8727524.
    View in: PubMed
  • Sakuma T, Suzuki S, Usuda K, Handa M, Okaniwa G, Nakada T, Fujimura S, Matthay MA. Preservation of alveolar epithelial fluid transport mechanisms in rewarmed human lung after severe hypothermia. J Appl Physiol (1985). 1996 May; 80(5):1681-6. PMID: 8727555.
    View in: PubMed
  • DiFederico EM, Harrison M, Matthay MA. Pulmonary edema in a woman following fetal surgery. Chest. 1996 Apr; 109(4):1114-7. PMID: 8635343.
    View in: PubMed
  • Matthay MA, Folkesson HG, Verkman AS. Salt and water transport across alveolar and distal airway epithelia in the adult lung. Am J Physiol. 1996 Apr; 270(4 Pt 1):L487-503. PMID: 8928808.
    View in: PubMed
  • Folkesson HG, Matthay MA, Frigeri A, Verkman AS. Transepithelial water permeability in microperfused distal airways. Evidence for channel-mediated water transport. J Clin Invest. 1996 Feb 1; 97(3):664-71. PMID: 8609221; PMCID: PMC507102.
  • Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener-Kronish JP, Locksley RM. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J Exp Med. 1996 Jan 1; 183(1):109-17. PMID: 8551213; PMCID: PMC2192426.
  • Garat C, Rezaiguia S, Meignan M, D'Ortho MP, Harf A, Matthay MA, Jayr C. Alveolar endotoxin increases alveolar liquid clearance in rats. J Appl Physiol (1985). 1995 Dec; 79(6):2021-8. PMID: 8847269.
    View in: PubMed
  • Doyle RL, Szaflarski N, Modin GW, Wiener-Kronish JP, Matthay MA. Identification of patients with acute lung injury. Predictors of mortality. Am J Respir Crit Care Med. 1995 Dec; 152(6 Pt 1):1818-24. PMID: 8520742.
    View in: PubMed
  • Hastings RH, Folkesson HG, Petersen V, Ciriales R, Matthay MA. Cellular uptake of albumin from lungs of anesthetized rabbits. Am J Physiol. 1995 Oct; 269(4 Pt 1):L453-62. PMID: 7485517.
    View in: PubMed
  • Folkesson HG, Matthay MA, Hébert CA, Broaddus VC. Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms. J Clin Invest. 1995 Jul; 96(1):107-16. PMID: 7615779; PMCID: PMC185178.
  • Rubenfeld GD, Doyle RL, Matthay MA. Evaluation of definitions of ARDS. Am J Respir Crit Care Med. 1995 Apr; 151(4):1270-1. PMID: 7697267.
    View in: PubMed
  • Pittet JF, Wiener-Kronish JP, Serikov V, Matthay MA. Resistance of the alveolar epithelium to injury from septic shock in sheep. Am J Respir Crit Care Med. 1995 Apr; 151(4):1093-100. PMID: 7697237.
    View in: PubMed
  • Schwartz DE, Matthay MA, Cohen NH. Death and other complications of emergency airway management in critically ill adults. A prospective investigation of 297 tracheal intubations. Anesthesiology. 1995 Feb; 82(2):367-76. PMID: 7856895.
    View in: PubMed
  • Schnapp LM, Chin DP, Szaflarski N, Matthay MA. Frequency and importance of barotrauma in 100 patients with acute lung injury. Crit Care Med. 1995 Feb; 23(2):272-8. PMID: 7867352.
    View in: PubMed
  • Matthay MA. Fibrosing alveolitis in the adult respiratory distress syndrome. Ann Intern Med. 1995 Jan 1; 122(1):65-6. PMID: 7985899.
    View in: PubMed
  • Kheradmand F, Folkesson HG, Shum L, Derynk R, Pytela R, Matthay MA. Transforming growth factor-alpha enhances alveolar epithelial cell repair in a new in vitro model. Am J Physiol. 1994 Dec; 267(6 Pt 1):L728-38. PMID: 7810677.
    View in: PubMed
  • Folkesson HG, Kheradmand F, Matthay MA. The effect of salt water on alveolar epithelial barrier function. Am J Respir Crit Care Med. 1994 Dec; 150(6 Pt 1):1555-63. PMID: 7952614.
    View in: PubMed
  • Sakuma T, Okaniwa G, Nakada T, Nishimura T, Fujimura S, Matthay MA. Alveolar fluid clearance in the resected human lung. Am J Respir Crit Care Med. 1994 Aug; 150(2):305-10. PMID: 8049807.
    View in: PubMed
  • Pittet JF, Wiener-Kronish JP, McElroy MC, Folkesson HG, Matthay MA. Stimulation of lung epithelial liquid clearance by endogenous release of catecholamines in septic shock in anesthetized rats. J Clin Invest. 1994 Aug; 94(2):663-71. PMID: 8040320; PMCID: PMC296144.
  • Jayr C, Garat C, Meignan M, Pittet JF, Zelter M, Matthay MA. Alveolar liquid and protein clearance in anesthetized ventilated rats. J Appl Physiol (1985). 1994 Jun; 76(6):2636-42. PMID: 7928894.
    View in: PubMed
  • Folkesson HG, Matthay MA, Hasegawa H, Kheradmand F, Verkman AS. Transcellular water transport in lung alveolar epithelium through mercury-sensitive water channels. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):4970-4. PMID: 7515184; PMCID: PMC43911.
  • Hastings RH, Wright JR, Albertine KH, Ciriales R, Matthay MA. Effect of endocytosis inhibitors on alveolar clearance of albumin, immunoglobulin G, and SP-A in rabbits. Am J Physiol. 1994 May; 266(5 Pt 1):L544-52. PMID: 8203547.
    View in: PubMed
  • Matthay MA. Function of the alveolar epithelial barrier under pathologic conditions. Chest. 1994 Mar; 105(3 Suppl):67S-74S. PMID: 8131616.
    View in: PubMed
  • Hasegawa H, Ma T, Skach W, Matthay MA, Verkman AS. Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. J Biol Chem. 1994 Feb 25; 269(8):5497-500. PMID: 7509789.
    View in: PubMed
  • Kelly BJ, Matthay MA. Prevalence and severity of neurologic dysfunction in critically ill patients. Influence on need for continued mechanical ventilation. Chest. 1993 Dec; 104(6):1818-24. PMID: 8252971.
    View in: PubMed
  • Matthay MA, Thiery JP, Lafont F, Stampfer F, Boyer B. Transient effect of epidermal growth factor on the motility of an immortalized mammary epithelial cell line. J Cell Sci. 1993 Nov; 106 ( Pt 3):869-78. PMID: 8308069.
    View in: PubMed
  • Matthay MA, Folkesson HG, Campagna A, Kheradmand F. Alveolar epithelial barrier and acute lung injury. New Horiz. 1993 Nov; 1(4):613-22. PMID: 8087581.
    View in: PubMed
  • Wiener-Kronish JP, Sakuma T, Kudoh I, Pittet JF, Frank D, Dobbs L, Vasil ML, Matthay MA. Alveolar epithelial injury and pleural empyema in acute P. aeruginosa pneumonia in anesthetized rabbits. J Appl Physiol (1985). 1993 Oct; 75(4):1661-9. PMID: 8282618.
    View in: PubMed
  • Pittet JF, Matthay MA, Pier G, Grady M, Wiener-Kronish JP. Pseudomonas aeruginosa-induced lung and pleural injury in sheep. Differential protective effect of circulating versus alveolar immunoglobulin G antibody. J Clin Invest. 1993 Sep; 92(3):1221-8. PMID: 8376581; PMCID: PMC288261.
  • Serikov VB, Grady M, Matthay MA. Effect of temperature on alveolar liquid and protein clearance in an in situ perfused goat lung. J Appl Physiol (1985). 1993 Aug; 75(2):940-7. PMID: 8226499.
    View in: PubMed
  • Cohen AB, Stevens MD, Miller EJ, Atkinson MA, Mullenbach G, Maunder RJ, Martin TR, Wiener-Kronish JP, Matthay MA. Neutrophil-activating peptide-2 in patients with pulmonary edema from congestive heart failure or ARDS. Am J Physiol. 1993 May; 264(5 Pt 1):L490-5. PMID: 8498526.
    View in: PubMed
  • Jayr C, Matthay MA, Goldstone J, Gold WM, Wiener-Kronish JP. Preoperative and intraoperative factors associated with prolonged mechanical ventilation. A study in patients following major abdominal vascular surgery. Chest. 1993 Apr; 103(4):1231-6. PMID: 8131471.
    View in: PubMed
  • Newman W, Beall LD, Carson CW, Hunder GG, Graben N, Randhawa ZI, Gopal TV, Wiener-Kronish J, Matthay MA. Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock. J Immunol. 1993 Jan 15; 150(2):644-54. PMID: 7678280.
    View in: PubMed
  • Sakuma T, Pittet JF, Jayr C, Matthay MA. Alveolar liquid and protein clearance in the absence of blood flow or ventilation in sheep. J Appl Physiol (1985). 1993 Jan; 74(1):176-85. PMID: 7680335.
    View in: PubMed
  • Espiritu RF, Pittet JF, Matthay M, Goetzl EJ. Neuropeptides in pulmonary edema fluid of adult respiratory distress syndrome. Inflammation. 1992 Oct; 16(5):509-17. PMID: 1428125.
    View in: PubMed
  • Hastings RH, Grady M, Sakuma T, Matthay M. Clearance of different-sized proteins from the alveolar space in humans and rabbits. J Appl Physiol (1985). 1992 Oct; 73(4):1310-6. PMID: 1447074.
    View in: PubMed
  • Cohen DS, Matthay M, Cogan MG, Murray JF. Pulmonary edema associated with salt water near-drowning: new insights. Am Rev Respir Dis. 1992 Sep; 146(3):794-6. PMID: 1519866.
    View in: PubMed
  • Segredo V, Caldwell JE, Matthay M, Sharma ML, Gruenke LD, Miller RD. Persistent paralysis in critically ill patients after long-term administration of vecuronium. N Engl J Med. 1992 Aug 20; 327(8):524-8. PMID: 1353252.
    View in: PubMed
  • Miller EJ, Cohen AB, Nagao S, Griffith D, Maunder RJ, Martin TR, Weiner-Kronish JP, Sticherling M, Christophers E, Matthay M. Elevated levels of NAP-1/interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortality. Am Rev Respir Dis. 1992 Aug; 146(2):427-32. PMID: 1489135.
    View in: PubMed
  • Kilpatrick SJ, Matthay M. Obstetric patients requiring critical care. A five-year review. Chest. 1992 May; 101(5):1407-12. PMID: 1582306.
    View in: PubMed
  • Callaham M, Barton C, Matthay M. Effect of epinephrine on the ability of end-tidal carbon dioxide readings to predict initial resuscitation from cardiac arrest. Crit Care Med. 1992 Mar; 20(3):337-43. PMID: 1541094.
    View in: PubMed
  • Jayr C, Matthay M. Alveolar and lung liquid clearance in the absence of pulmonary blood flow in sheep. J Appl Physiol (1985). 1991 Nov; 71(5):1679-87. PMID: 1761463.
    View in: PubMed
  • Wiener-Kronish JP, Albertine KH, Matthay M. Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin. J Clin Invest. 1991 Sep; 88(3):864-75. PMID: 1885774; PMCID: PMC295473.
  • Matthay M, Matthay RA. Critical care medicine. JAMA. 1991 Jun 19; 265(23):3109-11. PMID: 2041115.
    View in: PubMed
  • Smedira N, Gates L, Hastings R, Jayr C, Sakuma T, Pittet JF, Matthay M. Alveolar and lung liquid clearance in anesthetized rabbits. J Appl Physiol (1985). 1991 Apr; 70(4):1827-35. PMID: 2055861.
    View in: PubMed
  • Chatterjee K, Matthay M. Right-heart catheterization is a diagnostic procedure not a therapeutic intervention. J Intensive Care Med. 1991 Mar-Apr; 6(2):101-4. PMID: 10147954.
    View in: PubMed
  • Matthay M. Resolution of pulmonary edema. New insights. West J Med. 1991 Mar; 154(3):315-21. PMID: 2028590; PMCID: PMC1002752.
  • Wiedemann HP, Matthay MA, Gillis CN. Pulmonary endothelial cell injury and altered lung metabolic function. Early detection of the adult respiratory distress syndrome and possible functional significance. Clin Chest Med. 1990 Dec; 11(4):723-36. PMID: 2268998.
    View in: PubMed
  • Matthay M. The adult respiratory distress syndrome. Definition and prognosis. Clin Chest Med. 1990 Dec; 11(4):575-80. PMID: 2268989.
    View in: PubMed
  • Matthay M, Wiener-Kronish JP. Intact epithelial barrier function is critical for the resolution of alveolar edema in humans. Am Rev Respir Dis. 1990 Dec; 142(6 Pt 1):1250-7. PMID: 2252240.
    View in: PubMed
  • Rubin DB, Wiener-Kronish JP, Murray JF, Green DR, Turner J, Luce JM, Montgomery AB, Marks JD, Matthay M. Elevated von Willebrand factor antigen is an early plasma predictor of acute lung injury in nonpulmonary sepsis syndrome. J Clin Invest. 1990 Aug; 86(2):474-80. PMID: 2384595; PMCID: PMC296749.
  • Wiener-Kronish JP, Gropper MA, Matthay M. The adult respiratory distress syndrome: definition and prognosis, pathogenesis and treatment. Br J Anaesth. 1990 Jul; 65(1):107-29. PMID: 2200479.
    View in: PubMed
  • Heffner JE, Matthay M. The case for oxidants in the adult respiratory distress syndrome--"elementary, Dr. Watson". J Lab Clin Med. 1990 Apr; 115(4):394-5. PMID: 2324608.
    View in: PubMed
  • Urbanowicz JH, Shaaban MJ, Cohen NH, Cahalan MK, Botvinick EH, Chatterjee K, Schiller NB, Dae MW, Matthay M. Comparison of transesophageal echocardiographic and scintigraphic estimates of left ventricular end-diastolic volume index and ejection fraction in patients following coronary artery bypass grafting. Anesthesiology. 1990 Apr; 72(4):607-12. PMID: 2321775.
    View in: PubMed
  • Segredo V, Matthay M, Sharma ML, Gruenke LD, Caldwell JE, Miller RD. Prolonged neuromuscular blockade after long-term administration of vecuronium in two critically ill patients. Anesthesiology. 1990 Mar; 72(3):566-70. PMID: 1968730.
    View in: PubMed
  • Brüssel T, Matthay M, Chernow B. Pulmonary manifestations of endocrine and metabolic disorders. Clin Chest Med. 1989 Dec; 10(4):645-53. PMID: 2689069.
    View in: PubMed
  • Berthiaume Y, Albertine KH, Grady M, Fick G, Matthay M. Protein clearance from the air spaces and lungs of unanesthetized sheep over 144 h. J Appl Physiol (1985). 1989 Nov; 67(5):1887-97. PMID: 2600023.
    View in: PubMed
  • Martin TR, Pistorese BP, Chi EY, Goodman RB, Matthay M. Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability. J Clin Invest. 1989 Nov; 84(5):1609-19. PMID: 2553777; PMCID: PMC304027.
  • Matthay M. New modes of mechanical ventilation for ARDS. How should they be evaluated? Chest. 1989 Jun; 95(6):1175-7. PMID: 2721246.
    View in: PubMed
  • Baskin L, Mee S, Matthay M, Carroll PR. Ureteral obstruction caused by vasculitis. J Urol. 1989 Apr; 141(4):933-5. PMID: 2564444.
    View in: PubMed
  • Matthay M, Wiener-Kronish JP. Respiratory management after cardiac surgery. Chest. 1989 Feb; 95(2):424-34. PMID: 2914495.
    View in: PubMed
  • Matthay M. The adult respiratory distress syndrome. New insights into diagnosis, pathophysiology, and treatment. West J Med. 1989 Feb; 150(2):187-94. PMID: 2658327; PMCID: PMC1026332.
  • Hubbard RC, Casolaro MA, Mitchell M, Sellers SE, Arabia F, Matthay M, Crystal RG. Fate of aerosolized recombinant DNA-produced alpha 1-antitrypsin: use of the epithelial surface of the lower respiratory tract to administer proteins of therapeutic importance. Proc Natl Acad Sci U S A. 1989 Jan; 86(2):680-4. PMID: 2783491; PMCID: PMC286537.
  • Matthay M, Chatterjee K. Bedside catheterization of the pulmonary artery: risks compared with benefits. Ann Intern Med. 1988 Nov 15; 109(10):826-34. PMID: 3056159.
    View in: PubMed
  • Wiener-Kronish JP, Broaddus VC, Albertine KH, Gropper MA, Matthay M, Staub NC. Relationship of pleural effusions to increased permeability pulmonary edema in anesthetized sheep. J Clin Invest. 1988 Oct; 82(4):1422-9. PMID: 3170750; PMCID: PMC442700.
  • Murray JF, Matthay M, Luce JM, Flick MR. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis. 1988 Sep; 138(3):720-3. PMID: 3202424.
    View in: PubMed
  • Berthiaume Y, Broaddus VC, Gropper MA, Tanita T, Matthay M. Alveolar liquid and protein clearance from normal dog lungs. J Appl Physiol (1985). 1988 Aug; 65(2):585-93. PMID: 3170409.
    View in: PubMed
  • Aberle DR, Wiener-Kronish JP, Webb WR, Matthay MA. Hydrostatic versus increased permeability pulmonary edema: diagnosis based on radiographic criteria in critically ill patients. Radiology. 1988 Jul; 168(1):73-9. PMID: 3380985.
    View in: PubMed
  • Ratnoff WD, Matthay M, Wong MY, Ito Y, Vu KH, Wiener-Kronish J, Goetzl EJ. Sulfidopeptide-leukotriene peptidases in pulmonary edema fluid from patients with the adult respiratory distress syndrome. J Clin Immunol. 1988 Jul; 8(4):250-8. PMID: 2842367.
    View in: PubMed
  • Wiener-Kronish JP, Matthay MA. Pleural effusions associated with hydrostatic and increased permeability pulmonary edema. Chest. 1988 Apr; 93(4):852-8. PMID: 3349844.
    View in: PubMed
  • Wiener-Kronish JP, Goldstein R, Matthay RA, Biondi JW, Broaddus VC, Chatterjee K, Matthay MA. Lack of association of pleural effusion with chronic pulmonary arterial and right atrial hypertension. Chest. 1987 Dec; 92(6):967-70. PMID: 3677841.
    View in: PubMed
  • Dean NC, Amend WC, Matthay MA. Adult respiratory distress syndrome related to antilymphocyte globulin therapy. Chest. 1987 Apr; 91(4):619-20. PMID: 3549177.
    View in: PubMed
  • Berthiaume Y, Staub NC, Matthay M. Beta-adrenergic agonists increase lung liquid clearance in anesthetized sheep. J Clin Invest. 1987 Feb; 79(2):335-43. PMID: 2879851; PMCID: PMC424066.
  • Biondi JW, Hines RL, Barash PG, Baker CC, Matthay MA, Matthay RA. The adult respiratory distress syndrome. Yale J Biol Med. 1986 Nov-Dec; 59(6):575-97. PMID: 3538681; PMCID: PMC2590207.
  • Curtis JL, Mahlmeister M, Fink JB, Lampe G, Matthay MA, Stulbarg MS. Helium-oxygen gas therapy. Use and availability for the emergency treatment of inoperable airway obstruction. Chest. 1986 Sep; 90(3):455-7. PMID: 3743166.
    View in: PubMed
  • Gates LM, Matthay MA. Central intravascular pressure measurements: when should we believe them? J Thorac Imaging. 1986 Jul; 1(3):52-9. PMID: 3298681.
    View in: PubMed
  • Fein A, Wiener-Kronish JP, Niederman M, Matthay MA. Pathophysiology of the adult respiratory distress syndrome. What have we learned from human studies? Crit Care Clin. 1986 Jul; 2(3):429-53. PMID: 3331557.
    View in: PubMed
  • Hansen RM, Viquerat CE, Matthay MA, Wiener-Kronish JP, DeMarco T, Bahtia S, Marks JD, Botvinick EH, Chatterjee K. Poor correlation between pulmonary arterial wedge pressure and left ventricular end-diastolic volume after coronary artery bypass graft surgery. Anesthesiology. 1986 Jun; 64(6):764-70. PMID: 3487261.
    View in: PubMed
  • Bigby TD, Serota ML, Tierney LM, Matthay M. Clinical spectrum of pulmonary mucormycosis. Chest. 1986 Mar; 89(3):435-9. PMID: 3081299.
    View in: PubMed
  • Broaddus C, Matthay MA. Pulmonary embolism. Guide to diagnosis, treatment, and prevention. Postgrad Med. 1986 Mar; 79(4):333-7, 340-3. PMID: 3952050.
    View in: PubMed
  • Swerdlow BN, Mihm FG, Goetzl EJ, Matthay M. Leukotrienes in pulmonary edema fluid after cardiopulmonary bypass. Anesth Analg. 1986 Mar; 65(3):306-8. PMID: 3006549.
    View in: PubMed
  • Eisendrath SJ, Link N, Matthay M. Intensive care unit: how stressful for physicians? Crit Care Med. 1986 Feb; 14(2):95-8. PMID: 3943330.
    View in: PubMed
  • Wiener-Kronish JP, Matthay MA, Callen PW, Filly RA, Gamsu G, Staub NC. Relationship of pleural effusions to pulmonary hemodynamics in patients with congestive heart failure. Am Rev Respir Dis. 1985 Dec; 132(6):1253-6. PMID: 3907444.
    View in: PubMed
  • Matthay MA. Cellular basis for injury and repair in the adult respiratory distress syndrome. West J Med. 1985 Nov; 143(5):665-7. PMID: 3909644; PMCID: PMC1306449.
  • Matthay MA. Pathophysiology of pulmonary edema. Clin Chest Med. 1985 Sep; 6(3):301-14. PMID: 3907942.
    View in: PubMed
  • Matthay MA. Resolution of pulmonary edema. Mechanisms of liquid, protein, and cellular clearance from the lung. Clin Chest Med. 1985 Sep; 6(3):521-45. PMID: 3907951.
    View in: PubMed
  • Matthay MA, Berthiaume Y, Staub NC. Long-term clearance of liquid and protein from the lungs of unanesthetized sheep. J Appl Physiol (1985). 1985 Sep; 59(3):928-34. PMID: 4055578.
    View in: PubMed
  • Viquerat CE, Hansen RM, Botvinick EH, Dae MW, Wiener-Kronish JP, Matthay MA. Undrained bloody pericardial effusion in the early postoperative period after coronary bypass surgery: a prospective blood pool study. Am Heart J. 1985 Aug; 110(2):335-41. PMID: 3875274.
    View in: PubMed
  • Matthay MA, Eschenbacher WL, Goetzl EJ. Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome. J Clin Immunol. 1984 Nov; 4(6):479-83. PMID: 6511865.
    View in: PubMed
  • Colice GL, Matthay MA, Bass E, Matthay RA. Neurogenic pulmonary edema. Am Rev Respir Dis. 1984 Nov; 130(5):941-8. PMID: 6388446.
    View in: PubMed
  • Weinberg PF, Matthay MA, Webster RO, Roskos KV, Goldstein IM, Murray JF. Biologically active products of complement and acute lung injury in patients with the sepsis syndrome. Am Rev Respir Dis. 1984 Nov; 130(5):791-6. PMID: 6497161.
    View in: PubMed
  • Bongard FS, Matthay M, Mackersie RC, Lewis FR. Morphologic and physiologic correlates of increased extravascular lung water. Surgery. 1984 Aug; 96(2):395-403. PMID: 6463867.
    View in: PubMed
  • Wiedemann HP, Matthay MA, Matthay RA. Cardiovascular-pulmonary monitoring in the intensive care unit (Part 2). Chest. 1984 May; 85(5):656-68. PMID: 6713975.
    View in: PubMed
  • Wiedemann HP, Matthay MA, Matthay RA. Cardiovascular-pulmonary monitoring in the intensive care unit (Part 1). Chest. 1984 Apr; 85(4):537-49. PMID: 6368142.
    View in: PubMed
  • Prewitt RM, Matthay MA, Ghignone M. Hemodynamic management in the adult respiratory distress syndrome. Clin Chest Med. 1983 May; 4(2):251-68. PMID: 6342923.
    View in: PubMed
  • Matthay MA. Invasive hemodynamic monitoring in critically ill patients. Clin Chest Med. 1983 May; 4(2):233-49. PMID: 6342922.
    View in: PubMed
  • Eisendrath SJ, Matthay MA, Dunkel JA, Zimmerman JK, Layzer RB. Guillain-Barré syndrome: psychosocial aspects of management. Psychosomatics. 1983 May; 24(5):465-75. PMID: 6878601.
    View in: PubMed
  • Landolt CC, Matthay MA, Albertine KH, Roos PJ, Wiener-Kronish JP, Staub NC. Overperfusion, hypoxia, and increased pressure cause only hydrostatic pulmonary edema in anesthetized sheep. Circ Res. 1983 Mar; 52(3):335-41. PMID: 6825224.
    View in: PubMed
  • Matthay MA, Landolt CC, Staub NC. Differential liquid and protein clearance from the alveoli of anesthetized sheep. J Appl Physiol Respir Environ Exerc Physiol. 1982 Jul; 53(1):96-104. PMID: 7118651.
    View in: PubMed
  • Russell J, Follansbee S, Matthay M. Adult respiratory distress syndrome complicating diabetic ketoacidosis. West J Med. 1981 Aug; 135(2):148-50. PMID: 6792789; PMCID: PMC1273047.
  • Landolt CC, Matthay MA, Staub NC. Anatomic variations of efferent duct from caudal mediastinal lymph node in sheep. J Appl Physiol Respir Environ Exerc Physiol. 1981 Jun; 50(6):1372-4. PMID: 7263401.
    View in: PubMed
  • Matthay M, Addison TE, Ellinger G, Choy SH, Kaltreider HB. Chest mass with pleurisy. Chest. 1979 Oct; 76(4):453-4. PMID: 477435.
    View in: PubMed
  • Zwillich CW, Matthay M, Potts DE, Adler R, Hofeldt F, Weil JV. Thyrotoxicosis: comparison of effects of thyroid ablation and beta-adrenergic blockade on metabolic rate and ventilatory control. J Clin Endocrinol Metab. 1978 Mar; 46(3):491-500. PMID: 221522.
    View in: PubMed
  • Matthay M, Lindamood M, Steigerwald JC, Solomons C. Acute pseudogout in the absence of synovial fluid Leukocytes. J Rheumatol. 1977; 4(3):303-6. PMID: 926107.
    View in: PubMed
  • Matthay M, Matthay RA, Mills DM, Lakshminarayan S, Cotton E. Hypertrophic osteoarthropathy in adults with cystic fibrosis. Thorax. 1976 Oct; 31(5):572-5. PMID: 996819; PMCID: PMC470477.
  • Matthay RA, Matthay M, Weinberger MM. Grand mal seizure induced by oral theophylline. Thorax. 1976 Aug; 31(4):470-1. PMID: 823660; PMCID: PMC470462.
  • Michael's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    
    
    
     4/form>